Hypoxia response in asthma: Differential modulation on inflammation and epithelial injury

American Journal of Respiratory Cell and Molecular Biology

Volumn 47, Issue 1, 2012, Pages 1-10

  Ahmad, Tanveer ^a   Kumar, Manish ^a   Mabalirajan, Ulaganathan ^a   Pattnaik, Bijay ^a   Aggarwal, Shilpi ^a   Singh, Ranjana ^a   Singh, Suchita ^a   Mukerji, Mitali ^a   Ghosh, Balaram ^a   Agrawal, Anurag ^a  

^a CSIR INSTITUTE OF GENOMICS AND INTEGRATIVE BIOLOGY   (India)

Author keywords

Apoptosis; HIF 1 ; Hypoxia; PHD2

Indexed keywords

CHEMOKINE RECEPTOR CX3CR1; ENZYME INHIBITOR; ETHYL 3 4 DIHYDROXYBENZOIC ACID; HYDROLASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PROLYLHYDROXYLASE 2; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

AIRWAY REMODELING; ALLERGIC ASTHMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASPHYXIA; ASTHMA; BRONCHUS MUCOSA; CELL COMPARTMENTALIZATION; CELL DAMAGE; CONTROLLED STUDY; DISEASE EXACERBATION; ENZYME INHIBITION; EPITHELIUM CELL; HYPOXIA; LUNG ALVEOLUS EPITHELIUM; MALE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PHENOTYPE; PNEUMONIA; PROTEIN FUNCTION; RESPIRATORY TRACT ALLERGY; UPREGULATION;

AIRWAY REMODELING; ANIMALS; APOPTOSIS; ASTHMA; CELL HYPOXIA; HYDROXYBENZOATES; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INFLAMMATION; LUNG; MALE; METHACHOLINE CHLORIDE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PROCOLLAGEN-PROLINE DIOXYGENASE; RECEPTORS, CHEMOKINE; RESPIRATORY MUCOSA; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

MUS;

EID: 84863794783     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2011-0203OC     Document Type: Article

References (34)

1. Aerts JG, Amelink A, van der Leest C, Hegmans JP, Hemmes A, den Hamer B, Sterenborg HC, Hoogsteden HC, Lambrecht BN. HIF1a expression in bronchial biopsies correlates with tumor microvascular saturation determined using optical spectroscopy. Lung Cancer 2007; 57:317-321. (Pubitemid 47285423)
2. Polosukhin VV, Lawson WE, Milstone AP, Egunova SM, Kulipanov AG, Tchuvakin SG, Massion PP, Blackwell TS. Association of progressive structural changes in the bronchial epithelium with subepithelial fibrous remodeling: a potential role for hypoxia. Virchows Arch 2007;451:793-803. (Pubitemid 47497941)
3. Eltzschig HK, Carmeliet P. Hypoxia and Inflammation. N Engl J Med 2011;364:656-665.
4. Warner TD, Mitchell JA. HIF, stretching to get control of VEGF. Clin Sci 2003;105:393-394. (Pubitemid 37249162)
5. Ng I, Tan WL, Ng PY, Lim J. Hypoxia inducible factor-1alpha and expression of vascular endothelial growth factor and its receptors in cerebral arteriovenous malformations. J Clin Neurosci 2005;12:794-799. (Pubitemid 41411889)
6. Ueno M, Maeno T, Nomura M, Aoyagi-Ikeda K, Matsui H, Hara K, Tanaka T, Iso T, Suga T, Kurabayashi M. Hypoxia-inducible factor-1 {alpha} mediates TGF-{beta}-induced PAI-1 production in alveolar macrophages in pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 2011;300:L740-L752.
7. Halberg N, Khan T, Trujillo ME, Wernstedt-Asterholm I, Attie AD, Sherwani S, Wang ZV, Landskroner-Eiger S, Dineen S, Magalang UJ, et al. Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue. Mol Cell Biol 2009;29:4467-4483.
8. Krick S, Hanze J, Eul B, Savai R, Seay U, Grimminger F, Lohmeyer J, Klepetko W, Seeger W, Rose F. Hypoxia-driven proliferation of human pulmonary artery fibroblasts: cross-talk between HIF-1alpha and an autocrine angiotensin system. FASEB J 2005;19:857-859. (Pubitemid 40617408)
9. Saini Y, Kim KY, Lewandowski R, Bramble LA, Harkema JR, LaPres JJ. Role of hypoxia-inducible factor 1a in modulating cobalt-induced lung inflammation. Am J Physiol Lung Cell Mol Physiol 2010;298:L139-L147.
10. Edvardsen A, Akero A, Hardie JA, Ryg M, Eagan TM, Skjonsberg OH, Skjønsberg OH, Bakke PS. High prevalence of respiratory symptoms during air travel in patients with COPD. Respir Med 2011;105:50-56.
11. Semenza GL. Hypoxia-inducible factor 1 (HIF-1) pathway. Sci STKE 2007(407):cm8.
12. Simon MC, Keith B. The role of oxygen availability in embryonic development and stem cell function. Nat Rev Mol Cell Biol 2008;9:285-296. (Pubitemid 351430845)
13. Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 2001;107:43-54. (Pubitemid 32972036)
14. Aggarwal S, Negi S, Jha P, Singh PK, Stobdan T, Pasha MA, Ghosh S, Agrawal A; Indian Genome Variation Consortium, Prasher B, Mukerji M. EGLN1 involvement in high-altitude adaptation revealed through genetic analysis of extreme constitution types defined in Ayurveda. Proc Natl Acad Sci USA 2010;107:18961-18966.
15. Simonson TS, Yang Y, Huff CD, Yun H, Qin G, Witherspoon DJ, Bai Z, Lorenzo FR, Xing J, Jorde LB, et al. Genetic evidence for high-altitude adaptation in Tibet. Science 2010;329:72-75.
16. Mabalirajan U, Ahmad T, Leishangthem GD, Joseph DA, Dinda AK, Agrawal A, Ghosh B. Beneficial effects of high dose of L-arginine on airway hyperresponsiveness and airway inflammation in a murine model of asthma. J Allergy Clin Immunol 2010;125:626-635.
17. Ahmad T, Mabalirajan U, Sharma A, Aich J, Makhija L, Ghosh B, Agrawal A. Simvastatin improves epithelial dysfunction and airway hyperresponsiveness: from ADMA to asthma. Am J Respir Cell Mol Biol 2011;44:531-539.
18. Ahmad T, Mabalirajan U, Hasija K, Ghosh B, Agrawal A. Mepacrine treatment attenuates allergic airway remodeling segregated from airway inflammation in mice. Int Immunopharmacol 2011;11:74-78.
19. Mionnet C, Buatois V, Kanda A, Milcent V, Fleury S, Lair D, Langelot M, Lacoeuille Y, Hessel E, Coffman R, et al. CX3CR1 is required for airway inflammation by promoting T helper cell survival and maintenance in inflamed lung. Nat Med 2010;16:1305-1312.
20. Peyssonnaux C, Zinkernagel AS, Schuepbach RA, Rankin E, Vaulont S, Haase VH, Nizet V, Johnson RS. Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs). J Clin Invest 2007; 117:1926-1932. (Pubitemid 47036326)
21. Matrone C, Pignataro G, Molinaro P, Irace C, Scorziello A, Di Renzo GF, Annunziato L. HIF-1alpha reveals a binding activity to the promoter of iNOS gene after permanent middle cerebral artery occlusion. J Neurochem 2004;90:368-378. (Pubitemid 38938223)
22. Minamishima YA, Kaelin WG Jr. Reactivation of Hepatic EPO synthesis in mice after PHD loss. Science 2010;329:407.
23. Young HW, Williams OW, Chandra D, Bellinghausen LK, Pérez G, Suárez A, Tuvim MJ, Roy MG, Alexander SN, Moghaddam SJ, et al. Central role of Muc5ac expression in mucous metaplasia and its regulation by conserved 59 elements. Am J Respir Cell Mol Biol 2007; 37:273-290. (Pubitemid 350067607)
24. Metzen E, Stiehl DP, Doege K, Marxsen JH, Hellwig-Burgel T, Jelkmann W. Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia-responsive element. Biochem J 2005;387:711-717. (Pubitemid 40685705)
25. Karhausen J, Furuta GT, Tomaszewski JE, Johnson RS, Colgan SP, Haase VH. Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis. J Clin Invest 2004;114:1098-1106. (Pubitemid 39578699)
26. Vogtel M, Michels A. Role of intermittent hypoxia in the treatment of bronchial asthma and chronic obstructive pulmonary disease. Curr Opin Allergy Clin Immunol 2010;10:206-213.
27. Asemu G, Neckár J, Szárszoi O, Papousek F, Ostádal B, Kolar F. Effects of adaptation to intermittent high altitude hypoxia on ischemic ventricular arrhythmias in rats. Physiol Res 2000;49:597-606.
28. Campen MJ, Shimoda LA, O'Donnell CP. Acute and chronic cardiovascular effects of intermittent hypoxia in C57BL/6J mice. J Appl Physiol 2005;99:2028-2035. (Pubitemid 41547206)
29. Allakhverdi Z, Comeau MR, Jessup HK, Yoon BR, Brewer A, Chartier S, Paquette N, Ziegler SF, Sarfati M, Delespesse G. Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells. J Exp Med 2007;204:253-258. (Pubitemid 46294541)
30. Liu H, Xue W, Ge G, Luo X, Li Y, Xiang H, Ding X, Tian P, Tian X. Hypoxic preconditioning advances CXCR4 and CXCR7 expression by activating HIF-1alpha in MSCs. Biochem Biophys Res Commun 2010;401:509-515.
31. Feinman R, Deitch EA, Watkins AC, Abungu B, Colorado I, Kannan KB, Sheth SU, Caputo FJ, Lu Q, Ramanathan M, et al. HIF-1 mediates pathogenic inflammatory responses to intestinal ischemia-reperfusion injury. Am J Physiol Gastrointest Liver Physiol 2010;299: G833-G843.
32. Huerta-Yepez S, Baay-Guzman GJ, Bebenek IG, Hernandez-Pando R, Vega MI, Chi L, Riedl M, Diaz-Sanchez D, Kleerup E, Tashkin DP, et al. Hypoxia inducible factor promotes murine allergic airway-inflammation and is increased in asthma and rhinitis. Allergy 2011;66:909-918.
33. Rangasamy T, Semenza GL, Georas SN. What is hypoxia-inducible factor-1 doing in the allergic lung? Allergy 2011;66:815-817.
34. Wells SM, Buford MC, Migliaccio CT, Holian A. Elevated asymmetric dimethylarginine alters lung function and induces collagen deposition in mice. Am J Respir Cell Mol Biol 2009;40:179-188.