메뉴 건너뛰기




Volumn 8, Issue 5, 2012, Pages

Integrin α PAT-2/CDC-42 signaling is required for muscle-mediated clearance of apoptotic cells in Caenorhabditis elegans

Author keywords

[No Author keywords available]

Indexed keywords

CED 1 RECEPTOR; CELL PROTEIN; DOCK180 PROTEIN; ELMO PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GULP PROTEIN; HELMINTH PROTEIN; INA 1 PROTEIN; PROTEIN CDC42; PROTEIN PAT 2; PROTEIN UIG 1; UNCLASSIFIED DRUG; ACETYLTROPIC ACID 2 PYRIDYLMETHYLAMIDE; ACETYLTROPIC ACID 2-PYRIDYLMETHYLAMIDE; BENZENEACETAMIDE DERIVATIVE; CAENORHABDITIS ELEGANS PROTEIN; CARRIER PROTEIN; CDC42 PROTEIN, C ELEGANS; CED 1 PROTEIN, C ELEGANS; CED 12 PROTEIN, C ELEGANS; CED 6 PROTEIN, C ELEGANS; CED-1 PROTEIN, C ELEGANS; CED-12 PROTEIN, C ELEGANS; CED-6 PROTEIN, C ELEGANS; CELL CYCLE PROTEIN; CYTOSKELETON PROTEIN; EPTIFIBATIDE; GUANINE NUCLEOTIDE BINDING PROTEIN; INA 1 PROTEIN, C ELEGANS; INA-1 PROTEIN, C ELEGANS; INTEGRIN; MEMBRANE PROTEIN; PEPTIDE; PHOSPHOPROTEIN; PYRIDINE DERIVATIVE; UIG 1 PROTEIN, C ELEGANS; UIG-1 PROTEIN, C ELEGANS;

EID: 84863714678     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002663     Document Type: Article
Times cited : (29)

References (82)
  • 1
    • 0036791348 scopus 로고    scopus 로고
    • How death shapes life during development
    • Baehrecke EH, (2002) How death shapes life during development. Nat Rev Mol Cell Biol 3: 779-787.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 779-787
    • Baehrecke, E.H.1
  • 2
    • 8444252166 scopus 로고    scopus 로고
    • The engulfment process of programmed cell death in caenorhabditis elegans
    • Reddien PW, Horvitz HR, (2004) The engulfment process of programmed cell death in caenorhabditis elegans. Annu Rev Cell Dev Biol 20: 193-221.
    • (2004) Annu Rev Cell Dev Biol , vol.20 , pp. 193-221
    • Reddien, P.W.1    Horvitz, H.R.2
  • 3
    • 38049123476 scopus 로고    scopus 로고
    • Clearance of apoptotic cells by phagocytes
    • Erwig LP, Henson PM, (2008) Clearance of apoptotic cells by phagocytes. Cell Death Differ 15: 243-250.
    • (2008) Cell Death Differ , vol.15 , pp. 243-250
    • Erwig, L.P.1    Henson, P.M.2
  • 5
    • 77954396042 scopus 로고    scopus 로고
    • Clearance of apoptotic cells: implications in health and disease
    • Elliott MR, Ravichandran KS, (2010) Clearance of apoptotic cells: implications in health and disease. J Cell Biol 189: 1059-1070.
    • (2010) J Cell Biol , vol.189 , pp. 1059-1070
    • Elliott, M.R.1    Ravichandran, K.S.2
  • 6
    • 77649152255 scopus 로고    scopus 로고
    • Autoimmunity and the clearance of dead cells
    • Nagata S, Hanayama R, Kawane K, (2010) Autoimmunity and the clearance of dead cells. Cell 140: 619-630.
    • (2010) Cell , vol.140 , pp. 619-630
    • Nagata, S.1    Hanayama, R.2    Kawane, K.3
  • 7
    • 42549152012 scopus 로고    scopus 로고
    • Role of C. elegans TAT-1 protein in maintaining plasma membrane phosphatidylserine asymmetry
    • Darland-Ransom M, Wang X, Sun CL, Mapes J, Gengyo-Ando K, et al. (2008) Role of C. elegans TAT-1 protein in maintaining plasma membrane phosphatidylserine asymmetry. Science 320: 528-531.
    • (2008) Science , vol.320 , pp. 528-531
    • Darland-Ransom, M.1    Wang, X.2    Sun, C.L.3    Mapes, J.4    Gengyo-Ando, K.5
  • 8
    • 52049105429 scopus 로고    scopus 로고
    • Caenorhabditis elegans genes required for the engulfment of apoptotic corpses function in the cytotoxic cell deaths induced by mutations in lin-24 and lin-33
    • Galvin BD, Kim S, Horvitz HR, (2008) Caenorhabditis elegans genes required for the engulfment of apoptotic corpses function in the cytotoxic cell deaths induced by mutations in lin-24 and lin-33. Genetics 179: 403-417.
    • (2008) Genetics , vol.179 , pp. 403-417
    • Galvin, B.D.1    Kim, S.2    Horvitz, H.R.3
  • 9
    • 79952712455 scopus 로고    scopus 로고
    • A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells
    • Kao AW, Eisenhut RJ, Martens LH, Nakamura A, Huang A, et al. (2011) A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells. Proc Natl Acad Sci U S A 108: 4441-4446.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 4441-4446
    • Kao, A.W.1    Eisenhut, R.J.2    Martens, L.H.3    Nakamura, A.4    Huang, A.5
  • 10
  • 11
    • 0028788202 scopus 로고
    • Binding and phagocytosis of apoptotic vascular smooth muscle cells is mediated in part by exposure of phosphatidylserine
    • Bennett MR, Gibson DF, Schwartz SM, Tait JF, (1995) Binding and phagocytosis of apoptotic vascular smooth muscle cells is mediated in part by exposure of phosphatidylserine. Circ Res 77: 1136-1142.
    • (1995) Circ Res , vol.77 , pp. 1136-1142
    • Bennett, M.R.1    Gibson, D.F.2    Schwartz, S.M.3    Tait, J.F.4
  • 12
    • 0032444695 scopus 로고    scopus 로고
    • Endothelial liver cell recognition of apoptotic peripheral blood lymphocytes
    • Dini L, (1998) Endothelial liver cell recognition of apoptotic peripheral blood lymphocytes. Biochem Soc Trans 26: 635-639.
    • (1998) Biochem Soc Trans , vol.26 , pp. 635-639
    • Dini, L.1
  • 13
    • 0032870955 scopus 로고    scopus 로고
    • Resting and cytokine-stimulated human small airway epithelial cells recognize and engulf apoptotic eosinophils
    • Walsh GM, Sexton DW, Blaylock MG, Convery CM, (1999) Resting and cytokine-stimulated human small airway epithelial cells recognize and engulf apoptotic eosinophils. Blood 94: 2827-2835.
    • (1999) Blood , vol.94 , pp. 2827-2835
    • Walsh, G.M.1    Sexton, D.W.2    Blaylock, M.G.3    Convery, C.M.4
  • 14
    • 0034641931 scopus 로고    scopus 로고
    • Corpse clearance defines the meaning of cell death
    • Savill J, Fadok V, (2000) Corpse clearance defines the meaning of cell death. Nature 407: 784-788.
    • (2000) Nature , vol.407 , pp. 784-788
    • Savill, J.1    Fadok, V.2
  • 15
    • 36248987290 scopus 로고    scopus 로고
    • BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module
    • Park D, Tosello-Trampont AC, Elliott MR, Lu M, Haney LB, et al. (2007) BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module. Nature 450: 430-434.
    • (2007) Nature , vol.450 , pp. 430-434
    • Park, D.1    Tosello-Trampont, A.C.2    Elliott, M.R.3    Lu, M.4    Haney, L.B.5
  • 16
    • 70350376638 scopus 로고    scopus 로고
    • Stabilin-1 mediates phosphatidylserine-dependent clearance of cell corpses in alternatively activated macrophages
    • Park SY, Jung MY, Lee SJ, Kang KB, Gratchev A, et al. (2009) Stabilin-1 mediates phosphatidylserine-dependent clearance of cell corpses in alternatively activated macrophages. J Cell Sci 122: 3365-3373.
    • (2009) J Cell Sci , vol.122 , pp. 3365-3373
    • Park, S.Y.1    Jung, M.Y.2    Lee, S.J.3    Kang, K.B.4    Gratchev, A.5
  • 17
    • 37349029518 scopus 로고    scopus 로고
    • Rapid cell corpse clearance by stabilin-2, a membrane phosphatidylserine receptor
    • Park SY, Jung MY, Kim HJ, Lee SJ, Kim SY, et al. (2008) Rapid cell corpse clearance by stabilin-2, a membrane phosphatidylserine receptor. Cell Death Differ 15: 192-201.
    • (2008) Cell Death Differ , vol.15 , pp. 192-201
    • Park, S.Y.1    Jung, M.Y.2    Kim, H.J.3    Lee, S.J.4    Kim, S.Y.5
  • 18
    • 37049004424 scopus 로고    scopus 로고
    • TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells
    • Kobayashi N, Karisola P, Pena-Cruz V, Dorfman DM, Jinushi M, et al. (2007) TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells. Immunity 27: 927-940.
    • (2007) Immunity , vol.27 , pp. 927-940
    • Kobayashi, N.1    Karisola, P.2    Pena-Cruz, V.3    Dorfman, D.M.4    Jinushi, M.5
  • 19
    • 65549168745 scopus 로고    scopus 로고
    • Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation
    • Nakayama M, Akiba H, Takeda K, Kojima Y, Hashiguchi M, et al. (2009) Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation. Blood 113: 3821-3830.
    • (2009) Blood , vol.113 , pp. 3821-3830
    • Nakayama, M.1    Akiba, H.2    Takeda, K.3    Kojima, Y.4    Hashiguchi, M.5
  • 20
    • 0025164935 scopus 로고
    • Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis
    • Savill J, Dransfield I, Hogg N, Haslett C, (1990) Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis. Nature 343: 170-173.
    • (1990) Nature , vol.343 , pp. 170-173
    • Savill, J.1    Dransfield, I.2    Hogg, N.3    Haslett, C.4
  • 21
    • 3543053363 scopus 로고    scopus 로고
    • Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes
    • Albert ML, Pearce SF, Francisco LM, Sauter B, Roy P, et al. (1998) Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. J Exp Med 188: 1359-1368.
    • (1998) J Exp Med , vol.188 , pp. 1359-1368
    • Albert, M.L.1    Pearce, S.F.2    Francisco, L.M.3    Sauter, B.4    Roy, P.5
  • 22
    • 0035837323 scopus 로고    scopus 로고
    • Phagocytosis and clearance of apoptotic cells is mediated by MER
    • Scott RS, McMahon EJ, Pop SM, Reap EA, Caricchio R, et al. (2001) Phagocytosis and clearance of apoptotic cells is mediated by MER. Nature 411: 207-211.
    • (2001) Nature , vol.411 , pp. 207-211
    • Scott, R.S.1    McMahon, E.J.2    Pop, S.M.3    Reap, E.A.4    Caricchio, R.5
  • 23
    • 0026508561 scopus 로고
    • Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages
    • Fadok VA, Voelker DR, Campbell PA, Cohen JJ, Bratton DL, et al. (1992) Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J Immunol 148: 2207-2216.
    • (1992) J Immunol , vol.148 , pp. 2207-2216
    • Fadok, V.A.1    Voelker, D.R.2    Campbell, P.A.3    Cohen, J.J.4    Bratton, D.L.5
  • 24
    • 70349898677 scopus 로고    scopus 로고
    • The ins and outs of phospholipid asymmetry in the plasma membrane: roles in health and disease
    • Fadeel B, Xue D, (2009) The ins and outs of phospholipid asymmetry in the plasma membrane: roles in health and disease. Crit Rev Biochem Mol Biol 44: 264-277.
    • (2009) Crit Rev Biochem Mol Biol , vol.44 , pp. 264-277
    • Fadeel, B.1    Xue, D.2
  • 25
    • 36248944555 scopus 로고    scopus 로고
    • Identification of Tim4 as a phosphatidylserine receptor
    • Miyanishi M, Tada K, Koike M, Uchiyama Y, Kitamura T, et al. (2007) Identification of Tim4 as a phosphatidylserine receptor. Nature 450: 435-439.
    • (2007) Nature , vol.450 , pp. 435-439
    • Miyanishi, M.1    Tada, K.2    Koike, M.3    Uchiyama, Y.4    Kitamura, T.5
  • 26
    • 50249133197 scopus 로고    scopus 로고
    • Epidermal growth factor-like domain repeat of stabilin-2 recognizes phosphatidylserine during cell corpse clearance
    • Park SY, Kim SY, Jung MY, Bae DJ, Kim IS, (2008) Epidermal growth factor-like domain repeat of stabilin-2 recognizes phosphatidylserine during cell corpse clearance. Mol Cell Biol 28: 5288-5298.
    • (2008) Mol Cell Biol , vol.28 , pp. 5288-5298
    • Park, S.Y.1    Kim, S.Y.2    Jung, M.Y.3    Bae, D.J.4    Kim, I.S.5
  • 27
    • 0029910706 scopus 로고    scopus 로고
    • Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases
    • Nagata K, Ohashi K, Nakano T, Arita H, Zong C, et al. (1996) Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases. J Biol Chem 271: 30022-30027.
    • (1996) J Biol Chem , vol.271 , pp. 30022-30027
    • Nagata, K.1    Ohashi, K.2    Nakano, T.3    Arita, H.4    Zong, C.5
  • 28
    • 0345731228 scopus 로고    scopus 로고
    • The opsonin MFG-E8 is a ligand for the alphavbeta5 integrin and triggers DOCK180-dependent Rac1 activation for the phagocytosis of apoptotic cells
    • Akakura S, Singh S, Spataro M, Akakura R, Kim JI, et al. (2004) The opsonin MFG-E8 is a ligand for the alphavbeta5 integrin and triggers DOCK180-dependent Rac1 activation for the phagocytosis of apoptotic cells. Exp Cell Res 292: 403-416.
    • (2004) Exp Cell Res , vol.292 , pp. 403-416
    • Akakura, S.1    Singh, S.2    Spataro, M.3    Akakura, R.4    Kim, J.I.5
  • 29
    • 0033625871 scopus 로고    scopus 로고
    • alphavbeta5 integrin recruits the CrkII-Dock180-rac1 complex for phagocytosis of apoptotic cells
    • Albert ML, Kim JI, Birge RB, (2000) alphavbeta5 integrin recruits the CrkII-Dock180-rac1 complex for phagocytosis of apoptotic cells. Nat Cell Biol 2: 899-905.
    • (2000) Nat Cell Biol , vol.2 , pp. 899-905
    • Albert, M.L.1    Kim, J.I.2    Birge, R.B.3
  • 30
    • 14644411712 scopus 로고    scopus 로고
    • A role for Mer tyrosine kinase in alphavbeta5 integrin-mediated phagocytosis of apoptotic cells
    • Wu Y, Singh S, Georgescu MM, Birge RB, (2005) A role for Mer tyrosine kinase in alphavbeta5 integrin-mediated phagocytosis of apoptotic cells. J Cell Sci 118: 539-553.
    • (2005) J Cell Sci , vol.118 , pp. 539-553
    • Wu, Y.1    Singh, S.2    Georgescu, M.M.3    Birge, R.B.4
  • 31
    • 77956945047 scopus 로고    scopus 로고
    • Unexpected requirement for ELMO1 in clearance of apoptotic germ cells in vivo
    • Elliott MR, Zheng S, Park D, Woodson RI, Reardon MA, et al. (2010) Unexpected requirement for ELMO1 in clearance of apoptotic germ cells in vivo. Nature 467: 333-337.
    • (2010) Nature , vol.467 , pp. 333-337
    • Elliott, M.R.1    Zheng, S.2    Park, D.3    Woodson, R.I.4    Reardon, M.A.5
  • 32
    • 14844363449 scopus 로고    scopus 로고
    • Mannose-binding lectin-deficient mice display defective apoptotic cell clearance but no autoimmune phenotype
    • Stuart LM, Takahashi K, Shi L, Savill J, Ezekowitz RA, (2005) Mannose-binding lectin-deficient mice display defective apoptotic cell clearance but no autoimmune phenotype. J Immunol 174: 3220-3226.
    • (2005) J Immunol , vol.174 , pp. 3220-3226
    • Stuart, L.M.1    Takahashi, K.2    Shi, L.3    Savill, J.4    Ezekowitz, R.A.5
  • 33
    • 0009720857 scopus 로고
    • Purification and characterization of a bovine acetyl low density lipoprotein receptor
    • Kodama T, Reddy P, Kishimoto C, Krieger M, (1988) Purification and characterization of a bovine acetyl low density lipoprotein receptor. Proc Natl Acad Sci U S A 85: 9238-9242.
    • (1988) Proc Natl Acad Sci U S A , vol.85 , pp. 9238-9242
    • Kodama, T.1    Reddy, P.2    Kishimoto, C.3    Krieger, M.4
  • 34
    • 0032445073 scopus 로고    scopus 로고
    • Roles of ICAM-3 and CD14 in the recognition and phagocytosis of apoptotic cells by macrophages
    • Gregory CD, Devitt A, Moffatt O, (1998) Roles of ICAM-3 and CD14 in the recognition and phagocytosis of apoptotic cells by macrophages. Biochem Soc Trans 26: 644-649.
    • (1998) Biochem Soc Trans , vol.26 , pp. 644-649
    • Gregory, C.D.1    Devitt, A.2    Moffatt, O.3
  • 35
    • 0017618537 scopus 로고
    • Post-embryonic cell lineages of the nematode, Caenorhabditis elegans
    • Sulston JE, Horvitz HR, (1977) Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. Dev Biol 56: 110-156.
    • (1977) Dev Biol , vol.56 , pp. 110-156
    • Sulston, J.E.1    Horvitz, H.R.2
  • 36
    • 0018725140 scopus 로고
    • The postembryonic cell lineages of the hermaphrodite and male gonads in Caenorhabditis elegans
    • Kimble J, Hirsh D, (1979) The postembryonic cell lineages of the hermaphrodite and male gonads in Caenorhabditis elegans. Dev Biol 70: 396-417.
    • (1979) Dev Biol , vol.70 , pp. 396-417
    • Kimble, J.1    Hirsh, D.2
  • 37
    • 0020858899 scopus 로고
    • The embryonic cell lineage of the nematode Caenorhabditis elegans
    • Sulston JE, Schierenberg E, White JG, Thomson JN, (1983) The embryonic cell lineage of the nematode Caenorhabditis elegans. Dev Biol 100: 64-119.
    • (1983) Dev Biol , vol.100 , pp. 64-119
    • Sulston, J.E.1    Schierenberg, E.2    White, J.G.3    Thomson, J.N.4
  • 38
    • 0020059258 scopus 로고
    • Morphology of programmed cell death in the ventral nerve cord of Caenorhabditis elegans larvae
    • Robertson A, Thomson N, (1982) Morphology of programmed cell death in the ventral nerve cord of Caenorhabditis elegans larvae. J Embryol Exp Morphol 67: 89-100.
    • (1982) J Embryol Exp Morphol , vol.67 , pp. 89-100
    • Robertson, A.1    Thomson, N.2
  • 39
    • 0032511145 scopus 로고    scopus 로고
    • The C. elegans cell corpse engulfment gene ced-7 encodes a protein similar to ABC transporters
    • Wu YC, Horvitz HR, (1998) The C. elegans cell corpse engulfment gene ced-7 encodes a protein similar to ABC transporters. Cell 93: 951-960.
    • (1998) Cell , vol.93 , pp. 951-960
    • Wu, Y.C.1    Horvitz, H.R.2
  • 40
    • 0035846903 scopus 로고    scopus 로고
    • CED-1 is a transmembrane receptor that mediates cell corpse engulfment in C. elegans
    • Zhou Z, Hartwieg E, Horvitz HR, (2001) CED-1 is a transmembrane receptor that mediates cell corpse engulfment in C. elegans. Cell 104: 43-56.
    • (2001) Cell , vol.104 , pp. 43-56
    • Zhou, Z.1    Hartwieg, E.2    Horvitz, H.R.3
  • 41
    • 0033581828 scopus 로고    scopus 로고
    • Human CED-6 encodes a functional homologue of the Caenorhabditis elegans engulfment protein CED-6
    • Liu QA, Hengartner MO, (1999) Human CED-6 encodes a functional homologue of the Caenorhabditis elegans engulfment protein CED-6. Curr Biol 9: 1347-1350.
    • (1999) Curr Biol , vol.9 , pp. 1347-1350
    • Liu, Q.A.1    Hengartner, M.O.2
  • 42
    • 33646867879 scopus 로고    scopus 로고
    • C. elegans Dynamin mediates the signaling of phagocytic receptor CED-1 for the engulfment and degradation of apoptotic cells
    • Yu X, Odera S, Chuang CH, Lu N, Zhou Z, (2006) C. elegans Dynamin mediates the signaling of phagocytic receptor CED-1 for the engulfment and degradation of apoptotic cells. Dev Cell 10: 743-757.
    • (2006) Dev Cell , vol.10 , pp. 743-757
    • Yu, X.1    Odera, S.2    Chuang, C.H.3    Lu, N.4    Zhou, Z.5
  • 43
    • 77954242242 scopus 로고    scopus 로고
    • Caenorhabditis elegans transthyretin-like protein TTR-52 mediates recognition of apoptotic cells by the CED-1 phagocyte receptor
    • Wang X, Li W, Zhao D, Liu B, Shi Y, et al. (2010) Caenorhabditis elegans transthyretin-like protein TTR-52 mediates recognition of apoptotic cells by the CED-1 phagocyte receptor. Nat Cell Biol 12: 655-664.
    • (2010) Nat Cell Biol , vol.12 , pp. 655-664
    • Wang, X.1    Li, W.2    Zhao, D.3    Liu, B.4    Shi, Y.5
  • 44
    • 0345374587 scopus 로고    scopus 로고
    • Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12
    • Wang X, Wu YC, Fadok VA, Lee MC, Gengyo-Ando K, et al. (2003) Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12. Science 302: 1563-1566.
    • (2003) Science , vol.302 , pp. 1563-1566
    • Wang, X.1    Wu, Y.C.2    Fadok, V.A.3    Lee, M.C.4    Gengyo-Ando, K.5
  • 45
    • 77649151901 scopus 로고    scopus 로고
    • The Wnt pathway controls cell death engulfment, spindle orientation, and migration through CED-10/Rac
    • doi:10.1371/journal.pbio.1000297
    • Cabello J, Neukomm LJ, Gunesdogan U, Burkart K, Charette SJ, et al. (2010) The Wnt pathway controls cell death engulfment, spindle orientation, and migration through CED-10/Rac. PLoS Biol 8: e1000297 doi:10.1371/journal.pbio.1000297.
    • (2010) PLoS Biol , vol.8
    • Cabello, J.1    Neukomm, L.J.2    Gunesdogan, U.3    Burkart, K.4    Charette, S.J.5
  • 46
    • 77949487317 scopus 로고    scopus 로고
    • Engulfment of apoptotic cells in C. elegans is mediated by integrin alpha/SRC signaling
    • Hsu TY, Wu YC, (2010) Engulfment of apoptotic cells in C. elegans is mediated by integrin alpha/SRC signaling. Curr Biol 20: 477-486.
    • (2010) Curr Biol , vol.20 , pp. 477-486
    • Hsu, T.Y.1    Wu, Y.C.2
  • 47
    • 0032473981 scopus 로고    scopus 로고
    • C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180
    • Wu YC, Horvitz HR, (1998) C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180. Nature 392: 501-504.
    • (1998) Nature , vol.392 , pp. 501-504
    • Wu, Y.C.1    Horvitz, H.R.2
  • 48
    • 0033771902 scopus 로고    scopus 로고
    • CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans
    • Reddien PW, Horvitz HR, (2000) CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans. Nat Cell Biol 2: 131-136.
    • (2000) Nat Cell Biol , vol.2 , pp. 131-136
    • Reddien, P.W.1    Horvitz, H.R.2
  • 49
    • 17944376439 scopus 로고    scopus 로고
    • CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration
    • Gumienny TL, Brugnera E, Tosello-Trampont AC, Kinchen JM, Haney LB, et al. (2001) CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration. Cell 107: 27-41.
    • (2001) Cell , vol.107 , pp. 27-41
    • Gumienny, T.L.1    Brugnera, E.2    Tosello-Trampont, A.C.3    Kinchen, J.M.4    Haney, L.B.5
  • 50
    • 0035487807 scopus 로고    scopus 로고
    • C. elegans CED-12 acts in the conserved CrkII/DOCK180/Rac pathway to control cell migration and cell corpse engulfment
    • Wu YC, Tsai MC, Cheng LC, Chou CJ, Weng NY, (2001) C. elegans CED-12 acts in the conserved CrkII/DOCK180/Rac pathway to control cell migration and cell corpse engulfment. Dev Cell 1: 491-502.
    • (2001) Dev Cell , vol.1 , pp. 491-502
    • Wu, Y.C.1    Tsai, M.C.2    Cheng, L.C.3    Chou, C.J.4    Weng, N.Y.5
  • 51
    • 0035487646 scopus 로고    scopus 로고
    • The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway
    • Zhou Z, Caron E, Hartwieg E, Hall A, Horvitz HR, (2001) The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway. Dev Cell 1: 477-489.
    • (2001) Dev Cell , vol.1 , pp. 477-489
    • Zhou, Z.1    Caron, E.2    Hartwieg, E.3    Hall, A.4    Horvitz, H.R.5
  • 52
    • 0036045768 scopus 로고    scopus 로고
    • Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex
    • Brugnera E, Haney L, Grimsley C, Lu M, Walk SF, et al. (2002) Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex. Nat Cell Biol 4: 574-582.
    • (2002) Nat Cell Biol , vol.4 , pp. 574-582
    • Brugnera, E.1    Haney, L.2    Grimsley, C.3    Lu, M.4    Walk, S.F.5
  • 53
    • 72949117533 scopus 로고    scopus 로고
    • Caenorhabditis elegans myotubularin MTM-1 negatively regulates the engulfment of apoptotic cells
    • doi:10.1371/journal.pgen.1000679
    • Zou W, Lu Q, Zhao D, Li W, Mapes J, et al. (2009) Caenorhabditis elegans myotubularin MTM-1 negatively regulates the engulfment of apoptotic cells. PLoS Genet 5: e1000679 doi:10.1371/journal.pgen.1000679.
    • (2009) PLoS Genet , vol.5
    • Zou, W.1    Lu, Q.2    Zhao, D.3    Li, W.4    Mapes, J.5
  • 54
    • 79955552492 scopus 로고    scopus 로고
    • The phosphoinositide phosphatase MTM-1 regulates apoptotic cell corpse clearance through CED-5-CED-12 in C. elegans
    • Neukomm LJ, Nicot AS, Kinchen JM, Almendinger J, Pinto SM, et al. (2011) The phosphoinositide phosphatase MTM-1 regulates apoptotic cell corpse clearance through CED-5-CED-12 in C. elegans. Development 138: 2003-2014.
    • (2011) Development , vol.138 , pp. 2003-2014
    • Neukomm, L.J.1    Nicot, A.S.2    Kinchen, J.M.3    Almendinger, J.4    Pinto, S.M.5
  • 55
    • 14544290056 scopus 로고    scopus 로고
    • Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans
    • Kinchen JM, Cabello J, Klingele D, Wong K, Feichtinger R, et al. (2005) Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans. Nature 434: 93-99.
    • (2005) Nature , vol.434 , pp. 93-99
    • Kinchen, J.M.1    Cabello, J.2    Klingele, D.3    Wong, K.4    Feichtinger, R.5
  • 56
    • 78650512821 scopus 로고    scopus 로고
    • Loss of the RhoGAP SRGP-1 promotes the clearance of dead and injured cells in Caenorhabditis elegans
    • Neukomm LJ, Frei AP, Cabello J, Kinchen JM, Zaidel-Bar R, et al. (2011) Loss of the RhoGAP SRGP-1 promotes the clearance of dead and injured cells in Caenorhabditis elegans. Nat Cell Biol 13: 79-86.
    • (2011) Nat Cell Biol , vol.13 , pp. 79-86
    • Neukomm, L.J.1    Frei, A.P.2    Cabello, J.3    Kinchen, J.M.4    Zaidel-Bar, R.5
  • 57
    • 65949107540 scopus 로고    scopus 로고
    • Abl kinase inhibits the engulfment of apoptotic [corrected] cells in Caenorhabditis elegans
    • doi:10.1371/journal.pbio.1000099
    • Hurwitz ME, Vanderzalm PJ, Bloom L, Goldman J, Garriga G, et al. (2009) Abl kinase inhibits the engulfment of apoptotic [corrected] cells in Caenorhabditis elegans. PLoS Biol 7: e99 doi:10.1371/journal.pbio.1000099.
    • (2009) PLoS Biol , vol.7
    • Hurwitz, M.E.1    Vanderzalm, P.J.2    Bloom, L.3    Goldman, J.4    Garriga, G.5
  • 58
    • 0023666065 scopus 로고
    • Integrins: a family of cell surface receptors
    • Hynes RO, (1987) Integrins: a family of cell surface receptors. Cell 48: 549-554.
    • (1987) Cell , vol.48 , pp. 549-554
    • Hynes, R.O.1
  • 59
    • 0026770377 scopus 로고
    • Integrins: versatility, modulation, and signaling in cell adhesion
    • Hynes RO, (1992) Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69: 11-25.
    • (1992) Cell , vol.69 , pp. 11-25
    • Hynes, R.O.1
  • 60
    • 0028089203 scopus 로고
    • Genes critical for muscle development and function in Caenorhabditis elegans identified through lethal mutations
    • Williams BD, Waterston RH, (1994) Genes critical for muscle development and function in Caenorhabditis elegans identified through lethal mutations. J Cell Biol 124: 475-490.
    • (1994) J Cell Biol , vol.124 , pp. 475-490
    • Williams, B.D.1    Waterston, R.H.2
  • 61
    • 0028990430 scopus 로고
    • Characterization of beta pat-3 heterodimers, a family of essential integrin receptors in C. elegans
    • Gettner SN, Kenyon C, Reichardt LF, (1995) Characterization of beta pat-3 heterodimers, a family of essential integrin receptors in C. elegans. J Cell Biol 129: 1127-1141.
    • (1995) J Cell Biol , vol.129 , pp. 1127-1141
    • Gettner, S.N.1    Kenyon, C.2    Reichardt, L.F.3
  • 62
    • 0030762006 scopus 로고    scopus 로고
    • Neuronal migrations and axon fasciculation are disrupted in ina-1 integrin mutants
    • Baum PD, Garriga G, (1997) Neuronal migrations and axon fasciculation are disrupted in ina-1 integrin mutants. Neuron 19: 51-62.
    • (1997) Neuron , vol.19 , pp. 51-62
    • Baum, P.D.1    Garriga, G.2
  • 63
    • 0028055026 scopus 로고
    • Assembly of body wall muscle and muscle cell attachment structures in Caenorhabditis elegans
    • Hresko MC, Williams BD, Waterston RH, (1994) Assembly of body wall muscle and muscle cell attachment structures in Caenorhabditis elegans. J Cell Biol 124: 491-506.
    • (1994) J Cell Biol , vol.124 , pp. 491-506
    • Hresko, M.C.1    Williams, B.D.2    Waterston, R.H.3
  • 64
    • 0028089203 scopus 로고
    • Genes critical for muscle development and function in Caenorhabditis elegans identified through lethal mutations
    • Williams BD, Waterston RH, (1994) Genes critical for muscle development and function in Caenorhabditis elegans identified through lethal mutations. J Cell Biol 124 (4): 475-90.
    • (1994) J Cell Biol , vol.124 , Issue.4 , pp. 475-490
    • Williams, B.D.1    Waterston, R.H.2
  • 65
    • 38449083521 scopus 로고    scopus 로고
    • Sarcomere assembly in C. elegans muscle
    • (January 16, 2006), WormBook, ed. doi/10.1895/wormbook.1.81.1
    • Moerman DG, Williams BD, Sarcomere assembly in C. elegans muscle (January 16, 2006), WormBook, ed. The C. elegans Research Community, WormBook, doi/10.1895/wormbook.1.81.1,http://www.wormbook.org.
    • The C. elegans Research Community
    • Moerman, D.G.1    Williams, B.D.2
  • 66
    • 33646127607 scopus 로고    scopus 로고
    • FGF negatively regulates muscle membrane extension in Caenorhabditis elegans
    • Dixon SJ, Alexander M, Fernandes R, Ricker N, Roy PJ, (2006) FGF negatively regulates muscle membrane extension in Caenorhabditis elegans. Development 133: 1263-1275.
    • (2006) Development , vol.133 , pp. 1263-1275
    • Dixon, S.J.1    Alexander, M.2    Fernandes, R.3    Ricker, N.4    Roy, P.J.5
  • 67
    • 34347381114 scopus 로고    scopus 로고
    • Control of C. elegans hermaphrodite gonad size and shape by vab-3/Pax6-mediated regulation of integrin receptors
    • Meighan CM, Schwarzbauer JE, (2007) Control of C. elegans hermaphrodite gonad size and shape by vab-3/Pax6-mediated regulation of integrin receptors. Genes Dev 21: 1615-1620.
    • (2007) Genes Dev , vol.21 , pp. 1615-1620
    • Meighan, C.M.1    Schwarzbauer, J.E.2
  • 68
    • 0022497852 scopus 로고
    • Genetic control of programmed cell death in the nematode C. elegans
    • Ellis HM, Horvitz HR, (1986) Genetic control of programmed cell death in the nematode C. elegans. Cell 44: 817-829.
    • (1986) Cell , vol.44 , pp. 817-829
    • Ellis, H.M.1    Horvitz, H.R.2
  • 69
    • 0035735918 scopus 로고    scopus 로고
    • Cooperative regulation of AJM-1 controls junctional integrity in Caenorhabditis elegans epithelia
    • Koppen M, Simske JS, Sims PA, Firestein BL, Hall DH, et al. (2001) Cooperative regulation of AJM-1 controls junctional integrity in Caenorhabditis elegans epithelia. Nat Cell Biol 3: 983-991.
    • (2001) Nat Cell Biol , vol.3 , pp. 983-991
    • Koppen, M.1    Simske, J.S.2    Sims, P.A.3    Firestein, B.L.4    Hall, D.H.5
  • 70
    • 0027451263 scopus 로고
    • Sequence requirements for myosin gene expression and regulation in Caenorhabditis elegans
    • Okkema PG, Harrison SW, Plunger V, Aryana A, Fire A, (1993) Sequence requirements for myosin gene expression and regulation in Caenorhabditis elegans. Genetics 135: 385-404.
    • (1993) Genetics , vol.135 , pp. 385-404
    • Okkema, P.G.1    Harrison, S.W.2    Plunger, V.3    Aryana, A.4    Fire, A.5
  • 71
    • 0035067475 scopus 로고    scopus 로고
    • Phagocytosis and the actin cytoskeleton
    • May RC, Machesky LM, (2001) Phagocytosis and the actin cytoskeleton. J Cell Sci 114: 1061-1077.
    • (2001) J Cell Sci , vol.114 , pp. 1061-1077
    • May, R.C.1    Machesky, L.M.2
  • 72
    • 0034729916 scopus 로고    scopus 로고
    • Rho GTPases: molecular switches that control the organization and dynamics of the actin cytoskeleton
    • Hall A, Nobes CD, (2000) Rho GTPases: molecular switches that control the organization and dynamics of the actin cytoskeleton. Philos Trans R Soc Lond B Biol Sci 355: 965-970.
    • (2000) Philos Trans R Soc Lond B Biol Sci , vol.355 , pp. 965-970
    • Hall, A.1    Nobes, C.D.2
  • 73
    • 0031281917 scopus 로고    scopus 로고
    • GFP-moesin illuminates actin cytoskeleton dynamics in living tissue and demonstrates cell shape changes during morphogenesis in Drosophila
    • Edwards KA, Demsky M, Montague RA, Weymouth N, Kiehart DP, (1997) GFP-moesin illuminates actin cytoskeleton dynamics in living tissue and demonstrates cell shape changes during morphogenesis in Drosophila. Dev Biol 191: 103-117.
    • (1997) Dev Biol , vol.191 , pp. 103-117
    • Edwards, K.A.1    Demsky, M.2    Montague, R.A.3    Weymouth, N.4    Kiehart, D.P.5
  • 74
    • 33645521057 scopus 로고    scopus 로고
    • Two phases of astral microtubule activity during cytokinesis in C. elegans embryos
    • Motegi F, Velarde NV, Piano F, Sugimoto A, (2006) Two phases of astral microtubule activity during cytokinesis in C. elegans embryos. Dev Cell 10: 509-520.
    • (2006) Dev Cell , vol.10 , pp. 509-520
    • Motegi, F.1    Velarde, N.V.2    Piano, F.3    Sugimoto, A.4
  • 75
    • 25144506641 scopus 로고    scopus 로고
    • Identification of a novel Cdc42 GEF that is localized to the PAT-3-mediated adhesive structure
    • Hikita T, Qadota H, Tsuboi D, Taya S, Moerman DG, et al. (2005) Identification of a novel Cdc42 GEF that is localized to the PAT-3-mediated adhesive structure. Biochem Biophys Res Commun 335: 139-145.
    • (2005) Biochem Biophys Res Commun , vol.335 , pp. 139-145
    • Hikita, T.1    Qadota, H.2    Tsuboi, D.3    Taya, S.4    Moerman, D.G.5
  • 76
    • 0035195553 scopus 로고    scopus 로고
    • Three C. elegans Rac proteins and several alternative Rac regulators control axon guidance, cell migration and apoptotic cell phagocytosis
    • Lundquist EA, Reddien PW, Hartwieg E, Horvitz HR, Bargmann CI, (2001) Three C. elegans Rac proteins and several alternative Rac regulators control axon guidance, cell migration and apoptotic cell phagocytosis. Development 128 (22): 4475-88.
    • (2001) Development , vol.128 , Issue.22 , pp. 4475-4488
    • Lundquist, E.A.1    Reddien, P.W.2    Hartwieg, E.3    Horvitz, H.R.4    Bargmann, C.I.5
  • 77
    • 2442665179 scopus 로고    scopus 로고
    • Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice
    • Hanayama R, Tanaka M, Miyasaka K, Aozasa K, Koike M, et al. (2004) Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice. Science 304: 1147-1150.
    • (2004) Science , vol.304 , pp. 1147-1150
    • Hanayama, R.1    Tanaka, M.2    Miyasaka, K.3    Aozasa, K.4    Koike, M.5
  • 78
    • 0027057502 scopus 로고
    • Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells
    • Fadok VA, Savill JS, Haslett C, Bratton DL, Doherty DE, et al. (1992) Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells. J Immunol 149: 4029-4035.
    • (1992) J Immunol , vol.149 , pp. 4029-4035
    • Fadok, V.A.1    Savill, J.S.2    Haslett, C.3    Bratton, D.L.4    Doherty, D.E.5
  • 79
    • 0016063911 scopus 로고
    • The genetics of Caenorhabditis elegans
    • Brenner S, (1974) The genetics of Caenorhabditis elegans. Genetics 77: 71-94.
    • (1974) Genetics , vol.77 , pp. 71-94
    • Brenner, S.1
  • 80
    • 0034676457 scopus 로고    scopus 로고
    • Functional genomic analysis of C. elegans chromosome I by systematic RNA interference
    • Fraser AG, Kamath RS, Zipperlen P, Martinez-Campos M, Sohrmann M, et al. (2000) Functional genomic analysis of C. elegans chromosome I by systematic RNA interference. Nature 408: 325-330.
    • (2000) Nature , vol.408 , pp. 325-330
    • Fraser, A.G.1    Kamath, R.S.2    Zipperlen, P.3    Martinez-Campos, M.4    Sohrmann, M.5
  • 81
    • 0025942107 scopus 로고
    • Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences
    • Mello CC, Kramer JM, Stinchcomb D, Ambros V, (1991) Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences. EMBO J 10: 3959-3970.
    • (1991) EMBO J , vol.10 , pp. 3959-3970
    • Mello, C.C.1    Kramer, J.M.2    Stinchcomb, D.3    Ambros, V.4
  • 82
    • 0031830508 scopus 로고    scopus 로고
    • Caenorhabditis elegans SUR-5, a novel but conserved protein, negatively regulates LET-60 Ras activity during vulval induction
    • Gu T, Orita S, Han M, (1998) Caenorhabditis elegans SUR-5, a novel but conserved protein, negatively regulates LET-60 Ras activity during vulval induction. Mol Cell Biol 18: 4556-4564.
    • (1998) Mol Cell Biol , vol.18 , pp. 4556-4564
    • Gu, T.1    Orita, S.2    Han, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.