메뉴 건너뛰기




Volumn 13, Issue 1, 2011, Pages 79-86

Loss of the RhoGAP SRGP-1 promotes the clearance of dead and injured cells in Caenorhabditis elegans

Author keywords

[No Author keywords available]

Indexed keywords

RAC1 PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; SLIT ROBO GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN 1; UNCLASSIFIED DRUG;

EID: 78650512821     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb2138     Document Type: Article
Times cited : (53)

References (47)
  • 1
    • 0033593572 scopus 로고    scopus 로고
    • Cell death in development
    • Vaux, D. L. & Korsmeyer, S. J. Cell death in development. Cell 96, 245-254 (1999).
    • (1999) Cell , vol.96 , pp. 245-254
    • Vaux, D.L.1    Korsmeyer, S.J.2
  • 2
    • 1542357606 scopus 로고    scopus 로고
    • Apoptosis pathways in cancer and cancer therapy
    • Debatin, K.M. Apoptosis pathways in cancer and cancer therapy. Cancer Immunol. Immunother. 53, 153-159 (2004).
    • (2004) Cancer Immunol. Immunother. , vol.53 , pp. 153-159
    • Debatin, K.M.1
  • 4
    • 68149132139 scopus 로고    scopus 로고
    • Clearance of apoptotic corpses
    • Fullard, J. F., Kale, A. & Baker, N. E. Clearance of apoptotic corpses. Apoptosis 14, 1029-1037 (2009).
    • (2009) Apoptosis , vol.14 , pp. 1029-1037
    • Fullard, J.F.1    Kale, A.2    Baker, N.E.3
  • 5
    • 0035846903 scopus 로고    scopus 로고
    • CED-1 is a transmembrane receptor that mediates cell corpse engulfment in C. elegans
    • Zhou, Z., Hartwieg, E. & Horvitz, H. R. CED-1 is a transmembrane receptor that mediates cell corpse engulfment in C. elegans. Cell 104, 43-56 (2001).
    • (2001) Cell , vol.104 , pp. 43-56
    • Zhou, Z.1    Hartwieg, E.2    Horvitz, H.R.3
  • 6
    • 0032511145 scopus 로고    scopus 로고
    • The C elegans cell corpse engulfment gene ced-7 encodes a protein similar to ABC transporters
    • Wu, Y. C. & Horvitz, H. R. The C. elegans cell corpse engulfment gene ced-7 encodes a protein similar to ABC transporters. Cell 93, 951-960 (1998).
    • (1998) Cell , vol.93 , pp. 951-960
    • Wu, Y.C.1    Horvitz, H.R.2
  • 7
    • 33646867879 scopus 로고    scopus 로고
    • Elegans dynamin mediates the signaling of phagocytic receptor CED-1 for the engulfment and degradation of apoptotic cells
    • Yu, X., Odera, S., Chuang, C. H., Lu, N. & Zhou, Z. C. elegans dynamin mediates the signaling of phagocytic receptor CED-1 for the engulfment and degradation of apoptotic cells. Dev. Cell 10, 743-757 (2006).
    • (2006) Dev. Cell , vol.10 , pp. 743-757
    • Yu, X.1    Odera, S.2    Chuang, C.H.3    Lu, N.4    Zhou, Z.C.5
  • 8
    • 14544290056 scopus 로고    scopus 로고
    • Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans
    • Kinchen, J. M. et al. Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans. Nature 434, 93-99 (2005).
    • (2005) Nature , vol.434 , pp. 93-99
    • Kinchen, J.M.1
  • 9
    • 0032511234 scopus 로고    scopus 로고
    • Candidate adaptor protein CED-6 promotes the engulf-ment of apoptotic cells in C. elegans
    • Liu, Q. A. & Hengartner, M. O. Candidate adaptor protein CED-6 promotes the engulf-ment of apoptotic cells in C. elegans. Cell 93, 961-972 (1998).
    • (1998) Cell , vol.93 , pp. 961-972
    • Liu, Q.A.1    Hengartner, M.O.2
  • 10
    • 17944376439 scopus 로고    scopus 로고
    • CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration
    • Gumienny, T. L. et al. CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration. Cell 107, 27-41 (2001).
    • (2001) Cell , vol.107 , pp. 27-41
    • Gumienny, T.L.1
  • 11
    • 0032473981 scopus 로고    scopus 로고
    • C elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180
    • Wu, Y. C. & Horvitz, H. R. C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180. Nature 392, 501-504 (1998).
    • (1998) Nature , vol.392 , pp. 501-504
    • Wu, Y.C.1    Horvitz, H.R.2
  • 12
    • 19944376460 scopus 로고    scopus 로고
    • Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMO
    • De Bakker, C. D. et al. Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMO. Curr. Biol. 14, 2208-2216 (2004).
    • (2004) Curr. Biol. , vol.14 , pp. 2208-2216
    • De Bakker, C.D.1
  • 13
    • 0033771902 scopus 로고    scopus 로고
    • CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans
    • Reddien, P. W. & Horvitz, H. R. CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans. Nat. Cell Biol. 2, 131-136 (2000).
    • (2000) Nat. Cell Biol. , vol.2 , pp. 131-136
    • Reddien, P.W.1    Horvitz, H.R.2
  • 14
    • 20144372827 scopus 로고    scopus 로고
    • C-terminal SH3 domain of CrkII regulates the assembly and function of the DOCK180/ELMO Rac-GEF
    • Akakura, S. et al. C-terminal SH3 domain of CrkII regulates the assembly and function of the DOCK180/ELMO Rac-GEF. J. Cell Physiol. 204, 344-351 (2005).
    • (2005) J. Cell Physiol. , vol.204 , pp. 344-351
    • Akakura, S.1
  • 15
    • 34247530036 scopus 로고    scopus 로고
    • Identification of two signaling submodules within the CrkII/ELMO/Dock180 pathway regulating engulfment of apoptotic cells
    • Tosello-Trampont, A. C. et al. Identification of two signaling submodules within the CrkII/ELMO/Dock180 pathway regulating engulfment of apoptotic cells. Cell Death Differ. 14, 963-972 (2007).
    • (2007) Cell Death Differ. , vol.14 , pp. 963-972
    • Tosello-Trampont, A.C.1
  • 16
    • 85042810004 scopus 로고    scopus 로고
    • Abl kinase inhibits the engulfment of apoptotic cells in Caenorhabditis elegans
    • Hurwitz, M. E. et al. Abl kinase inhibits the engulfment of apoptotic cells in Caenorhabditis elegans. PLoS Biol. 7, e99 (2009).
    • (2009) PLoS Biol. , vol.7
    • Hurwitz, M.E.1
  • 17
    • 77649151901 scopus 로고    scopus 로고
    • The Wnt pathway controls cell death engulfment, spindle orientation, and migration through CED-10/Rac
    • Cabello, J. et al. The Wnt pathway controls cell death engulfment, spindle orientation, and migration through CED-10/Rac. PLoS Biol. 8, e1000297 (2010).
    • (2010) PLoS Biol. , vol.8
    • Cabello, J.1
  • 18
    • 77949487317 scopus 로고    scopus 로고
    • Engulfment of apoptotic cells in C. elegans is mediated by integrin α/SRC signaling
    • Hsu, T. Y. & Wu, Y. C. Engulfment of apoptotic cells in C. elegans is mediated by integrin α/SRC signaling. Curr. Biol. 20, 477-486 (2010).
    • (2010) Curr. Biol. , vol.20 , pp. 477-486
    • Hsu, T.Y.1    Wu, Y.C.2
  • 19
    • 7444270371 scopus 로고    scopus 로고
    • Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library
    • Rual, J. F. et al. Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library. Genome Res. 14, 2162-2168 (2004).
    • (2004) Genome Res. , vol.14 , pp. 2162-2168
    • Rual, J.F.1
  • 20
    • 0038725897 scopus 로고    scopus 로고
    • Genome-wide RNAi screening in Caenorhabditis elegans
    • Kamath, R. S. & Ahringer, J. Genome-wide RNAi screening in Caenorhabditis elegans. Methods 30, 313-321 (2003).
    • (2003) Methods , vol.30 , pp. 313-321
    • Kamath, R.S.1    Ahringer, J.2
  • 21
    • 0020858899 scopus 로고
    • The embryonic cell lineage of the nematode Caenorhabditis elegans
    • Sulston, J. E., Schierenberg, E., White, J. G. & Thomson, J. N. The embryonic cell lineage of the nematode Caenorhabditis elegans. Dev. Biol. 100, 64-119 (1983).
    • (1983) Dev. Biol. , vol.100 , pp. 64-119
    • Sulston, J.E.1    Schierenberg, E.2    White, J.G.3    Thomson, J.N.4
  • 22
    • 34447550617 scopus 로고    scopus 로고
    • Journey to the grave: Signaling events regulating removal of apoptotic cells
    • Kinchen, J. & Ravichandran, K. Journey to the grave: signaling events regulating removal of apoptotic cells. J. Cell Sci. 120, 2143-2149 (2007).
    • (2007) J. Cell Sci. , vol.120 , pp. 2143-2149
    • Kinchen, J.1    Ravichandran, K.2
  • 23
    • 0032524885 scopus 로고    scopus 로고
    • The C elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl2like protein CED-9
    • Conradt, B. & Horvitz, H. R. The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl2like protein CED-9. Cell 93, 519-529 (1998).
    • (1998) Cell , vol.93 , pp. 519-529
    • Conradt, B.1    Horvitz, H.R.2
  • 24
    • 56449091763 scopus 로고    scopus 로고
    • The WAVE/SCAR complex promotes polarized cell movements and actin enrichment in epithelia during C. elegans embryogenesis
    • Patel, F. B. et al. The WAVE/SCAR complex promotes polarized cell movements and actin enrichment in epithelia during C. elegans embryogenesis. Dev. Biol. 324, 297-309 (2008).
    • (2008) Dev. Biol. , vol.324 , pp. 297-309
    • Patel, F.B.1
  • 25
    • 18144437689 scopus 로고    scopus 로고
    • The structure of the GTPase-activating domain from p50rhoGAP
    • Barrett, T. et al. The structure of the GTPase-activating domain from p50rhoGAP. Nature 385, 458-461 (1997).
    • (1997) Nature , vol.385 , pp. 458-461
    • Barrett, T.1
  • 26
    • 36248987290 scopus 로고    scopus 로고
    • BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/ Dock180/Rac module
    • Park, D. et al. BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/ Dock180/Rac module. Nature 450, 430-434 (2007).
    • (2007) Nature , vol.450 , pp. 430-434
    • Park, D.1
  • 27
    • 78349302731 scopus 로고    scopus 로고
    • The F-BAR domain of SRGP-1 facilitates cell-cell adhesion during C. elegans morphogenesis
    • Zaidel-Bar, R. et al. The F-BAR domain of SRGP-1 facilitates cell-cell adhesion during C. elegans morphogenesis. J. Cell Biol. 191, 761-769 (2010).
    • (2010) J. Cell Biol. , vol.191 , pp. 761-769
    • Zaidel-Bar, R.1
  • 28
    • 0033579464 scopus 로고    scopus 로고
    • Sequence and structure-based prediction of eukaryotic protein phosphorylation sites
    • Blom, N., Gammeltoft, S. & Brunak, S. Sequence and structure-based prediction of eukaryotic protein phosphorylation sites. J. Mol. Biol. 294, 1351-1362 (1999).
    • (1999) J. Mol. Biol. , vol.294 , pp. 1351-1362
    • Blom, N.1    Gammeltoft, S.2    Brunak, S.3
  • 29
    • 77950594242 scopus 로고    scopus 로고
    • Subcellular membrane curvature mediated by the BAR domain superfamily proteins
    • Suetsugu, S., Toyooka, K. & Senju, Y. Subcellular membrane curvature mediated by the BAR domain superfamily proteins. Semin. Cell Dev. Biol. 21, 340-349 (2010).
    • (2010) Semin. Cell Dev. Biol. , vol.21 , pp. 340-349
    • Suetsugu, S.1    Toyooka, K.2    Senju, Y.3
  • 30
    • 77953244134 scopus 로고    scopus 로고
    • FCHo proteins are nucleators of clathrin-mediated endocytosis
    • Henne, W. M. et al. FCHo proteins are nucleators of clathrin-mediated endocytosis. Science 328, 1281-1284 (2010).
    • (2010) Science , vol.328 , pp. 1281-1284
    • Henne, W.M.1
  • 31
    • 69449100707 scopus 로고    scopus 로고
    • The F-BAR domain of srGAP2 induces membrane protrusions required for neuronal migration and morphogenesis
    • Guerrier, S. et al. The F-BAR domain of srGAP2 induces membrane protrusions required for neuronal migration and morphogenesis. Cell 138, 990-1004 (2009).
    • (2009) Cell , vol.138 , pp. 990-1004
    • Guerrier, S.1
  • 32
    • 33845729889 scopus 로고    scopus 로고
    • SWAN1 a Caenorhabditis elegans WD repeat protein of the AN11 family, is a negative regulator of Rac GTPase function
    • Yang, Y., Lu, J., Rovnak, J., Quackenbush, S. L. & Lundquist, E. A. SWAN1, a Caenorhabditis elegans WD repeat protein of the AN11 family, is a negative regulator of Rac GTPase function. Genetics 174, 1917-1932 (2006).
    • (2006) Genetics , vol.174 , pp. 1917-1932
    • Yang, Y.1    Lu, J.2    Rovnak, J.3    Quackenbush, S.L.4    Lundquist, E.A.5
  • 33
    • 72949117533 scopus 로고    scopus 로고
    • Caenorhabditis elegans myotubularin MTM-1 negatively regulates the engulfment of apoptotic cells
    • Zou, W. et al. Caenorhabditis elegans myotubularin MTM-1 negatively regulates the engulfment of apoptotic cells. PLoS Genet. 5, e1000679 (2009).
    • (2009) PLoS Genet. , vol.5
    • Zou, W.1
  • 34
    • 0035849886 scopus 로고    scopus 로고
    • Phagocytosis promotes programmed cell death in C. elegans
    • Reddien, P. W., Cameron, S. & Horvitz, H. R. Phagocytosis promotes programmed cell death in C. elegans. Nature 412, 198-202 (2001).
    • (2001) Nature , vol.412 , pp. 198-202
    • Reddien, P.W.1    Cameron, S.2    Horvitz, H.R.3
  • 35
    • 0035849895 scopus 로고    scopus 로고
    • Engulfment genes cooperate with ced-3 to promote cell death in Caenorhabditis elegans
    • Hoeppner, D. J., Hengartner, M. O. & Schnabel, R. Engulfment genes cooperate with ced-3 to promote cell death in Caenorhabditis elegans. Nature 412, 202-206 (2001).
    • (2001) Nature , vol.412 , pp. 202-206
    • Hoeppner, D.J.1    Hengartner, M.O.2    Schnabel, R.3
  • 36
    • 0033671313 scopus 로고    scopus 로고
    • A common set of engulf-ment genes mediates removal of both apoptotic and necrotic cell corpses in C. elegans
    • Chung, S., Gumienny, T. L., Hengartner, M. O. & Driscoll, M. A common set of engulf-ment genes mediates removal of both apoptotic and necrotic cell corpses in C. elegans. Nat. Cell Biol. 2, 931-937 (2000).
    • (2000) Nat. Cell Biol. , vol.2 , pp. 931-937
    • Chung, S.1    Gumienny, T.L.2    Hengartner, M.O.3    Driscoll, M.4
  • 37
    • 52049105429 scopus 로고    scopus 로고
    • Caenorhabditis elegans genes required for the engulfment of apoptotic corpses function in the cytotoxic cell deaths induced by mutations in lin-24 and lin-33
    • Galvin, B. D., Kim, S. & Horvitz, H. R. Caenorhabditis elegans genes required for the engulfment of apoptotic corpses function in the cytotoxic cell deaths induced by mutations in lin-24 and lin-33. Genetics 179, 403-417 (2008).
    • (2008) Genetics , vol.179 , pp. 403-417
    • Galvin, B.D.1    Kim, S.2    Horvitz, H.R.3
  • 38
    • 0033166503 scopus 로고    scopus 로고
    • DEG/ENaC channels: A touchy superfamily that watches its salt
    • Mano, I. & Driscoll, M. DEG/ENaC channels: a touchy superfamily that watches its salt. Bioessays 21, 568-578 (1999).
    • (1999) Bioessays , vol.21 , pp. 568-578
    • Mano, I.1    Driscoll, M.2
  • 39
    • 54049126471 scopus 로고    scopus 로고
    • Intersubunit interactions between mutant DEG/ENaCs induce synthetic neurotoxicity
    • Zhang, W. et al. Intersubunit interactions between mutant DEG/ENaCs induce synthetic neurotoxicity. Cell Death Differ. 15, 1794-1803 (2008).
    • (2008) Cell Death Differ. , vol.15 , pp. 1794-1803
    • Zhang, W.1
  • 40
    • 34250025633 scopus 로고    scopus 로고
    • Engulfment is required for cell competition
    • Li, W. & Baker, N. E. Engulfment is required for cell competition. Cell 129, 1215-1225 (2007).
    • (2007) Cell , vol.129 , pp. 1215-1225
    • Li, W.1    Baker, N.E.2
  • 41
    • 0016063911 scopus 로고
    • The genetics of Caenorhabditis elegans
    • Brenner, S. The genetics of Caenorhabditis elegans. Genetics 77, 71-94 (1974).
    • (1974) Genetics , vol.77 , pp. 71-94
    • Brenner, S.1
  • 42
    • 0017618537 scopus 로고
    • Post-embryonic cell lineages of the nematode, Caenorhabditis elegans
    • Sulston, J. E. & Horvitz, H. R. Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. Dev. Biol. 56, 110-156 (1977).
    • (1977) Dev. Biol. , vol.56 , pp. 110-156
    • Sulston, J.E.1    Horvitz, H.R.2
  • 43
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski, P. & Sacchi, N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159 (1987).
    • (1987) Anal. Biochem. , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 44
    • 0031569851 scopus 로고    scopus 로고
    • Assessing normal embryogen-esis in Caenorhabditis elegans using a 4D microscope: Variability of development and regional specification
    • Schnabel, R., Hutter, H., Moerman, D. & Schnabel, H. Assessing normal embryogen-esis in Caenorhabditis elegans using a 4D microscope: variability of development and regional specification. Dev. Biol. 184, 234-265 (1997).
    • (1997) Dev. Biol. , vol.184 , pp. 234-265
    • Schnabel, R.1    Hutter, H.2    Moerman, D.3    Schnabel, H.4
  • 45
    • 0347379920 scopus 로고    scopus 로고
    • Engulfment of apop-totic cells is negatively regulated by Rho-mediated signaling
    • Tosello-Trampont, A.C., Nakada-Tsukui, K. & Ravichandran, K.S. Engulfment of apop-totic cells is negatively regulated by Rho-mediated signaling. J. Biol .Chem. 278, 49911-49919 (2003).
    • (2003) J. Biol .Chem. , vol.278 , pp. 49911-49919
    • Tosello-Trampont, A.C.1    Nakada-Tsukui, K.2    Ravichandran, K.S.3
  • 46
    • 43049147117 scopus 로고    scopus 로고
    • A pathway for phagosome maturation during engulfment of apop-totic cells
    • Kinchen, J. M. et al. A pathway for phagosome maturation during engulfment of apop-totic cells. Nat. Cell. Biol. 10, 556-566 (2008).
    • (2008) Nat. Cell. Biol. , vol.10 , pp. 556-566
    • Kinchen, J.M.1
  • 47
    • 77956945047 scopus 로고    scopus 로고
    • Unexpected requirement for ELMO1 in clearance of apoptotic germ cells in vivo
    • Elliott, M. R. et al. Unexpected requirement for ELMO1 in clearance of apoptotic germ cells in vivo. Nature 467, 333-337 (2010).
    • (2010) Nature , vol.467 , pp. 333-337
    • Elliott, M.R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.