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Volumn 218, Issue , 2012, Pages 170-180

Neurobehavioral abnormalities in a brain-specific NADPH-cytochrome P450 reductase knockout mouse model

Author keywords

Brain; Cytochrome P450; Fear conditioning; Memory; Mice; NADPH cytochrome P450 reductase

Indexed keywords

CYTOCHROME P450; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

EID: 84863784286     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2012.05.027     Document Type: Article
Times cited : (4)

References (51)
  • 2
    • 67349176113 scopus 로고    scopus 로고
    • Intrasession and intersession habituation in mice: from inbred strain variability to linkage analysis
    • Bolivar V.J. Intrasession and intersession habituation in mice: from inbred strain variability to linkage analysis. Neurobiol Learn Mem 2009, 92:206-214.
    • (2009) Neurobiol Learn Mem , vol.92 , pp. 206-214
    • Bolivar, V.J.1
  • 3
    • 0347626155 scopus 로고    scopus 로고
    • Exploratory activity and fear conditioning abnormalities develop early in R6/2 Huntington's disease transgenic mice
    • Bolivar V.J., Manley K., Messer A. Exploratory activity and fear conditioning abnormalities develop early in R6/2 Huntington's disease transgenic mice. Behav Neurosci 2003, 117:1233-1242.
    • (2003) Behav Neurosci , vol.117 , pp. 1233-1242
    • Bolivar, V.J.1    Manley, K.2    Messer, A.3
  • 4
    • 0034928118 scopus 로고    scopus 로고
    • Inbred strain variation in contextual and cued fear conditioning behavior
    • Bolivar V.J., Pooler O., Flaherty L. Inbred strain variation in contextual and cued fear conditioning behavior. Mamm Genome 2001, 12:651-656.
    • (2001) Mamm Genome , vol.12 , pp. 651-656
    • Bolivar, V.J.1    Pooler, O.2    Flaherty, L.3
  • 6
    • 0028071507 scopus 로고
    • Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein
    • Bourtchuladze R., Frenguelli B., Blendy J., Cioffi D., Schutz G., Silva A.J. Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein. Cell 1994, 79:59-68.
    • (1994) Cell , vol.79 , pp. 59-68
    • Bourtchuladze, R.1    Frenguelli, B.2    Blendy, J.3    Cioffi, D.4    Schutz, G.5    Silva, A.J.6
  • 9
    • 0037151258 scopus 로고    scopus 로고
    • Evaluation of the elevated plus-maze and open-field tests for the assessment of anxiety-related behaviour in inbred mice
    • Carola V., D'Olimpio F., Brunamonti E., Mangia F., Renzi P. Evaluation of the elevated plus-maze and open-field tests for the assessment of anxiety-related behaviour in inbred mice. Behav Brain Res 2002, 134:49-57.
    • (2002) Behav Brain Res , vol.134 , pp. 49-57
    • Carola, V.1    D'Olimpio, F.2    Brunamonti, E.3    Mangia, F.4    Renzi, P.5
  • 11
    • 0037151046 scopus 로고    scopus 로고
    • Accelerated plaque accumulation, associative learning deficits, and up-regulation of alpha 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins
    • Dineley K.T., Xia X., Bui D., Sweatt J.D., Zheng H. Accelerated plaque accumulation, associative learning deficits, and up-regulation of alpha 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins. J Biol Chem 2002, 277:22768-22780.
    • (2002) J Biol Chem , vol.277 , pp. 22768-22780
    • Dineley, K.T.1    Xia, X.2    Bui, D.3    Sweatt, J.D.4    Zheng, H.5
  • 12
    • 0033624837 scopus 로고    scopus 로고
    • CaMKIIalpha-Cre transgene expression and recombination patterns in the mouse brain
    • Dragatsis I., Zeitlin S. CaMKIIalpha-Cre transgene expression and recombination patterns in the mouse brain. Genesis 2000, 26:133-135.
    • (2000) Genesis , vol.26 , pp. 133-135
    • Dragatsis, I.1    Zeitlin, S.2
  • 13
    • 80053302109 scopus 로고    scopus 로고
    • Behavioral and genetic investigations of low exploratory behavior in Il18r1(-/-) mice: we can't always blame it on the targeted gene
    • Eisener-Dorman A.F., Lawrence D.A., Bolivar V.J. Behavioral and genetic investigations of low exploratory behavior in Il18r1(-/-) mice: we can't always blame it on the targeted gene. Brain Behav Immun 2010, 24:1116-1125.
    • (2010) Brain Behav Immun , vol.24 , pp. 1116-1125
    • Eisener-Dorman, A.F.1    Lawrence, D.A.2    Bolivar, V.J.3
  • 14
    • 47949113625 scopus 로고    scopus 로고
    • Deletion of the NADPH-cytochrome P450 reductase gene in cardiomyocytes does not protect mice against doxorubicin-mediated acute cardiac toxicity
    • Fang C., Gu J., Xie F., Behr M., Yang W., Abel E.D., Ding X. Deletion of the NADPH-cytochrome P450 reductase gene in cardiomyocytes does not protect mice against doxorubicin-mediated acute cardiac toxicity. Drug Metab Dispos 2008, 36:1722-1728.
    • (2008) Drug Metab Dispos , vol.36 , pp. 1722-1728
    • Fang, C.1    Gu, J.2    Xie, F.3    Behr, M.4    Yang, W.5    Abel, E.D.6    Ding, X.7
  • 15
    • 0038507099 scopus 로고    scopus 로고
    • Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase
    • Gu J., Weng Y., Zhang Q.Y., Cui H., Behr M., Wu L., Yang W., Zhang L., Ding X. Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase. J Biol Chem 2003, 278:25895-25901.
    • (2003) J Biol Chem , vol.278 , pp. 25895-25901
    • Gu, J.1    Weng, Y.2    Zhang, Q.Y.3    Cui, H.4    Behr, M.5    Wu, L.6    Yang, W.7    Zhang, L.8    Ding, X.9
  • 16
    • 0037475157 scopus 로고    scopus 로고
    • Predominantly neuronal expression of cytochrome P450 isoforms CYP3A11 and CYP3A13 in mouse brain
    • Hagemeyer C.E., Rosenbrock H., Ditter M., Knoth R., Volk B. Predominantly neuronal expression of cytochrome P450 isoforms CYP3A11 and CYP3A13 in mouse brain. Neuroscience 2003, 117:521-529.
    • (2003) Neuroscience , vol.117 , pp. 521-529
    • Hagemeyer, C.E.1    Rosenbrock, H.2    Ditter, M.3    Knoth, R.4    Volk, B.5
  • 18
    • 0037790603 scopus 로고    scopus 로고
    • Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase
    • Henderson C.J., Otto D.M., Carrie D., Magnuson M.A., McLaren A.W., Rosewell I., Wolf C.R. Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase. J Biol Chem 2003, 278:13480-13486.
    • (2003) J Biol Chem , vol.278 , pp. 13480-13486
    • Henderson, C.J.1    Otto, D.M.2    Carrie, D.3    Magnuson, M.A.4    McLaren, A.W.5    Rosewell, I.6    Wolf, C.R.7
  • 21
  • 24
    • 0034076609 scopus 로고    scopus 로고
    • Emotion circuits in the brain
    • LeDoux J.E. Emotion circuits in the brain. Annu Rev Neurosci 2000, 23:155-184.
    • (2000) Annu Rev Neurosci , vol.23 , pp. 155-184
    • LeDoux, J.E.1
  • 25
    • 0029584276 scopus 로고
    • Substrates of human hepatic cytochrome P450 3A4
    • Li A.P., Kaminski D.L., Rasmussen A. Substrates of human hepatic cytochrome P450 3A4. Toxicology 1995, 104:1-8.
    • (1995) Toxicology , vol.104 , pp. 1-8
    • Li, A.P.1    Kaminski, D.L.2    Rasmussen, A.3
  • 26
    • 34247270767 scopus 로고    scopus 로고
    • Hepatic cytochrome P450 reductase-null mice reveal a second microsomal reductase for squalene monooxygenase
    • Li L., Porter T.D. Hepatic cytochrome P450 reductase-null mice reveal a second microsomal reductase for squalene monooxygenase. Arch Biochem Biophys 2007, 461:76-84.
    • (2007) Arch Biochem Biophys , vol.461 , pp. 76-84
    • Li, L.1    Porter, T.D.2
  • 27
    • 34249009984 scopus 로고    scopus 로고
    • Expression and function of cytochrome p450 in brain drug metabolism
    • Meyer R.P., Gehlhaus M., Knoth R., Volk B. Expression and function of cytochrome p450 in brain drug metabolism. Curr Drug Metab 2007, 8:297-306.
    • (2007) Curr Drug Metab , vol.8 , pp. 297-306
    • Meyer, R.P.1    Gehlhaus, M.2    Knoth, R.3    Volk, B.4
  • 28
    • 0036874345 scopus 로고    scopus 로고
    • Drug-metabolizing cytochrome P450s in the brain
    • Miksys S.L., Tyndale R.F. Drug-metabolizing cytochrome P450s in the brain. J Psychiatry Neurosci 2002, 27:406-415.
    • (2002) J Psychiatry Neurosci , vol.27 , pp. 406-415
    • Miksys, S.L.1    Tyndale, R.F.2
  • 29
    • 79952120271 scopus 로고    scopus 로고
    • Subregion-specific p300 conditional knock-out mice exhibit long-term memory impairments
    • Oliveira A.M., Estevez M.A., Hawk J.D., Grimes S., Brindle P.K., Abel T. Subregion-specific p300 conditional knock-out mice exhibit long-term memory impairments. Learn Mem 2011, 18:161-169.
    • (2011) Learn Mem , vol.18 , pp. 161-169
    • Oliveira, A.M.1    Estevez, M.A.2    Hawk, J.D.3    Grimes, S.4    Brindle, P.K.5    Abel, T.6
  • 30
    • 0041468898 scopus 로고    scopus 로고
    • Identification of novel roles of the cytochrome p450 system in early embryogenesis: effects on vasculogenesis and retinoic Acid homeostasis
    • Otto D.M., Henderson C.J., Carrie D., Davey M., Gundersen T.E., Blomhoff R., Adams R.H., Tickle C., Wolf C.R. Identification of novel roles of the cytochrome p450 system in early embryogenesis: effects on vasculogenesis and retinoic Acid homeostasis. Mol Cell Biol 2003, 23:6103-6116.
    • (2003) Mol Cell Biol , vol.23 , pp. 6103-6116
    • Otto, D.M.1    Henderson, C.J.2    Carrie, D.3    Davey, M.4    Gundersen, T.E.5    Blomhoff, R.6    Adams, R.H.7    Tickle, C.8    Wolf, C.R.9
  • 32
    • 33645106219 scopus 로고    scopus 로고
    • Cholesterol-metabolizing cytochromes P450
    • Pikuleva I.A. Cholesterol-metabolizing cytochromes P450. Drug Metab Dispos 2006, 34:513-520.
    • (2006) Drug Metab Dispos , vol.34 , pp. 513-520
    • Pikuleva, I.A.1
  • 33
    • 51749097102 scopus 로고    scopus 로고
    • Neurosteroid biosynthesis regulates sexually dimorphic fear and aggressive behavior in mice
    • Pinna G., Agis-Balboa R.C., Pibiri F., Nelson M., Guidotti A., Costa E. Neurosteroid biosynthesis regulates sexually dimorphic fear and aggressive behavior in mice. Neurochem Res 2008, 33:1990-2007.
    • (2008) Neurochem Res , vol.33 , pp. 1990-2007
    • Pinna, G.1    Agis-Balboa, R.C.2    Pibiri, F.3    Nelson, M.4    Guidotti, A.5    Costa, E.6
  • 34
    • 0025784027 scopus 로고
    • Cytochrome P-450. Multiplicity of isoforms, substrates, and catalytic and regulatory mechanisms
    • Porter T.D., Coon M.J. Cytochrome P-450. Multiplicity of isoforms, substrates, and catalytic and regulatory mechanisms. J Biol Chem 1991, 266:13469-13472.
    • (1991) J Biol Chem , vol.266 , pp. 13469-13472
    • Porter, T.D.1    Coon, M.J.2
  • 35
    • 0028880959 scopus 로고
    • Hippocampal long-term potentiation is normal in heme oxygenase-2 mutant mice
    • Poss K.D., Thomas M.J., Ebralidze A.K., O'Dell T.J., Tonegawa S. Hippocampal long-term potentiation is normal in heme oxygenase-2 mutant mice. Neuron 1995, 15:867-873.
    • (1995) Neuron , vol.15 , pp. 867-873
    • Poss, K.D.1    Thomas, M.J.2    Ebralidze, A.K.3    O'Dell, T.J.4    Tonegawa, S.5
  • 36
    • 0037470154 scopus 로고    scopus 로고
    • The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review
    • Prut L., Belzung C. The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review. Eur J Pharmacol 2003, 463:3-33.
    • (2003) Eur J Pharmacol , vol.463 , pp. 3-33
    • Prut, L.1    Belzung, C.2
  • 38
    • 0035968215 scopus 로고    scopus 로고
    • Neurosteroid hydroxylase CYP7B: vivid reporter activity in dentate gyrus of gene-targeted mice and abolition of a widespread pathway of steroid and oxysterol hydroxylation
    • Rose K., Allan A., Gauldie S., Stapleton G., Dobbie L., Dott K., Martin C., Wang L., Hedlund E., Seckl J.R., Gustafsson J.A., Lathe R. Neurosteroid hydroxylase CYP7B: vivid reporter activity in dentate gyrus of gene-targeted mice and abolition of a widespread pathway of steroid and oxysterol hydroxylation. J Biol Chem 2001, 276:23937-23944.
    • (2001) J Biol Chem , vol.276 , pp. 23937-23944
    • Rose, K.1    Allan, A.2    Gauldie, S.3    Stapleton, G.4    Dobbie, L.5    Dott, K.6    Martin, C.7    Wang, L.8    Hedlund, E.9    Seckl, J.R.10    Gustafsson, J.A.11    Lathe, R.12
  • 39
    • 67650751079 scopus 로고    scopus 로고
    • Cholesterol 24-hydroxylase: an enzyme of cholesterol turnover in the brain
    • Russell D.W., Halford R.W., Ramirez D.M., Shah R., Kotti T. Cholesterol 24-hydroxylase: an enzyme of cholesterol turnover in the brain. Annu Rev Biochem 2009, 78:1017-1040.
    • (2009) Annu Rev Biochem , vol.78 , pp. 1017-1040
    • Russell, D.W.1    Halford, R.W.2    Ramirez, D.M.3    Shah, R.4    Kotti, T.5
  • 40
    • 0015501157 scopus 로고
    • Immunochemical evidence for an association of heme oxygenase with the microsomal electron transport system
    • Schacter B.A., Nelson E.B., Marver H.S., Masters B.S. Immunochemical evidence for an association of heme oxygenase with the microsomal electron transport system. J Biol Chem 1972, 247:3601-3607.
    • (1972) J Biol Chem , vol.247 , pp. 3601-3607
    • Schacter, B.A.1    Nelson, E.B.2    Marver, H.S.3    Masters, B.S.4
  • 41
    • 0037155271 scopus 로고    scopus 로고
    • Association of multiple developmental defects and embryonic lethality with loss of microsomal NADPH-cytochrome P450 oxidoreductase
    • Shen A.L., O'Leary K.A., Kasper C.B. Association of multiple developmental defects and embryonic lethality with loss of microsomal NADPH-cytochrome P450 oxidoreductase. J Biol Chem 2002, 277:6536-6541.
    • (2002) J Biol Chem , vol.277 , pp. 6536-6541
    • Shen, A.L.1    O'Leary, K.A.2    Kasper, C.B.3
  • 45
    • 24744466284 scopus 로고    scopus 로고
    • Hepatic gene expression changes in mouse models with liver-specific deletion or global suppression of the NADPH-cytochrome P450 reductase gene. Mechanistic implications for the regulation of microsomal cytochrome P450 and the fatty liver phenotype
    • Weng Y., DiRusso C.C., Reilly A.A., Black P.N., Ding X. Hepatic gene expression changes in mouse models with liver-specific deletion or global suppression of the NADPH-cytochrome P450 reductase gene. Mechanistic implications for the regulation of microsomal cytochrome P450 and the fatty liver phenotype. J Biol Chem 2005, 280:31686-31698.
    • (2005) J Biol Chem , vol.280 , pp. 31686-31698
    • Weng, Y.1    DiRusso, C.C.2    Reilly, A.A.3    Black, P.N.4    Ding, X.5
  • 46
    • 34548029142 scopus 로고    scopus 로고
    • Determination of the role of target tissue metabolism in lung carcinogenesis using conditional cytochrome P450 reductase-null mice
    • Weng Y., Fang C., Turesky R.J., Behr M., Kaminsky L.S., Ding X. Determination of the role of target tissue metabolism in lung carcinogenesis using conditional cytochrome P450 reductase-null mice. Cancer Res 2007, 67:7825-7832.
    • (2007) Cancer Res , vol.67 , pp. 7825-7832
    • Weng, Y.1    Fang, C.2    Turesky, R.J.3    Behr, M.4    Kaminsky, L.S.5    Ding, X.6
  • 48
    • 33751100895 scopus 로고    scopus 로고
    • Central administration of a cytochrome P450-7B product 7 alpha-hydroxypregnenolone improves spatial memory retention in cognitively impaired aged rats
    • Yau J.L., Noble J., Graham M., Seckl J.R. Central administration of a cytochrome P450-7B product 7 alpha-hydroxypregnenolone improves spatial memory retention in cognitively impaired aged rats. J Neurosci 2006, 26:11034-11040.
    • (2006) J Neurosci , vol.26 , pp. 11034-11040
    • Yau, J.L.1    Noble, J.2    Graham, M.3    Seckl, J.R.4
  • 49
    • 61449095680 scopus 로고    scopus 로고
    • An intestinal epithelium-specific cytochrome P450 (P450) reductase-knockout mouse model: direct evidence for a role of intestinal p450s in first-pass clearance of oral nifedipine
    • Zhang Q.Y., Fang C., Zhang J., Dunbar D., Kaminsky L., Ding X. An intestinal epithelium-specific cytochrome P450 (P450) reductase-knockout mouse model: direct evidence for a role of intestinal p450s in first-pass clearance of oral nifedipine. Drug Metab Dispos 2009, 37:651-657.
    • (2009) Drug Metab Dispos , vol.37 , pp. 651-657
    • Zhang, Q.Y.1    Fang, C.2    Zhang, J.3    Dunbar, D.4    Kaminsky, L.5    Ding, X.6
  • 50
    • 0032955088 scopus 로고    scopus 로고
    • On the respective roles of nitric oxide and carbon monoxide in long-term potentiation in the hippocampus
    • Zhuo M., Laitinen J.T., Li X.C., Hawkins R.D. On the respective roles of nitric oxide and carbon monoxide in long-term potentiation in the hippocampus. Learn Mem 1999, 6:63-76.
    • (1999) Learn Mem , vol.6 , pp. 63-76
    • Zhuo, M.1    Laitinen, J.T.2    Li, X.C.3    Hawkins, R.D.4
  • 51
    • 0033305132 scopus 로고    scopus 로고
    • Neurosteroidogenesis in astrocytes, oligodendrocytes, and neurons of cerebral cortex of rat brain
    • Zwain I.H., Yen S.S. Neurosteroidogenesis in astrocytes, oligodendrocytes, and neurons of cerebral cortex of rat brain. Endocrinology 1999, 140:3843-3852.
    • (1999) Endocrinology , vol.140 , pp. 3843-3852
    • Zwain, I.H.1    Yen, S.S.2


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