Snake venomics of Macrovipera mauritanica from Morocco, and assessment of the para-specific immunoreactivity of an experimental monospecific and a commercial antivenoms

Journal of Proteomics

Volumn 75, Issue 8, 2012, Pages 2431-2441

  Makran, Bouchra ^a   Fahmi, Laila ^a   Pla, Davinia ^b   Sanz, Libia ^b   Oukkache, Naoual ^a   Lkhider, Mustapha ^c   Ghalim, Noreddine ^a   Calvete, Juan J ^b,d  

^a Institut Pasteur du Maroc   (Morocco)

^b INSTITUTO DE BIOMEDICINA DE VALENCIA   (Spain)

^c FACULTÉ DES SCIENCES   (Morocco)

^d UNIVERSITAT POLITÈCNICA DE VALÈNCIA   (Spain)

Author keywords

Antivenomics; Macrovipera mauritanica; Mass spectrometry; Monospecific antivenom; Snake venomics; Venom proteome

Indexed keywords

COLUBER LEBETINUS VENOM ANTISERUM; MACROVIPERA LEBETINA VENOM ANTISERUM; PROTEOME; SNAKE VENOM; SNAKE VENOM ANTISERUM; UNCLASSIFIED DRUG;

AFFINITY CHROMATOGRAPHY; ARTICLE; IMMUNOREACTIVITY; MACROVIPERA LEBETINA; MACROVIPERA MAURITANICA; NONHUMAN; POISONOUS SNAKE; PRIORITY JOURNAL; PROTEIN ANALYSIS;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; ANTIVENINS; COMMERCE; CROTALID VENOMS; DRUGS, INVESTIGATIONAL; GEOGRAPHY; IMMUNOPRECIPITATION; MIDDLE EAST; MOROCCO; PROTEOME; SNAKES; TUNISIA;

MACROVIPERA; MACROVIPERA LEBETINA; MACROVIPERA MAURITANICA;

EID: 84859265057     PISSN: 18743919     EISSN: 18767737     Source Type: Journal    
DOI: 10.1016/j.jprot.2012.02.022     Document Type: Article

References (68)

1. De Smedt J. The Vipers of Europe 2006, JDS Verlag, 340 pp.
2. Mallow D., Ludwig D., Nilson G. True Vipers: Natural History and Toxinology of Old World Vipers 2003, Krieger Publishing Company, 359 pp.
3. Garrigues T., Dauga C., Ferquel E., Choumet V., Failloux A.B. Molecular phylogeny of Vipera Laurenti, 1768 and the related genera Macrovipera (Reuss, 1927) and Daboia (Gray, 1842), with comments about neurotoxic Vipera aspis aspis populations. Mol Phylogenet Evol 2005, 35:35-47.
4. Lenk P., Kalyabina S., Wink M., Joger U. Evolutionary relationships among the true vipers (Reptilia: Viperidae) inferred from mitochondrial DNA sequences. Mol Phylogenet Evol 2001, 19:94-104.
5. David P., Ineich I. Les serpents venimeux du monde: Systématique et répatition. Dumerilia, Publications de l'Association des Amis du Laboratoire des Reptiles et Amphibiens du Muséum national d'Histoire naturelle de Paris 1999, 3:3-499.
6. McDiarmid R.W., Campbell J.A., Touré T.A. Snake Species of the World: A Taxonomic and Geographic Reference 1999, XII:1-XII:511. Herpetologist League, Washington DC.
7. Phelps T. Old World Vipers. A Natural History of the Azemiopinae, and Viperinae 2010, Edition Chimaira.
8. Timms J. Macrovipera mauritanica: The Moorish viper. Reptilia 2004, 35:48-54.
9. WHO Regional Office for Africa Guidelines for the Prevention and Clinical Management of Snakebite in Africa, Brazzaville 2010.
10. Vidal L. Les complications secondaires des morsures de serpents au Maroc. Leur traitement par l'heppannothrapie. Resultatr de 63 cas traits de 1954 a mai 1962. Maroc Med 1962, 41:784-789.
11. Chafiq F., Rhalem N., Ouammi L., Fekhaoui M., Semlali I., Soulaymani A., et al. Profil épidémiologique des cas de morsures de serpents déclarés au Centre Anti Poison du Maroc (1980 à 2008). Toxicologie Maroc - Publication officielle du centre anti poison du Maroc, Ministre de Sante 2011, 9:6-10.
12. Geniez P., Ineich I., Ben Kirane C., Bons J. Les serpents venimeux du Maroc: Position systématique et état des connaissances sur leur distribution. Actes Inst. Agronom. Vet. Hassan II 1992, 12:37-48.
13. Göçmen B., Arikan H., Özbel Y., Mermer A., Ciçek K. Clinical, physiological and serological observations of a human following a venomous bite by Macrovipera lebetina Lebetina (Reptilia: Serpentes). Türkiye Parazitol Derg 2006, 30:158-162.
14. Lamb L., Ross D.A., Lalloo D.G., Green A., Morgan E.R., Warrell D.A. Management of venomous bites and stings in British military personnel deployed in Iraq, Afghanistan and Cyprus. J R Army Med Corps 2008, 154:1-40. (Supplement).
15. Bazaa A., Marrakchi N., El Ayeb M., Sanz L., Calvete J.J. Snake venomics: comparative analysis of the venom proteomes of the Tunisian snake Cerastes cerastes, Cerastes vipera and Macrovipera lebetina. Proteomics 2005, 6:4223-4235.
16. Sanz L., Ayvazyan N., Calvete J.J. Snake venomics of the Armenian mountain vipers Macrovipera lebetina obtusa and Vipera raddei. J Proteomics 2008, 71:198-209.
17. Calvete J.J., Sanz L., Angulo Y., Lomonte B., Gutiérrez J.M. Venoms, venomics, antivenomics. FEBS Lett 2009, 583:1736-1743.
18. Calvete J.J. Antivenomics and venom phenotyping: a marriage of convenience to address the performance and range of clinical use of antivenoms. Toxicon 2010, 56:1284-1291.
19. Calvete J.J. Snake Venomics, Antivenomics, and Venom Phenotyping: The Ménage à Trois of proteomic tools aimed at understanding the biodiversity of venoms. Toxins and Hemostasis 2010, 45-72. Springer, Amsterdam. R.M. Kini, K. Clemetson, F. Markland, M.A. McLane, T. Morita (Eds.).
20. Raw I., Guidolin R., Higashi H.G., Kelen E.M.A. Antivenins in Brazil: Preparation. Handbook of Natural Toxins 1991, 557-811. Marcel Dekker, New York. A. Tu (Ed.).
21. Practical Handbook of Biochemistry and Molecular Biology 1992, CRC Press, Boston. D.G. Fasman (Ed.).
22. Fahmi L, Makran B, Plá D, Sanz L, Lkhider M, Harrison RA, Ghalim N, Calvete JJ. Snake venomics of Cerastes cerastes from Morocco and assessment of the immunoreactivity of experimental and commercial antivenoms towards the venoms of C. vipera and geographic variants of C. cerastes. J. Proteomics .
23. Calvete J.J. Brief history and molecular determinants of snake venom disintegrin evolution. Toxins and Hemostasis: from Bench to Bedside 2010, 285-300. Springer, Amsterdam. R.M. Kini, F. Markland, M.A. McLane, T. Morita (Eds.).
24. Kini R., Evans H.J. Structural domains in venom proteins: evidence that metalloproteinases and nonenzymatic platelet aggregation inhibitors (disintegrins) from snake venoms are derived by proteolysis from a common precursor. Toxicon 1992, 30:265-293.
25. Okuda D., Koike H., Morita T. A new gene structure of the disintegrin family: a subunit of dimeric disintegrin has a short coding region. Biochemistry 2002, 41:14248-14254.
26. Takeda S., Takeya H., Iwanaga S. Snake venom metalloproteinases: structure, function and relevance to the mammalian ADAM/ADAMTS family proteins. Biochim Biophys Acta 2012, 1824:164-176.
27. Fox J.W., Serrano S.M. Structural considerations of the snake venom metalloproteinases, key members of the M12 reprolysin family of metalloproteinases. Toxicon 2005, 45:969-985.
28. Fox J.W., Serrano S.M.T. Insights into and speculations about snake venom metalloproteinase (SVMP) synthesis, folding and disulfide bond formation and their contribution to venom complexity. FEBS J 2008, 275:3016-3030.
29. Gutiérrez J.M., Rucavado A., Escalante T., Díaz C. Hemorrhage induced by snake venom metalloproteinases: biochemical and biophysical mechanisms involved in microvessel damage. Toxicon 2005, 45:997-1011.
30. Escalante T., Rucavado A., Fox J.W., Gutiérrez J.M. Key events in microvascular damage induced by snake venom hemorrhagic metalloproteinases. J Proteomics 2011, 74:1781-1794.
31. Escalante T., Shannon J., Moura-da-Silva A.M., Gutiérrez J.M., Fox J.W. Novel insights into capillary vessel basement membrane damage by snake venom hemorrhagic metalloproteinases: a biochemical and immunohistochemical study. Arch Biochem Biophys 2006, 455:144-153.
32. Gasmi A., Srairi A., Karoui H., El Ayeb M. Amino acid sequence of VlF: identification in the C-terminal domain of residues common to non-hemorrhagic metalloproteinases from snake venoms. Biochim Biophys Acta 2000, 1481:209-212.
33. Patiño A.C., Pereañez J.A., Núñez V., Benjumea D.M., Fernandez M., Rucavado A., et al. Isolation and biological characterization of Batx-I, a weak hemorrhagic and fibrinogenolytic PI metalloproteinase from Colombian Bothrops atrox venom. Toxicon 2010, 56:936-943.
34. Gasmi A., Srairi N., Guermazi S., Dekhil H., Karoui H., El Ayeb M. Amino acid structure and characterization of a heterodimeric disintegrin from Vipera lebetina venom. Biochem Biophys Acta 2001, 1547:51-56.
35. Eble J.A., Bruckner P., Mayer U. Vipera lebetina venom contains two disintegrins inhibiting laminin-binding beta1 integrins. J Biol Chem 2003, 278:26488-26496.
36. Sajevic A., Leonardi A., Križaj I. Haemostatically active proteins in snake venoms. Toxicon 2011, 57:627-645.
37. Markland F.S. Snake venom proteins acting on hemostasis. Toxicon 1998, 36:1749-1800.
38. Siigur E., Aaspollu A., Siigur J. Molecular cloning and sequence analysis of a cDNA for factor V activating enzyme. Biochem Biophys Res Commun 1999, 262:328-332.
39. Siigur E., Aaspollu A., Siigur J. Anticoagulant serine fibrinogenases from Vipera lebetina venom: structure-function relationships. Thromb Haemost 2003, 89:826-831.
40. Siigur E., Tonismagi K., Trummal K., Samel M., Vija H., Aaspollu A., et al. A new tyrosine-specific chymotrypsin-like and angiotensin-degrading serine proteinase from Vipera lebetina snake venom. Biochimie 2011, 93:321-330.
41. Chow W.M., Liu W.H., Chen K.C., Chang L.S. Structure-function studies on inhibitory activity of Bungarus multicinctus protease inhibitor-like protein on matrix metalloprotease-2, and invasion and migration of human neuroblastoma SK-N-SH cells. Toxicon 2010, 55:353-360.
42. Inagaki H, Kimoto H, Yamauchi Y, Toriba M, Kubo T. Functional characterization of Kunitz-type protease inhibitor Pr-mulgins identified from New Guinean Pseudechis australis.
43. Sarray S., Srairi N., Luis J., Marvaldi J., El Ayeb M., Marrakchi N. Lebecetin, a C-lectin protein from the venom of Macrovipera lebetina that inhibits platelet aggregation and adhesion of cancerous cells. Haemostasis 2001, 31:173-176.
44. Sarray S., Srairi N., Hatmi M., Luis J., Louzir H., Regaya I., et al. Lebecetin, a potent antiplatelet C-type lectin from Macrovipera lebetina venom. Biochim Biophys Acta 2003, 1651:30-40.
45. Barbouche R., Marrakchi N., Mansuelle P., Krifi M., Fenouillet E., Rochat H., et al. Novel anti-platelet aggregation polypeptides from Vipera lebetina venom: isolation and characterization. FEBS Lett 1996, 392:6-10.
46. Marrakchi N., Mabrouk K., Regaya I., Sarray S., Fathallah M., Rochat H., et al. Lebetin peptides: potent platelet aggregation inhibitors. Haemostasis 2001, 31:207-210.
47. 2 homologues of snake venoms: biological activities and their possible adaptive roles. Protein Pept Lett 2009, 16:860-876.
48. 2: insights into the mechanisms of local and systemic myotoxicity. Toxicon 2003, 42:915-931.
49. 2 from Viperidae snake venoms: how do they induce skeletal muscle damage?. Acta Chim Slov 2011, 58:647-659.
50. Potter L.R., Yoder A.R., Flora D.R., Antos L.K., Dickey D.M. Natriuretic peptides: their structures, receptors, physiologic functions and therapeutic applications. Handb Exp Pharmacol 2009, 191:341-366.
51. Gasmi A., Abidi F., Srairi N., Oijatayer A., Karoui H., El Ayeb M. Purification and characterization of a growth factor-like which increases capillary permeability from Vipera lebetina venom. Biochem Biophys Res Commun 2000, 268:69-72.
52. Olfa K.Z., José L., Salma D., Amine B., Najet S.A., Nicolas A., et al. Lebestatin, a disintegrin from Macrovipera venom, inhibits integrin-mediated cell adhesion, migration and angiogenesis. Lab Invest 2005, 85:1507-1516.
53. 1 integrin. Curr Pharm Des 2007, 13:2853-2859.
54. 1 integrin in vitro and angiogenesis in vivo. Cancer Res 2003, 63:2020-2023.
55. 1 integrin. Biochem J 2009, 417:95-101.
56. Carbajo R.J., Sanz L., Mosulén S., Pérez A., Marcinkiewicz C., Pineda-Lucena A., et al. NMR structure and dynamics of recombinant wild type and mutated jerdostatin, a selective inhibitor of integrin α1β1. Proteins 2011, 79:2530-2542.
57. Juárez P., Comas I., González-Candelas F., Calvete J.J. Evolution of snake venom disintegrins by positive Darwinian selection. Mol Biol Evol 2008, 25:2391-2407.
58. Gasmi A., Bourcier C., Aloui Z., Srairi N., Marchetti S., Gimond C., et al. Complete structure of an increasing capillary permeability protein (ICPP) purified from Vipera lebetina venom. ICPP is angiogenic via vascular endothelial growth factor receptor signalling. J Biol Chem 2002, 277:29992-29998.
59. Durban J., Juárez P., Angulo Y., Lomonte B., Flores-Diaz M., Alape-Girón A., et al. Profiling the venom gland transcriptomes of Costa Rican snakes by 454 pyrosequencing. BMC Genomics 2011, 12:259.
60. Fox J.W., Ma L., Nelson K., Sherman N.E., Serrano S.M.T. Comparison of indirect and direct approaches using ion-trap and Fourier transform ion cyclotron resonance mass spectrometry for exploring viperid venom proteomes. Toxicon 2006, 47:700-714.
61. Calvete J.J., Fasoli E., Sanz L., Boschetti E., Righetti P.G. Exploring the venom proteome of the western diamondback rattlesnake, Crotalus atrox, via snake venomics and combinatorial peptide ligand library approaches. J Proteome Res 2009, 8:3055-3067.
62. Chani M., L'kassimi H., Abouzahir A., Nazi M., Mion G. Cas clinique. À propos de trois observations d'envenimations vipe ́rines graves au Maroc. Ann Fr Anesth Reanim 2008, 27:330-334.
63. Harrison R.A., Cook D.A., Renjifo C., Casewell N.R., Currier R.B., Wagstaff S.C. Research strategies to improve snakebite treatment: challenges and progress. J Proteomics 2011, 74:1768-1780.
64. Williams D.J., Gutiérrez J.M., Calvete J.J., Wüster W., Ratanabanangkoon K., Paiva O., et al. Ending the drought: new strategies for improving the flow of affordable, effective antivenoms in Asia and Africa. J Proteomics 2011, 74:1735-1767.
65. Gutiérrez J.M., Lomonte B., León G., Alape-Girón A., Flores-Díaz M., Sanz L., et al. Snake venomics and antivenomics: proteomic tools in the design and control of antivenoms for the treatment of snakebite envenoming. J Proteomics 2009, 72:165-182.
66. Calvete J.J. Proteomic tools against the neglected pathology of snake bite envenoming. Expert Rev Proteomics 2011, 8:739-758.
67. Georgieva D., Arni R.K., Betzel C. Proteome analysis of snake venom toxins: pharmacological insights. Expert Rev Proteomics 2008, 5:787-797.
68. Archundia I.G., de Roodt A.R., Ramos-Cerrillo B., Chippaux J.P., Olguín-Pérez L., Alagón A., et al. Neutralization of Vipera and Macrovipera venoms by two experimental polyvalent antisera: a study of paraspecificity. Toxicon 2011, 57:1049-1056.