Precise manipulation of the Clostridium difficile chromosome reveals a lack of association between the tcdC genotype and toxin production

Applied and Environmental Microbiology

Volumn 78, Issue 13, 2012, Pages 4683-4690

  Cartman, Stephen T ^a   Kelly, Michelle L ^a   Heeg, Daniela ^a   Heap, John T ^a,b   Minton, Nigel P ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CLOSTRIDIUM DIFFICILE; FRAME-SHIFT MUTATION; GENETIC MANIPULATIONS; NEGATIVE REGULATORS; NUCLEOTIDE SUBSTITUTION; POTENTIALLY FATAL; PRECISE MANIPULATION; TOXIN PRODUCTION; VIRULENCE FACTORS; WILD TYPES;

CLOSTRIDIUM; ESCHERICHIA COLI; GENES; RESTORATION;

TOXIC MATERIALS;

BACTERIAL DNA; BACTERIAL PROTEIN; BACTERIAL TOXIN; REPRESSOR PROTEIN; TCDC PROTEIN, CLOSTRIDIUM DIFFICILE;

BACTERIUM; CHROMOSOME; DIARRHEAL DISEASE; FUNCTIONAL ROLE; GENE EXPRESSION; GENETICS; GENOTYPE; MUTATION; PATHOGEN; POLYMERASE CHAIN REACTION; TOXIN; VIRULENCE;

ARTICLE; BIOSYNTHESIS; CHEMISTRY; CLOSTRIDIUM DIFFICILE; DNA SEQUENCE; ESCHERICHIA COLI; FRAMESHIFT MUTATION; GENE DELETION; GENE EXPRESSION REGULATION; GENETIC RECOMBINATION; GENETICS; GENOTYPE; METABOLISM; METHODOLOGY; MICROBIAL GENETICS; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PATHOGENICITY;

BACTERIAL PROTEINS; BACTERIAL TOXINS; CLOSTRIDIUM DIFFICILE; DNA, BACTERIAL; ESCHERICHIA COLI; FRAMESHIFT MUTATION; GENE DELETION; GENETICS, MICROBIAL; GENOTYPE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, INSERTIONAL; RECOMBINATION, GENETIC; REPRESSOR PROTEINS; SEQUENCE ANALYSIS, DNA;

CLOSTRIDIUM DIFFICILE; ESCHERICHIA COLI;

EID: 84863792386     PISSN: 00992240     EISSN: 10985336     Source Type: Journal    
DOI: 10.1128/AEM.00249-12     Document Type: Article

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