Th17 cells in autoimmune demyelinating disease

Seminars in Immunopathology

Volumn 32, Issue 1, 2010, Pages 71-77

  Segal, Benjamin Matthew ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Autoimmunity; Experimental autoimmune encephalomyelitis; Interleukin 17; Multiple sclerosis; Neuroimmunology; Th17 cells

Indexed keywords

BIOLOGICAL MARKER; INTERLEUKIN 17; MYELIN;

DEMYELINATING DISEASE; DISEASE MARKER; HUMAN; OUTCOME ASSESSMENT; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REVIEW; SCREENING; T LYMPHOCYTE; TH17 CELL;

ANIMALS; AUTOIMMUNITY; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; HUMANS; INTERLEUKIN-17; MULTIPLE SCLEROSIS; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 77949656747     PISSN: 18632297     EISSN: 18632300     Source Type: Journal    
DOI: 10.1007/s00281-009-0186-z     Document Type: Review

References (72)

1. T Olsson 1992 Cytokines in neuroinflammatory disease: role of myelin autoreactive T cell production of interferon-gamma J Neuroimmunol 40 211 218 10.1016/0165-5728(92)90135-8 1:CAS:528:DyaK3sXnvVKkuw%3D%3D 1430152
2. SS Zamvil L Steinman 1990 The T lymphocyte in experimental allergic encephalomyelitis Annu Rev Immunol 8 579 621 10.1146/annurev.iy.08.040190.003051 1:CAS:528:DyaK3cXkslGqsb4%3D 2188675
3. RS Liblau SM Singer HO McDevitt 1995 Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases Immunol Today 16 34 38 10.1016/0167-5699(95)80068-9 1:CAS:528:DyaK2MXjsVyjtrY%3D 7880387
4. R Benvenuto M Paroli C Buttinelli A Franco V Barnaba C Fieschi F Balsano 1992 Tumor necrosis factor-alpha and interferon-gamma synthesis by cerebrospinal fluid-derived T cell clones in multiple sclerosis Ann N Y Acad Sci 650 341 346 10.1111/j.1749-6632.1992.tb49149.x 1:CAS:528:DyaK38XlsV2isbY%3D 1605492
5. RL Hirsch HS Panitch KP Johnson 1985 Lymphocytes from multiple sclerosis patients produce elevated levels of gamma interferon in vitro J Clin Immunol 5 386 389 10.1007/BF00915335 1:STN:280:DyaL287ht1Cgug%3D%3D 3936865
6. SJ Khoury WW Hancock HL Weiner 1992 Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain J Exp Med 176 1355 1364 10.1084/jem.176.5.1355 1:CAS:528:DyaK38XmtFSmsLs%3D 1383385
7. JE Merrill DH Kono J Clayton DG Ando DR Hinton FM Hofman 1992 Inflammatory leukocytes and cytokines in the peptide-induced disease of experimental allergic encephalomyelitis in SJL and B10.PL mice Proc Natl Acad Sci USA 89 574 578 10.1073/pnas.89.2.574 1:CAS:528:DyaK38XhtVChsbw%3D 1370583
8. U Traugott P Lebon 1988 Multiple sclerosis: involvement of interferons in lesion pathogenesis Ann Neurol 24 243 251 10.1002/ana.410240211 1:STN:280:DyaL1M%2FisVGhtQ%3D%3D 2460022
9. RR Voskuhl R Martin C Bergman M Dalal NH Ruddle HF McFarland 1993 T helper 1 (Th1) functional phenotype of human myelin basic protein-specific T lymphocytes Autoimmunity 15 137 143 10.3109/08916939309043888 1:STN:280:DyaK2c%2FjtlSgsQ%3D%3D 7692995
10. A Khoruts SD Miller MK Jenkins 1995 Neuroantigen-specific Th2 cells are inefficient suppressors of experimental autoimmune encephalomyelitis induced by effector Th1 cells J Immunol 155 5011 5017 1:CAS:528:DyaK2MXptlejsbs%3D 7594508
11. JL Baron JA Madri NH Ruddle G Hashim CA Janeway Jr 1993 Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma J Exp Med 177 57 68 10.1084/jem.177.1.57 1:CAS:528: DyaK3sXlsl2quw%3D%3D 7678116 (Pubitemid 23008085)
12. HS Panitch RL Hirsch AS Haley KP Johnson 1987 Exacerbations of multiple sclerosis in patients treated with gamma interferon Lancet 1 893 895 10.1016/S0140-6736(87)92863-7 1:STN:280:DyaL2s7ntFylug%3D%3D 2882294
13. KE Balashov DR Smith SJ Khoury DA Hafler HL Weiner 1997 Increased interleukin 12 production in progressive multiple sclerosis: induction by activated CD4+ T cells via CD40 ligand Proc Natl Acad Sci USA 94 599 603 10.1073/pnas.94.2.599 1:CAS:528:DyaK2sXnslOhsw%3D%3D 9012830 (Pubitemid 27053679)
14. M Comabella K Balashov S Issazadeh D Smith HL Weiner SJ Khoury 1998 Elevated interleukin-12 in progressive multiple sclerosis correlates with disease activity and is normalized by pulse cyclophosphamide therapy J Clin Invest 102 671 678 10.1172/JCI3125 1:CAS:528:DyaK1cXlsFartbs%3D 9710434
15. K Fassbender A Ragoschke S Rossol A Schwartz O Mielke A Paulig M Hennerici 1998 Increased release of interleukin-12p40 in MS: association with intracerebral inflammation Neurology 51 753 758 1:CAS:528:DyaK1cXmtlOksr4%3D 9748022
16. P Monteyne B Guillaume CJ Sindic 1998 B7-1 (CD80), B7-2 (CD86), interleukin-12 and transforming growth factor-beta mRNA expression in CSF and peripheral blood mononuclear cells from multiple sclerosis patients J Neuroimmunol 91 198 203 10.1016/S0165-5728(98)00180-5 1:CAS:528: DyaK1cXnt1ejtbk%3D 9846836 (Pubitemid 28545260)
17. A Windhagen J Newcombe F Dangond C Strand MN Woodroofe ML Cuzner DA Hafler 1995 Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions J Exp Med 182 1985 1996 10.1084/jem.182.6.1985 1:CAS:528:DyaK2MXpslymu7s%3D 7500044
18. S Issazadeh JC Lorentzen MI Mustafa B Hojeberg A Mussener T Olsson 1996 Cytokines in relapsing experimental autoimmune encephalomyelitis in DA rats: persistent mRNA expression of proinflammatory cytokines and absent expression of interleukin-10 and transforming growth factor-beta J Neuroimmunol 69 103 115 10.1016/0165-5728(96)00076-8 1:CAS:528:DyaK28Xltlyit7g%3D 8823381
19. BM Segal EM Shevach 1996 IL-12 unmasks latent autoimmune disease in resistant mice J Exp Med 184 771 775 10.1084/jem.184.2.771 1:CAS:528: DyaK28XltVCrtr0%3D 8786337
20. T Smith AK Hewson CI Kingsley JP Leonard ML Cuzner 1997 Interleukin-12 induces relapse in experimental allergic encephalomyelitis in the Lewis rat Am J Pathol 150 1909 1917 1:CAS:528:DyaK2sXktFalu7s%3D 9176384
21. P Deshpande IL King BM Segal 2006 IL-12 driven upregulation of P-selectin ligand on myelin-specific T cells is a critical step in an animal model of autoimmune demyelination J Neuroimmunol 173 35 44 10.1016/j.jneuroim.2005.11.016 1:CAS:528:DC%2BD28Xis1Srs7s%3D 16413063
22. KE Waldburger RC Hastings RG Schaub SJ Goldman JP Leonard 1996 Adoptive transfer of experimental allergic encephalomyelitis after in vitro treatment with recombinant murine interleukin-12. Preferential expansion of interferon-gamma-producing cells and increased expression of macrophage-associated inducible nitric oxide synthase as immunomodulatory mechanisms Am J Pathol 148 375 382 1:CAS:528:DyaK28Xit1Cns7o%3D 8579100
23. CS Constantinescu M Wysocka B Hilliard ES Ventura E Lavi G Trinchieri A Rostami 1998 Antibodies against IL-12 prevent superantigen-induced and spontaneous relapses of experimental autoimmune encephalomyelitis J Immunol 161 5097 5104 1:CAS:528:DyaK1cXntVWlurg%3D 9794448
24. JP Leonard KE Waldburger SJ Goldman 1995 Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12 J Exp Med 181 381 386 10.1084/jem.181.1.381 1:CAS:528:DyaK2MXisl2rs7g%3D 7528773
25. BM Segal BK Dwyer EM Shevach 1998 An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease J Exp Med 187 537 546 10.1084/jem.187.4.537 1:CAS:528:DyaK1cXhtFCqtLs%3D 9463404 (Pubitemid 28093356)
26. B Becher BG Durell RJ Noelle 2002 Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12 J Clin Invest 110 493 497 1:CAS:528:DC%2BD38XmsVSiurc%3D 12189243
27. IA Ferber S Brocke C Taylor-Edwards W Ridgway C Dinisco L Steinman D Dalton CG Fathman 1996 Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE) J Immunol 156 5 7 1:CAS:528:DyaK28XlsVGj 8598493
28. B Gran GX Zhang S Yu J Li XH Chen ES Ventura M Kamoun A Rostami 2002 IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination J Immunol 169 7104 7110 1:CAS:528:DC%2BD38XpsFGjtr8%3D 12471147
29. DO Willenborg S Fordham CC Bernard WB Cowden IA Ramshaw 1996 IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis J Immunol 157 3223 3227 1:CAS:528:DyaK28Xmtlahtbw%3D 8871615
30. DO Willenborg SA Fordham MA Staykova IA Ramshaw WB Cowden 1999 IFN-gamma is critical to the control of murine autoimmune encephalomyelitis and regulates both in the periphery and in the target tissue: a possible role for nitric oxide J Immunol 163 5278 5286 1:CAS:528:DyaK1MXntlKku7Y%3D 10553050
31. GX Zhang B Gran S Yu J Li I Siglienti X Chen M Kamoun A Rostami 2003 Induction of experimental autoimmune encephalomyelitis in IL-12 receptor-beta 2-deficient mice: IL-12 responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system J Immunol 170 2153 2160 1:CAS:528:DC%2BD3sXht12hsrk%3D 12574388
32. Ali Shokrgozar M, Sarial S, Amirzargar A, Shokri F, Rezaei N, Arjang Z, Radfar J, Yousefi-Behzadi M, Ali Sahraian M, Lotfi J (2009) IL-2, IFN-gamma, and IL-12 gene polymorphisms and susceptibility to multiple sclerosis. J Clin Immunol 29:747-751
33. AB Begovich M Chang SJ Caillier D Lew JJ Catanese J Wang SL Hauser JR Oksenberg 2007 The autoimmune disease-associated IL12B and IL23R polymorphisms in multiple sclerosis Hum Immunol 68 934 937 10.1016/j.humimm.2007.09.005 1:CAS:528:DC%2BD2sXhsVentLvP 18082575 (Pubitemid 350235722)
34. MA Hall E McGlinn G Coakley SA Fisher K Boki D Middleton E Kaklamani H Moutsopoulos TP Loughran Jr WE Ollier GS Panayi JS Lanchbury 2000 Genetic polymorphism of IL-12 p40 gene in immune-mediated disease Genes Immun 1 219 224 10.1038/sj.gene.6363661 1:CAS:528:DC%2BD3cXktlyhur4%3D 11196715
35. T van Veen JB Crusius HM Schrijver G Bouma J Killestein L van Winsen A Salvador Pena CH Polman BM Uitdehaag 2001 Interleukin-12p40 genotype plays a role in the susceptibility to multiple sclerosis Ann Neurol 50 275 10.1002/ana.1107 11506417
36. B Oppmann R Lesley B Blom JC Timans Y Xu B Hunte F Vega N Yu J Wang K Singh F Zonin E Vaisberg T Churakova M Liu D Gorman J Wagner S Zurawski Y Liu JS Abrams KW Moore D Rennick R de Waal-Malefyt C Hannum JF Bazan RA Kastelein 2000 Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12 Immunity 13 715 772 10.1016/S1074-7613(00)00070-4 1:CAS:528:DC%2BD3cXovV2ht7c%3D 11114383
37. DJ Cua J Sherlock Y Chen CA Murphy B Joyce B Seymour L Lucian W To S Kwan T Churakova S Zurawski M Wiekowski SA Lira D Gorman RA Kastelein JD Sedgwick 2003 Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain Nature 421 744 748 10.1038/nature01355 1:CAS:528:DC%2BD3sXhsV2rsbs%3D 12610626 (Pubitemid 36227625)
38. E Bettelli Y Carrier W Gao T Korn TB Strom M Oukka HL Weiner VK Kuchroo 2006 Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells Nature 441 235 238 10.1038/nature04753 1:CAS:528:DC%2BD28XksVGns7g%3D 16648838
39. CL Langrish Y Chen WM Blumenschein J Mattson B Basham JD Sedgwick T McClanahan RA Kastelein DJ Cua 2005 IL-23 drives a pathogenic T cell population that induces autoimmune inflammation J Exp Med 201 233 240 10.1084/jem.20041257 1:CAS:528:DC%2BD2MXot12mtA%3D%3D 15657292 (Pubitemid 40189432)
40. CA Murphy CL Langrish Y Chen W Blumenschein T McClanahan RA Kastelein JD Sedgwick DJ Cua 2003 Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation J Exp Med 198 1951 1957 10.1084/jem.20030896 1:CAS:528:DC%2BD3sXpvFakur4%3D 14662908 (Pubitemid 38032126)
41. MA Kroenke TJ Carlson AV Andjelkovic BM Segal 2008 IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition J Exp Med 205 1535 1541 10.1084/jem.20080159 1:CAS:528:DC%2BD1cXosVKktrc%3D 18573909
42. L Durelli L Conti M Clerico D Boselli G Contessa P Ripellino B Ferrero P Eid F Novelli 2009 T-helper 17 cells expand in multiple sclerosis and are inhibited by interferon-beta Ann Neurol 65 499 509 10.1002/ana.21652 1:CAS:528:DC%2BD1MXnvFahsL0%3D 19475668
43. D Matusevicius P Kivisakk B He N Kostulas V Ozenci S Fredrikson H Link 1999 Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis Mult Scler 5 101 104 1:CAS:528: DyaK1MXjtFyms70%3D 10335518
44. A Vaknin-Dembinsky K Balashov HL Weiner 2006 IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production J Immunol 176 7768 7774 1:CAS:528:DC%2BD28Xlt1Cksbs%3D 16751425
45. C Lock G Hermans R Pedotti A Brendolan E Schadt H Garren A Langer-Gould S Strober B Cannella J Allard P Klonowski A Austin N Lad N Kaminski SJ Galli JR Oksenberg CS Raine R Heller L Steinman 2002 Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis Nat Med 8 500 508 10.1038/nm0502-500 1:CAS:528:DC%2BD38Xjt1Kgur8%3D 11984595 (Pubitemid 34546753)
46. JS Tzartos MA Friese MJ Craner J Palace J Newcombe MM Esiri L Fugger 2008 Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis Am J Pathol 172 146 155 10.2353/ajpath.2008.070690 1:CAS:528:DC%2BD1cXhslOmur0%3D 18156204
47. M Montes X Zhang L Berthelot DA Laplaud S Brouard J Jin S Rogan D Armao V Jewells JP Soulillou S Markovic-Plese 2009 Oligoclonal myelin-reactive T-cell infiltrates derived from multiple sclerosis lesions are enriched in Th17 cells Clin Immunol 130 133 144 10.1016/j.clim.2008.08.030 1:CAS:528: DC%2BD1MXht1aksg%3D%3D 18977698
48. JK Kolls A Linden 2004 Interleukin-17 family members and inflammation Immunity 21 467 476 10.1016/j.immuni.2004.08.018 1:CAS:528:DC%2BD2cXpvVygt7k%3D 15485625 (Pubitemid 39370503)
49. F Aloisi A Care G Borsellino P Gallo S Rosa A Bassani A Cabibbo U Testa G Levi C Peschle 1992 Production of hemolymphopoietic cytokines (IL-6, IL-8, colony-stimulating factors) by normal human astrocytes in response to IL-1 beta and tumor necrosis factor-alpha J Immunol 149 2358 2366 1:CAS:528: DyaK3sXitVKqtQ%3D%3D 1382099
50. J Das Sarma B Ciric R Marek S Sadhukhan ML Caruso J Shafagh DC Fitzgerald KS Shindler A Rostami 2009 Functional interleukin-17 receptor A is expressed in central nervous system glia and upregulated in experimental autoimmune encephalomyelitis J Neuroinflammation 6 14 10.1186/1742-2094-6-14 19400960
51. R Filipovic I Jakovcevski N Zecevic 2003 GRO-alpha and CXCR2 in the human fetal brain and multiple sclerosis lesions Dev Neurosci 25 279 290 10.1159/000072275 1:CAS:528:DC%2BD3sXntFSltbs%3D 12966224 (Pubitemid 37100220)
52. T Carlson M Kroenke P Rao TE Lane B Segal 2008 The Th17-ELR+ CXC chemokine pathway is essential for the development of central nervous system autoimmune disease J Exp Med 205 811 823 10.1084/jem.20072404 1:CAS:528:DC%2BD1cXkvVyrsrs%3D 18347102
53. H Kebir K Kreymborg I Ifergan A Dodelet-Devillers R Cayrol M Bernard F Giuliani N Arbour B Becher A Prat 2007 Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation Nat Med 13 1173 1175 10.1038/nm1651 1:CAS:528:DC%2BD2sXhtFagsbzK 17828272 (Pubitemid 47530640)
54. L Pelus D Horowitz S Cooper A King 2002 Peripheral blood stem cell mobilization. A role for CXC chemokines Crit Rev Oncol Hematol 43 257 275 10.1016/S1040-8428(01)00202-5 12270782 (Pubitemid 35335309)
55. IL King TL Dickendesher BM Segal 2009 Circulating Ly-6C+ myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease Blood 113 3190 3197 10.1182/blood-2008-07-168575 1:CAS:528:DC%2BD1MXksFWqsLY%3D 19196868
56. SL Bailey B Schreiner EJ McMahon SD Miller 2007 CNS myeloid DCs presenting endogenous myelin peptides 'preferentially' polarize CD4+ T(H)-17 cells in relapsing EAE Nat Immunol 8 172 180 10.1038/ni1430 1:CAS:528: DC%2BD2sXnt1KitQ%3D%3D 17206145 (Pubitemid 46152648)
57. EB Samoilova JL Horton B Hilliard TS Liu Y Chen 1998 IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: roles of IL-6 in the activation and differentiation of autoreactive T cells J Immunol 161 6480 6486 1:CAS:528:DyaK1cXotFWqs7c%3D 9862671
58. CA Jacobs PE Baker ER Roux KS Picha B Toivola S Waugh MK Kennedy 1991 Experimental autoimmune encephalomyelitis is exacerbated by IL-1 alpha and suppressed by soluble IL-1 receptor J Immunol 146 2983 2989 1:CAS:528: DyaK3MXlvVWhs78%3D 1826702
59. H Ogura M Murakami Y Okuyama M Tsuruoka C Kitabayashi M Kanamoto M Nishihara Y Iwakura T Hirano 2008 Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction Immunity 29 628 636 10.1016/j.immuni.2008.07.018 1:CAS:528:DC%2BD1cXhtlWntb%2FN 18848474
60. EC Nowak CT Weaver H Turner S Begum-Haque B Becher B Schreiner AJ Coyle LH Kasper RJ Noelle 2009 IL-9 as a mediator of Th17-driven inflammatory disease J Exp Med 206 1653 1660 10.1084/jem.20090246 1:CAS:528:DC%2BD1MXps1enurs%3D 19596803
61. S Haak AL Croxford K Kreymborg FL Heppner S Pouly B Becher A Waisman 2009 IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice J Clin Invest 119 61 69 1:CAS:528:DC%2BD1MXmtFChsw%3D%3D 19075395
62. T Ishizu M Osoegawa FJ Mei H Kikuchi M Tanaka Y Takakura M Minohara H Murai F Mihara T Taniwaki J Kira 2005 Intrathecal activation of the IL-17/IL-8 axis in opticospinal multiple sclerosis Brain 128 988 1002 10.1093/brain/awh453 15743872 (Pubitemid 40675455)
63. M Ukkonen K Wu B Reipert P Dastidar I Elovaara 2007 Cell surface adhesion molecules and cytokine profiles in primary progressive multiple sclerosis Mult Scler 13 701 707 10.1177/1352458506075378 1:CAS:528:DC%2BD2sXpt1egtrY%3D 17613596 (Pubitemid 47074091)
64. E Scarpini D Galimberti P Baron R Clerici M Ronzoni G Conti G Scarlato 2002 IP-10 and MCP-1 levels in CSF and serum from multiple sclerosis patients with different clinical subtypes of the disease J Neurol Sci 195 41 46 10.1016/S0022-510X(01)00680-3 1:CAS:528:DC%2BD38XhsFWgsbY%3D 11867072
65. Y Chen CL Langrish B McKenzie B Joyce-Shaikh JS Stumhofer T McClanahan W Blumenschein T Churakovsa J Low L Presta CA Hunter RA Kastelein DJ Cua 2006 Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis J Clin Invest 116 1317 1326 10.1172/JCI25308 1:CAS:528:DC%2BD28XksVWns7w%3D 16670771
66. Y Sonobe J Liang S Jin G Zhang H Takeuchi T Mizuno A Suzumura 2008 Microglia express a functional receptor for interleukin-23 Biochem Biophys Res Commun 370 129 133 10.1016/j.bbrc.2008.03.059 1:CAS:528:DC%2BD1cXks1Kis78%3D 18358830
67. BM Segal CS Constantinescu A Raychaudhuri L Kim R Fidelus-Gort LH Kasper 2008 Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study Lancet Neurol 7 796 804 10.1016/S1474-4422(08)70173-X 1:CAS:528:DC%2BD1cXhtFWmsLrO 18703004
68. M Chen G Chen H Nie X Zhang X Niu YC Zang SM Skinner JZ Zhang JM Killian J Hong 2009 Regulatory effects of IFN-beta on production of osteopontin and IL-17 by CD4+ T cells in MS Eur J Immunol 39 2525 2536 10.1002/eji.200838879 1:CAS:528:DC%2BD1MXhtVKrtr3K 19670379
69. ML Shinohara JH Kim VA Garcia H Cantor 2008 Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin Immunity 29 68 78 10.1016/j.immuni.2008.05.008 1:CAS:528:DC%2BD1cXptF2mtLg%3D 18619869
70. X Zhang J Jin Y Tang D Speer D Sujkowska S Markovic-Plese 2009 IFN-beta1a inhibits the secretion of Th17-polarizing cytokines in human dendritic cells via TLR7 up-regulation J Immunol 182 3928 3936 10.4049/jimmunol.0802226 1:CAS:528:DC%2BD1MXis12htLw%3D 19265172
71. B Guo EY Chang G Cheng 2008 The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice J Clin Invest 118 1680 1690 10.1172/JCI33342 1:CAS:528:DC%2BD1cXlsF2ntL0%3D 18382764
72. M Liu X Hu Y Wang F Peng Y Yang X Chen Z Lu X Zheng 2009 Effect of high-dose methylprednisolone treatment on Th17 cells in patients with multiple sclerosis in relapse Acta Neurol Scand 120 235 241 10.1111/j.1600-0404.2009. 01158.x 1:CAS:528:DC%2BD1MXhtlyqsbrN 19769778