Fenofibrate inhibited the differentiation of T helper 17 cells in vitro

PPAR Research

Volumn , Issue , 2012, Pages

  Zhou, Zhou ^a   Sun, Weiliang ^a   Liang, Ying ^a   Gao, Yanxiang ^a   Kong, Wei ^a   Guan, Youfei ^a   Feng, Juan ^a   Wang, Xian ^a  

^a PEKING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 [2 [3 CYCLOHEXYL 1 (4 CYCLOHEXYLBUTYL)UREIDO]ETHYL]PHENYLTHIO] 2 METHYLPROPIONIC ACID; BEZAFIBRATE; FENOFIBRATE; INTERLEUKIN 17; INTERLEUKIN 21; INTERLEUKIN 6; PIRINIXIC ACID; STAT3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ATHEROSCLEROSIS; AUTOIMMUNITY; CELL ACTIVITY; COLITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; IN VITRO STUDY; LYMPHOCYTE DIFFERENTIATION; MULTIPLE SCLEROSIS; NONHUMAN; TH17 CELL;

EID: 84863699030     PISSN: 16874757     EISSN: 16874765     Source Type: Journal    
DOI: 10.1155/2012/145654     Document Type: Article

References (50)

1. Ohashi P. S., T-cell signalling and autoimmunity: molecular mechanisms of disease Nature Reviews Immunology 2002 2 6 427 438 (Pubitemid 37328750)
2. Taleb S., Tedgui A., Mallat Z., Interleukin-17: friend or foe in atherosclerosis? Current Opinion in Lipidology 2010 21 5 404 408
3. Segal B. M., Th17 cells in autoimmune demyelinating disease Seminars in Immunopathology 2010 32 1 71 77
4. Brand S., Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease Gut 2009 58 8 1152 1167
5. Pernis A. B., Th17 cells in rheumatoid arthritis and systemic lupus erythematosus Journal of Internal Medicine 2009 265 6 644 652
6. Emamaullee J. A., Davis J., Merani S., Toso C., Elliott J. F., Thiesen A., Shapiro A. M. J., Inhibition of Th17 cells regulates autoimmune diabetes in NOD mice Diabetes 2009 58 6 1302 1311
7. Dart M. L., Jankowska-Gan E., Huang G., Roenneburg D. A., Keller M. R., Torrealba J. R., Rhoads A., Kim B., Bobadilla J. L., Haynes L. D., Wilkes D. S., Burlingham W. J., Greenspan D. S., Interleukin-17-dependent autoimmunity to collagen type v in atherosclerosis Circulation Research 2010 107 9 1106 1116
8. Smith E., Prasad K. M. R., Butcher M., Dobrian A., Kolls J. K., Ley K., Galkina E., Blockade of interleukin-17A results in reduced atherosclerosis in apolipoprotein E-deficient mice Circulation 2010 121 15 1746 1755
9. Gao Q., Jiang Y., Ma T., Zhu F., Gao F., Zhang P., Guo C., Wang Q., Wang X., Ma C., Zhang Y., Chen W., Zhang L., A critical function of Th17 proinflammatory cells in the development of atherosclerotic plaque in mice Journal of Immunology 2010 185 10 5820 5827
10. Hansson G. K., Mechanisms of disease: inflammation, atherosclerosis, and coronary artery disease The New England Journal of Medicine 2005 352 16 1685 1626
11. Taleb S., Romain M., Ramkhelawon B., Uyttenhove C., Pasterkamp G., Herbin O., Esposito B., Perez N., Yasukawa H., Van Snick J., Yoshimura A., Tedgui A., Mallat Z., Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis Journal of Experimental Medicine 2009 206 10 2067 2077
12. Zhang Q., Zeng X., Guo J., Wang X., Oxidant stress mechanism of homocysteine potentiating Con A-induced proliferation in murine splenic T lymphocytes Cardiovascular Research 2002 53 4 1035 1042 (Pubitemid 34261042)
13. Feng J., Zhang Z., Kong W., Liu B., Xu Q., Wang X., Regulatory T cells ameliorate hyperhomocysteinaemia-accelerated atherosclerosis in apoE-/-mice Cardiovascular Research 2009 84 1 155 163
14. Ahmed W., Ziouzenkova O., Brown J., Devchand P., Francis S., Kadakia M., Kanda T., Orasanu G., Sharlach M., Zandbergen F., Plutzky J., PPARs and their metabolic modulation: new mechanisms for transcriptional regulation? Journal of Internal Medicine 2007 262 2 184 198 (Pubitemid 47087629)
15. Zambon A., Gervois P., Pauletto P., Fruchart J. C., Staels B., Modulation of hepatic inflammatory risk markers of cardiovascular diseases by PPAR- activators: clinical and experimental evidence Arteriosclerosis, Thrombosis, and Vascular Biology 2006 26 5 977 986 (Pubitemid 43732101)
16. Israelian-Konaraki Z., Reaven P. D., Peroxisome proliferator-activated receptor-alpha and atherosclerosis: from basic mechanisms to clinical implications Cardiology in Review 2005 13 5 240 246 (Pubitemid 41197252)
17. Brown J. D., Plutzky J., Peroxisome proliferator-activated receptors as transcriptional nodal points and therapeutic targets Circulation 2007 115 4 518 533 (Pubitemid 46184203)
18. Han S. H., Quon M. J., Koh K. K., Beneficial vascular and metabolic effects of peroxisome proliferator-activated receptor- activators Hypertension 2005 46 5 1086 1092 (Pubitemid 41533006)
19. Lovett-Racke A. E., Hussain R. Z., Northrop S., Choy J., Rocchini A., Matthes L., Chavis J. A., Diab A., Drew P. D., Racke M. K., Peroxisome proliferator-activated receptor agonists as therapy for autoimmune disease Journal of Immunology 2004 172 9 5790 5798 (Pubitemid 38542085)
20. Lee J. W., Bajwa P. J., Carson M. J., Jeske D. R., Cong Y., Elson C. O., Lytle C., Straus D. S., Fenofibrate represses interleukin-17 and interferon- expression and improves colitis in interleukin-10-deficient mice Gastroenterology 2007 133 1 108 123 (Pubitemid 47031123)
21. Marx N., Kehrle B., Kohlhammer K., Grb M., Koenig W., Hombach V., Libby P., Plutzky J., PPAR activators as antiinflammatory mediators in human T lymphocytes: implications for atherosclerosis and transplantation-associated arteriosclerosis Circulation Research 2002 90 6 703 710 (Pubitemid 34640890)
22. Chen Z., Laurence A., O'Shea J. J., Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation Seminars in Immunology 2007 19 6 400 408
23. Ivanov I. I., Zhou L., Littman D. R., Transcriptional regulation of Th17 cell differentiation Seminars in Immunology 2007 19 6 409 417 (Pubitemid 351274050)
24. Zhou L., Lopes J. E., Chong M. M. W., Ivanov I. I., Min R., Victora G. D., Shen Y., Du J., Rubtsov Y. P., Rudensky A. Y., Ziegler S. F., Littman D. R., TGF- -induced Foxp3 inhibits TH17 cell differentiation by antagonizing ROR t function Nature 2008 453 7192 236 240 (Pubitemid 351667978)
25. Wang L., Zheng J., Bai X., Liu B., Liu C. J., Xu Q., Zhu Y., Wang N., Kong W., Wang X., ADAMTS-7 mediates vascular smooth muscle cell migration and neointima formation in balloon-injured rat arteries Circulation Research 2009 104 5 688 698
26. Dai J., Li W., Chang L., Zhang Z., Tang C., Wang N., Zhu Y., Wang X., Role of redox factor-1 in hyperhomocysteinemia-accelerated atherosclerosis Free Radical Biology and Medicine 2006 41 10 1566 1577 (Pubitemid 44528255)
27. Harrington L. E., Hatton R. D., Mangan P. R., Turner H., Murphy T. L., Murphy K. M., Weaver C. T., Interleukin 17-producing CD4 + effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages Nature Immunology 2005 6 11 1123 1132 (Pubitemid 41541790)
28. Park H., Li Z., Yang X. O., Chang S. H., Nurieva R., Wang Y. H., Wang Y., Hood L., Zhu Z., Tian Q., Dong C., A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17 Nature Immunology 2005 6 11 1133 1141 (Pubitemid 41541791)
29. Duhaney T. A. S., Cui L., Rude M. K., Lebrasseur N. K., Ngoy S., De Silva D. S., Siwik D. A., Liao R., Sam F., Peroxisome proliferator-activated receptor -independent actions of fenofibrate exacerbates left ventricular dilation and fibrosis in chronic pressure overload Hypertension 2007 49 5 1084 1094 (Pubitemid 351664324)
30. Yamashita M., Peroxisome proliferator-activated receptor -independent effects of peroxisome proliferators on cysteinyl leukotriene production in mast cells European Journal of Pharmacology 2007 556 13 172 180 (Pubitemid 46073991)
31. Kim J., Ahn J. H., Kim J. H., Yu Y. S., Kim H. S., Ha J., Shinn S. H., Oh Y. S., Fenofibrate regulates retinal endothelial cell survival through the AMPK signal transduction pathway Experimental Eye Research 2007 84 5 886 893 (Pubitemid 46590130)
32. Chanda D., Lee C. H., Kim Y. H., Noh J. R., Kim D. K., Park J. H., Hwang J. H., Lee M. R., Jeong K. H., Lee I. K., Kweon G. R., Shong M., Oh G. T., Chiang J. Y. L., Choi H. S., Fenofibrate differentially regulates plasminogen activator inhibitor-1 gene expression via adenosine monophosphate-activated protein kinase-dependent induction of orphan nuclear receptor small heterodimer partner Hepatology 2009 50 3 880 892
33. Joe Y., Do M. H., Seo E., Kang S., Park H. T., Yun J., Lee H. J., Fenofibrate antagonizes Chk2 activation by inducing Wip1 expression: implications for cell proliferation and tumorigenesis Life Sciences 2010 86 19-20 716 721
34. Mucida D., Park Y., Kim G., Turovskaya O., Scott I., Kronenberg M., Cheroutre H., Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid Science 2007 317 5835 256 260 (Pubitemid 47076203)
35. Veldhoen M., Hirota K., Westendorf A. M., Buer J., Dumoutier L., Renauld J. C., Stockinger B., The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins Nature 2008 453 7191 106 109 (Pubitemid 351630329)
36. Cui G., Qin X., Wu L., Zhang Y., Sheng X., Yu Q., Sheng H., Xi B., Zhang J. Z., Zang Y. Q., Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation Journal of Clinical Investigation 2011 121 2 658 670
37. Kanakasabai S., Chearwae W., Walline C. C., Iams W., Adams S. M., Bright J. J., Peroxisome proliferator-activated receptor agonists inhibit T helper type 1 (Th1) and Th17 responses in experimental allergic encephalomyelitis Immunology 2010 130 4 572 588
38. Klotz L., Burgdorf S., Dani I., Saijo K., Flossdorf J., Hucke S., Alferink J., Novak N., Beyer M., Mayer G., Langhans B., Klockgether T., Waisman A., Eberl G., Schultze J., Famulok M., Kolanus W., Glass C., Kurts C., Knolle P. A., The nuclear receptor PPAR selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity Journal of Experimental Medicine 2009 206 10 2079 2089
39. Yang X. O., Panopoulos A. D., Nurieva R., Seon H. C., Wang D., Watowich S. S., Dong C., STAT3 regulates cytokine-mediated generation of inflammatory helper T cells Journal of Biological Chemistry 2007 282 13 9358 9363 (Pubitemid 47104613)
40. Chen Z., Laurence A., Kanno Y., Pacher-Zavisin M., Zhu B.-M., Tato C., Yoshimura A., Hennighausen L., O'Shea J. J., Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells Proceedings of the National Academy of Sciences of the United States of America 2006 103 21 8137 8142 (Pubitemid 43801065)
41. Beurel E., Yeh W. I., Michalek S. M., Harrington L. E., Jope R. S., Glycogen synthase kinase-3 is an early determinant in the differentiation of pathogenic Th17 cells Journal of Immunology 2011 186 3 1391 1398
42. Locke N. R., Patterson S. J., Hamilton M. J., Sly L. M., Krystal G., Levings M. K., SHIP regulates the reciprocal development of T regulatory and Th17 cells Journal of Immunology 2009 183 2 975 983
43. Xiao S., Jin H., Korn T., Liu S. M., Oukka M., Lim B., Kuchroo V. K., Retinoic acid increases Foxp3 + regulatory T cells and inhibits development of Th17 cells by enhancing TGF- -driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression Journal of Immunology 2008 181 4 2277 2284
44. Chen C., Liu X., Wan B., Zhang J. Z., Regulatory properties of copolymer I in Th17 differentiation by altering STAT3 phosphorylation Journal of Immunology 2009 183 1 246 253
45. Monari C., Bevilacqua S., Piccioni M., Pericolini E., Perito S., Calvitti M., Bistoni F., Kozel T. R., Vecchiarelli A., A microbial polysaccharide reduces the severity of rheumatoid arthritis by influencing Th17 differentiation and proinflammatory cytokines production Journal of Immunology 2009 183 1 191 200
46. Gervois P., Kleemann R., Pilon A., Percevault F., Koenig W., Staels B., Kooistra T., Global suppression of IL-6-induced acute phase response gene expression after chronic in Vivo treatment with the peroxisome proliferator-activated receptor- activator fenofibrate Journal of Biological Chemistry 2004 279 16 16154 16160 (Pubitemid 38509307)
47. Park S. Y., Cho Y. R., Finck B. N., Kim H. J., Higashimori T., Hong E. G., Lee M. K., Danton C., Deshmukh S., Cline G. W., Wu J. J., Bennett A. M., Rothermel B., Kalinowski A., Russell K. S., Kim Y. B., Kelly D. P., Kim J. E., Cardiac-specific overexpression of peroxisome proliferator-activated receptor- causes insulin resistance in heart and liver Diabetes 2005 54 9 2514 2524 (Pubitemid 41233572)
48. Dong C., TH17 cells in development: an updated view of their molecular identity and genetic programming Nature Reviews Immunology 2008 8 5 337 348 (Pubitemid 351595217)
49. Zhou Z., Liang Y., Gao Y., Kong W., Feng J., Wang X., Fenofibrate enhances the in vitro differentiation of Foxp3 + regulatory T cells in mice PPAR Research 2012 2012 10
50. Damsker J. M., Hansen A. M., Caspi R. R., Th1 and Th17 cells: adversaries and collaborators Annals of the New York Academy of Sciences 2010 1183 211 221