-
2
-
-
33646345376
-
Ubiquitin ligases: Cell-cycle control and cancer
-
Nakayama, K.I. & Nakayama, K. Ubiquitin ligases: cell-cycle control and cancer. Nat. Rev. Cancer 6, 369-381 (2006).
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 369-381
-
-
Nakayama, K.I.1
Nakayama, K.2
-
3
-
-
0032576605
-
Aggresomes: A cellular response to misfolded proteins
-
Johnston, J.A., Ward, C.L. & Kopito, R.R. Aggresomes: a cellular response to misfolded proteins. J. Cell Biol. 143, 1883-1898 (1998).
-
(1998)
J. Cell Biol.
, vol.143
, pp. 1883-1898
-
-
Johnston, J.A.1
Ward, C.L.2
Kopito, R.R.3
-
4
-
-
44849094781
-
Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging
-
Morimoto, R.I. Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging. Genes Dev. 22, 1427-1438 (2008).
-
(2008)
Genes Dev.
, vol.22
, pp. 1427-1438
-
-
Morimoto, R.I.1
-
5
-
-
39349083915
-
Adapting proteostasis for disease intervention
-
Balch, W.E., Morimoto, R.I., Dillin, A. & Kelly, J.W. Adapting proteostasis for disease intervention. Science 319, 916-919 (2008).
-
(2008)
Science
, vol.319
, pp. 916-919
-
-
Balch, W.E.1
Morimoto, R.I.2
Dillin, A.3
Kelly, J.W.4
-
6
-
-
0036692065
-
Dynamics of protein turnover, a missing dimension in proteomics
-
Pratt, J.M. et al. Dynamics of protein turnover, a missing dimension in proteomics. Mol. Cell. Proteomics 1, 579-591 (2002).
-
(2002)
Mol. Cell. Proteomics
, vol.1
, pp. 579-591
-
-
Pratt, J.M.1
-
7
-
-
79951472959
-
Proteome half-life dynamics in living human cells
-
Eden, E. et al. Proteome half-life dynamics in living human cells. Science 331, 764-768 (2011).
-
(2011)
Science
, vol.331
, pp. 764-768
-
-
Eden, E.1
-
8
-
-
34250668269
-
Method for real-time monitoring of protein degradation at the single cell level
-
Zhang, L. et al. Method for real-time monitoring of protein degradation at the single cell level. Biotechniques 42, 446-450 (2007).
-
(2007)
Biotechniques
, vol.42
, pp. 446-450
-
-
Zhang, L.1
-
9
-
-
55849136903
-
Global protein stability profiling in mammalian cells
-
Yen, H.-C.S., Xu, Q., Chou, D.M., Zhao, Z. & Elledge, S.J. Global protein stability profiling in mammalian cells. Science 322, 918-923 (2008).
-
(2008)
Science
, vol.322
, pp. 918-923
-
-
Yen, H.-C.S.1
Xu, Q.2
Chou, D.M.3
Zhao, Z.4
Elledge, S.J.5
-
10
-
-
33947355325
-
Single-cell quantification of molecules and rates using open-source microscope-based cytometry
-
Gordon, A. et al. Single-cell quantification of molecules and rates using open-source microscope-based cytometry. Nat. Methods 4, 175-181 (2007).
-
(2007)
Nat. Methods
, vol.4
, pp. 175-181
-
-
Gordon, A.1
-
11
-
-
55849133733
-
Identification of SCF ubiquitin ligase substrates by global protein stability profiling
-
Yen, H.-C.S. & Elledge, S.J. Identification of SCF ubiquitin ligase substrates by global protein stability profiling. Science 322, 923-929 (2008).
-
(2008)
Science
, vol.322
, pp. 923-929
-
-
Yen, H.-C.S.1
Elledge, S.J.2
-
12
-
-
79955894911
-
Genetically encodable fluorescent biosensors for tracking signaling dynamics in living cells
-
Newman, R.H., Fosbrink, M.D. & Zhang, J. Genetically encodable fluorescent biosensors for tracking signaling dynamics in living cells. Chem. Rev. 111, 3614-3666 (2011).
-
(2011)
Chem. Rev.
, vol.111
, pp. 3614-3666
-
-
Newman, R.H.1
Fosbrink, M.D.2
Zhang, J.3
-
13
-
-
79957843777
-
Modern fluorescent proteins and imaging technologies to study gene expression, nuclear localization, and dynamics
-
Wu, B., Piatkevich, K.D., Lionnet, T., Singer, R.H. & Verkhusha, V.V. Modern fluorescent proteins and imaging technologies to study gene expression, nuclear localization, and dynamics. Curr. Opin. Cell Biol. 23, 310-317 (2011).
-
(2011)
Curr. Opin. Cell Biol.
, vol.23
, pp. 310-317
-
-
Wu, B.1
Piatkevich, K.D.2
Lionnet, T.3
Singer, R.H.4
Verkhusha, V.V.5
-
14
-
-
0034711442
-
"Fluorescent timer": Protein that changes color with time
-
Terskikh, A. et al. "Fluorescent timer": protein that changes color with time. Science 290, 1585-1588 (2000).
-
(2000)
Science
, vol.290
, pp. 1585-1588
-
-
Terskikh, A.1
-
15
-
-
58249123661
-
Monomeric fluorescent timers that change color from blue to red report on cellular trafficking
-
Subach, F.V. et al. Monomeric fluorescent timers that change color from blue to red report on cellular trafficking. Nat. Chem. Biol. 5, 118-126 (2009).
-
(2009)
Nat. Chem. Biol.
, vol.5
, pp. 118-126
-
-
Subach, F.V.1
-
16
-
-
75649133578
-
Age-dependent preferential dense-core vesicle exocytosis in neuroendocrine cells revealed by newly developed monomeric fluorescent timer protein
-
Tsuboi, T., Kitaguchi, T., Karasawa, S., Fukuda, M. & Miyawaki, A. Age-dependent preferential dense-core vesicle exocytosis in neuroendocrine cells revealed by newly developed monomeric fluorescent timer protein. Mol. Biol. Cell 21, 87-94 (2010).
-
(2010)
Mol. Biol. Cell
, vol.21
, pp. 87-94
-
-
Tsuboi, T.1
Kitaguchi, T.2
Karasawa, S.3
Fukuda, M.4
Miyawaki, A.5
-
17
-
-
34547659144
-
Bright monomeric red fluorescent protein with an extended fluorescence lifetime
-
Merzlyak, E.M. et al. Bright monomeric red fluorescent protein with an extended fluorescence lifetime. Nat. Methods 4, 555-557 (2007).
-
(2007)
Nat. Methods
, vol.4
, pp. 555-557
-
-
Merzlyak, E.M.1
-
18
-
-
30544433196
-
Engineering and characterization of a superfolder green fluorescent protein
-
Pédelacq, J.-D., Cabantous, S., Tran, T., Terwilliger, T.C. & Waldo, G.S. Engineering and characterization of a superfolder green fluorescent protein. Nat. Biotechnol. 24, 79-88 (2006).
-
(2006)
Nat. Biotechnol.
, vol.24
, pp. 79-88
-
-
Pédelacq, J.-D.1
Cabantous, S.2
Tran, T.3
Terwilliger, T.C.4
Waldo, G.S.5
-
19
-
-
0035890168
-
Modes of spindle pole body inheritance and segregation of the Bfa1p-Bub2p checkpoint protein complex
-
Pereira, G., Tanaka, T.U., Nasmyth, K. & Schiebel, E. Modes of spindle pole body inheritance and segregation of the Bfa1p-Bub2p checkpoint protein complex. EMBO J. 20, 6359-6370 (2001).
-
(2001)
EMBO J.
, vol.20
, pp. 6359-6370
-
-
Pereira, G.1
Tanaka, T.U.2
Nasmyth, K.3
Schiebel, E.4
-
20
-
-
0345255797
-
Visualization of protein compartmentation within the plasma membrane of living yeast cells
-
Malínská, K., Malínský, J., Opekarová, M. & Tanner, W. Visualization of protein compartmentation within the plasma membrane of living yeast cells. Mol. Biol. Cell 14, 4427-4436 (2003).
-
(2003)
Mol. Biol. Cell
, vol.14
, pp. 4427-4436
-
-
Malínská, K.1
Malínský, J.2
Opekarová, M.3
Tanner, W.4
-
21
-
-
0034644626
-
Plasma membrane compartmentalization in yeast by messenger RNA transport and a septin diffusion barrier
-
Takizawa, P.A., DeRisi, J.L., Wilhelm, J.E. & Vale, R.D. Plasma membrane compartmentalization in yeast by messenger RNA transport and a septin diffusion barrier. Science 290, 341-344 (2000).
-
(2000)
Science
, vol.290
, pp. 341-344
-
-
Takizawa, P.A.1
Derisi, J.L.2
Wilhelm, J.E.3
Vale, R.D.4
-
22
-
-
0034623789
-
Multigenerational cortical inheritance of the Rax2 protein in orienting polarity and division in yeast
-
Chen, T. et al. Multigenerational cortical inheritance of the Rax2 protein in orienting polarity and division in yeast. Science 290, 1975-1978 (2000).
-
(2000)
Science
, vol.290
, pp. 1975-1978
-
-
Chen, T.1
-
23
-
-
77953893804
-
The nuclear pore complex: Bridging nuclear transport and gene regulation
-
Strambio-De-Castillia, C., Niepel, M. & Rout, M.P. The nuclear pore complex: bridging nuclear transport and gene regulation. Nat. Rev. Mol. Cell Biol. 11, 490-501 (2010).
-
(2010)
Nat. Rev. Mol. Cell Biol.
, vol.11
, pp. 490-501
-
-
Strambio-De-Castillia, C.1
Niepel, M.2
Rout, M.P.3
-
24
-
-
58249089343
-
Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells
-
D'Angelo, M.A., Raices, M., Panowski, S.H. & Hetzer, M.W. Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells. Cell 136, 284-295 (2009).
-
(2009)
Cell
, vol.136
, pp. 284-295
-
-
D'Angelo, M.A.1
Raices, M.2
Panowski, S.H.3
Hetzer, M.W.4
-
25
-
-
0029900425
-
Nic96p is required for nuclear pore formation and functionally interacts with a novel nucleoporin Nup188p
-
Zabel, U. et al. Nic96p is required for nuclear pore formation and functionally interacts with a novel nucleoporin, Nup188p. J. Cell Biol. 133, 1141-1152 (1996).
-
(1996)
J. Cell Biol.
, vol.133
, pp. 1141-1152
-
-
Zabel, U.1
-
26
-
-
65649114446
-
The nucleoporins Nup170p and Nup157p are essential for nuclear pore complex assembly
-
Makio, T. et al. The nucleoporins Nup170p and Nup157p are essential for nuclear pore complex assembly. J. Cell Biol. 185, 459-473 (2009).
-
(2009)
J. Cell Biol.
, vol.185
, pp. 459-473
-
-
Makio, T.1
-
27
-
-
55849153499
-
Replicative aging in yeast: The means to the end
-
Steinkraus, K.A., Kaeberlein, M. & Kennedy, B.K. Replicative aging in yeast: the means to the end. Annu. Rev. Cell Dev. Biol. 24, 29-54 (2008).
-
(2008)
Annu. Rev. Cell Dev. Biol.
, vol.24
, pp. 29-54
-
-
Steinkraus, K.A.1
Kaeberlein, M.2
Kennedy, B.K.3
-
28
-
-
0030776030
-
Nuclear pore complex number and distribution throughout the Saccharomyces cerevisiae cell cycle by three-dimensional reconstruction from electron micrographs of nuclear envelopes
-
Winey, M., Yarar, D., Giddings, T.H. & Mastronarde, D.N. Nuclear pore complex number and distribution throughout the Saccharomyces cerevisiae cell cycle by three-dimensional reconstruction from electron micrographs of nuclear envelopes. Mol. Biol. Cell 8, 2119-2132 (1997).
-
(1997)
Mol. Biol. Cell
, vol.8
, pp. 2119-2132
-
-
Winey, M.1
Yarar, D.2
Giddings, T.H.3
Mastronarde, D.N.4
-
29
-
-
77954893577
-
Segregation of yeast nuclear pores
-
Khmelinskii, A., Keller, P.J., Lorenz, H., Schiebel, E. & Knop, M. Segregation of yeast nuclear pores. Nature 466, E1 (2010).
-
(2010)
Nature
, vol.466
-
-
Khmelinskii, A.1
Keller, P.J.2
Lorenz, H.3
Schiebel, E.4
Knop, M.5
-
30
-
-
0037062424
-
A monomeric red fluorescent protein
-
Campbell, R.E. et al. A monomeric red fluorescent protein. Proc. Natl. Acad. Sci. USA 99, 7877-7882 (2002).
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 7877-7882
-
-
Campbell, R.E.1
-
31
-
-
76249091039
-
Recombination-induced tag exchange to track old and new proteins
-
Verzijlbergen, K.F. et al. Recombination-induced tag exchange to track old and new proteins. Proc. Natl. Acad. Sci. USA 107, 64-68 (2010).
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 64-68
-
-
Verzijlbergen, K.F.1
-
32
-
-
84859393636
-
Organelle segregation during mitosis: Lessons from asymmetrically dividing cells
-
Ouellet, J. & Barral, Y. Organelle segregation during mitosis: Lessons from asymmetrically dividing cells. J. Cell Biol. 196, 305-313 (2012).
-
(2012)
J. Cell Biol.
, vol.196
, pp. 305-313
-
-
Ouellet, J.1
Barral, Y.2
-
33
-
-
79960683356
-
The N-end rule pathway and regulation by proteolysis
-
Varshavsky, A. The N-end rule pathway and regulation by proteolysis. Protein Sci. 20, 1298-1345 (2011).
-
(2011)
Protein Sci.
, vol.20
, pp. 1298-1345
-
-
Varshavsky, A.1
-
34
-
-
33748377124
-
Quantification of protein half-lives in the budding yeast proteome
-
Belle, A., Tanay, A., Bitincka, L., Shamir, R. & O'Shea, E.K. Quantification of protein half-lives in the budding yeast proteome. Proc. Natl. Acad. Sci. USA 103, 13004-13009 (2006).
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 13004-13009
-
-
Belle, A.1
Tanay, A.2
Bitincka, L.3
Shamir, R.4
O'Shea, E.K.5
-
35
-
-
0033529707
-
Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis
-
Winzeler, E.A. et al. Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science 285, 901-906 (1999).
-
(1999)
Science
, vol.285
, pp. 901-906
-
-
Winzeler, E.A.1
-
36
-
-
34247575803
-
High-throughput strain construction and systematic synthetic lethal screening in Saccharomyces cerevisiae
-
Tong, A.H.Y. & Boone, C. High-throughput strain construction and systematic synthetic lethal screening in Saccharomyces cerevisiae. Methods Microbiol. 36, 369-386 (2007).
-
(2007)
Methods Microbiol.
, vol.36
, pp. 369-386
-
-
Tong, A.H.Y.1
Boone, C.2
-
37
-
-
77149120798
-
N-terminal acetylation of cellular proteins creates specific degradation signals
-
Hwang, C.-S., Shemorry, A. & Varshavsky, A. N-terminal acetylation of cellular proteins creates specific degradation signals. Science 327, 973-977 (2010).
-
(2010)
Science
, vol.327
, pp. 973-977
-
-
Hwang, C.-S.1
Shemorry, A.2
Varshavsky, A.3
-
38
-
-
0035887277
-
A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation
-
Swanson, R., Locher, M. & Hochstrasser, M. A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation. Genes Dev. 15, 2660-2674 (2001).
-
(2001)
Genes Dev.
, vol.15
, pp. 2660-2674
-
-
Swanson, R.1
Locher, M.2
Hochstrasser, M.3
-
39
-
-
0036753063
-
Multiple associated proteins regulate proteasome structure and function
-
Leggett, D.S. et al. Multiple associated proteins regulate proteasome structure and function. Mol. Cell 10, 495-507 (2002).
-
(2002)
Mol. Cell
, vol.10
, pp. 495-507
-
-
Leggett, D.S.1
-
40
-
-
78649894111
-
The N-end rule pathway is mediated by a complex of the RING-type Ubr1 and HECT-type Ufd4 ubiquitin ligases
-
Hwang, C.-S., Shemorry, A., Auerbach, D. & Varshavsky, A. The N-end rule pathway is mediated by a complex of the RING-type Ubr1 and HECT-type Ufd4 ubiquitin ligases. Nat. Cell Biol. 12, 1177-1185 (2010).
-
(2010)
Nat. Cell Biol.
, vol.12
, pp. 1177-1185
-
-
Hwang, C.-S.1
Shemorry, A.2
Auerbach, D.3
Varshavsky, A.4
-
41
-
-
38349006477
-
Advances in fluorescent protein technology
-
Shaner, N.C., Patterson, G.H. & Davidson, M.W. Advances in fluorescent protein technology. J. Cell Sci. 120, 4247-4260 (2007).
-
(2007)
J. Cell Sci.
, vol.120
, pp. 4247-4260
-
-
Shaner, N.C.1
Patterson, G.H.2
Davidson, M.W.3
-
42
-
-
77958143259
-
Reverse genetics in eukaryotes
-
Hardy, S., Legagneux, V., Audic, Y. & Paillard, L. Reverse genetics in eukaryotes. Biol. Cell 102, 561-580 (2010).
-
(2010)
Biol. Cell
, vol.102
, pp. 561-580
-
-
Hardy, S.1
Legagneux, V.2
Audic, Y.3
Paillard, L.4
-
43
-
-
79959210305
-
A conditional knockout resource for the genome-wide study of mouse gene function
-
Skarnes, W.C. et al. A conditional knockout resource for the genome-wide study of mouse gene function. Nature 474, 337-342 (2011).
-
(2011)
Nature
, vol.474
, pp. 337-342
-
-
Skarnes, W.C.1
-
44
-
-
80053343092
-
TAL effectors: Customizable proteins for DNA targeting
-
Bogdanove, A.J. & Voytas, D.F. TAL effectors: customizable proteins for DNA targeting. Science 333, 1843-1846 (2011).
-
(2011)
Science
, vol.333
, pp. 1843-1846
-
-
Bogdanove, A.J.1
Voytas, D.F.2
-
45
-
-
79959487394
-
Out with the old, in with the new? Comparing methods for measuring protein degradation
-
Yewdell, J.W., Lacsina, J.R., Rechsteiner, M.C. & Nicchitta, C.V. Out with the old, in with the new? Comparing methods for measuring protein degradation. Cell Biol. Int. 35, 457-462 (2011).
-
(2011)
Cell Biol. Int.
, vol.35
, pp. 457-462
-
-
Yewdell, J.W.1
Lacsina, J.R.2
Rechsteiner, M.C.3
Nicchitta, C.V.4
-
46
-
-
36749045172
-
The molecular architecture of the nuclear pore complex
-
Alber, F. et al. The molecular architecture of the nuclear pore complex. Nature 450, 695-701 (2007).
-
(2007)
Nature
, vol.450
, pp. 695-701
-
-
Alber, F.1
-
47
-
-
4444271170
-
A versatile toolbox for PCR-based tagging of yeast genes: New fluorescent proteins, more markers and promoter substitution cassettes
-
Janke, C. et al. A versatile toolbox for PCR-based tagging of yeast genes: new fluorescent proteins, more markers and promoter substitution cassettes. Yeast 21, 947-962 (2004).
-
(2004)
Yeast
, vol.21
, pp. 947-962
-
-
Janke, C.1
-
48
-
-
11144267737
-
Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein
-
Shaner, N.C. et al. Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein. Nat. Biotechnol. 22, 1567-1572 (2004).
-
(2004)
Nat. Biotechnol.
, vol.22
, pp. 1567-1572
-
-
Shaner, N.C.1
-
49
-
-
0037012847
-
Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells
-
Zacharias, D.A., Violin, J.D., Newton, A.C. & Tsien, R.Y. Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells. Science 296, 913-916 (2002).
-
(2002)
Science
, vol.296
, pp. 913-916
-
-
Zacharias, D.A.1
Violin, J.D.2
Newton, A.C.3
Tsien, R.Y.4
-
50
-
-
0023003380
-
In vivo half-life of a protein is a function of its amino-terminal residue
-
Bachmair, A., Finley, D. & Varshavsky, A. In vivo half-life of a protein is a function of its amino-terminal residue. Science 234, 179-186 (1986).
-
(1986)
Science
, vol.234
, pp. 179-186
-
-
Bachmair, A.1
Finley, D.2
Varshavsky, A.3
-
51
-
-
77951959633
-
EBImage-an R package for image processing with applications to cellular phenotypes
-
Pau, G., Fuchs, F., Sklyar, O., Boutros, M. & Huber, W. EBImage-an R package for image processing with applications to cellular phenotypes. Bioinformatics 26, 979-981 (2010).
-
(2010)
Bioinformatics
, vol.26
, pp. 979-981
-
-
Pau, G.1
Fuchs, F.2
Sklyar, O.3
Boutros, M.4
Huber, W.5
-
53
-
-
32344448950
-
Statistical practice in high-throughput screening data analysis
-
Malo, N., Hanley, J.A., Cerquozzi, S., Pelletier, J. & Nadon, R. Statistical practice in high-throughput screening data analysis. Nat. Biotechnol. 24, 167-175 (2006).
-
(2006)
Nat. Biotechnol.
, vol.24
, pp. 167-175
-
-
Malo, N.1
Hanley, J.A.2
Cerquozzi, S.3
Pelletier, J.4
Nadon, R.5
|