Platelet endothelial cell adhesion molecule in cell signaling and thrombosis

Molecular and Cellular Biochemistry

Volumn 253, Issue 1-2, 2003, Pages 151-158

  Gong, NanLing ^a   Chatterjee, Subroto ^a,b  

^a Johns Hopkins Singapore   (Singapore)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Atherosclerosis; Cell adhesion and trans endothelial migration; Inflammation; Intracellular signaling; PECAM 1; Regulation; Structure; Thrombosis

Indexed keywords

CD31 ANTIGEN; CELL ADHESION MOLECULE; IMMUNOGLOBULIN;

APOPTOSIS; ATHEROGENESIS; ATHEROSCLEROSIS; BLOOD VESSEL WALL; CELL MIGRATION; CYTOLOGY; ENDOTHELIUM; HUMAN; INFLAMMATION; INTRACELLULAR SPACE; MONOCYTE; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE; THROMBOSIS;

ANTIGENS, CD31; APOPTOSIS; ARTERIOSCLEROSIS; CELL ADHESION; CELL COMMUNICATION; CELL MOVEMENT; ENDOTHELIUM, VASCULAR; HUMANS; NEOPLASMS; T-LYMPHOCYTES; THROMBOSIS; TUMOR CELLS, CULTURED;

EID: 0142212370     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1026016628386     Document Type: Review

References (88)

1. DeLisser HM, Christofidou-Solomidou M, Strieter RM, Burdick MD, Robinson CS, Wexler RS, Kerr JS, Garlanda C, Merwin JR, Madri JA, Albelda SM: Involvement of endothelial PECAM-1/CD31 in angiogenesis. Am J Pathol 151: 671-677, 1997
2. Newman PJ: The biology of PECAM-1. J Clin Invest 99: 3-8, 1997
3. Newman PJ: Switched at birth: A new family for PECAM-1. J Clin Invest 103: 5-9, 1999
4. Fujiwara K, Masuda M, Osawa M, Kano Y, Katoh K: Is PECAM-1 a mechanoresponsive molecule? Cell Struct Funct 26: 11-17, 2001
5. Gumina RJ, el Schultz J, Yao Z, Kenny D, Warltier DC, Newman PJ, Gross GJ: Antibody to platelet/endothelial cell adhesion molecule-1 reduces myocardial infarct size in a rat model of ischemia-reperfusion injury. Circulation 94: 3327-3333, 1996
6. Kirschbaum NE, Gumina RJ, Newman PJ: Organization of the gene for human platelet/endothelial cell adhesion molecule-1 shows alternatively spliced isoforms and a functionally complex cytoplasmic domain. Blood 84: 4028-4037, 1994
7. Sun J, Paddock C, Shubert J, Zhang HB, Amin K, Newman PJ, Albelda SM: Contributions of the extracellular and cytoplasmic domains of platelet-endothelial cell adhesion molecule-1 (PECAM-1/CD31) in regulating cell-cell localization. J Cell Sci 113: 1459-1469, 2002
8. Serebruany VL, Murugesan SR, Pothula A, Atar D, Lowry DR, O'Connor CM, Gurbel PA: Increased soluble platelet/endothelial cellular adhesion molecule-1 and osteonectin levels in patients with severe congestive heart failure. Independence of disease etiology, and antecedent aspirin therapy. Eur J Heart Fail 1: 243-249, 1999
9. Serebruany VL, Murugesan SR, Pothula A, Semaan H, Gurbel PA: Soluble PECAM-1, but not P-selectin, nor osteonectin identify acute myocardial infarction in patients presenting with chest pain. Cardiology 91: 50-55, 1999
10. Gurbel PA, Serebruany VL, Shustov AR, Dalesandro M, Gumbs CI, Grablutz LB, Bahr RD, Ohman EM, Topol EJ: Increased baseline levels of platelet P-selectin, and platelet-endothelial cell adhesion molecule-1 in patients with acute myocardial infarction as predictors of unsuccessful thrombolysis. Coron Artery Dis 9: 451-456, 1998
11. Gumina RJ, Kirschbaum NE, Piotrowski K, Newman PJ: Characterization of the human platelet/endothelial cell adhesion molecule-1 promoter: Identification of a GATA-2 binding element required for optimal transcriptional activity. Blood 89: 1260-1269, 1997
12. Botella LM, Puig-Kroger A, Almendro N, Sanchez-Elsner T, Munoz E, Corbi A, Bernabeu C: Identification of a functional NF-kappa B site in the platelet endothelial cell adhesion molecule-1 promoter. J Immunol 164: 1372-1378, 2000
13. Cabanas C, Sanchez-Madrid F, Bellon T, Figdor CG, Te Velde AA, Fernandez JM, Acevedo A, Bernabeu C: Characterization of a novel myeloid antigen regulated during differentiation of monocytic cells. Eur J Immunol 19: 1373-1378, 1989
14. Almendro N, Bellon T, Rius C, Lastres P, Langa C, Corbi A, Bernabeu C: Cloning of the human platelet endothelial cell adhesion molecule-1 promoter and its tissue-specific expression. Structural and functional characterization. J Immunol 157: 5411-5421, 1996
15. Goldberger A, Middleton KA, Newman PJ: Changes in expression of the cell adhesion molecule PECAM-1 (CD31) during differentiation of human leukemic cell lines. Tissue Antigens 44: 285-293, 1994
16. Rival Y, Del Maschio A, Rabiet MJ, Dejana E, Duperray A: Inhibition of platelet endothelial cell adhesion molecule-1 synthesis and leukocyte transmigration in endothelial cells by the combined action of TNF-alpha and IFN-gamma. J Immunol 157: 1233-1241, 1996
17. Raab M, Daxecker H, Markovic S, Karimi A, Griesmacher A, Mueller MM: Variation of adhesion molecule expression on human umbilical vein endothelial cells upon multiple cytokine application. Clin Chim Acta 321: 11-16, 2002
18. Minehata K, Mukouyama YS, Sekiguchi T, Hara T, Miyajima A: Macrophage colony stimulating factor modulates the development of hematopoiesis by stimulating the differentiation of endothelial cells in the AGM region. Blood 99: 2360-2368, 2002
19. Shih SC, Robinson GS, Perruzzi CA, Calvo A, Desai K, Green JE, Ali IU, Smith LE, Senger DR: Molecular profiling of angiogenesis markers. Am J Pathol 161: 35-41, 2002
20. Gong NL, Chowdhury SH, Wei HM, Lim YL, Chatterjee S: Lactosylceramide recruits phospholipase A2 to stimulate PECAM-1 expression in human monocytes and adhesion to endothelial cells. (in preparation)
21. Martin S, Chatterjee S: Spingolipids in atherosclerosis. Adv Cell Aging Gerontol Res 12: 71-96, 2003
22. Bhunia AK, Arai T, Bulkley G, Chatterjee S: Lactosylceramide mediates tumor necrosis factor-alpha-induced intercellular adhesion molecule-1 (ICAM-1) expression and the adhesion of neutrophil in human umbilical vein endothelial cells. J Biol Chem 273: 34349-34357, 1998
23. Albelda SM, Muller WA, Buck CA, Newman PJ: Molecular and cellular properties of PECAM-1 (endoCAM/CD31): A novel vascular cell-cell adhesion molecule. J Cell Biol 114: 1059-1068, 1991
24. Xie Y, Muller WA: Molecular cloning and adhesive properties of murine platelet/endothelial cell adhesion molecule 1. Proc Natl Acad Sci USA 90: 5569-5573, 1993
25. Fawcett J, Buckley C, Holness CL, Bird IN, Spragg JH, Saunders J, Harris A, Simmons DL: Mapping the homotypic binding sites in CD31 and the role of CD31 adhesion in the formation of interendothelial cell contacts. J Cell Biol 128: 1229-1241, 1995
26. Sun J, Williams J, Yan HC, Amin KM, Albelda SM, DeLisser HM: Platelet endothelial cell adhesion molecule-1 (PECAM-1) homophilic adhesion is mediated by immunoglobulin-like domains 1 and 2 and depends on the cytoplasmic domain and the level of surface expression. J Biol Chem 271: 18561-18570, 1996
27. Newton JP, Buckley CD, Jones EY, Simmons DL: Residues on both faces of the first immunoglobulin fold contribute to homophilic binding sites of PECAM-1/CD31. J Biol Chem 272: 20555-20563, 1997
28. Muller WA, Berman ME, Newman PJ, DeLisser HM, Albelda SM: A heterophilic adhesion mechanism for platelet/endothelial cell adhesion molecule 1 (CD31). J Exp Med 175: 1401-1404, 1992
29. DeLisser HM, Yan HC, Newman PJ, Muller WA, Buck CA, Albelda SM: Platelet/endothelial cell adhesion molecule-1 (CD31)-mediated cellular aggregation involves cell surface glycosaminoglycans. J Biol Chem 268: 16037-16046, 1993
30. Sun QH, Paddock C, Visentin GP, Zukowski MM, Muller WA, Newman PJ: Cell surface glycosaminoglycans do not serve as ligands for PECAM-1. PECAM-1 is not a heparin-binding protein. J Biol Chem 273: 11483-11490, 1998
31. Piali L, Hammel P, Uherek C, Bachmann F, Gisler RH, Dunon D, Imhof BA: CD31/PECAM-1 is a ligand for alpha v beta 3 integrin involved in adhesion of leukocytes to endothelium. J Cell Biol 130: 451-460, 1995
32. Buckley CD, Doyonnas R, Newton JP, Blystone SD, Brown EJ, Watt SM, Simmons DL: Identification of alpha v beta 3 as a heterotypic ligand for CD31/PECAM-1. J Cell Sci 109: 437-445, 1996
33. Deaglio S, Morra M, Mallone R, Ausiello CM, Prager E, Garbarino G, Dianzani U, Stockinger H, Malavasi F: Human CD38 (ADP-ribosyl cyclase) is a counterreceptor of CD31, an Ig superfamily member. J Immunol 160: 395-402, 1998
34. Muller WA, Weigl SA, Deng X, Phillips DM: PECAM-1 is required for transendothelial migration of leukocytes. J Exp Med 178: 449-460, 1993
35. Berman ME, Xie Y, Muller WA: Roles of platelet/endothelial cell adhesion molecule-1 (PECAM-1, CD31) in natural killer cell transendothelial migration and beta 2 integrin activation. J Immunol 156: 1515-1524, 1996
36. Vaporciyan AA, DeLisser HM, Yan HC, Mendiguren II, Thom SR, Jones ML, Ward PA, Albelda SM: Involvement of platelet-endothelial cell adhesion molecule-1 in neutrophil recruitment in vivo. Science 262: 1580-1582, 1993
37. Bogen S, Pak J, Garifallou M, Deng X, Muller WA: Monoclonal antibody to murine PECAM-1 (CD31) blocks acute inflammation in vivo. J Exp Med 179: 1059-1064, 1994
38. Liao F, Huynh HK, Eiroa A, Greene T, Polizzi E, Muller WA: Migration of monocytes across endothelium and passage through extracellular matrix involve separate molecular domains of PECAM-1. J Exp Med 182: 1337-1343, 1995
39. Wakelin MW, Sanz MJ, Dewar A, Albelda SM, Larkin SW, Boughton-Smith N, Williams TJ, Nourshargh S: An anti-platelet-endothelial cell adhesion molecule-1 antibody inhibits leukocyte extravasation from mesenteric microvessels in vivo by blocking the passage through the basement membrane. J Exp Med 184: 229-239, 1996
40. Duncan GS, Andrew DP, Takimoto H, Kaufman SA, Yoshida H, Spellberg J, Luis de la Pompa J, Elia A, Wakeham A, Karan-Tamir B, Muller WA, Senaldi G, Zukowski MM, Mak TW: Genetic evidence for functional redundancy of platelet/endothelial cell adhesion molecule-1 (PECAM-1): CD31-deficient mice reveal PECAM-1-dependent and PECAM-1-independent functions. J Immunol 162: 3022-3030, 1999
41. Thompson RD, Noble KE, Larbi KY, Dewar A, Duncan GS, Mak TW, Nourshargh S: Platelet-endothelial cell adhesion molecule-1 (PECAM-1)-deficient mice demonstrate a transient and cytokine-specific role for PECAM-1 in leukocyte migration through the perivascular basement membrane. Blood 97: 1854-1860, 2001
42. Graesser D, Solowiej A, Bruckner M, Osterweil E, Juedes A, Davis S, Ruddle NH, Engelhardt B, Madri JA: Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1-deficient mice. J Clin Invest 109: 383-392, 2002
43. Tanaka Y, Albelda SM, Horgan KJ, van Seventer GA, Shimizu Y, Newman W, Hallam J, Newman PJ, Buck CA, Shaw S: CD31 expressed on distinctive T cell subsets is a preferential amplifier of beta 1 integrin-mediated adhesion. J Exp Med 176: 245-253, 1992
44. + hemopoietic progenitor cells. J Immunol 153: 4673-4683, 1994
45. Piali L, Albelda SM, Baldwin HS, Hammel P, Gisler RH, Imhof BA: Murine platelet endothelial cell adhesion molecule (PECAM-1)/CD31 modulates beta 2 integrins on lymphokine-activated killer cells. Eur J Immunol 23: 2464-2471, 1993
46. Berman ME, Muller WA: Ligation of platelet/endothelial cell adhesion molecule (PECAM-1/CD31) on monocytes and neutrophils increases binding capacity of leukocyte CR3 (CD11b/CD18). J Immunol 154: 299-307, 1995
47. Varon D, Jackson DE, Shenkman B, Dardik R, Tamarin I, Savion N, Newman PJ: Platelet/endothelial cell adhesion molecule-1 serves as a costimulatory agonist receptor that modulates integrin-dependent adhesion and aggregation of human platelets. Blood 91: 500-507, 1998
48. Newman PJ, Hillery CA, Albrecht R, Parise LV, Berndt MC, Mazurov AV, Dunlop LC, Zhang J, Rittenhouse SE: Activation-dependent changes in human platelet PECAM-1: Phosphorylation, cytoskeletal association, and surface membrane redistribution. J Cell Biol 119: 239-246, 1992
49. Zehnder JL, Hirai K, Shatsky M, McGregor JL, Levitt LJ, Leung LL: The cell adhesion molecule CD31 is phosphorylated after cell activation. Down-regulation of CD31 in activated T lymphocytes. J Biol Chem 267: 5243-5249, 1992
50. Lastres P, Almendro N, Bellon T, Lopez-Guerrero JA, Eritja R, Bernabeu C: Functional regulation of platelet/endothelial cell adhesion molecule-1 by TGFbeta 1 in promonocytic U-937 cells. J Immunol 153: 4206-4218, 1994
51. Jackson DE, Ward CM, Wang R, Newman PJ: The protein-tyrosine phosphatase SHP-2 binds platelet/endothelial cell adhesion molecule-1 (PECAM-1) and forms a distinct signaling complex during platelet aggregation. Evidence for a mechanistic link between PECAM-1- and integrin-mediated cellular signaling. J Biol Chem 272: 6986-6993, 1997
52. Sagawa K, Swaim W, Zhang J, Unsworth E, Siraganian RP: Aggregation of the high affinity IgE receptor results in the tyrosine phosphorylation of the surface adhesion protein PECAM-1 (CD31). J Biol Chem 272: 13412-13418, 1997
53. Lu TT, Yan LG, Madri JA: Integrin engagement mediates tyrosine dephosphorylation on platelet-endothelial cell adhesion molecule 1. Proc Natl Acad Sci USA 93: 11808-11813, 1996
54. Harada N, Masuda M, Fujiwara K: Fluid flow and osmotic stress induce tyrosine phosphorylation of an endothelial cell 128 kDa surface glycoprotein. Biochem Biophys Res Commun 214: 69-74, 1995
55. Osawa M, Masuda M, Harada N, Lopes RB, Fujiwara K: Tyrosine phosphorylation of platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) in mechanically stimulated vascular endothelial cells. Eur J Cell Biol 72: 229-237, 1997
56. Ochi H, Kume N, Nishi E, Moriwaki H, Masuda M, Fujiwara K, Kita T: Tyrosine phosphorylation of platelet endothelial cell adhesion molecule-1 induced by lysophosphatidylcholine in cultured endothelial cells. Biochem Biophys Res Commun 243: 862-868, 1998
57. Kalra VK, Shen Y, Sultana C, Rattan V: Hypoxia induces PECAM-1 phosphorylation and transendothelial migration of monocytes. Am J Physiol 271: H2025-H2034, 1996
58. Schimmenti LA, Yan HC, Madri JA, Albelda SM: Platelet endothelial cell adhesion molecule, PECAM-1, modulates cell migration. J Cell Physiol 153: 417-428, 1992
59. Pinter E, Barreuther M, Lu T, Imhof BA, Madri JA: Platelet-endothelial cell adhesion molecule-1 (PECAM-1/CD31) tyrosine phosphorylation state changes during vasculogenesis in the murine conceptus. Am J Pathol 150: 1523-1530, 1997
60. Pinter E, Mahooti S, Wang Y, Imhof BA, Madri JA: Hyperglycemia-induced vasculopathy in the murine vitelline vasculature: Correlation with PECAM-1/CD31 tyrosine phosphorylation state. Am J Pathol 154: 1367-1379, 1999
61. Jackson DE, Kupcho KR, Newman PJ: Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of platelet/endothelial cell adhesion molecule-1 (PECAM-1) that are required for the cellular association and activation of the protein-tyrosine phosphatase, SHP-2. J Biol Chem 272: 24868-24875, 1997
62. Hua CT, Gamble JR, Vadas MA, Jackson DE: Recruitment and activation of SHP-1 protein-tyrosine phosphatase by human platelet endothelial cell adhesion molecule-1 (PECAM-1). Identification of immunoreceptor tyrosine-based inhibitory motif-like binding motifs and substrates. J Biol Chem 273: 28332-28340, 1998
63. Vivier E, Daeron M: Immunoreceptor tyrosine-based inhibition motifs. Immunol Today 18: 286-291, 1997
64. Pumphrey NJ, Taylor V, Freeman S, Douglas MR, Bradfield PF, Young SP, Lord JM, Wakelam MJ, Bird IN, Salmon M, Buckley CD: Differential association of cytoplasmic signaling molecules SHP-1, SHP-2, SHIP and phospholipase Cgamma1 with PECAM-1/CD31. FEBS Lett 450: 77-83, 1999
65. Pellegatta F, Chierchia SL, Zocchi MR: Functional association of platelet endothelial cell adhesion molecule-1 and phosphoinositide 3-kinase in human neutrophils. J Biol Chem 273: 27768-27771, 1998
66. Ilan N, Mahooti S, Rimm DL, Madri JA: PECAM-1 (CD31) functions as a reservoir for and a modulator of tyrosine-phosphorylated beta-catenin. J Cell Sci 112: 3005-3014, 1999
67. Ilan N, Cheung L, Pinter E, Madri JA: Platelet-endothelial cell adhesion molecule-1 (CD31), a scaffolding molecule for selected catenin family members whose binding is mediated by different tyrosine and serine/threonine phosphorylation. J Biol Chem 275: 21435-21443, 2000
68. Novak A, Dedhar S: Signaling through beta-catenin and Lef/Tcf. Cell Mol Life Sci 56: 523-537, 1999
69. Jones KL, Hughan SC, Dopheide SM, Farndale RW, Jackson SP, Jackson DE: Platelet endothelial cell adhesion molecule-1 is a negative regulator of platelet-collagen interactions. Blood 98: 1456-1463, 2001
70. Gurubhagavatula I, Amrani Y, Pratico D, Ruberg FL, Albelda SM, Panettieri RA Jr: Engagement of human PECAM-1 (CD31) on human endothelial cells increases intracellular calcium ion concentration and stimulates prostacyclin release. J Clin Invest 101: 212-222, 1998
71. Ji G, O'Brien CD, Feldman M, Manevich Y, Lim P, Sun J, Albelda SM, Kotlikoff MI: PECAM-1 (CD31) regulates a hydrogen peroxide-activated nonselective cation channel in endothelial cells. J Cell Biol 157: 173-184, 2002
72. Jackson DE, Loo RO, Holyst MT, Newman PJ: Identification and characterization of functional cation coordination sites in platelet endothelial cell adhesion molecule-1. Biochemistry 36: 9395-9404, 1997
73. Evans PC, Taylor ER, Kilshaw PJ: Signaling through CD31 protects endothelial cells from apoptosis. Transplantation 71: 457-460, 2001
74. Ilan N, Mohsenin A, Cheung L, Madri JA: PECAM-1 shedding during apoptosis generates a membrane-anchored truncated molecule with unique signaling characteristics. Faseb J 15: 362-372, 2001
75. Brown S, Heinisch I, Ross E, Shaw K, Buckley CD, Savill J: Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment. Nature 418: 200-203, 2002
76. Newman DK, Hoffman SL, Kotamraju S, Kalyanaraman B, Newman P: Nitration of the tyrosine-based inhibitory motif of PECAM-1 promotes binding of the protein tyrosine phosphatase, SHP-2. ATVB Annual Meeting Proceedings. 6: (abstr), 10, 2002
77. Wilkinson R, Lyons AB, Roberts D, Wong MX, Bartley PA, Jackson DE: Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) acts as a regulator of B cell development, B-cell antigen receptor (BCR)-mediated activation, and autoimmune disease. Blood 100; 184-193, 2002
78. Davies MJ, Gordon JL, Gearing AJ, Pigott R, Woolf N, Katz D, Kyriakopoulos A: The expression of the adhesion molecules ICAM-1, VCAM-1, PECAM, and E-selectin in human atherosclerosis. J Pathol 171: 223-229, 1993
79. Masuda M, Takahashi H: Adhesion of leukocytes to endothelial cells in atherosclerosis. Rinsho Byori 46: 1149-1155, 1998
80. Wenzel K, Baumann G, Felix SB: The homozygous combination of Leu125Val and Ser563Asn polymorphisms in the PECAM1 (CD31) gene is associated with early severe coronary heart disease. Hum Mutat 14: 545, 1999
81. Gardemann A, Knapp A, Katz N, Tillmanns H, Haberbosch W: No evidence for the CD31 C/G gene polymorphism as an independent risk factor of coronary heart disease. Thromb Haemost 83: 629, 2000
82. Sasaoka T, Kimura A, Hohta SA, Fukuda N, Kurosawa T, Izumi T: Polymorphisms in the platelet-endothelial cell adhesion molecule-1 (PECAM-1) gene, Asn563Ser and Gly670Arg, associated with myocardial infarction in the Japanese. Ann NY Acad Sci 947: 259-269, 2001
83. Andreotti F, Porto I, Crea F, Maseri A: Inflammatory gene polymorphisms and ischaemic heart disease: Review of population association studies. Heart 87: 107-112, 2002
84. Mahooti S, Graesser D, Patil S, Newman P, Duncan G, Mak T, Madri JA: PECAM-1 (CD31) expression modulates bleeding time in vivo. Am J Pathol 157: 75-81, 2000
85. Vollmar B, Schmits R, Kunz D, Menger MD: Lack of in vivo function of CD31 in vascular thrombosis. Thromb Haemost 85: 160-164, 2001
86. Matsumura T, Wolff K, Petzelbauer P: Endothelial cell tube formation depends on cadherin 5 and CD31 interactions with filamentous actin. J Immunol 158: 3408-3416, 1997
87. Cao G, O'Brien CD, Zhou Z, Sanders SM, Greenbaum JN, Makrigiannakis A, DeLisser HM: Involvement of human PECAM-1 in angiogenesis and in vitro endothelial cell migration. Am J Physiol Cell Physiol 282: C1181-1190, 2002
88. Tang DG, Chen YQ, Newman PJ, Shi L, Gao X, Diglio CA, Honn KV: Identification of PECAM-1 in solid tumor cells and its potential involvement in tumor cell adhesion to endothelium. J Biol Chem 268: 22883-22894, 1993