Recombinant expression of mutants of the Frankenstein disintegrin, RTS-ocellatusin. Evidence for the independent origin of RGD and KTS/RTS disintegrins

Toxicon

Volumn 60, Issue 4, 2012, Pages 665-675

  Sanz Soler, Raquel ^a   Lorente, Carolina ^a   Company, Beatriz ^a   Sanz, Libia ^a   Juárez, Paula ^a   Pérez, Alicia ^a   Zhang, Yun ^b   Jin, Yang ^b   Chen, Runqiang ^c   Eble, Johannes A ^d   Calvete, Juan J ^a   Bolás, Gema ^a  

^a INSTITUTO DE BIOMEDICINA DE VALENCIA   (Spain)

^b KUNMING INSTITUTE OF ZOOLOGY   (China)

^c LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^d Center for Molecular Medicine   (Germany)

Author keywords

Evolution of disintegrins; Jerdostatin; Ocellatusin; Recombinant RGD disintegrin; Recombinant RTS KTS disintegrin

Indexed keywords

DISINTEGRIN; RECOMBINANT ARGINYLTHREONYLSERYLOCELLATUSIN; RECOMBINANT JERDOSTATIN; RECOMBINANT OCELLATUSIN; RECOMBINANT PROTEIN; SNAKE VENOM; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 1;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CROTALINAE; ELAPIDAE; HUMAN; HUMAN CELL; IGUANIDAE; LACERTIDAE; LIZARD; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MOTIF; SNAKE; THROMBOCYTE AGGREGATION INHIBITION; VIPERINAE;

AMINO ACID SEQUENCE; ANIMALS; DISINTEGRINS; EVOLUTION, MOLECULAR; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PHYLOGENY; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN MULTIMERIZATION; RECOMBINANT FUSION PROTEINS; SNAKE VENOMS; SPECIES SPECIFICITY; VIPER VENOMS; VIPERIDAE;

CROTALINAE; ELAPIDAE; IGUANIA; IGUANIDAE; LACERTIDAE; REPTILIA; SERPENTES; SQUAMATA; VIPERINAE;

EID: 84863785112     PISSN: 00410101     EISSN: 18793150     Source Type: Journal    
DOI: 10.1016/j.toxicon.2012.05.010     Document Type: Article

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