-
1
-
-
5144221336
-
Can guideline-defined asthma control be achieved? The gaining optimal asthma control study
-
DOI 10.1164/rccm.200401-033OC
-
Bateman ED, Boushey HA, Bousquet J, Busse WW, Clark TJ, Pauwels RA, et al., Can guideline-defined asthma control be achieved? The Gaining Optimal Asthma ControL study. Am J Respir Crit Care Med 2004; 170: 836-844. (Pubitemid 39346477)
-
(2004)
American Journal of Respiratory and Critical Care Medicine
, vol.170
, Issue.8
, pp. 836-844
-
-
Bateman, E.D.1
Boushey, H.A.2
Bousquet, J.3
Busse, W.W.4
Clark, T.J.H.5
Pauwels, R.A.6
Pedersen, S.E.7
-
3
-
-
0037097861
-
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
-
DOI 10.1101/gad.991402
-
Lando D, Peet DJ, Gorman JJ, Whelan DA, Whitelaw ML, Bruick RK,. FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev 2002; 16: 1466-1471. (Pubitemid 34686328)
-
(2002)
Genes and Development
, vol.16
, Issue.12
, pp. 1466-1471
-
-
Lando, D.1
Peet, D.J.2
Gorman, J.J.3
Whelan, D.A.4
Whitelaw, M.L.5
Bruick, R.K.6
-
4
-
-
0036873485
-
Harnessing the response to tissue hypoxia: HIF-1α and therapeutic angiogenesis
-
DOI 10.1016/S1050-1738(02)00186-X, PII S105017380200186X
-
Vincent KA, Feron O, Kelly RA,. Harnessing the response to tissue hypoxia: HIF-1 alpha and therapeutic angiogenesis. Trends Cardiovasc Med 2002; 12: 362-367. (Pubitemid 36092127)
-
(2002)
Trends in Cardiovascular Medicine
, vol.12
, Issue.8
, pp. 362-367
-
-
Vincent, K.A.1
Feron, O.2
Kelly, R.A.3
-
5
-
-
35848938945
-
The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1α and HIF-2α
-
DOI 10.1091/mbc.E06-05-0419
-
Hu CJ, Sataur A, Wang L, Chen H, Simon MC,. The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha. Mol Biol Cell 2007; 18: 4528-4542. (Pubitemid 350060179)
-
(2007)
Molecular Biology of the Cell
, vol.18
, Issue.11
, pp. 4528-4542
-
-
Hu, C.-J.1
Sataur, A.2
Wang, L.3
Chen, H.4
Simon, M.C.5
-
6
-
-
34247219188
-
Target gene selectivity of hypoxia-inducible factor-α in renal cancer cells is conveyed by post-DNA-binding mechanisms
-
DOI 10.1038/sj.bjc.6603675, PII 6603675
-
Lau KW, Tian YM, Raval RR, Ratcliffe PJ, Pugh CW,. Target gene selectivity of hypoxia-inducible factor-alpha in renal cancer cells is conveyed by post-DNA-binding mechanisms. Br J Cancer 2007; 96: 1284-1292. (Pubitemid 46625064)
-
(2007)
British Journal of Cancer
, vol.96
, Issue.8
, pp. 1284-1292
-
-
Lau, K.W.1
Tian, Y.-M.2
Raval, R.R.3
Ratcliffe, P.J.4
Pugh, C.W.5
-
7
-
-
35548940240
-
Neovastat (Æ-941) inhibits the airway inflammation via VEGF and HIF-2α suppression
-
DOI 10.1016/j.vph.2007.08.009, PII S1537189107001310
-
Lee SY, Chung SM,. Neovastat (AE-941) inhibits the airway inflammation via VEGF and HIF-2 alpha suppression. Vascul Pharmacol 2007; 47: 313-318. (Pubitemid 350008133)
-
(2007)
Vascular Pharmacology
, vol.47
, Issue.5-6
, pp. 313-318
-
-
Lee, S.Y.1
Chung, S.-M.2
-
8
-
-
33845921613
-
Expression of vascular endothelial growth factor and hypoxia-inducible factor in the airway of asthmatic patients
-
Lee SY, Kwon S, Kim KH, Moon HS, Song JS, Park SH, et al., Expression of vascular endothelial growth factor and hypoxia-inducible factor in the airway of asthmatic patients. Ann Allergy Asthma Immunol 2006; 97: 794-799. (Pubitemid 46032432)
-
(2006)
Annals of Allergy, Asthma and Immunology
, vol.97
, Issue.6
, pp. 794-799
-
-
Lee, S.Y.1
Kwon, S.2
Kim, K.H.3
Moon, H.S.4
Song, J.S.5
Park, S.H.6
Kim, Y.K.7
-
9
-
-
53949101360
-
2-Methoxyestradiol (2-ME) reduces the airway inflammation and remodeling in an experimental mouse model
-
Huerta-Yepez S, Baay-Guzman GJ, Garcia-Zepeda R, Hernandez-Pando R, Vega MI, Gonzalez-Bonilla C, et al., 2-Methoxyestradiol (2-ME) reduces the airway inflammation and remodeling in an experimental mouse model. Clin Immunol 2008; 129: 313-324.
-
(2008)
Clin Immunol
, vol.129
, pp. 313-324
-
-
Huerta-Yepez, S.1
Baay-Guzman, G.J.2
Garcia-Zepeda, R.3
Hernandez-Pando, R.4
Vega, M.I.5
Gonzalez-Bonilla, C.6
-
10
-
-
58149160405
-
Enhanced interferon-gamma gene expression in T Cells and reduced ovalbumin-dependent lung eosinophilia in hypoxia-inducible factor-1-alpha- deficient mice
-
Guo J, Lu W, Shimoda LA, Semenza GL, Georas SN,. Enhanced interferon-gamma gene expression in T Cells and reduced ovalbumin-dependent lung eosinophilia in hypoxia-inducible factor-1-alpha-deficient mice. Int Arch Allergy Immunol 2009; 149: 98-102.
-
(2009)
Int Arch Allergy Immunol
, vol.149
, pp. 98-102
-
-
Guo, J.1
Lu, W.2
Shimoda, L.A.3
Semenza, G.L.4
Georas, S.N.5
-
11
-
-
4444378175
-
Increased levels of hypoxia-sensitive proteins in allergic airway inflammation
-
DOI 10.1164/rccm.200402-178OC
-
Fajardo I, Svensson L, Bucht A, Pejler G,. Increased levels of hypoxia-sensitive proteins in allergic airway inflammation. Am J Respir Crit Care Med 2004; 170: 477-484. (Pubitemid 39209127)
-
(2004)
American Journal of Respiratory and Critical Care Medicine
, vol.170
, Issue.5
, pp. 477-484
-
-
Fajardo, I.1
Svensson, L.2
Bucht, A.3
Pejler, G.4
-
12
-
-
0033777202
-
Conditional disruption of the aryl hydrocarbon receptor nuclear translocator (Arnt) gene leads to loss of target gene induction by the aryl hydrocarbon receptor and hypoxia-inducible factor 1alpha
-
Tomita S, Sinal CJ, Yim SH, Gonzalez FJ,. Conditional disruption of the aryl hydrocarbon receptor nuclear translocator (Arnt) gene leads to loss of target gene induction by the aryl hydrocarbon receptor and hypoxia-inducible factor 1alpha. Mol Endocrinol 2000; 14: 1674-1681.
-
(2000)
Mol Endocrinol
, vol.14
, pp. 1674-1681
-
-
Tomita, S.1
Sinal, C.J.2
Yim, S.H.3
Gonzalez, F.J.4
-
13
-
-
0347986779
-
Alteration of the 4-sphingenine scaffolds of ceramides in keratinocyte-specific Arnt-deficient mice affects skin barrier function
-
DOI 10.1172/JCI200318513
-
Takagi S, Tojo H, Tomita S, Sano S, Itami S, Hara M, et al., Alteration of the 4-sphingenine scaffolds of ceramides in keratinocyte-specific Arnt-deficient mice affects skin barrier function. J Clin Invest 2003; 112: 1372-1382. (Pubitemid 38057691)
-
(2003)
Journal of Clinical Investigation
, vol.112
, Issue.9
, pp. 1372-1382
-
-
Takagi, S.1
Tojo, H.2
Tomita, S.3
Sano, S.4
Itami, S.5
Hara, M.6
Inoue, S.7
Horie, K.8
Kondoh, G.9
Hosokawa, K.10
Gonzalez, F.J.11
Takeda, J.12
-
14
-
-
0037449522
-
Therapeutic efficacy of an E. coli strain carrying an ovalbumin allergenic peptide as a fused protein to OMPC in a murine model of allergic airway inflammation
-
DOI 10.1016/S0264-410X(02)00244-X, PII S0264410X0200244X
-
Yepez SH, Pando RH, Argumedo LS, Paredes MV, Cueto AH, Isibasi A, et al., Therapeutic efficacy of an E coli strain carrying an ovalbumin allergenic peptide as a fused protein to OMPC in a murine model of allergic airway inflammation. Vaccine 2003; 21: 566-578. (Pubitemid 36091944)
-
(2003)
Vaccine
, vol.21
, Issue.5-6
, pp. 566-578
-
-
Yepez, S.H.1
Pando, R.H.2
Argumedo, L.S.3
Paredes, M.V.4
Cueto, A.H.5
Isibasi, A.6
Bonilla, C.R.G.7
-
15
-
-
0023760434
-
Enhanced ELISA: How to measure less than 10 picograms of a specific protein (immunoglobulin) in less than 8 hours
-
Macy E, Kemeny M, Saxon A,. Enhanced ELISA: how to measure less than 10 picograms of a specific protein (immunoglobulin) in less than 8 hours. FASEB J 1988; 2: 3003-3009. (Pubitemid 18261419)
-
(1988)
FASEB Journal
, vol.2
, Issue.14
, pp. 3003-3009
-
-
Macy, E.1
Kemeny, M.2
Saxon, A.3
-
17
-
-
0029928689
-
CDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt)
-
Hirose K, Morita M, Ema M, Mimura J, Hamada H, Fujii H, et al., cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt). Mol Cell Biol 1996; 16: 1706-1713.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 1706-1713
-
-
Hirose, K.1
Morita, M.2
Ema, M.3
Mimura, J.4
Hamada, H.5
Fujii, H.6
-
18
-
-
0031971047
-
Expression of ARNT, ARNT2, HIF1α, HIF2α and Ah receptor mRNAs in the developing mouse
-
DOI 10.1016/S0925-4773(98)00038-0, PII S0925477398000380
-
Jain S, Maltepe E, Lu MM, Simon C, Bradfield CA,. Expression of ARNT, ARNT2, HIF1 alpha, HIF2 alpha and Ah receptor mRNAs in the developing mouse. Mech Dev 1998; 73: 117-123. (Pubitemid 28218548)
-
(1998)
Mechanisms of Development
, vol.73
, Issue.1
, pp. 117-123
-
-
Jain, S.1
Maltepe, E.2
Lu, M.M.3
Simon, C.4
Bradfield, C.A.5
-
19
-
-
17544384815
-
ARNT-deficient mice and placental differentiation
-
DOI 10.1006/dbio.1997.8758
-
Kozak KR, Abbott B, Hankinson O,. ARNT-deficient mice and placental differentiation. Dev Biol 1997; 191: 297-305. (Pubitemid 28282914)
-
(1997)
Developmental Biology
, vol.191
, Issue.2
, pp. 297-305
-
-
Kozak, K.R.1
Abbott, B.2
Hankinson, O.3
-
20
-
-
0030943461
-
Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT
-
DOI 10.1038/386403a0
-
Maltepe E, Schmidt JV, Baunoch D, Bradfield CA, Simon MC,. Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT. Nature 1997; 386: 403-407. (Pubitemid 27154481)
-
(1997)
Nature
, vol.386
, Issue.6623
, pp. 403-407
-
-
Maltepe, E.1
Schmidt, J.V.2
Baunoch, D.3
Bradfield, C.A.4
Simon, M.C.5
-
21
-
-
0023021512
-
Partial identity of the 2-oxoglutarate and ascorbate binding sites of prolyl 4-hydroxylase
-
Majamaa K, Gunzler V, Hanauske-Abel HM, Myllyla R, Kivirikko KI,. Partial identity of the 2-oxoglutarate and ascorbate binding sites of prolyl 4-hydroxylase. J Biol Chem 1986; 261: 7819-7823. (Pubitemid 17208708)
-
(1986)
Journal of Biological Chemistry
, vol.261
, Issue.17
, pp. 7819-7823
-
-
Majamaa, K.1
Gunzler, V.2
Hanauske-Abel, H.M.3
-
22
-
-
0037048648
-
The prolyl 4-hydroxylase inhibitor ethyl-3,4-dihydroxybenzoate generates effective iron deficiency in cultured cells
-
Wang J, Buss JL, Chen G, Ponka P, Pantopoulos K,. The prolyl 4-hydroxylase inhibitor ethyl-3,4-dihydroxybenzoate generates effective iron deficiency in cultured cells. FEBS Lett 2002; 529: 309-312.
-
(2002)
FEBS Lett
, vol.529
, pp. 309-312
-
-
Wang, J.1
Buss, J.L.2
Chen, G.3
Ponka, P.4
Pantopoulos, K.5
-
23
-
-
4444229716
-
Inhibition of mitochondrial respiration by the anticancer agent 2-methoxyestradiol
-
DOI 10.1016/j.bbrc.2004.07.204, PII S0006291X04017255
-
Hagen T, D'Amico G, Quintero M, Palacios-Callender M, Hollis V, Lam F, et al., Inhibition of mitochondrial respiration by the anticancer agent 2-methoxyestradiol. Biochem Biophys Res Commun 2004; 322: 923-929. (Pubitemid 39164441)
-
(2004)
Biochemical and Biophysical Research Communications
, vol.322
, Issue.3
, pp. 923-929
-
-
Hagen, T.1
D'Amico, G.2
Quintero, M.3
Palacios-Callender, M.4
Hollis, V.5
Lam, F.6
Moncada, S.7
-
24
-
-
10744231706
-
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF
-
DOI 10.1016/S1535-6108(03)00077-1, PII S1535610803000771
-
Mabjeesh NJ, Escuin D, LaVallee TM, Pribluda VS, Swartz GM, Johnson MS, et al., 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Cancer Cell 2003; 3: 363-375. (Pubitemid 38340305)
-
(2003)
Cancer Cell
, vol.3
, Issue.4
, pp. 363-375
-
-
Mabjeesh, N.J.1
Escuin, D.2
LaVallee, T.M.3
Pribluda, V.S.4
Swartz, G.M.5
Johnson, M.S.6
Willard, M.T.7
Zhong, H.8
Simons, J.W.9
Giannakakou, P.10
-
25
-
-
0036533666
-
Contribution of vascular endothelial growth factor to airway hyperresponsiveness and inflammation in a murine model of toluene diisocyanate-induced asthma
-
Lee YC, Kwak YG, Song CH,. Contribution of vascular endothelial growth factor to airway hyperresponsiveness and inflammation in a murine model of toluene diisocyanate-induced asthma. J Immunol 2002; 168: 3595-3600. (Pubitemid 34250430)
-
(2002)
Journal of Immunology
, vol.168
, Issue.7
, pp. 3595-3600
-
-
Lee, Y.C.1
Kwak, Y.-G.2
Song, C.H.3
-
26
-
-
38049153144
-
A novel thiol compound, N-acetylcysteine amide, attenuates allergic airway disease by regulating activation of NF-kappaB and hypoxia-inducible factor-1alpha
-
Lee KS, Kim SR, Park HS, Park SJ, Min KH, Lee KY, et al., A novel thiol compound, N-acetylcysteine amide, attenuates allergic airway disease by regulating activation of NF-kappaB and hypoxia-inducible factor-1alpha. Exp Mol Med 2007; 39: 756-768.
-
(2007)
Exp Mol Med
, vol.39
, pp. 756-768
-
-
Lee, K.S.1
Kim, S.R.2
Park, H.S.3
Park, S.J.4
Min, K.H.5
Lee, K.Y.6
-
27
-
-
0026625037
-
Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor
-
Reyes H, Reisz-Porszasz S, Hankinson O,. Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor. Science 1992; 256: 1193-1195.
-
(1992)
Science
, vol.256
, pp. 1193-1195
-
-
Reyes, H.1
Reisz-Porszasz, S.2
Hankinson, O.3
-
28
-
-
0031041307
-
Two murine homologs of the Drosophila single-minded protein that interact with the mouse aryl hydrocarbon receptor nuclear translocator protein
-
DOI 10.1074/jbc.272.7.4451
-
Probst MR, Fan CM, Tessier-Lavigne M, Hankinson O,. Two murine homologs of the Drosophila single-minded protein that interact with the mouse aryl hydrocarbon receptor nuclear translocator protein. J Biol Chem 1997; 272: 4451-4457. (Pubitemid 27078523)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.7
, pp. 4451-4457
-
-
Probst, M.R.1
Fan, C.-M.2
Tessier-Lavigne, M.3
Hankinson, O.4
-
29
-
-
0347986677
-
Identification of a Novel Basic Helix-Loop-Helix-PAS Factor, NXF, Reveals a Sim2 Competitive, Positive Regulatory Role in Dendritic-Cytoskeleton Modulator Drebrin Gene Expression
-
DOI 10.1128/MCB.24.2.608-616.2004
-
Ooe N, Saito K, Mikami N, Nakatuka I, Kaneko H,. Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression. Mol Cell Biol 2004; 24: 608-616. (Pubitemid 38057913)
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.2
, pp. 608-616
-
-
Ooe, N.1
Saito, K.2
Mikami, N.3
Nakatuka, I.4
Kaneko, H.5
-
30
-
-
0037155908
-
Differential activities of murine Single Minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/Per-Arnt-Sim homology transcription factors
-
DOI 10.1074/jbc.M110752200
-
Woods SL, Whitelaw ML,. Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors. J Biol Chem 2002; 277: 10236-10243. (Pubitemid 34968138)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.12
, pp. 10236-10243
-
-
Woods, S.L.1
Whitelaw, M.L.2
-
31
-
-
49449095646
-
Activation of the aryl hydrocarbon receptor is essential for mediating the anti-inflammatory effects of a novel low-molecular-weight compound
-
Lawrence BP, Denison MS, Novak H, Vorderstrasse BA, Harrer N, Neruda W, et al., Activation of the aryl hydrocarbon receptor is essential for mediating the anti-inflammatory effects of a novel low-molecular-weight compound. Blood 2008; 112: 1158-1165.
-
(2008)
Blood
, vol.112
, pp. 1158-1165
-
-
Lawrence, B.P.1
Denison, M.S.2
Novak, H.3
Vorderstrasse, B.A.4
Harrer, N.5
Neruda, W.6
-
32
-
-
74949098305
-
Role of hypoxia-inducible factor 1{alpha} in modulating cobalt-induced lung inflammation
-
Saini Y, Kim KY, Lewandowski R, Bramble LA, Harkema JR, Lapres JJ,. Role of hypoxia-inducible factor 1{alpha} in modulating cobalt-induced lung inflammation. Am J Physiol Lung Cell Mol Physiol 2010; 298: L139-L147.
-
(2010)
Am J Physiol Lung Cell Mol Physiol
, vol.298
-
-
Saini, Y.1
Kim, K.Y.2
Lewandowski, R.3
Bramble, L.A.4
Harkema, J.R.5
Lapres, J.J.6
-
33
-
-
76349095132
-
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
-
Semenza GL,. Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene 2010; 29: 625-634.
-
(2010)
Oncogene
, vol.29
, pp. 625-634
-
-
Semenza, G.L.1
-
34
-
-
72849115544
-
Development of HIF-1 inhibitors for cancer therapy
-
Onnis B, Rapisarda A, Melillo G,. Development of HIF-1 inhibitors for cancer therapy. J Cell Mol Med 2009; 13: 2780-2786.
-
(2009)
J Cell Mol Med
, vol.13
, pp. 2780-2786
-
-
Onnis, B.1
Rapisarda, A.2
Melillo, G.3
|