Structural requirements of KTS-disintegrins for inhibition of α 1β1 integrin

Biochemical Journal

Volumn 417, Issue 1, 2009, Pages 95-101

  Brown, Meghan C ^a   Eble, Johannes A ^b   Calvete, Juan J ^c   Marcinkiewicz, Cezary ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^c INSTITUTO DE BIOMEDICINA DE VALENCIA   (Spain)

Author keywords

Integrin 1 1 inhibitor; KTS disintegrin; Obtustatin; Recombinant disintegrin; Structure function correlation; Viperistatin

Indexed keywords

KTS-DISINTEGRIN; OBTUSTATIN; RECOMBINANT DISINTEGRIN; STRUCTURE-FUNCTION CORRELATION; VIPERISTATIN;

ADHESION; AMINO ACIDS; CELL ADHESION;

DISINTEGRATION;

ALANINE; ARGININE; DISINTEGRIN; LEUCINE; LYSINE; OBTUSTATIN; SERINE; SNAKE VENOM; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 1; VIPERISTATIN; COLLAGEN TYPE 4; OBTUSTATIN, VIPERA LEBETINA OBTUSA; RECOMBINANT PROTEIN; VIPER VENOM;

AMINO ACID SUBSTITUTION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL ADHESION; CONTROLLED STUDY; PRIORITY JOURNAL; PROTEIN MOTIF; STRUCTURE ACTIVITY RELATION; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CHEMISTRY; COMPUTER SIMULATION; DRUG ANTAGONISM; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; METABOLISM; MOLECULAR GENETICS; MUTATION; PROTEIN BINDING; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; CELL ADHESION; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COLLAGEN TYPE IV; COMPUTER SIMULATION; DISINTEGRINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; INTEGRIN ALPHA1BETA1; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN BINDING; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SNAKE VENOMS; STRUCTURE-ACTIVITY RELATIONSHIP; VIPER VENOMS;

EID: 58249089742     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20081403     Document Type: Article

References (41)

1. Calvete, J. J. (1999) Platelet integrin GPIIb/IIIa: structure-function correlations. An update and lessons from other integrins. Proc. Soc. Exp. Biol. Med. 222, 29-38
2. Hynes, R. O. (2002) Integrins: bidirectional, allosteric signaling machines. Cell 110, 673-687
3. Takagi, J. and Springer, T. A. (2002) Integrin activation and structural rearrangement. Immunol. Rev. 186, 141-163
4. Berrier, A. L. and Yamada, K. M. (2007) Cell-matrix adhesion. J. Cell. Physiol. 213, 565-573
5. Luo, B. H., Carman, C. V. and Springer, T. A. (2007) Structural basis of integrin regulation and signaling. Annu. Rev. Immunol. 25, 619-647
6. Eble, J. A. (2005) Collagen-binding integrins as pharmaceutical targets. Curr. Pharm. Des. 11, 867-880
7. McCall, K. D. and Zutter, M. M. (2008) Collagen receptor integrins: rising to the challenge. Curr. Drug Targets 9, 139-149
8. Hughes, A. L. (2001) Evolution of the integrin α and β families. J. Mol. Evol. 52, 63-72
9. Leitinger, B. and Hogg, N. (1999) Integrin I domains and their function. Biochem. Soc. Trans. 27, 826-832
10. 1 integrins. J. Biol. Chem. 274, 32182-32191
11. 1 integrin in vitro and angiogenesis in vivo. Cancer Res. 63, 2020-2023
12. 1 integrin. FEBS Lett. 577, 478-482
13. 1 integrin. Curr. Pharm. Des. 13, 2853-2859
14. Sanz, L., Bazaa, A., Marrakchi, N., Pérez, A., Chenik, M., Bel Lasfer, Z., El Ayeb, M. and Calvete, J. J. (2006) Molecular cloning of disintegrins from Cerastes vipera and Macrovipera lebetina transmediterranea venom gland cDNA libraries: insight into the evolution of the snake venom integrin-inhibition system. Biochem. J. 395, 385-392
15. Ogawa, T., Chijiwa, T., Oda-Ueda, N. and Ohno, M. (2005) Molecular diversity and accelerated evolution of C-type lectin-like proteins from snake venom. Toxicon 45, 1-14
16. Niewiarowski, S., McLane, M. A., Kloczewiak M. and Stewart, G. J. (1994) Disintegrins and other naturally occurring antagonists of platelet fibrinogen receptors. Semin. Hematol. 31, 289-300
17. Marcinkiewicz, C. (2005) Functional characteristic of snake venom disintegrins: potential therapeutic implication. Curr. Pharm. Des. 11, 815-827
18. Calvete, J. J., Marcinkiewicz, C., Monleon, D., Esteve, V., Celda, B., Juarez, P. and Sanz, L. (2005) Snake venom disintegrins: evolution of structure and function. Toxicon 45, 1063-1074
19. Koh, D. C., Armugam, A. and Jeyaseelan, K. (2006) Snake venom components and their applications in biomedicine. Cell. Mol. Life Sci. 63, 3030-3041
20. Scarborough, R. M., Rose, J. W., Hsu, M. A., Phillips, D. R., Fried, V. A., Campbell, A. M., Nannizzi, L. and Charo, I. F. (1991) Barbourin. A GPIIb-IIIa-specific integrin antagonist from the venom of Sistrurus m. barbouri. J. Biol. Chem. 266, 9359-9362
21. 1 integrin. Biochemistry 38, 13302-13309
22. 1 integrins. Biochemistry 41, 2014-2021
23. Moreno-Murciano, M. P., Monleón, D. D., Calvete, J. J., Celda, B. and Marcinkiewicz, C. (2003) Amino acid sequence and homology modeling of obtustatin, a novel non-RGD-containing short disintegrin isolated from the venom of Vipera lebetina obtusa. Protein Sci. 12, 366-371
24. Brown, M. C., Staniszewska I., Del Valle, L., Tuszynski, G. P. and Marcinkiewicz, C. (2008) Angiostatic activity of obtustatin as α1β1 integrin inhibitor in experimental melanoma growth. Int. J. Cancer 123, 2195-2203
25. Bazaa, A., Marrakchi, N., El Ayeb, M., Sanz, L. and Calvete, J. J. (2005) Snake venomics: comparative analysis of the venom proteomes of the Tunisian snakes Cerastes cerastes, Cerastes vipera and Macrovipera lebetina. Proteomics 5, 4223-4235
26. Olfa, K. Z., José, L., Salma, D., Amine, B., Najet, S. A., Nicolas, A., Maxime, L., Raoudha, Z., Kamel, M., Jacques, M. et al. (2005) Lebestatin, a disintegrin from Macrovipera venom, inhibits integrin-mediated cell adhesion, migration and angiogenesis. Lab. Invest. 85, 1507-1516
27. 1 integrin. J. Biol. Chem. 280, 40714-40722
28. Moreno-Murciano, M. P., Monleón, D., Marcinkiewicz, C., Calvete, J. J. and Celda, B. (2003) NMR solution structure of the non-RGD disintegrin obtustatin. J. Mol. Biol. 329, 135-145
29. Monleón, D., Moreno-Murciano, M. P., Kovacs, H., Marcinkiewicz, C., Calvete, J. J. and Celda, B. (2003) Concerted motions of the integrin-binding loop and the C-terminal tail of the non-RGD disintegrin obtustatin. J. Biol. Chem. 278, 45570-45576
30. 1 integrins. Biochemistry 43, 1639-1647
31. Smith, D. B. and Johnson, K. S. (1988) Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene 67, 31-40
32. 3 integrins and expression of ligand-induced binding site. Blood 90, 1565-1575
33. 1 recognition site in its C-terminal domains. J. Biol. Chem. 281, 25745-25756
34. Brunger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S. et al. (1998) Crystallography and NMR system: a new software suite for macromolecular structure determination. Acta Crystallogr. D Biol. Crystallogr. 54, 905-921
35. Reference deleted
36. Humphries, M. J. (2004) Monoclonal antibodies as probes of integrin priming and activation. Biochem. Soc. Trans. 32, 407-411
37. Weskamp, G., Krätzschmar, J., Reid, M. S. and Blobel, C. P. (1996) MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains. J. Cell Biol. 132, 717-726
38. Trowbridge, P. W. and Frisque, R. J. (1995) Identification of three new JC virus proteins generated by alternative splicing of the early viral mRNA. J. Neurovirol. 1, 195-206
39. 1 integrins. J. Biol. Chem. 269, 20233-20238
40. 3 integrins. FEBS Lett. 391, 139-143
41. Lu, X., Rahman, S., Kakkar, V. V. and Authi, K. S. (1996) Substitutions of proline 42 to alanine and methionine 46 to asparagine around the RGD domain of the neurotoxin dendroaspin alter its preferential antagonism to that resembling the disintegrin elegantin. J. Biol. Chem. 271, 289-294