-
1
-
-
0036527429
-
Protein kinases: the major drug targets of the twenty-first century?
-
Cohen, P. (2002) Protein kinases: the major drug targets of the twenty-first century? Nat. Rev. Drug Discov., 1, 309-315.
-
(2002)
Nat. Rev. Drug Discov.
, vol.1
, pp. 309-315
-
-
Cohen, P.1
-
2
-
-
0037032835
-
The protein kinase complement of the human genome
-
Manning, G., Whyte, D.B., Martinez, R., Hunter, T., and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934.
-
(2002)
Science
, vol.298
, pp. 1912-1934
-
-
Manning, G.1
Whyte, D.B.2
Martinez, R.3
Hunter, T.4
Sudarsanam, S.5
-
3
-
-
0029947186
-
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
-
Druker, B.J., Tamura, S., Buchdunger, E., Ohno, S., Segal, G.M., Fanning, S., Zimmermann, J., and Lyndon, N.B. (1996) Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat. Med., 2, 561-566.
-
(1996)
Nat. Med.
, vol.2
, pp. 561-566
-
-
Druker, B.J.1
Tamura, S.2
Buchdunger, E.3
Ohno, S.4
Segal, G.M.5
Fanning, S.6
Zimmermann, J.7
Lyndon, N.B.8
-
4
-
-
34447544253
-
BCRABL tyrosine kinase inhibitors for chronic myelogenous leukemia
-
Schiffer, C.A. (2007) BCRABL tyrosine kinase inhibitors for chronic myelogenous leukemia. N. Engl. J. Med., 357, 258-265.
-
(2007)
N. Engl. J. Med.
, vol.357
, pp. 258-265
-
-
Schiffer, C.A.1
-
5
-
-
0037186915
-
Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia
-
Kantarjian, H., Sawyers, C., Hochhaus, A., Guilhot, F., Schiffer, C., Gambacorti-Passerini, C., Niederwieser, D., Resta, D., Capdeville, R., Zoellner, U., Talpaz, M., and Druker, B. (2002) Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia. N. Engl. J. Med., 346, 645-652.
-
(2002)
N. Engl. J. Med.
, vol.346
, pp. 645-652
-
-
Kantarjian, H.1
Sawyers, C.2
Hochhaus, A.3
Guilhot, F.4
Schiffer, C.5
Gambacorti-Passerini, C.6
Niederwieser, D.7
Resta, D.8
Capdeville, R.9
Zoellner, U.10
Talpaz, M.11
Druker, B.12
-
6
-
-
33845444046
-
Five year follow-up of patients receiving imatinib for chronic myeloid leukemia
-
Drucker, B.J., Guilhot, F., O'Brien, S.G., Gathmann, I., Kantarjian, H., Gattermann, N., Deininger, M.W.N., Silver, R.T., Goldman, J.M., Stone, R.M., Cervantes, N., Hochhaus, A., Powell, B.L., Gabrilove, J.L., Rousselot, P., Reiffers, J., Cornelissen, J.J., Hughs, T., Agis, H., Fischer, T., Verhoef, G., Shepherd, J., Saglio, G., Gratwohl, A., Nielsen, J.L., Radich, J.P., Simonsson, B., Taylor, K., Baccarani, J.P., So, C., Letvak, L., and Larson, R. (2006) Five year follow-up of patients receiving imatinib for chronic myeloid leukemia. N. Engl. J. Med., 355, 2408-2417.
-
(2006)
N. Engl. J. Med.
, vol.355
, pp. 2408-2417
-
-
Drucker, B.J.1
Guilhot, F.2
O'Brien, S.G.3
Gathmann, I.4
Kantarjian, H.5
Gattermann, N.6
Deininger, M.W.N.7
Silver, R.T.8
Goldman, J.M.9
Stone, R.M.10
Cervantes, N.11
Hochhaus, A.12
Powell, B.L.13
Gabrilove, J.L.14
Rousselot, P.15
Reiffers, J.16
Cornelissen, J.J.17
Hughs, T.18
Agis, H.19
Fischer, T.20
Verhoef, G.21
Shepherd, J.22
Saglio, G.23
Gratwohl, A.24
Nielsen, J.L.25
Radich, J.P.26
Simonsson, B.27
Taylor, K.28
Baccarani, J.P.29
So, C.30
Letvak, L.31
Larson, R.32
more..
-
7
-
-
20144388183
-
Response and resistance in 300 patients with BCR-ABL-positive leukemias treated with imatinib in a single center: a 4.5-year follow-up
-
Lahaye, T., Riehm, B., Berger, U., Paschka, P., Muller, M.C., Kreil, S., Merx, K., Schwindel, U., Schoch, C.,Hehlmann, R., and Hochhaus, A. (2005) Response and resistance in 300 patients with BCR-ABL-positive leukemias treated with imatinib in a single center: a 4.5-year follow-up. Cancer, 103, 1659-1669.
-
(2005)
Cancer
, vol.103
, pp. 1659-1669
-
-
Lahaye, T.1
Riehm, B.2
Berger, U.3
Paschka, P.4
Muller, M.C.5
Kreil, S.6
Merx, K.7
Schwindel, U.8
Schoch, C.9
Hehlmann, R.10
Hochhaus, A.11
-
8
-
-
10444280878
-
Strategies to overcome resistance to targeted protein kinase inhibitors
-
Daub, H., Specht, K., and Ullrich, A. (2004) Strategies to overcome resistance to targeted protein kinase inhibitors. Nat. Rev. Drug Discov., 3, 1001-1010.
-
(2004)
Nat. Rev. Drug Discov.
, vol.3
, pp. 1001-1010
-
-
Daub, H.1
Specht, K.2
Ullrich, A.3
-
9
-
-
0345600892
-
Resistance to imatinib (Glivec): update on clinical mechanisms
-
Weisberg, E. and Griffen, J.D. (2003) Resistance to imatinib (Glivec): update on clinical mechanisms. Drug Resist. Updates, 6, 231-238.
-
(2003)
Drug Resist. Updates
, vol.6
, pp. 231-238
-
-
Weisberg, E.1
Griffen, J.D.2
-
10
-
-
30644462841
-
Targeted CML therapy: controlling drug resistance, seeking cure
-
O'Hare, T., Corbin, A.S., and Druker, B.J. (2006) Targeted CML therapy: controlling drug resistance, seeking cure. Curr. Opin. Genet. Dev., 16, 92-99.
-
(2006)
Curr. Opin. Genet. Dev.
, vol.16
, pp. 92-99
-
-
O'Hare, T.1
Corbin, A.S.2
Druker, B.J.3
-
11
-
-
0030029143
-
Discovery of a novel, potent, and Src-selective tyrosine kinase inhibitor. Study of Lck- and Fyn T-dependent T cell activation
-
Hanke, J.H., Gardner, J.P., Dow, R.L., Changelian, P.S., Brissette, W.H., Weringer, E.J., Pollok, B.A., and Connelly, P.A. (1996) Discovery of a novel, potent, and Src-selective tyrosine kinase inhibitor. Study of Lck- and Fyn T-dependent T cell activation. J. Biol. Chem., 271, 695-701.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 695-701
-
-
Hanke, J.H.1
Gardner, J.P.2
Dow, R.L.3
Changelian, P.S.4
Brissette, W.H.5
Weringer, E.J.6
Pollok, B.A.7
Connelly, P.A.8
-
12
-
-
0026522204
-
Profound block in thymocyte development in mice lacking p56lck
-
Molina, T.J., Kishihara, K., Siderovski, D.P., van Ewijk, W., Narendran, A., Timms, E.,Wakeham, A., Paige, C.J., Hartman, K.-U., Veilette, A., Davison, D., and Mak, T.W. (1992) Profound block in thymocyte development in mice lacking p56lck. Nature, 357, 161-164.
-
(1992)
Nature
, vol.357
, pp. 161-164
-
-
Molina, T.J.1
Kishihara, K.2
Siderovski, D.P.3
van Ewijk, W.4
Narendran, A.5
Timms, E.6
Wakeham, A.7
Paige, C.J.8
Hartman, K.-U.9
Veilette, A.10
Davison, D.11
Mak, T.W.12
-
13
-
-
0028288927
-
The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction
-
Chan, A.C., Desai, D.M., and Weiss, A.C. (1994) The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction. Ann. Rev. Immunol., 12, 555-592.
-
(1994)
Ann. Rev. Immunol.
, vol.12
, pp. 555-592
-
-
Chan, A.C.1
Desai, D.M.2
Weiss, A.C.3
-
14
-
-
0034837053
-
Lck inhibitors as a therapeutic approach to autoimmune disease and transplant rejection
-
Kamens, J.S., Ratnofsky, S.E., and Hirst, G.C. (2001) Lck inhibitors as a therapeutic approach to autoimmune disease and transplant rejection. Curr. Opin. Invest. Drugs, 2, 1213-1219.
-
(2001)
Curr. Opin. Invest. Drugs
, vol.2
, pp. 1213-1219
-
-
Kamens, J.S.1
Ratnofsky, S.E.2
Hirst, G.C.3
-
15
-
-
0000328787
-
Tyrosine kinase src inhibitors: potential therapeutic applications
-
Susa, M. and Teti, A. (2000) Tyrosine kinase src inhibitors: potential therapeutic applications. Drug News Perspect., 13, 169-175.
-
(2000)
Drug News Perspect
, vol.13
, pp. 169-175
-
-
Susa, M.1
Teti, A.2
-
16
-
-
10744220619
-
Discovery and initial SAR of 2-amino-5-carboxamidothiazoles as inhibitors of the Src-family kinsae p56lck
-
Wityak, J., Das, J., Moquin, R.V., Shen, Z., Lin, J., Chen, P., Doweyko, A.M., Pitt, S., Pang, S., Shen, D.R., Fang, Q., de Fex, H.F., Schieven, G.L., Kanner, S.B., and Barrish, J.C. (2003) Discovery and initial SAR of 2-amino-5-carboxamidothiazoles as inhibitors of the Src-family kinsae p56lck. Bioorg. Med. Chem. Lett., 13, 4007-4010.
-
(2003)
Bioorg. Med. Chem. Lett.
, vol.13
, pp. 4007-4010
-
-
Wityak, J.1
Das, J.2
Moquin, R.V.3
Shen, Z.4
Lin, J.5
Chen, P.6
Doweyko, A.M.7
Pitt, S.8
Pang, S.9
Shen, D.R.10
Fang, Q.11
de Fex, H.F.12
Schieven, G.L.13
Kanner, S.B.14
Barrish, J.C.15
-
17
-
-
84961978146
-
Discovery of 2-phenylaminoimidazo[4,5-h]isoquinolin-9-ones: a new class of inhibitors of Lck kinase
-
Snow, R.J., Cardozo, M.G., Morwick, T.M., Busacca, C.A., Dong, Y., Eckner, R.J., Jacober, S., Jakes, S., Kapadia, S., Lukas, S., Panzenbeck, M., Peet, G.W., Peterson, J.D., Prokopowicz, A.S., III, Sellati, R., Tolbert, R.M., Tschantz, M.A., and Moss, N. (2002) Discovery of 2-phenylaminoimidazo[4,5-h]isoquinolin-9-ones: a new class of inhibitors of Lck kinase. J. Med. Chem., 45, 3394-3405.
-
(2002)
J. Med. Chem.
, vol.45
, pp. 3394-3405
-
-
Snow, R.J.1
Cardozo, M.G.2
Morwick, T.M.3
Busacca, C.A.4
Dong, Y.5
Eckner, R.J.6
Jacober, S.7
Jakes, S.8
Kapadia, S.9
Lukas, S.10
Panzenbeck, M.11
Peet, G.W.12
Peterson, J.D.13
Prokopowicz III, A.S.14
Sellati, R.15
Tolbert, R.M.16
Tschantz, M.A.17
Moss, N.18
-
18
-
-
4143153835
-
Imidazoquinoxaline Src-family kinase p56Lck inhibitors: SAR, QSAR, and the discovery of (S)-N-(2-chloro-6-methylphenyl)-2-(3-methyl-1-piperazinyl)imidazo[1,5-a] pyrido[3,2-e] pyrazin-6-amine (BMS-279700) as a potent and orally active inhibitor with excellent in vivo anti-inflammatory activity
-
Chen, P., Doweyko, A.M., Norris, D., Gu, H.H., Spergel, S.H., Das, J., Moquin, R.V., Lin, J., Wityak, J., Iwanowicz, E.J., McIntyre, K.W., Shuster, D.J., Behnia, K., Chong, S., deFex, H., Pang, S., Pitt, S., Shen, D.R., Thrall, S., Stanley, P., Kocy, O.R., Witmer, M.R., Kanner, S.B., Schieven, G.L., and Barrish, J.C. (2004) Imidazoquinoxaline Src-family kinase p56Lck inhibitors: SAR, QSAR, and the discovery of (S)-N-(2-chloro-6-methylphenyl)-2-(3-methyl-1-piperazinyl)imidazo[1,5-a] pyrido[3,2-e] pyrazin-6-amine (BMS-279700) as a potent and orally active inhibitor with excellent in vivo anti-inflammatory activity. J. Med. Chem., 47, 4517-4529.
-
(2004)
J. Med. Chem.
, vol.47
, pp. 4517-4529
-
-
Chen, P.1
Doweyko, A.M.2
Norris, D.3
Gu, H.H.4
Spergel, S.H.5
Das, J.6
Moquin, R.V.7
Lin, J.8
Wityak, J.9
Iwanowicz, E.J.10
McIntyre, K.W.11
Shuster, D.J.12
Behnia, K.13
Chong, S.14
deFex, H.15
Pang, S.16
Pitt, S.17
Shen, D.R.18
Thrall, S.19
Stanley, P.20
Kocy, O.R.21
Witmer, M.R.22
Kanner, S.B.23
Schieven, G.L.24
Barrish, J.C.25
more..
-
19
-
-
12444332625
-
Molecular design, synthesis and structure activity relationships leading to the potent and selective p56lck inhibitor BMS-243117
-
Das, J., Lin, J., Moquin, R.V., Shen, Z., Spergel, S.H., Wityak, J., Doweyko, A.M., deFex, H.R., Fang, Q., Pang, S., Pitt, S., Shen, D.R., Schieven, G.L., and Barrish, J.C. (2003) Molecular design, synthesis and structure activity relationships leading to the potent and selective p56lck inhibitor BMS-243117. Bioorg. Med. Chem. Lett., 13, 2145-2149.
-
(2003)
Bioorg. Med. Chem. Lett.
, vol.13
, pp. 2145-2149
-
-
Das, J.1
Lin, J.2
Moquin, R.V.3
Shen, Z.4
Spergel, S.H.5
Wityak, J.6
Doweyko, A.M.7
deFex, H.R.8
Fang, Q.9
Pang, S.10
Pitt, S.11
Shen, D.R.12
Schieven, G.L.13
Barrish, J.C.14
-
20
-
-
10744226526
-
Discovery of 2-amino-heteroarylbenzothiazole-6-anilides as potent p56lck inhibitors
-
Das, J., Moquin, R.V., Lin, J., Liu, C., Doweyko, A.M., deFex, H.R., Fang, Q., Pang, S., Pitt, S., Shen, D.R., Schieven, G.L., Barrish, J.C., and Wityak, J. (2003) Discovery of 2-amino-heteroarylbenzothiazole-6-anilides as potent p56lck inhibitors. Bioorg. Med. Chem. Lett., 13, 2587-2590.
-
(2003)
Bioorg. Med. Chem. Lett.
, vol.13
, pp. 2587-2590
-
-
Das, J.1
Moquin, R.V.2
Lin, J.3
Liu, C.4
Doweyko, A.M.5
deFex, H.R.6
Fang, Q.7
Pang, S.8
Pitt, S.9
Shen, D.R.10
Schieven, G.L.11
Barrish, J.C.12
Wityak, J.13
-
21
-
-
8844271817
-
Discovery of novel 2-(aminoheteroaryl)-thiazole-5-carboxamides as potent and orally active Src-family kinase p56lck inhibitors
-
Chen, P., Norris, D., Das, J., Spergel, S.H., Wityak, J., Leith, L., Zhao, R., Chen, B.-C., Pitt, S., Pang, S., Shen, D.R., Zhang, R., deFex, H.R., Doweyko, A.M., McIntyre, K.W., Shuster, D.J., Behnia, K., Schieven, G., and Barrish, J. (2004) Discovery of novel 2-(aminoheteroaryl)-thiazole-5-carboxamides as potent and orally active Src-family kinase p56lck inhibitors. Bioorg. Med. Chem. Lett., 143, 6061-6066.
-
(2004)
Bioorg. Med. Chem. Lett.
, vol.143
, pp. 6061-6066
-
-
Chen, P.1
Norris, D.2
Das, J.3
Spergel, S.H.4
Wityak, J.5
Leith, L.6
Zhao, R.7
Chen, B.-C.8
Pitt, S.9
Pang, S.10
Shen, D.R.11
Zhang, R.12
deFex, H.R.13
Doweyko, A.M.14
McIntyre, K.W.15
Shuster, D.J.16
Behnia, K.17
Schieven, G.18
Barrish, J.19
-
22
-
-
33750989362
-
2-Aminothiazole as a novel kinase inhibitor template. Structure activity relationship studies towards the discovery of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-m ethyl-4-pyrimidinyl] amino]-1,3-thiazole-5-carboxamide (dasatinib, BMS-354825) as a potent pan-Src kinase inhibitor
-
Das, J., Chen, P., Norris, D., Padmanabha, R., Lin, J., Moquin, R.V., Shen, Z., Cook, L.S., Doweyko, A.M., Pitt, S., Pang, S., Shen, D.R., Fang, Q., de Fex, H.F., McIntyre, K.W., Shuster, D.J., Gillooly, K.M., Behnia, K., Schieven, G.L., Wityak, J., and Barrish, J.C. (2006) 2-Aminothiazole as a novel kinase inhibitor template. Structure activity relationship studies towards the discovery of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-m ethyl-4-pyrimidinyl] amino]-1,3-thiazole-5-carboxamide (dasatinib, BMS-354825) as a potent pan-Src kinase inhibitor. J. Med. Chem., 49, 6819-6832.
-
(2006)
J. Med. Chem.
, vol.49
, pp. 6819-6832
-
-
Das, J.1
Chen, P.2
Norris, D.3
Padmanabha, R.4
Lin, J.5
Moquin, R.V.6
Shen, Z.7
Cook, L.S.8
Doweyko, A.M.9
Pitt, S.10
Pang, S.11
Shen, D.R.12
Fang, Q.13
de Fex, H.F.14
McIntyre, K.W.15
Shuster, D.J.16
Gillooly, K.M.17
Behnia, K.18
Schieven, G.L.19
Wityak, J.20
Barrish, J.C.21
more..
-
23
-
-
19944428353
-
Discovery of N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-me thylpyrimidin-4-ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/ Abl kinase inhibitor with potent antitumor activity in preclinical assays
-
Lombardo, L.J., Lee, F.Y., Chen, P., Norris, D., Barrish, J.C., Behnia, K.,Castaneda, S., Cornelius, L., Das, J., Doweyko, A.M., Fairchild, C., Hunt, J.T., Inigo, I., Kamath, A., Kan, D.,Marathe, P., Pang, S., Pitt, S., Schieven, G.L., Schmidt, R.J., Tokarski, J., Wen, M.-L., Wityak, J., and Borzilleri, R.M. (2004) Discovery of N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-me thylpyrimidin-4-ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/ Abl kinase inhibitor with potent antitumor activity in preclinical assays. J. Med. Chem., 47, 6658-6661.
-
(2004)
J. Med. Chem.
, vol.47
, pp. 6658-6661
-
-
Lombardo, L.J.1
Lee, F.Y.2
Chen, P.3
Norris, D.4
Barrish, J.C.5
Behnia, K.6
Castaneda, S.7
Cornelius, L.8
Das, J.9
Doweyko, A.M.10
Fairchild, C.11
Hunt, J.T.12
Inigo, I.13
Kamath, A.14
Kan, D.15
Marathe, P.16
Pang, S.17
Pitt, S.18
Schieven, G.L.19
Schmidt, R.J.20
Tokarski, J.21
Wen, M.-L.22
Wityak, J.23
Borzilleri, R.M.24
more..
-
24
-
-
37249048453
-
Preclinical pharmacokinetics and in vitro metabolism of dasatinib (BMS-354825): a potent oral multi-targeted kinase inhibitor Src and Bcr-Abl
-
Kamath, A.V., Wang, J., Lee, F.Y., and Marathe, P.H. (2008) Preclinical pharmacokinetics and in vitro metabolism of dasatinib (BMS-354825): a potent oral multi-targeted kinase inhibitor Src and Bcr-Abl. Cancer Chemother. Pharmacol., 61, 365-376.
-
(2008)
Cancer Chemother. Pharmacol.
, vol.61
, pp. 365-376
-
-
Kamath, A.V.1
Wang, J.2
Lee, F.Y.3
Marathe, P.H.4
-
25
-
-
33745283618
-
The structure of dasatinib (BMS-354825) bound to activated Abl kinase domain elucidates its inhibitory activity against imatinib-resistant Abl mutants
-
Tokarski, J.S., Newitt, J.A., Chang, C.Y.J., Cheng, J.D., Wittekind, M., Kiefer, S.E., Kish, K., Lee, F.Y.F., Borzilleri, R., Lombardo, L.J., Xie, D., Zhang, Y., and Klei, H.E. (2006) The structure of dasatinib (BMS-354825) bound to activated Abl kinase domain elucidates its inhibitory activity against imatinib-resistant Abl mutants. Cancer Res., 66, 5790-5797.
-
(2006)
Cancer Res
, vol.66
, pp. 5790-5797
-
-
Tokarski, J.S.1
Newitt, J.A.2
Chang, C.Y.J.3
Cheng, J.D.4
Wittekind, M.5
Kiefer, S.E.6
Kish, K.7
Lee, F.Y.F.8
Borzilleri, R.9
Lombardo, L.J.10
Xie, D.11
Zhang, Y.12
Klei, H.E.13
-
26
-
-
0036682301
-
Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571)
-
Nagar, B., Bornmann, W.G., Pellicena, P., Schindler, T., Veach, D.R., Miller, W.T., Clarkson, B., andKuriyan, J. (2002)Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571). Cancer Res., 62, 4236-4243.
-
(2002)
Cancer Res
, vol.62
, pp. 4236-4243
-
-
Nagar, B.1
Bornmann, W.G.2
Pellicena, P.3
Schindler, T.4
Veach, D.R.5
Miller, W.T.6
Clarkson, B.7
Kuriyan, J.8
-
27
-
-
21144451094
-
In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants
-
O'Hare, T.,Walters, D.K., Stoffregen, E.P., Jia, T., Manley, P.W., Mestan, J., Cowan-Jacob, S.W., Lee, F.Y., Heinrich, M.C., Deininger, M.W.N., and Druker, B.J. (2005) In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants. Cancer Res., 65, 4500-4505.
-
(2005)
Cancer Res
, vol.65
, pp. 4500-4505
-
-
O'Hare, T.1
Walters, D.K.2
Stoffregen, E.P.3
Jia, T.4
Manley, P.W.5
Mestan, J.6
Cowan-Jacob, S.W.7
Lee, F.Y.8
Heinrich, M.C.9
Deininger, M.W.N.10
Druker, B.J.11
-
28
-
-
3142676436
-
Overriding imatinib resistance with a novel Abl kinase inhibitor
-
Shah, N.P., Tran, C., Lee, F.Y., Chen, P., Norris, D., and Sawyers, C.L. (2005) Overriding imatinib resistance with a novel Abl kinase inhibitor. Science, 305, 399-401.
-
(2005)
Science
, vol.305
, pp. 399-401
-
-
Shah, N.P.1
Tran, C.2
Lee, F.Y.3
Chen, P.4
Norris, D.5
Sawyers, C.L.6
-
29
-
-
33745102555
-
Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias
-
Moshe, T., Shah, N.P., Kantarjian, H., Donato, N., Nicoll, J., Paquette, R., Cortes, J., O'Brien, S., Nicaise, C., Bleickardt, E., Blackwood-Chirchir, M.A., Iyer, V., Chen, T.-T., Huang, F., Decillis, A.P., and Sawyers, C.L. (2006) Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N. Engl. J. Med., 354, 2531-2541.
-
(2006)
N. Engl. J. Med.
, vol.354
, pp. 2531-2541
-
-
Moshe, T.1
Shah, N.P.2
Kantarjian, H.3
Donato, N.4
Nicoll, J.5
Paquette, R.6
Cortes, J.7
O'Brien, S.8
Nicaise, C.9
Bleickardt, E.10
Blackwood-Chirchir, M.A.11
Iyer, V.12
Chen, T.-T.13
Huang, F.14
Decillis, A.P.15
Sawyers, C.L.16
-
30
-
-
33947280081
-
Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapy
-
Hochhaus, A., Kantarjian, H.M., Baccarani, M., Lipton, J.H., Apperley, J.F., Druker, B.J., Facon, T., Goldberg, S.L., Cervantes, F., Niederwieser, D., Silver, R.T., Stone, R.M., Hughes, T.P., Muller, M.C., Ezzeddine, R., Countouriotis, A.M., and Shah, N.P. (2007) Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapy. Blood, 109, 2303-2309.
-
(2007)
Blood
, vol.109
, pp. 2303-2309
-
-
Hochhaus, A.1
Kantarjian, H.M.2
Baccarani, M.3
Lipton, J.H.4
Apperley, J.F.5
Druker, B.J.6
Facon, T.7
Goldberg, S.L.8
Cervantes, F.9
Niederwieser, D.10
Silver, R.T.11
Stone, R.M.12
Hughes, T.P.13
Muller, M.C.14
Ezzeddine, R.15
Countouriotis, A.M.16
Shah, N.P.17
-
31
-
-
34248324467
-
Dasatinib induces significant hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in accelerated phase
-
Guilhot, F., Apperley, J., Kim, D.-W., Bullorsky, E.O., Baccarani, M., Roboz, G.J., Amadori, S., de Souza, C.A., Lipton, J.H., Hochhaus, A., Heim, D., Larson, R.A., Branford, S., Muller, M.C., Agarwal, P., Gollerkeri, A., and Talpaz, M. (2007) Dasatinib induces significant hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in accelerated phase. Blood, 109, 4143-4150.
-
(2007)
Blood
, vol.109
, pp. 4143-4150
-
-
Guilhot, F.1
Apperley, J.2
Kim, D.-W.3
Bullorsky, E.O.4
Baccarani, M.5
Roboz, G.J.6
Amadori, S.7
de Souza, C.A.8
Lipton, J.H.9
Hochhaus, A.10
Heim, D.11
Larson, R.A.12
Branford, S.13
Muller, M.C.14
Agarwal, P.15
Gollerkeri, A.16
Talpaz, M.17
-
32
-
-
33947356135
-
Dasatinib induces complete hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in blast crisis
-
Cortes, J., Rousselot, P., Kim, D.-W., Ritchie, E., Hamerschlak, N., Coutre, S., Hochhaus, A., Guilhot, F., Saglio, G., Apperley, J., Ottmann, O., Shah, N., Erben, P., Branford, S., Agarwal, P., Gollerkeri, A., and Baccarani, M. (2007) Dasatinib induces complete hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in blast crisis. Blood, 109, 3207-3213.
-
(2007)
Blood
, vol.109
, pp. 3207-3213
-
-
Cortes, J.1
Rousselot, P.2
Kim, D.-W.3
Ritchie, E.4
Hamerschlak, N.5
Coutre, S.6
Hochhaus, A.7
Guilhot, F.8
Saglio, G.9
Apperley, J.10
Ottmann, O.11
Shah, N.12
Erben, P.13
Branford, S.14
Agarwal, P.15
Gollerkeri, A.16
Baccarani, M.17
-
33
-
-
34249074686
-
Dasatinib or highdose imatinib for chronic-phase chronic myeloid leukemia after failure of first-line imatinib: a randomized phase 2 trial
-
Kantarjian, H., Pasquini, R., Hamerschlak, N., Rousselot, P., Holowiecki, J., Jootar, S., Robak, T., Khoroshko, N., Masszi, T., Skotnicki, A., Hellmann, A., Zaritsky, A., Golenkov, A., Radich, J., Hughes, T., Countouriotis, A., and Shah, N. (2007) Dasatinib or highdose imatinib for chronic-phase chronic myeloid leukemia after failure of first-line imatinib: a randomized phase 2 trial. Blood, 109, 5143-5150.
-
(2007)
Blood
, vol.109
, pp. 5143-5150
-
-
Kantarjian, H.1
Pasquini, R.2
Hamerschlak, N.3
Rousselot, P.4
Holowiecki, J.5
Jootar, S.6
Robak, T.7
Khoroshko, N.8
Masszi, T.9
Skotnicki, A.10
Hellmann, A.11
Zaritsky, A.12
Golenkov, A.13
Radich, J.14
Hughes, T.15
Countouriotis, A.16
Shah, N.17
-
34
-
-
34247644944
-
Resistance to dasatinib in Philadelphia-positive leukemia patients and the presence or the selection of mutations at residues 315 and 317 in the BCR-ABL kinase domain
-
Soverini, S., Colarossi, S., Gnani, A., Castagnetti, F., Rosti, G., Bosi, C., Paolini, S., Rondoni, M., Piccaluga, P.P., Palandri, F., Giannoulia, P., Marzocchi, G., Luatti, S., Testoni, N., Iacobucci, I., Cilloni, D., Saglio, G., Baccarani, M., and Martinelli, G. (2007) Resistance to dasatinib in Philadelphia-positive leukemia patients and the presence or the selection of mutations at residues 315 and 317 in the BCR-ABL kinase domain. Haematologica, 92, 401-404.
-
(2007)
Haematologica
, vol.92
, pp. 401-404
-
-
Soverini, S.1
Colarossi, S.2
Gnani, A.3
Castagnetti, F.4
Rosti, G.5
Bosi, C.6
Paolini, S.7
Rondoni, M.8
Piccaluga, P.P.9
Palandri, F.10
Giannoulia, P.11
Marzocchi, G.12
Luatti, S.13
Testoni, N.14
Iacobucci, I.15
Cilloni, D.16
Saglio, G.17
Baccarani, M.18
Martinelli, G.19
-
35
-
-
34548701082
-
Dasatinib, an orally active small molecule inhibitor of both the src and abl kinases, selectively inhibits growth of basal-type/"triple-negative" breast cancer cell lines growing in vitro
-
Finn, R.S., Dering, J., Ginther, C., Wilson, C.A., Glaspy, P., Tchekmedyian, N., and Slamon, D.J. (2007) Dasatinib, an orally active small molecule inhibitor of both the src and abl kinases, selectively inhibits growth of basal-type/"triple-negative" breast cancer cell lines growing in vitro. Breast Cancer Res. Treat., 105, 319-326.
-
(2007)
Breast Cancer Res. Treat.
, vol.105
, pp. 319-326
-
-
Finn, R.S.1
Dering, J.2
Ginther, C.3
Wilson, C.A.4
Glaspy, P.5
Tchekmedyian, N.6
Slamon, D.J.7
-
36
-
-
33947225176
-
Identification of candidate molecular markers predicting sensitivity in solid tumors to dasatinib: rationale for patient selection
-
Huang, F., Reeves, K., Han, X., Fairchild, C., Platero, S., Wong, T.W., Lee, F., Shaw, P., and Clark, E. (2007) Identification of candidate molecular markers predicting sensitivity in solid tumors to dasatinib: rationale for patient selection. Cancer Res., 67, 2226-2238.
-
(2007)
Cancer Res
, vol.67
, pp. 2226-2238
-
-
Huang, F.1
Reeves, K.2
Han, X.3
Fairchild, C.4
Platero, S.5
Wong, T.W.6
Lee, F.7
Shaw, P.8
Clark, E.9
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