Reducing glycosphingolipid biosynthesis in airway cells partially ameliorates disease manifestations in a mouse model of asthma

International Immunology

Volumn 22, Issue 7, 2010, Pages 593-603

  Karman, Jozsef ^a   Tedstone, Jennifer L ^a   Gumlaw, Nathan K ^a   Zhu, Yunxiang ^a   Yew, Nelson ^a   Siegel, Craig ^a   Guo, Shuling ^b   Siwkowski, Andrew ^b   Ruzek, Melanie ^a   Jiang, Canwen ^a   Cheng, Seng H ^a  

^a GENZYME CORPORATION   (United States)

^b ISIS PHARMACEUTICALS   (United States)

Author keywords

Asthma; Glycosphingolipids; Lipid rafts; Mast cells

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CALCIUM ION; CERAMIDE GLUCOSYLTRANSFERASE; CERAMIDE GLUCOSYLTRANSFERASE INHIBITOR; DEXAMETHASONE; GANGLIOSIDE GM3 SYNTHASE; GENZ 123346; GLYCOSPHINGOLIPID; LACTOSYLCERAMIDE SYNTHASE; METHACHOLINE; OVALBUMIN; PHOSPHOLIPASE C GAMMA2; PROTEIN KINASE SYK; SYNTHETASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; BIOSYNTHESIS; BRONCHUS HYPERREACTIVITY; CALCIUM CELL LEVEL; CELL ACTIVATION; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; KNOCKOUT MOUSE; MAST CELL; MAST CELL DEGRANULATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; RAT; RESPIRATORY TRACT INFLAMMATION; SIGNAL TRANSDUCTION;

ANIMALS; ASTHMA; CELL DEGRANULATION; DIOXANES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOSYLTRANSFERASES; GLYCOSPHINGOLIPIDS; MAST CELLS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR WEIGHT; OLIGONUCLEOTIDES, ANTISENSE; OVALBUMIN; PHOSPHOLIPASE C GAMMA; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PYRROLIDINES; SIALYLTRANSFERASES; SIGNAL TRANSDUCTION;

EID: 77954264041     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxq044     Document Type: Article

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