Genes differentially regulated by NKX2-3 in B cells between ulcerative colitis and Crohn's disease patients and possible involvement of EGR1

Inflammation

Volumn 35, Issue 3, 2012, Pages 889-899

  Yu, Wei ^a   Lin, Zhenwu ^a,c   Hegarty, John P ^a   Chen, Xi ^b   Kelly, Ashley A ^a   Wang, Yunhua ^a   Poritz, Lisa S ^a   Koltun, Walter A ^a,c  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

Author keywords

cDNA microarray; EGR1; Gene regulation; NKX2 3; UC

Indexed keywords

EARLY GROWTH RESPONSE FACTOR 1; MESSENGER RNA;

ARTICLE; B LYMPHOCYTE; CELL GROWTH; CLINICAL ARTICLE; CONTROLLED STUDY; CROHN DISEASE; DNA MICROARRAY; DOWN REGULATION; EGR1 GENE; GENE; GENE CONTROL; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; INFLAMMATION; NKX2-3 GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ULCERATIVE COLITIS; UPREGULATION;

B-LYMPHOCYTES; CELL LINE; COLITIS, ULCERATIVE; CROHN DISEASE; DOWN-REGULATION; EARLY GROWTH RESPONSE PROTEIN 1; FEMALE; GENE EXPRESSION REGULATION; HOMEODOMAIN PROTEINS; HUMANS; INTESTINES; MALE; MIDDLE AGED; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 84863798199     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-011-9390-9     Document Type: Article

References (39)

1. Burczynski, M.E., R.L. Peterson, N.C. Twine, K.A. Zuberek, B.J. Brodeur, L. Casciotti, V. Maganti, P.S. Reddy, A. Strahs, F. Immermann, W. Spinelli, U. Schwertschlag, A.M. Slager, M.M. Cotreau, and A.J. Dorner. 2006. Molecular classification of Crohn's disease and ulcerative colitis patients using transcriptional profiles in peripheral blood mononuclear cells. Journal of Molecular Diagnostics 8: 51-61. (Pubitemid 43257434)
2. Costello, C.M., N. Mah, R. Hasler, P. Rosenstiel, G.H. Waetzig, A. Hahn, T. Lu, Y. Gurbuz, S. Nikolaus, M. Albrecht, J. Hampe, R. Lucius, G. Kloppel, H. Eickhoff, H. Lehrach, T. Lengauer, and S. Schreiber. 2005. Dissection of the inflammatory bowel disease transcriptome using genome-wide cDNA microarrays. PLoS Medicine 2: e199.
3. Cho, J.H. 2008. The genetics and immunopathogenesis of inflammatory bowel disease. Nature Reviews Immunology 8: 458-466. (Pubitemid 351733422)
4. WTCCC. 2007. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447: 661-678.
5. Franke, A., T. Balschun, T.H. Karlsen, J. Hedderich, S. May, T. Lu, D. Schuldt, S. Nikolaus, P. Rosenstiel, M. Krawczak, and S. Schreiber. 2008. Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. Nature Genetics 40: 713-715. (Pubitemid 351748866)
6. Buchberger, A., O. Pabst, T. Brand, K. Seidl, and H.H. Arnold. 1996. Chick NKx-2.3 represents a novel family member of vertebrate homologues to the Drosophila homeobox gene tinman: Differential expression of cNKx-2.3 and cNKx-2.5 during heart and gut development. Mechanisms of Development 56: 151-163. (Pubitemid 26182628)
7. Fu, Y., W. Yan, T.J. Mohun, and S.M. Evans. 1998. Vertebrate tinman homologues XNKX2-3 and XNkx2-5 are required for heart formation in a functionally redundant manner. Development 125: 4439-4449. (Pubitemid 28564288)
8. Pabst, O., R. Forster, M. Lipp, H. Engel, and H.H. Arnold. 2000. NKX2.3 is required for MAdCAM-1 expression and homing of lymphocytes in spleen and mucosa-associated lymphoid tissue. The EMBO Journal 19: 2015-2023. (Pubitemid 30237577)
9. Wang, C.C., C. Biben, L. Robb, F. Nassir, L. Barnett, N.O. Davidson, F. Koentgen, D. Tarlinton, and R.P. Harvey. 2000. Homeodomain factor NKX2-3 controls regional expression of leukocyte homing coreceptor MAdCAM-1 in specialized endothelial cells of the viscera. Developmental Biology 224: 152-167. (Pubitemid 30661001)
10. Yu, W., Z. Lin, A.A. Kelly, J.P. Hegarty, L.S. Poritz, Y. Wang, T. Li, S. Schreiber, and W.A. Koltun. 2009. Association of a NKX2-3 polymorphism with Crohn's disease and expression of Nkx2-3 is up-regulated in B cell lines and intestinal tissues with Crohn's disease. Journal of Crohn's & Colitis 3: 189-195.
11. Yu, W., Z. Lin, J.P. Hegarty, G. John, X. Chen, P.W. Faber, A.A. Kelly, Y. Wang, L.S. Poritz, S. Schreiber, and W.A. Koltun. 2010. Genes regulated by Nkx2-3 in siRNA-mediated knockdown B cells: implication of endothelin-1 in inflammatory bowel disease. Molecular Genetics and Metabolism 100: 88-95.
12. Yu, W., J.P. Hegarty, A. Berg, X. Chen, G. West, A.A. Kelly, Y. Wang, L.S. Poritz, W.A. Koltun, and Z. Lin. 2011. NKX2-3 transcriptional regulation of endothelin-1 and VEGF signaling in human intestinal microvascular endothelial cells. PloS One 6: e20454.
13. Yu, W., Z. Lin, D.M. Pastor, J.P. Hegarty, X. Chen, A.A. Kelly, Y. Wang, L.S. Poritz, and W.A. Koltun. 2010. Genes regulated by Nkx2-3 in sporadic and inflammatory bowel disease-associated colorectal cancer cell lines. Digestive Diseases and Sciences 55: 3171-3180.
14. Smyth, G.K., J. Michaud, and H.S. Scott. 2005. Use of within-array replicate spots for assessing differential expression in microarray experiments. Bioinformatics 21: 2067-2075. (Pubitemid 40668046)
15. Gashler, A., and V.P. Sukhatme. 1995. Early growth response protein 1 (Egr-1): Prototype of a zinc-finger family of transcription factors. Progress in Nucleic Acid Research and Molecular Biology 50: 191-224.
16. McMahon, S.B., and J.G. Monroe. 1996. The role of early growth response gene 1 (egr-1) in regulation of the immune response. Journal of Leukocyte Biology 60: 159-166. (Pubitemid 26300998)
17. Pritchard, M.T., and L.E. Nagy. 2005. Ethanol-induced liver injury: Potential roles for egr-1. Alcoholism, Clinical and Experimental Research 29: 146S-150S. (Pubitemid 43194342)
18. Subbaramaiah, K., K. Yoshimatsu, E. Scherl, K.M. Das, K.D. Glazier, D. Golijanin, R.A. Soslow, T. Tanabe, H. Naraba, and A.J. Dannenberg. 2004. Microsomal prostaglandin E synthase-1 is overexpressed in inflammatory bowel disease. Evidence for involvement of the transcription factor Egr-1. Journal of Biological Chemistry 279: 12647-12658. (Pubitemid 38445836)
19. Brandtzaeg, P. 2007. Induction of secretory immunity and memory at mucosal surfaces. Vaccine 25: 5467-5484. (Pubitemid 47031365)
20. Takahasi, F., H.S. Shah, L.S. Wise, and K.M. Das. 1990. Circulating antibodies against human colonic extract enriched with a 40 kDa protein in patients with ulcerative colitis. Gut 31: 1016-1020. (Pubitemid 20295937)
21. Baggiolini, M. 1998. Chemokines and leukocyte traffic. Nature 392: 565-568. (Pubitemid 28207705)
22. Schall, T.J., J. Jongstra, B.J. Dyer, J. Jorgensen, C. Clayberger, M. M. Davis, and A.M. Krensky. 1988. A human T cell-specific molecule is a member of a new gene family. The Journal of Immunology 141: 1018-1025.
23. McCormack, G., D. Moriarty, D.P. O'Donoghue, P.A. McCormick, K. Sheahan, and A.W. Baird. 2001. Tissue cytokine and chemokine expression in inflammatory bowel disease. Inflammation Research 50: 491-495. (Pubitemid 32999710)
24. Morteau, O., I. Castagliuolo, A. Mykoniatis, J. Zacks, M. Wlk, B. Lu, C. Pothoulakis, N.P. Gerard, and C. Gerard. 2002. Genetic deficiency in the chemokine receptor CCR1 protects against acute Clostridium difficile toxin A enteritis in mice. Gastroenterology 122: 725-733. (Pubitemid 34173824)
25. Banks, C., A. Bateman, R. Payne, P. Johnson, and N. Sheron. 2003. Chemokine expression in IBD. Mucosal chemokine expression is unselectively increased in both ulcerative colitis and Crohn's disease. The Journal of Pathology 199: 28-35. (Pubitemid 36054726)
26. Vainer, B., O.H. Nielsen, and T. Horn. 1998. Expression of Eselectin, sialyl Lewis X, and macrophage inflammatory protein-1alpha by colonic epithelial cells in ulcerative colitis. Digestive Diseases and Sciences 43: 596-608. (Pubitemid 28155583)
27. Taquet, N., S. Dumont, J.L. Vonesch, D. Hentsch, J.M. Reimund, and C.D. Muller. 2009. Differential between protein and mRNA expression of CCR7 and SSTR5 receptors in Crohn's disease patients. Mediators Inflamm 2009: 285812.
28. Heidemann, J., H. Ogawa, P. Rafiee, N. Lugering, C. Maaser, W. Domschke, D.G. Binion, and M.B. Dwinell. 2004. Mucosal angiogenesis regulation by CXCR4 and its ligand CXCL12 expressed by human intestinal microvascular endothelial cells. American Journal of Physiology. Gastrointestinal and Liver Physiology 286: G1059-1068. (Pubitemid 38715670)
29. Luo, Y., J. Lathia, M. Mughal, and M.P. Mattson. 2008. SDF1alpha/CXCR4 signaling, via ERKs and the transcription factor Egr1, induces expression of a 67-kDa form of glutamic acid decarboxylase in embryonic hippocampal neurons. Journal of Biological Chemistry 283: 24789-24800.
30. Thiel, G., and G. Cibelli. 2002. Regulation of life and death by the zinc finger transcription factor Egr-1. Journal of Cellular Physiology 193: 287-292.
31. Yan, S.F., N. Mackman, W. Kisiel, D.M. Stern, and D.J. Pinsky. 1999. Hypoxia/Hypoxemia-Induced activation of the procoagulant pathways and the pathogenesis of ischemia-associated thrombosis. Arteriosclerosis, Thrombosis, and Vascular Biology 19: 2029-2035.
32. Yan, S.F., T. Fujita, J. Lu, K. Okada, Y. Shan Zou, N. Mackman, D.J. Pinsky, and D.M. Stern. 2000. Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress. Nature Medicine 6: 1355-1361. (Pubitemid 32001019)
33. Schmidt, J., B. Stoffels, B.A. Moore, R.S. Chanthaphavong, A.R. Mazie, B.M. Buchholz, and A.J. Bauer. 2008. Proinflammatory role of leukocyte-derived Egr-1 in the development of murine postoperative ileus. Gastroenterology 135: 926-936. 936 e1-2.
34. Saadane, N., L. Alpert, and L.E. Chalifour. 2000. Altered molecular response to adrenoreceptor-induced cardiac hypertrophy in Egr-1-deficient mice. American Journal of Physiology. Heart and Circulatory Physiology 278: H796-805. (Pubitemid 30152536)
35. Hemish, J., N. Nakaya, V. Mittal, and G. Enikolopov. 2003. Nitric oxide activates diverse signaling pathways to regulate gene expression. Journal of Biological Chemistry 278: 42321-42329. (Pubitemid 37310501)
36. Chiu, J.J., B.S. Wung, H.J. Hsieh, L.W. Lo, and D.L. Wang. 1999. Nitric oxide regulates shear stress-induced early growth response-1. Expression via the extracellular signal-regulated kinase pathway in endothelial cells. Circulation Research 85: 238-246. (Pubitemid 29377295)
37. Cross, R.K., and K.T. Wilson. 2003. Nitric oxide in inflammatory bowel disease. Inflammatory Bowel Diseases 9: 179-89. (Pubitemid 36592449)
38. Pabst, O., R. Zweigerdt, and H.H. Arnold. 1999. Targeted disruption of the homeobox transcription factor Nkx2-3 in mice results in postnatal lethality and abnormal development of small intestine and spleen. Development 126: 2215-2225. (Pubitemid 29271706)
39. Lees, C.W., J.C. Barrett, M. Parkes, and J. Satsangi. 2011. New IBD genetics: common pathways with other diseases. Gut (in press).