Discovery of 2-phenylamino-imidazo[4,5-h]isoquinolin-9-ones: A new class of inhibitors of lck kinase

Journal of Medicinal Chemistry

Volumn 45, Issue 16, 2002, Pages 3394-3405

  Snow, Roger J ^a   Cardozo, Mario G ^a   Morwick, Tina M ^a   Busacca, Carl A ^a   Dong, Yong ^a   Eckner, Robert J ^a   Jacober, Stephen ^a   Jakes, Scott ^a   Kapadia, Suresh ^a   Lukas, Susan ^a   Panzenbeck, Maret ^a   Peet, Gregory W ^a   Peterson, Jeffrey D ^a   Prokopowicz III, Anthony S ^a   Sellati, Rosemarie ^a   Tolbert, Robert M ^a   Tschantz, Matt A ^a   Moss, Neil ^a  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2,6 DICHLOROPHENYLAMINO) 6,6 DIMETHYL 1H,6H IMIDAZO[4,5 H]ISOQUINOLINE 7,9 DIONE; 2 (2,6 DICHLOROPHENYLAMINO) 6,7 DIMETHYL 1,8 DIHYDROIMIDAZO[4,5 H]ISOQUINOLIN 9 ONE; ADENOSINE TRIPHOSPHATE; IMIDE; ISOQUINOLINE DERIVATIVE; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SELECTIVITY; FEMALE; HUMAN; HUMAN CELL; HYDROGEN BOND; IC 50; MOLECULAR MODEL; MOUSE; NONHUMAN; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION;

EID: 84961978146     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020113o     Document Type: Article

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