Lactosylceramide synthase as a therapeutic target to mitigate multiple human diseases in animal models

Advances in Experimental Medicine and Biology

Volumn 749, Issue , 2012, Pages 153-169

  Chatterjee, Subroto ^a   Alsaeedi, Nezar ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 DECANOYLAMINO 3 MORPHOLINO 1 PHENYL 1 PROPANOL; CERAMIDE GLUCOSYLTRANSFERASE; CERAMIDE GLUCOSYLTRANSFERASE INHIBITOR; GALACTOSYLTRANSFERASE; GALACTOSYLTRANSFERASE V; GENZ 123346; GLUCOSYLCERAMIDE; LACTOSYLCERAMIDE; LACTOSYLCERAMIDE SYNTHASE; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; SYNTHETASE; UNCLASSIFIED DRUG; VASCULOTROPIN;

AGING; ASTHMA; ATHEROSCLEROTIC PLAQUE; CALORIC RESTRICTION; CANCER CELL; CELL PROLIFERATION; COLORECTAL CANCER; CONFERENCE PAPER; DRUG DETERMINATION; DRUG EFFICACY; DRUG STRUCTURE; ELASTICITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GAUCHER DISEASE; GLIOBLASTOMA; HUMAN; HYPERLIPIDEMIA; KIDNEY CANCER; KIDNEY POLYCYSTIC DISEASE; MOLECULAR BIOLOGY; NONHUMAN; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; RESPIRATORY TRACT DISEASE; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; SQUAMOUS CELL CARCINOMA; TREATMENT RESPONSE; WOUND HEALING;

ANIMALS; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; ENZYME INHIBITORS; GALACTOSYLTRANSFERASES; HUMANS;

ANIMALIA;

EID: 84863752786     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4614-3381-1_11     Document Type: Conference Paper

References (47)

1. Arai T, Bhunia AK, Chatterjee S et al (1998) Lactosylceramide stimulates human neutrophils to upregulate Mac-1, adhere to endothelium, and generate reactive oxygen metabolites in vitro. Circ Res 82:54054-7
2. Berliner JA, Heinecke JW (1996) The role of oxidized lipoproteins in atherogenesis. Free Radic Biol Med 20:707-727
3. Bhunia AK, Arai T, Bulkley G et al (1998) Lactosylceramide mediates tumor necrosis factoralpha- induced intercellular adhesion molecule-1 (ICAM-1) expression and the adhesion of neutrophil in human umbilical vein endothelial cells. J Biol Chem 273:34349-34357
4. Bischoff SC (2007) Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data. Nat Rev Immunol 7:93-104
5. Chae SS, Paik JH, Furneaux H, Hla T (2004) Requirement for sphingosine 1-phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference. J Clin Invest 114: 1082-1089
6. Chatterjee S (1991) Lactosylceramide stimulates aortic smooth muscle cell proliferation. Biochem Biophys Res Commun 181:554-61
7. Chatterjee S (1993) Regulation of synthesis of lactosylceramide in normal and tumor proximal tubular cells. Biochim Biophys Acta Lipids Lipid Metab 1167:339-344
8. Chatterjee S, Ghosh N (1990) Phosphatidylcholine stimulates the activity of UDP-Gal beta 1-4 galactosyltransferase in normal human kidney proximal tumour cells. Indian J Biochem Biophys 27:375-378
9. Chatterjee S, Pandey A (2008) The Yin and Yang of lactosylceramide metabolism: implications in cell function. Biochim Biophys Acta 1780:370-382
10. Chatterjee S, Kwiterovich PO, Gupta P et al (1983) Localization of urinary lactosylceramide in cytoplasmic vesicles of renal tubular cells in homozygous familial hypercholesterolemia. Proc Natl Acad Sci USA 80:1313-1317
11. Chatterjee S, Ghosh N, Khurana S (1992) Purification of uridine diphosphate-galactose:glucosyl ceramide, beta 1-4 galactosyltransferase from human kidney. J Biol Chem 267:7148-7153
12. Chatterjee S, Cleveland T, Shi WY et al (1996a) Studies of the action of ceramide-like substances (D- and L-PDMP) on sphingolipid glycosyltransferases and purified lactosylceramide synthase. Glycoconj J 13:481-486
13. Chatterjee S, Shi WY, Wilson P et al (1996b) Role of lactosylceramide and MAP kinase in the proliferation of proximal tubular cells in human polycystic kidney disease. J Lipid Res 37:1334-1344
14. Chatterjee S, Bhunia AK, Snowden A (1997) Oxidized low density lipoproteins stimulate galactosyltransferase activity, Ras activation, p44 mitogen activated protein kinase and c-Fos expression in aortic smooth muscle cells. Glycobiology 7:703-710
15. Chatterjee S, Berliner JA, Subbanagounder GG et al (2004) Identification of a biologically active component in minimally oxidized low density lipoprotein (MM-LDL) responsible for aortic smooth muscle cell proliferation. Glycoconj J 20:331-318
16. Chatterjee S, Kolmakova A, Rajesh M (2008) Regulation of lactosylceramide synthase (Glucosylceramide b -1,4- galactosyltransferase), implication as a drug target. Curr Drug Targets 9(4):272-281
17. Goldstein JL, Brown MS (2009) The LDL receptor. Arterioscler Thromb Vasc Biol 29:431-438
18. Gong NL, Chatterjee S (2003) Platelet endothelial cell adhesion molecule in cell signaling and thrombosis. Mol Cell Biochem 253:151-158
19. Hakomori SI, Murakami WT (1968) Glycolipids of hamster fi broblasts and derived malignanttransformed cell lines. Proc Natl Acad Sci USA 59:254-261
20. Hernandez-Corbacho MJ, Jenkins RW, Clarke CJ, Hannun YA, Obeid LM et al (2011) Accumulation of long-chain glycosphingolipids during aging is prevented by caloric restriction. PLoS One 6:20411-20420
21. Iwamoto T, Fukumoko S, Kanaoka K et al (2001) Lactosylceramide is essential for the osteoclastogenesis mediated by macrophage-colony-stimulating factor and receptor activator of nuclear factor-Kappa B ligand. J Biol Chem 276(49):46031-8
22. Jiang J, Shen J, Wu T (2006) Down-regulation of beta1, 4-galactosyltransferase V is a critical part of etoposipde-induced apoptotic process and could be mediated by decreasing Sp1 levels in human glioma cells. Glycobiology 16:1045-1051
23. Kamani M, Mylvaganam M, Tian R, Rigat B, Binnington B, Lingwood C (2011) Adamantyl glycosphingolipids provide a new approach to the selective regulation of cellular glycosphingolipid metabolism. J Biol Chem 286:21413-21426
24. Karman J, Tedstone JL, Gumlaw NK et al (2010) Reducing glycosphingolipid biosynthesis in airway cells partially ameliorates disease manifestations in a mouse model of asthma. Int Immunol 22:593-603
25. Kijimoto S, Hakomori S (1971) Enhanced glycolipid: A- galactosyltransferase activity in contactinhibited hamster cells, and loss of this response in polyoma transformants. Biochem Biophys Res Commun 44:557-563
26. Kolmakova A, Chatterjee S (2005) Platelet derived growth factor recruits lactosylceramide to induce cell proliferation in UDP Gal:GlcCer: Beta1 - ≥ 4 galactosyltransferase (GalT-V) in mutant Chinese hamster ovary cells. Glycoconj J 22:401-407
27. Kolmakova A, Rajesh M, Zang D et al (2009) VEGF recruits lactosylceramide to induce endothelial cell adhesion molecule expression and angiogenesis in vitro and in vivo. Glycoconj J 26: 547-558
28. Kolter T, Proia RL, Sandhoff K (2002) Combinatorial ganglioside biosynthesis. J Biol Chem 277:25859-25862
29. Kumagai T, Tanaka M, Yokogama M et al (2010) Involvement of murine beta-1,4-galactosyltransferase V in lactosylceramide biosynthesis. Glycoconj J 27:685-695
30. Li L, Davie JR (2010) The role of Sp1 and Sp3 in normal and cancer cell biology. Ann Anat 192:275-283
31. Limayem V, Li X, Hahn C, Xia P, Berndt MC, Vadas MA, Gamble JR (2005) Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3 K/Akt and regulation of Bcl-2 family members. Blood 105:3169-3177
32. Lo NW, Shaper JH, Pevsner J et al (1998) The expanding beta 4-galactosyltransferase gene family: messages from the databanks. Glycobiology 8(5):517-526
33. Mirkin BL, Clark SH, Zhang C (2002) Inhibition of human neuroblastoma cell proliferation and EGF receptor phosphorylation by gangliosides GM1, GM3, GD1A and GT1B. Cell Prolif 35:105-115
34. Miyagi T, Wada T, Yamaguchi K (2008) Roles of plasma membrane-associated sialidase NEU3 in human cancers. Biochim Biophys Acta 1780:532-537
35. Natoli TA, Smith LA, Rogers KA et al (2010) Inhibition of glucosylceramide accumulation results in effective blockade of polycystic kidney disease in mouse models. Nat Med 16:788-792
36. Nomura T, Takizawa M, Aoki S et al (1998) Purification, cDNA cloning, and expression of UDP-Gal: glucosylceramide beta-1,4-galactosyltransferase from rat brain. J Biol Chem 273:13570-13577
37. Pandey S, Murphy RF, Agrawal DK (2007) Recent advances in the immunobiology of ceramide. Exp Mol Pathol 82:298-309
38. Pannu R, Singh AK, Singh I (2005) A novel role of lactosylceramide in the regulation of tumor necrosis factor alpha-mediated proliferation of rat primary astrocytes. Implications for astrogliosis following neurotrauma. J Biol Chem 280:13742-13751
39. Radin N (1993) Use of an inhibitor of glucosylceramide synthesis, D-1-phenyl-2- decanoylamino- 3-morpholino-1 -propanol. Neuroprotocols 3:145-155
40. Rajesh M, Kolmakova A, Chatterjee S (2005) Novel role of lactosylceramide in vascular endothelial growth factor-mediated angiogenesis in human endothelial cells. Circ Res 97:796-804
41. Rapport MM, Graf L, Skipski VP et al (1958) Cytolipin H, a pure lipid hapten isolated from human carcinoma. Nature 18:1803-1804
42. Rusciani A, Duca L, Startelet H et al (2011) Elastin peptides signaling relies on neuraminidase-1- dependent lactosylceramide generation. PLoS One 5(11):e14010
43. Subroto Chatterjee Patent application title: Methods for treatment of angiogenesis. US Patent# AA61K39395FI.
44. Watson AD, Leitinger N, Novab M (1997) Structural identification by mass spectrometry of oxidized phospholipids in minimally oxidized low density lipoprotein t hat induce monocyte/ endothelial interactions and evidence for their presence in vivo. J Biol Chem 272: 13597-13607
45. Wei Y, Zhou F, Ge Y et al (2010a) Regulation of the beta1,4- galactosyltransferase I promoter by E2F. J Biochem 148:263-271
46. Wei Y, Zhou F, Gj He Y et al (2010) Beta1,4-galactosyltransferase V regulates self-renewal of glioma-initiating cell. Biochem Biophys Res Commun 396:602-607
47. Yamakawa T, Nagai Y (1978) Glycolipids at the cell surface and their biological functions. Trends Biochem Sci 3:128-131