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Volumn 7, Issue 4, 2009, Pages 0876-0891

Abl kinase inhibits the engulfment of apopotic cells in Caenorhabditis elegans

Author keywords

[No Author keywords available]

Indexed keywords

ABELSON KINASE; ABELSON KINASE 1; ABL KIPROTEIN ABI 1; ACTIN; ADAPTOR PROTEIN; BINDING PROTEIN; PROTEIN CED 10 RAC; PROTEIN CED 2 CRKLL; UNCLASSIFIED DRUG;

EID: 65949107540     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.1000099     Document Type: Article
Times cited : (44)

References (87)
  • 1
    • 42049092972 scopus 로고    scopus 로고
    • Regulation of actin assembly associated with protrusion and adhesion in cell migration
    • Le Clainche C, Carlier M (2008) Regulation of actin assembly associated with protrusion and adhesion in cell migration. Physiol Rev 88: 489-513.
    • (2008) Physiol Rev , vol.88 , pp. 489-513
    • Le Clainche, C.1    Carlier, M.2
  • 2
    • 34547663507 scopus 로고    scopus 로고
    • Kedrin D, Rheenen J, Hernandez L, Condeelis J, Segall J (2007) Cell motility and cytoskelet al. regulation in invasion and metastasis. J Mammary Gland Biol Neoplasia 12: 143-152.
    • Kedrin D, Rheenen J, Hernandez L, Condeelis J, Segall J (2007) Cell motility and cytoskelet al. regulation in invasion and metastasis. J Mammary Gland Biol Neoplasia 12: 143-152.
  • 3
    • 15944373937 scopus 로고    scopus 로고
    • Clearance of apoptotic cells in Caenorhabditis elegans
    • Mangahas P, Zhou Z (2005) Clearance of apoptotic cells in Caenorhabditis elegans. Semin Cell Dev Biol 16: 295-306.
    • (2005) Semin Cell Dev Biol , vol.16 , pp. 295-306
    • Mangahas, P.1    Zhou, Z.2
  • 4
    • 0032511145 scopus 로고    scopus 로고
    • The C. elegans cell corpse engulfment gene ced-7 encodes a protein similar to ABC transporters
    • Wu YC, Horvitz H. R. (1998) The C. elegans cell corpse engulfment gene ced-7 encodes a protein similar to ABC transporters. Cell 93: 951-960.
    • (1998) Cell , vol.93 , pp. 951-960
    • Wu, Y.C.1    Horvitz, H.R.2
  • 5
    • 34547743049 scopus 로고    scopus 로고
    • Two alternative mechanisms that regulate the presentation of apoptotic cell engulfment signal in Caenorhabditis elegans
    • Venegas V, Zhou Z (2007) Two alternative mechanisms that regulate the presentation of apoptotic cell engulfment signal in Caenorhabditis elegans. Mol Biol Cell 18: 3180-3192.
    • (2007) Mol Biol Cell , vol.18 , pp. 3180-3192
    • Venegas, V.1    Zhou, Z.2
  • 6
    • 0037449889 scopus 로고    scopus 로고
    • EMI domains are widespread and reveal the probable orthologs of the Caenorhabditis elegans CED-1 protein
    • Callebaut I, Mignotte V, Souchet M, Mornon JP (2003) EMI domains are widespread and reveal the probable orthologs of the Caenorhabditis elegans CED-1 protein. Biochem Biophys Res Comm 300: 619-623.
    • (2003) Biochem Biophys Res Comm , vol.300 , pp. 619-623
    • Callebaut, I.1    Mignotte, V.2    Souchet, M.3    Mornon, J.P.4
  • 7
    • 0032511234 scopus 로고    scopus 로고
    • Candidate adaptor protein CED-6 promotes the engulfment of apoptotic cells in C. elegans
    • Liu QA, Hengartner M (1998) Candidate adaptor protein CED-6 promotes the engulfment of apoptotic cells in C. elegans. Cell 93: 961-972.
    • (1998) Cell , vol.93 , pp. 961-972
    • Liu, Q.A.1    Hengartner, M.2
  • 8
    • 0033581828 scopus 로고    scopus 로고
    • Human CED-6 encodes a functional homologue of the Caenorhabditis elegans engulfment protein CED-6
    • Liu QA, Hengartner M (1999) Human CED-6 encodes a functional homologue of the Caenorhabditis elegans engulfment protein CED-6. Curr Biol 9: 1347-1350.
    • (1999) Curr Biol , vol.9 , pp. 1347-1350
    • Liu, Q.A.1    Hengartner, M.2
  • 9
    • 33646867879 scopus 로고    scopus 로고
    • Yu X, Odera S, Chuang C, Lu N, Zhou Z (2006) C. elegans Dynamin mediates the signaling of phagocytic receptor CED-1 for the engulfment and degradation of apoptotic cells. Dev Cell 10: 743-757.
    • Yu X, Odera S, Chuang C, Lu N, Zhou Z (2006) C. elegans Dynamin mediates the signaling of phagocytic receptor CED-1 for the engulfment and degradation of apoptotic cells. Dev Cell 10: 743-757.
  • 10
    • 41749109981 scopus 로고    scopus 로고
    • Phagocytic receptor CED-1 initiates a signaling pathway for degrading engulfed apoptotic cells
    • doi:10. 1371/journal.pbio.0060061
    • Yu X, Lu N, Zhou Z (2008) Phagocytic receptor CED-1 initiates a signaling pathway for degrading engulfed apoptotic cells. Plos Biol 6: e61. doi:10. 1371/journal.pbio.0060061
    • (2008) Plos Biol , vol.6
    • Yu, X.1    Lu, N.2    Zhou, Z.3
  • 12
    • 0033771902 scopus 로고    scopus 로고
    • CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans
    • Reddien PW, Horvitz HR (2000) CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans. Nat Cell Biol 2: 131-136.
    • (2000) Nat Cell Biol , vol.2 , pp. 131-136
    • Reddien, P.W.1    Horvitz, H.R.2
  • 13
    • 0032473981 scopus 로고    scopus 로고
    • Wu YC, Horvitz HR (1998) C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180. Nature 392: 501-504.
    • Wu YC, Horvitz HR (1998) C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180. Nature 392: 501-504.
  • 14
    • 0035487646 scopus 로고    scopus 로고
    • Zhou Z, Caron E, Hartwieg E, Hall A, Horvitz HR (2001) The C. elegans PH domain protein CED-12 regulates cytoskelet al. reorganization via a Rho/Rac GTPase signaling pathway. Dev Cell 1: 477-489.
    • Zhou Z, Caron E, Hartwieg E, Hall A, Horvitz HR (2001) The C. elegans PH domain protein CED-12 regulates cytoskelet al. reorganization via a Rho/Rac GTPase signaling pathway. Dev Cell 1: 477-489.
  • 15
    • 0035487807 scopus 로고    scopus 로고
    • Wu YC, Tsai MC, Cheng LC, Chou CJ, Weng NY (2001) C. elegans CED-12 acts in the conserved crkII/DOCK180/Rac pathway to control cell migration and cell corpse engulfment. Dev Cell 1: 491-502.
    • Wu YC, Tsai MC, Cheng LC, Chou CJ, Weng NY (2001) C. elegans CED-12 acts in the conserved crkII/DOCK180/Rac pathway to control cell migration and cell corpse engulfment. Dev Cell 1: 491-502.
  • 16
    • 17944376439 scopus 로고    scopus 로고
    • CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration
    • Gumienny TL, Brugnera E, Tosello-Trampont AC, Kinchen J, Haney L, et al. (2001) CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration. Cell 107: 27-41.
    • (2001) Cell , vol.107 , pp. 27-41
    • Gumienny, T.L.1    Brugnera, E.2    Tosello-Trampont, A.C.3    Kinchen, J.4    Haney, L.5
  • 17
    • 0033625871 scopus 로고    scopus 로고
    • alphavbeta5 integrin recruits the CrkII-Dock180-rac1 complex for phagocytosis of apoptotic cells
    • Albert ML, Kim JI, Birge RB (2000) alphavbeta5 integrin recruits the CrkII-Dock180-rac1 complex for phagocytosis of apoptotic cells. Nat Cell Biol 2: 899-905.
    • (2000) Nat Cell Biol , vol.2 , pp. 899-905
    • Albert, M.L.1    Kim, J.I.2    Birge, R.B.3
  • 18
    • 0036045768 scopus 로고    scopus 로고
    • Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex
    • Brugnera E, Haney L, Grimsley C, Lu M, Walk S, et al. (2002) Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex. Nat Cell Biol: 10.:
    • (2002) Nat Cell Biol , vol.10
    • Brugnera, E.1    Haney, L.2    Grimsley, C.3    Lu, M.4    Walk, S.5
  • 19
    • 14544290056 scopus 로고    scopus 로고
    • Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans
    • Kinchen JM, Cabello J, Klingele D, Wong K, Feichtinger R, et al. (2005) Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans. Nature 434: 93-99.
    • (2005) Nature , vol.434 , pp. 93-99
    • Kinchen, J.M.1    Cabello, J.2    Klingele, D.3    Wong, K.4    Feichtinger, R.5
  • 20
    • 0037069690 scopus 로고    scopus 로고
    • Rho GTPases in cell biology
    • Etienne-Manneville S, Hall A (2002) Rho GTPases in cell biology. Nature 420: 629-635.
    • (2002) Nature , vol.420 , pp. 629-635
    • Etienne-Manneville, S.1    Hall, A.2
  • 21
    • 0345374587 scopus 로고    scopus 로고
    • Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12
    • Wang X, Wu YC, Fadok VA, Lee MC, Gengyo-Ando K, et al. (2003) Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12. Science 302: 1563-1566.
    • (2003) Science , vol.302 , pp. 1563-1566
    • Wang, X.1    Wu, Y.C.2    Fadok, V.A.3    Lee, M.C.4    Gengyo-Ando, K.5
  • 22
    • 0035195553 scopus 로고    scopus 로고
    • Three C. elegans Rac proteins and several alternative Rac regulators control axon guidance, cell migration and apoptotic cell phagocytosis
    • Lundquist EA, Reddien PW, Hartwieg E, Horvitz HR, Bargmann CI (2001) Three C. elegans Rac proteins and several alternative Rac regulators control axon guidance, cell migration and apoptotic cell phagocytosis. Development 128: 4475-4488.
    • (2001) Development , vol.128 , pp. 4475-4488
    • Lundquist, E.A.1    Reddien, P.W.2    Hartwieg, E.3    Horvitz, H.R.4    Bargmann, C.I.5
  • 23
    • 19944376460 scopus 로고    scopus 로고
    • Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMO
    • deBakker CD, Haney LB, Kinchen JM, Grimsley C, Lu M, et al. (2004) Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMO. Curr Biol 14: 2208-2216.
    • (2004) Curr Biol , vol.14 , pp. 2208-2216
    • deBakker, C.D.1    Haney, L.B.2    Kinchen, J.M.3    Grimsley, C.4    Lu, M.5
  • 24
    • 0346496472 scopus 로고    scopus 로고
    • How do Abl family kinases regulate cell shape and movement?
    • Hernández S (2004) How do Abl family kinases regulate cell shape and movement? Trends Cell Biol 14: 36-44.
    • (2004) Trends Cell Biol , vol.14 , pp. 36-44
    • Hernández, S.1
  • 25
    • 0035844250 scopus 로고    scopus 로고
    • Inhibition of cell migration by Abl family tyrosine kinases through uncoupling of Crk-CAS complexes
    • Kain KH, Klemke RL (2001) Inhibition of cell migration by Abl family tyrosine kinases through uncoupling of Crk-CAS complexes. J Biol Chem 276: 16185-16192.
    • (2001) J Biol Chem , vol.276 , pp. 16185-16192
    • Kain, K.H.1    Klemke, R.L.2
  • 26
    • 0032937828 scopus 로고    scopus 로고
    • Cycling, stressed-out and nervous: Cellular functions of c-Abl
    • Van Etten RA (1999) Cycling, stressed-out and nervous: cellular functions of c-Abl. Trends Cell Biol 9: 179-186.
    • (1999) Trends Cell Biol , vol.9 , pp. 179-186
    • Van Etten, R.A.1
  • 27
    • 0034670036 scopus 로고    scopus 로고
    • The molecular biology of chronic myeloid leukemia
    • Deininger MW, Goldman JM, Melo JV (2000) The molecular biology of chronic myeloid leukemia. Blood 96: 3343-3356.
    • (2000) Blood , vol.96 , pp. 3343-3356
    • Deininger, M.W.1    Goldman, J.M.2    Melo, J.V.3
  • 28
    • 1342300625 scopus 로고    scopus 로고
    • Mechanisms of transformation by the oncogene: New perspectives in the post-imatinib era
    • Vanetten R (2004) Mechanisms of transformation by the oncogene: new perspectives in the post-imatinib era. Leuk Res 28: 21-28.
    • (2004) Leuk Res , vol.28 , pp. 21-28
    • Vanetten, R.1
  • 29
    • 33746646032 scopus 로고    scopus 로고
    • The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl-Crk pathway
    • Noren N, Foos G, Hauser C, Pasquale E (2006) The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl-Crk pathway. Nat Cell Biol 8: 815-825.
    • (2006) Nat Cell Biol , vol.8 , pp. 815-825
    • Noren, N.1    Foos, G.2    Hauser, C.3    Pasquale, E.4
  • 30
    • 15244339164 scopus 로고    scopus 로고
    • Imatinib mesylate inhibits the profibrogenic activity of TGF-beta and prevents bleomycin-mediated lung fibrosis
    • Daniels CE, Wilkes MC, Edens M, Kottom TJ, Murphy SJ, et al. (2004) Imatinib mesylate inhibits the profibrogenic activity of TGF-beta and prevents bleomycin-mediated lung fibrosis. J Clin Invest 114: 1308-1316.
    • (2004) J Clin Invest , vol.114 , pp. 1308-1316
    • Daniels, C.E.1    Wilkes, M.C.2    Edens, M.3    Kottom, T.J.4    Murphy, S.J.5
  • 31
    • 33748760321 scopus 로고    scopus 로고
    • Transforming Growth Factor beta activation of c-Abl Is independent of receptor internalization and regulated by Phosphatidylinositol 3-Kinase and PAK2 in mesenchymal cultures
    • Wilkes M (2006) Transforming Growth Factor beta activation of c-Abl Is independent of receptor internalization and regulated by Phosphatidylinositol 3-Kinase and PAK2 in mesenchymal cultures. J Biol Chem 281: 27846-27854.
    • (2006) J Biol Chem , vol.281 , pp. 27846-27854
    • Wilkes, M.1
  • 32
    • 3543028056 scopus 로고    scopus 로고
    • Caenorhabditis elegans ABL-1 antagonizes p53-mediated germline apoptosis after ionizing irradiation
    • Deng X, Hofmann E, Villanueva A, Hobert O, Capodieci P, et al. (2004) Caenorhabditis elegans ABL-1 antagonizes p53-mediated germline apoptosis after ionizing irradiation. Nat Genet 36: 906-912.
    • (2004) Nat Genet , vol.36 , pp. 906-912
    • Deng, X.1    Hofmann, E.2    Villanueva, A.3    Hobert, O.4    Capodieci, P.5
  • 33
    • 33746098167 scopus 로고    scopus 로고
    • The Caenorhabditis elegans ABL-1 tyrosine kinase Is required for Shigella flexneri pathogenesis
    • Burton E (2006) The Caenorhabditis elegans ABL-1 tyrosine kinase Is required for Shigella flexneri pathogenesis. Applied Env Microbiol 72: 5043-5051.
    • (2006) Applied Env Microbiol , vol.72 , pp. 5043-5051
    • Burton, E.1
  • 34
    • 35348858150 scopus 로고    scopus 로고
    • Sheffield M, Loveless T, Hardin J, Pettitt J (2007) C. elegans Enabled exhibits novel interactions with N-WASP, Abl, and cell-cell junctions. Curr Biol 17: 1791-1796.
    • Sheffield M, Loveless T, Hardin J, Pettitt J (2007) C. elegans Enabled exhibits novel interactions with N-WASP, Abl, and cell-cell junctions. Curr Biol 17: 1791-1796.
  • 35
    • 0026051936 scopus 로고
    • Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans
    • Ellis RE, Jacobson DM, Horvitz HR (1991) Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans. Genetics 129: 79-94.
    • (1991) Genetics , vol.129 , pp. 79-94
    • Ellis, R.E.1    Jacobson, D.M.2    Horvitz, H.R.3
  • 36
    • 0020858899 scopus 로고
    • The embryonic cell lineage of the nematode Caenorhabditis elegans
    • Sulston JE, Schierenberg E, White JG, Thomson JN (1983) The embryonic cell lineage of the nematode Caenorhabditis elegans. Dev Biol 100: 64-119.
    • (1983) Dev Biol , vol.100 , pp. 64-119
    • Sulston, J.E.1    Schierenberg, E.2    White, J.G.3    Thomson, J.N.4
  • 37
    • 0032728443 scopus 로고    scopus 로고
    • Mutational analysis of the Caenorhabditis elegans cell-death gene ced-3
    • Shaham S, Reddien PW, Davies B, Horvitz HR (1999) Mutational analysis of the Caenorhabditis elegans cell-death gene ced-3. Genetics 153: 1655-1671.
    • (1999) Genetics , vol.153 , pp. 1655-1671
    • Shaham, S.1    Reddien, P.W.2    Davies, B.3    Horvitz, H.R.4
  • 38
    • 0035849886 scopus 로고    scopus 로고
    • Phagocytosis promotes programmed cell death in C. elegans
    • Reddien PW, Cameron S, Horvitz HR (2001) Phagocytosis promotes programmed cell death in C. elegans. Nature 412: 198-202.
    • (2001) Nature , vol.412 , pp. 198-202
    • Reddien, P.W.1    Cameron, S.2    Horvitz, H.R.3
  • 39
    • 0017618537 scopus 로고
    • Post-embryonic cell lineages of the nematode, Caenorhabditis elegans
    • Sulston JE, Horvitz HR (1977) Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. Dev Biol 56: 110-156.
    • (1977) Dev Biol , vol.56 , pp. 110-156
    • Sulston, J.E.1    Horvitz, H.R.2
  • 40
    • 0035849895 scopus 로고    scopus 로고
    • Engulfment genes cooperate with ced-3 to promote cell death in Caenorhabditis elegans
    • Hoeppner DJ, Hengartner M, Schnabel R (2001) Engulfment genes cooperate with ced-3 to promote cell death in Caenorhabditis elegans. Nature 412: 202-206.
    • (2001) Nature , vol.412 , pp. 202-206
    • Hoeppner, D.J.1    Hengartner, M.2    Schnabel, R.3
  • 41
    • 34250025633 scopus 로고    scopus 로고
    • Engulfment is required for cell competition
    • Li W, Baker N (2007) Engulfment is required for cell competition. Cell 129: 1215-1225.
    • (2007) Cell , vol.129 , pp. 1215-1225
    • Li, W.1    Baker, N.2
  • 42
    • 65949085133 scopus 로고    scopus 로고
    • Wood Wand C. elegans Research Community (1988) The Nematode Caenorhabditis elegans. Plainview (New York): Cold Spring Harbor Laboratory Press. 667 p.
    • Wood Wand C. elegans Research Community (1988) The Nematode Caenorhabditis elegans. Plainview (New York): Cold Spring Harbor Laboratory Press. 667 p.
  • 43
    • 0035427387 scopus 로고    scopus 로고
    • Cell migration in invertebrates: Clues from border and distal tip cells
    • Lehmann R (2001) Cell migration in invertebrates: clues from border and distal tip cells. Curr Opin Genet Dev 11: 457-463.
    • (2001) Curr Opin Genet Dev , vol.11 , pp. 457-463
    • Lehmann, R.1
  • 44
    • 0028233970 scopus 로고
    • The nuclear tyrosine kinase c-Abl negatively regulates cell growth
    • Sawyers CL, McLaughlin J, Goga A, Havlik M, Witte O (1994) The nuclear tyrosine kinase c-Abl negatively regulates cell growth. Cell 77: 121-131.
    • (1994) Cell , vol.77 , pp. 121-131
    • Sawyers, C.L.1    McLaughlin, J.2    Goga, A.3    Havlik, M.4    Witte, O.5
  • 45
    • 0025606428 scopus 로고
    • A novel tyrosine kinase-independent function of Drosophila abl correlates with proper subcellular localization
    • Henkemeyer M, West SR, Gertler FB, Hoffmann FM (1990) A novel tyrosine kinase-independent function of Drosophila abl correlates with proper subcellular localization. Cell 63: 949-960.
    • (1990) Cell , vol.63 , pp. 949-960
    • Henkemeyer, M.1    West, S.R.2    Gertler, F.B.3    Hoffmann, F.M.4
  • 46
    • 0027511824 scopus 로고
    • SH1 domain autophosphorylation of P210 BCR/ABL is required for transformation but not growth factor independence
    • Pendergast AM, Gishizky ML, Havlik MH, Witte ON (1993) SH1 domain autophosphorylation of P210 BCR/ABL is required for transformation but not growth factor independence. Mol Cell Biol 13: 1728-1736.
    • (1993) Mol Cell Biol , vol.13 , pp. 1728-1736
    • Pendergast, A.M.1    Gishizky, M.L.2    Havlik, M.H.3    Witte, O.N.4
  • 47
    • 12344309528 scopus 로고    scopus 로고
    • The conserved kinase UNC-51 acts with VAB-8 and UNC-14 to regulate axon outgrowth in C. elegans
    • Lai T, Garriga G (2004) The conserved kinase UNC-51 acts with VAB-8 and UNC-14 to regulate axon outgrowth in C. elegans. Development 131: 5991-6000.
    • (2004) Development , vol.131 , pp. 5991-6000
    • Lai, T.1    Garriga, G.2
  • 48
    • 0028844631 scopus 로고
    • Abl-interactor-1, a novel SH3 protein binding to the carboxy-terminal portion of the Abl protein, suppresses v-abl transforming activity
    • Shi Y, Alin K, Goff S (1995) Abl-interactor-1, a novel SH3 protein binding to the carboxy-terminal portion of the Abl protein, suppresses v-abl transforming activity. Genes Dev 9: 2583-2597.
    • (1995) Genes Dev , vol.9 , pp. 2583-2597
    • Shi, Y.1    Alin, K.2    Goff, S.3
  • 49
    • 11944275667 scopus 로고
    • Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity
    • Dai Z, Pendergast A (1995) Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity. Genes Dev 9: 2569-2582.
    • (1995) Genes Dev , vol.9 , pp. 2569-2582
    • Dai, Z.1    Pendergast, A.2
  • 50
    • 0033796315 scopus 로고    scopus 로고
    • Abl interactor 1 binds to sos and inhibits epidermal growth factor-and v-Abl-induced activation of extracellular signalregulated kinases
    • Fan PD, Goff SP (2000) Abl interactor 1 binds to sos and inhibits epidermal growth factor-and v-Abl-induced activation of extracellular signalregulated kinases. Mol Cell Biol 20: 7591-7601.
    • (2000) Mol Cell Biol , vol.20 , pp. 7591-7601
    • Fan, P.D.1    Goff, S.P.2
  • 51
    • 0033575909 scopus 로고    scopus 로고
    • Drosophila abelson interacting protein (dAbi) is a positive regulator of abelson tyrosine kinase activity
    • Juang JL, Hoffmann FM (1999) Drosophila abelson interacting protein (dAbi) is a positive regulator of abelson tyrosine kinase activity. Oncogene 18: 5138-5147.
    • (1999) Oncogene , vol.18 , pp. 5138-5147
    • Juang, J.L.1    Hoffmann, F.M.2
  • 52
    • 0037821787 scopus 로고    scopus 로고
    • Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase
    • Tani K, Sato S, Sukezane T, Kojima H, Hirose H, et al. (2003) Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase. J Biol Chem 278: 21685-21692.
    • (2003) J Biol Chem , vol.278 , pp. 21685-21692
    • Tani, K.1    Sato, S.2    Sukezane, T.3    Kojima, H.4    Hirose, H.5
  • 53
    • 12844251861 scopus 로고    scopus 로고
    • Abelsoninteractor-1 promotes WAVE2 membrane translocation and Abelsonmediated tyrosine phosphorylation required for WAVE2 activation
    • Leng Y, Zhang J, Badour K, Arpaia E, Freeman S, et al. (2005) Abelsoninteractor-1 promotes WAVE2 membrane translocation and Abelsonmediated tyrosine phosphorylation required for WAVE2 activation. Proc Natl Acad Sci U S A 102: 1098-1103.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 1098-1103
    • Leng, Y.1    Zhang, J.2    Badour, K.3    Arpaia, E.4    Freeman, S.5
  • 54
    • 20444428743 scopus 로고    scopus 로고
    • Identification of B cell adaptor for PI3-kinase (BCAP) as an Abl interactor 1-regulated substrate of Abl kinases
    • Maruoka M, Suzuki J, Kawata S, Yoshida K, Hirao N, et al. (2005) Identification of B cell adaptor for PI3-kinase (BCAP) as an Abl interactor 1-regulated substrate of Abl kinases. FEBS Letters 579: 2986-2990.
    • (2005) FEBS Letters , vol.579 , pp. 2986-2990
    • Maruoka, M.1    Suzuki, J.2    Kawata, S.3    Yoshida, K.4    Hirao, N.5
  • 55
    • 34249284476 scopus 로고    scopus 로고
    • Abi-1 forms an epidermal growth factorinducible complex with Cbl: Role in receptor endocytosis
    • Tanos B, Pendergast A (2007) Abi-1 forms an epidermal growth factorinducible complex with Cbl: Role in receptor endocytosis. Cell Signal 19: 1602-1609.
    • (2007) Cell Signal , vol.19 , pp. 1602-1609
    • Tanos, B.1    Pendergast, A.2
  • 56
    • 33947107564 scopus 로고    scopus 로고
    • Abelson interacting protein 1 (Abi-1) is essential for dendrite morphogenesis and synapse formation
    • Proepper C, Johannsen S, Liebau S, Dahl J, Vaida B, et al. (2007) Abelson interacting protein 1 (Abi-1) is essential for dendrite morphogenesis and synapse formation. EMBO J 26: 1397-1409.
    • (2007) EMBO J , vol.26 , pp. 1397-1409
    • Proepper, C.1    Johannsen, S.2    Liebau, S.3    Dahl, J.4    Vaida, B.5
  • 57
    • 36148944457 scopus 로고    scopus 로고
    • The involvement of Abl and PTP61F in the regulation of Abi protein localization and stability and lamella formation in Drosophila S2 cells
    • Huang CH, Lin TY, Pan RL, Juang JL (2007) The involvement of Abl and PTP61F in the regulation of Abi protein localization and stability and lamella formation in Drosophila S2 cells. J Biol Chem 282: 32442-32452.
    • (2007) J Biol Chem , vol.282 , pp. 32442-32452
    • Huang, C.H.1    Lin, T.Y.2    Pan, R.L.3    Juang, J.L.4
  • 58
    • 0037102301 scopus 로고    scopus 로고
    • Eden S, Rohatgi R, Podtelejnikov A, Mann M, Kirschner M (2002) Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. Nature 418: 790-793.
    • Eden S, Rohatgi R, Podtelejnikov A, Mann M, Kirschner M (2002) Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. Nature 418: 790-793.
  • 59
    • 46449098660 scopus 로고    scopus 로고
    • WAVE and Arp2/3 jointly inhibit filopodium formation by entering into a complex with mDia2
    • Beli P, Mascheroni D, Xu D, Innocenti M (2008) WAVE and Arp2/3 jointly inhibit filopodium formation by entering into a complex with mDia2. Nat Cell Biol 10: 849-857.
    • (2008) Nat Cell Biol , vol.10 , pp. 849-857
    • Beli, P.1    Mascheroni, D.2    Xu, D.3    Innocenti, M.4
  • 60
    • 27144493410 scopus 로고    scopus 로고
    • Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes
    • Innocenti M, Gerboth S, Rottner K, Lai F, Hertzog M, et al. (2005) Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes. Nat Cell Biol 7: 969-976.
    • (2005) Nat Cell Biol , vol.7 , pp. 969-976
    • Innocenti, M.1    Gerboth, S.2    Rottner, K.3    Lai, F.4    Hertzog, M.5
  • 61
    • 0033575885 scopus 로고    scopus 로고
    • Scita G, Nordstrom J, Carbone R, Tenca P, Giardina G, et al. (1999) EPS8 and E3B1 transduce signals from Ras to Rac. Nature 401: 290-293.
    • Scita G, Nordstrom J, Carbone R, Tenca P, Giardina G, et al. (1999) EPS8 and E3B1 transduce signals from Ras to Rac. Nature 401: 290-293.
  • 62
    • 2442702981 scopus 로고    scopus 로고
    • Abl interactor 1 (Abi-1) wave-binding and SNARE domains regulate its nucleocytoplasmic shuttling, lamellipodium localization, and wave-1 levels
    • Echarri A, Lai MJ, Robinson MR, Pendergast AM (2004) Abl interactor 1 (Abi-1) wave-binding and SNARE domains regulate its nucleocytoplasmic shuttling, lamellipodium localization, and wave-1 levels. Mol Cell Biol 24: 4979-4993.
    • (2004) Mol Cell Biol , vol.24 , pp. 4979-4993
    • Echarri, A.1    Lai, M.J.2    Robinson, M.R.3    Pendergast, A.M.4
  • 63
    • 0032578911 scopus 로고    scopus 로고
    • Specific interference by ingested dsRNA
    • Timmons L, Fire A (1998) Specific interference by ingested dsRNA. Nature 395: 854.
    • (1998) Nature , vol.395 , pp. 854
    • Timmons, L.1    Fire, A.2
  • 64
    • 0035229245 scopus 로고    scopus 로고
    • Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans
    • Kamath RS, Martinez-Campos M, Zipperlen P, Fraser AG, Ahringer J (2001) Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans. Genome Biol 2: 1-10.
    • (2001) Genome Biol , vol.2 , pp. 1-10
    • Kamath, R.S.1    Martinez-Campos, M.2    Zipperlen, P.3    Fraser, A.G.4    Ahringer, J.5
  • 65
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, et al. (1998) Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391: 806-811.
    • (1998) Nature , vol.391 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5
  • 66
    • 56449091763 scopus 로고    scopus 로고
    • The WAVE/SCAR complex promotes polarized cell movements and actin enrichment in epithelia during C. elegans embryogenesis
    • Patel F, Bernadskaya Y, Chen E, Jobanputra A, Pooladi Z, et al. (2008) The WAVE/SCAR complex promotes polarized cell movements and actin enrichment in epithelia during C. elegans embryogenesis. Dev Biol 324: 297-309.
    • (2008) Dev Biol , vol.324 , pp. 297-309
    • Patel, F.1    Bernadskaya, Y.2    Chen, E.3    Jobanputra, A.4    Pooladi, Z.5
  • 67
    • 0036499989 scopus 로고    scopus 로고
    • The GEX-2 and GEX-3 proteins are required for tissue morphogenesis and cell migrations in C. elegans
    • Soto MC, Qadota H, Kasuya K, Inoue M, Tsuboi D, et al. (2002) The GEX-2 and GEX-3 proteins are required for tissue morphogenesis and cell migrations in C. elegans. Genes Dev 16: 620-632.
    • (2002) Genes Dev , vol.16 , pp. 620-632
    • Soto, M.C.1    Qadota, H.2    Kasuya, K.3    Inoue, M.4    Tsuboi, D.5
  • 68
    • 0028243505 scopus 로고
    • c-Abl kinase regulates the protein binding activity of c-Crk
    • Feller S, Knudsen B, Hanafusa H (1994) c-Abl kinase regulates the protein binding activity of c-Crk. EMBO J 13: 2341-2351.
    • (1994) EMBO J , vol.13 , pp. 2341-2351
    • Feller, S.1    Knudsen, B.2    Hanafusa, H.3
  • 69
    • 30044438580 scopus 로고    scopus 로고
    • Zipfel P, Bunnell S, Witherow D, Gu J, Chislock E, et al. (2006) Role for the Abi/Wave protein complex in T cell receptor-mediated proliferation and cytoskelet al. remodeling. Curr Biol 16: 35-46.
    • Zipfel P, Bunnell S, Witherow D, Gu J, Chislock E, et al. (2006) Role for the Abi/Wave protein complex in T cell receptor-mediated proliferation and cytoskelet al. remodeling. Curr Biol 16: 35-46.
  • 70
    • 33845729889 scopus 로고    scopus 로고
    • SWAN-1, a Caenorhabditis elegans WD repeat protein of the AN11 family, is a negative regulator of Rac GTPase function
    • Yang Y, Lu J, Rovnak J, Quackenbush SL, Lundquist EA (2006) SWAN-1, a Caenorhabditis elegans WD repeat protein of the AN11 family, is a negative regulator of Rac GTPase function. Genetics 174: 1917-1932.
    • (2006) Genetics , vol.174 , pp. 1917-1932
    • Yang, Y.1    Lu, J.2    Rovnak, J.3    Quackenbush, S.L.4    Lundquist, E.A.5
  • 71
    • 0347379920 scopus 로고    scopus 로고
    • Engulfment of apoptotic cells is negatively regulated by Rho-mediated signaling
    • Tosello-Trampont AC, Nakada-Tsukui K, Ravichandran KS (2003) Engulfment of apoptotic cells is negatively regulated by Rho-mediated signaling. J Biol Chem 278: 49911-49919.
    • (2003) J Biol Chem , vol.278 , pp. 49911-49919
    • Tosello-Trampont, A.C.1    Nakada-Tsukui, K.2    Ravichandran, K.S.3
  • 72
    • 33646828766 scopus 로고    scopus 로고
    • Opposite effects of rho family GTPases on engulfment of apoptotic cells by macrophages
    • Nakaya M (2006) Opposite effects of rho family GTPases on engulfment of apoptotic cells by macrophages. J Biol Chem 281: 8836-8842.
    • (2006) J Biol Chem , vol.281 , pp. 8836-8842
    • Nakaya, M.1
  • 73
    • 34249018367 scopus 로고    scopus 로고
    • GEFs and GAPs: Critical elements in the control of small G proteins
    • Bos JL, Rehmann H, Wittinghofer A (2007) GEFs and GAPs: critical elements in the control of small G proteins. Cell 129: 865-877.
    • (2007) Cell , vol.129 , pp. 865-877
    • Bos, J.L.1    Rehmann, H.2    Wittinghofer, A.3
  • 74
    • 36248962144 scopus 로고    scopus 로고
    • A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion
    • Overholtzer M, Mailleux AA, Mouneimne G, Normand G, Schnitt SJ, et al. (2007) A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion. Cell 131: 966-979.
    • (2007) Cell , vol.131 , pp. 966-979
    • Overholtzer, M.1    Mailleux, A.A.2    Mouneimne, G.3    Normand, G.4    Schnitt, S.J.5
  • 75
    • 26844468253 scopus 로고    scopus 로고
    • Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte
    • Gardai SJ, McPhillips KA, Frasch SC, Janssen WJ, Starefeldt A, et al. (2005) Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte. Cell 123: 321-334.
    • (2005) Cell , vol.123 , pp. 321-334
    • Gardai, S.J.1    McPhillips, K.A.2    Frasch, S.C.3    Janssen, W.J.4    Starefeldt, A.5
  • 76
    • 0036164008 scopus 로고    scopus 로고
    • Impaired uptake of apoptotic cells into tingible body macrophages in germinal centers of patients with systemic lupus erythematosus
    • Baumann I, Kolowos W, Voll RE, Manger B, Gaipl U, et al. (2002) Impaired uptake of apoptotic cells into tingible body macrophages in germinal centers of patients with systemic lupus erythematosus. Arthritis Rheum 46: 191-201.
    • (2002) Arthritis Rheum , vol.46 , pp. 191-201
    • Baumann, I.1    Kolowos, W.2    Voll, R.E.3    Manger, B.4    Gaipl, U.5
  • 77
    • 2442665179 scopus 로고    scopus 로고
    • Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice
    • Hanayama R, Tanaka M, Miyasaka K, Aozasa K, Koike M, et al. (2004) Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice. Science 304: 1147-1150.
    • (2004) Science , vol.304 , pp. 1147-1150
    • Hanayama, R.1    Tanaka, M.2    Miyasaka, K.3    Aozasa, K.4    Koike, M.5
  • 78
    • 0029947186 scopus 로고    scopus 로고
    • Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
    • Druker BJ, Tamura S, Buchdunger E, Ohno S, Segal GM, et al. (1996) Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med 2: 561-566.
    • (1996) Nat Med , vol.2 , pp. 561-566
    • Druker, B.J.1    Tamura, S.2    Buchdunger, E.3    Ohno, S.4    Segal, G.M.5
  • 79
    • 13844251975 scopus 로고    scopus 로고
    • Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl
    • Weisberg E, Manley P, Breitenstein W, Bruggen J, Cowanjacob S, et al. (2005) Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl. Cancer Cell 7: 129-141.
    • (2005) Cancer Cell , vol.7 , pp. 129-141
    • Weisberg, E.1    Manley, P.2    Breitenstein, W.3    Bruggen, J.4    Cowanjacob, S.5
  • 80
    • 0016063911 scopus 로고
    • The genetics of Caenorhabditis elegans
    • Brenner S (1974) The genetics of Caenorhabditis elegans. Genetics 77: 71-94.
    • (1974) Genetics , vol.77 , pp. 71-94
    • Brenner, S.1
  • 81
    • 65949115485 scopus 로고    scopus 로고
    • Riddle DL, Blumenthal T, Meyer BJ, Priess JR (1997) C. elegans II. Plainview (New York): Cold Spring Harbor Laboratory Press. 1222 p.
    • Riddle DL, Blumenthal T, Meyer BJ, Priess JR (1997) C. elegans II. Plainview (New York): Cold Spring Harbor Laboratory Press. 1222 p.
  • 83
    • 67449124505 scopus 로고    scopus 로고
    • Vanderzalm PJ, Pandey A, Hurwitz ME, Bloom L, Horvitz HR, et al. (2009) C. elegans CARMIL negatively regulates UNC-73/Trio function during neuronal development. Development 136: 1201-1210.
    • Vanderzalm PJ, Pandey A, Hurwitz ME, Bloom L, Horvitz HR, et al. (2009) C. elegans CARMIL negatively regulates UNC-73/Trio function during neuronal development. Development 136: 1201-1210.
  • 84
    • 0020557883 scopus 로고
    • Mutations affecting programmed cell deaths in the nematode Caenorhabditis elegans
    • Hedgecock EM, Sulston JE, Thomson JN (1983) Mutations affecting programmed cell deaths in the nematode Caenorhabditis elegans. Science 20: 1277-1279.
    • (1983) Science , vol.20 , pp. 1277-1279
    • Hedgecock, E.M.1    Sulston, J.E.2    Thomson, J.N.3
  • 85
    • 0017230019 scopus 로고
    • Development of the reproductive system of Caenorhabditis elegans
    • Hirsh D, Oppenheim D, Klass M (1976) Development of the reproductive system of Caenorhabditis elegans. Dev Biol 49: 200-219.
    • (1976) Dev Biol , vol.49 , pp. 200-219
    • Hirsh, D.1    Oppenheim, D.2    Klass, M.3
  • 86
    • 0032814355 scopus 로고    scopus 로고
    • Mutations affecting symmetrical migration of distal tip cells in Caenorhabditis elegans
    • Nishiwaki K (1999) Mutations affecting symmetrical migration of distal tip cells in Caenorhabditis elegans. Genetics 152: 985-997.
    • (1999) Genetics , vol.152 , pp. 985-997
    • Nishiwaki, K.1
  • 87
    • 0030965832 scopus 로고    scopus 로고
    • The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation
    • Bloom L, Horvitz HR (1997) The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation. Proc Natl Acad Sci U S A 94: 3414-3419.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 3414-3419
    • Bloom, L.1    Horvitz, H.R.2


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