Hypoxia/hypoxemia-induced activation of the procoagulant pathways and the pathogenesis of ischemia-associated thrombosis

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 19, Issue 9, 1999, Pages 2029-2035

  Yan, Shi Fang ^a   Mackman, Nigel ^b   Kisiel, Walter ^a   Stern, David M ^a   Pinsky, David J ^a  

^a Columbia University ^*  (United States)

^b BURNHAM INSTITUTE   (United States)

Author keywords

Egr 1; Hypoxia; Ischemia; PAI 1; Tissue factor

Indexed keywords

FIBRIN; OXYGEN; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROCOAGULANT; THROMBOPLASTIN; TRANSCRIPTION FACTOR;

FIBRIN DEPOSITION; HUMAN; HYPOXEMIA; HYPOXIA; ISCHEMIA; MONONUCLEAR PHAGOCYTE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; THROMBOSIS; TRANSCRIPTION REGULATION; VASCULAR SMOOTH MUSCLE;

EID: 0032828231     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.19.9.2029     Document Type: Review

References (41)

1. Virchow R. Gessamelte Abhandlungen zur Wissenschaftlichen Medicin. Frankfurt: A M Von Meidinger Sohn; 1856:525-520.
2. 2 in venous valve pockets: Its possible bearing on thrombogenesis. Br J Surg. 1981;68:166-170.
3. Malone P. A hypothesis concerning the aetiology of venous thrombosis. Med Hypothesis. 1991;5:189-201.
4. Malone PC, Morris CJ. The sequestration and margination of platelets and leukocytes in veins during conditions of hypokinetic and anaemic hypoxia: Potential significance in clinical postoperative venous thrombosis. J Pathol. 1978;125:119-129.
5. Millet J, Vaillot M, Theveniaux J, Brown NL. Experimental venous thrombosis induced by homologous serum in the rat. Thromb Res. 1996; 81:497-502.
6. Bara L, Bloch MF, Samama MM. A comparative study of recombinant hirudin and standard heparin in the Wessler model. Thromb Res. 1992; 68:167-174.
7. Folkman J. Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis. N Engl J Med. 1995; 333:1757-1763.
8. Zhang Y, Deng Y, Wendt T, Liliensiek B, Bierhaus A, Greten J, He W, Hach-Wunderle V, Waldherr R, Ziegler R, Mannel D, Stern DM, Nawroth PP. Intravenous somatic gene transfer with antisense tissue factor restores blood flow by reducing tumor necrosis factor-induced tissue factor expression and fibrin deposition in mouse meth-A sarcoma. J Clin Invest. 1996;97:2213-2224.
9. Hamer JD, Malone PC. Experimental deep venous thrombogenesis by a non-invasive method. Ann R Coll Surg Engl. 1984;66:416-419.
10. Lewis DM, Bradwell AR, Shore AC, Beaman M, Tooke JE. Capillary filtration coefficient and urinary albumin leak at altitude. Eur J Clin Invest. 1997;27:64-68.
11. Hultgren HN. High-altitude pulmonary edema: Current concepts. Annu Rev Med. 1996;47:267-284.
12. Severinghaus JW. Hypothetical roles of angiogenesis, osmotic swelling, and ischemia in high-altitude cerebral edema. J Appl Physiol. 1995;79: 375-379.
13. Johnson TS, Rock PB. Current concepts. Acute mountain sickness. N Engl J Med. 1988;319:841-845.
14. Krakauer J. Into Thin Air: A Personal Account of the Mount Everest Disaster. New York: Anchor Books; 1997.
15. Pinsky DJ, Naka Y, Liao H, Oz MC, Wagner DD, Mayadas TN, Johnson RC, Hynes RO, Heath M, Lawson CA, Stern DM. Hypoxia-induced exocytosis of endothelial cell Weibel-Palade bodies. A mechanism for rapid neutrophil recruitment after cardiac preservation. J Clin Invest. 1996;97:493-500.
16. Weiler-Guettler H, Christie PD, Beeler DL, Healy AM, Hancock WW, Rayburn H, Edelberg JM, Rosenberg RD. A targeted point mutation in thrombomodulin generates viable mice with a prethrombotic state. J Clin Invest. 1998;101:1983-1991.
17. Healy AM, Hancock WW, Christie PD, Rayburn HB, Rosenberg RD. Intravascular coagulation activation in a murine model of thrombo-modulin deficiency: Effects of lesion size, age, and hypoxia on fibrin deposition. Blood. 1998;92:4188-4197.
18. Lawson CA, Yan S-D, Yan S-F, Liao H, Chen G, Sobel J, Kisiel W, Stern DM, Pinsky DJ. Monocytes and tissue factor promote thrombosis in a murine model of oxygen deprivation. J Clin Invest. 1997;99:1729-1738.
19. Shreeniwas R, Koga S, Karakurum M, Pinsky D, Kaiser E, Brett J, Wolitzky BA, Norton C, Plocinski J, Benjamin W, Burns DK, Goldstein A, Stern D. Hypoxia-mediated induction of endothelial cell interleukin-1a. An autocrine mechanism promoting expression of leukocyte adhesion molecules on the vessel surface. J Clin Invest. 1992;90: 2333-2339.
20. Yan S-F, Zou YS, Gao Y, Zhai C, Mackman N, Lee SL, Milbrandt J, Pinsky D, Kisiel W, Stern D. Tissue factor transcription driven by Egr-1 is a critical mechanism of murine pulmonary fibrin deposition in hypoxia. Proc Natl Acad Sci U S A. 1998;95:8298-8303.
21. Parry GC, Erlich JH, Carmeliet P, Luther T, Mackman N. Low levels of tissue factor are compatible with development and hemostasis in mice. J Clin Invest. 1998;101:560-569.
22. Khachigian LM, Lindner V, Williams AJ, Collins T. Egr-1-induced endothelial gene expression: A common theme in vascular injury. Science. 1996;271:1427-1431.
23. Khachigian LM, Williams AJ, Collins T. Interplay of Sp1 and Egr-1 in the proximal platelet-derived growth factor A-chain promoter in cultured vascular endothelial cells. J Biol Chem. 1995;270:27679-27686.
24. Yan S-F, Gao Y, Zhai C, Stern DM. Hypoxia-triggered signal transduction mechanisms underlying induction of tissue factor. Circulation. 1998;98:I-40.
25. Ogawa S, Shreeniwas R, Brett J, Clauss M, Furie M, Stern DM. The effect of hypoxia on capillary endothelial cell function: modulation of barrier and coagulant function. Br J Haematol. 1990;75:517-524.
26. Pinsky DJ, Liao H, Lawson CA, Yan S-F, Chen J, Carmeliet P, Loskutoff DJ, Stern DM. Coordinated induction of plasminogen activator inhibitor-1 (PAI-1) and inhibition of plasminogen activator gene expression by hypoxia promotes pulmonary vascular fibrin deposition. J Clin Invest. 1998;102:919-928.
27. Firth JD, Ebert BL, Ratcliffe PJ. Hypoxic regulation of lactate dehydrogenase A. Interaction between hypoxia-inducible factor 1 and cAMP response elements. J Biol Chem. 1995;270:21021-21027.
28. Semenza GL, Roth PH, Fang HM, Wang GL. Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J Biol Chem. 1994;269:23757-23763.
29. Firth JD, Ebert BL, Pugh CW, Ratcliffe PJ. Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: Similarities with the erythropoietin 3′ enhancer. Proc Natl Acad Sci U S A. 1994;91:6496-6500.
30. Iyer NV, Kotch LE, Agani F, Leung SW, Laughner E, Wenger RH, Gearhart JD, Lawler AM, Yu AY, Semenza GL. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev. 1998;12:149-162.
31. Rupee RA, Baeuerle PA. The genomic response of tumor cells to hypoxia and reoxygenation. Differential activation of transcription factors AP-1 and NF-kappa B. Eur J Biochem. 1995;234:632-640.
32. Kerppola TK, Curran T. Maf and Nrl can bind to AP-1 sites and form heterodimers with Fos and Jun. Oncogene. 1994;9:675-684.
33. Okuno H, Akahori A, Sato H, Xanthoudakis S, Curran T, Iba H. Escape from redox regulation enhances the transforming activity of Fos. Oncogene. 1993;8:695-701.
34. Abate C, Curran T. Encounters with Fos and Jun on the road to AP-1. Semin Cancer Biol. 1990;1:19-26.
35. Karakurum M, Shreeniwas R, Chen J, Pinsky D, Yan SD, Anderson M, Sunouchi K, Major J, Hamilton T, Kuwabara K, et al. Hypoxic induction of interleukin-8 gene expression in human endothelial cells. J Clin Invest. 1994;93:1564-1570.
36. Krishnaraju K, Nguyen HQ, Liebermann DA, Hoffman B. The zinc finger transcription factor Egr-1 potentiates macrophage differentiation of hematopoietic cells. Mol Cell Biol. 1995;15:5499-5507.
37. Lee SL, Wang Y, Milbrandt J. Unimpaired macrophage differentiation and activation in mice lacking the zinc finger transplantation factor NGFI-A (EGR1). Mol Cell Biol. 1996;16:4566-4572.
38. Khachigian LM, Collins T. Inducible expression of Egr-1-dependent genes. A paradigm of transcriptional activation in vascular endothelium. Circ Res. 1997;81:457-461.
39. Schecter AD, Giesen PL, Taby O, Rosenfield CL, Rossikhina M, Fyfe BSK, Fallon JT, Nemerson Y, Taubman MB. Tissue factor expression in human arterial smooth muscle cells. TF is present in three cellular pools after growth factor stimulation. J Clin Invest. 1997;100: 2276-2285.
40. Schecter AD, Rollins BJ, Zhang YJ, Charo IF, Fallon JT, Rossikhina MG, Nemerson Y, Taubman MB. Tissue factor is induced by monocyte chemoattractant protein-1 in human aortic smooth muscle and THP-1 cells. J Biol Chem. 1997;272:28568-28573.
41. Lee S-H, Starky PM, Gordon S. Quantitative analysis of total macrophage content in adult mouse tissues. J Exp Med. 1985;161:475-489.