Mapping the ligand-binding pocket of integrin α5β1 using a gain-of-function approach

Biochemical Journal

Volumn 424, Issue 2, 2009, Pages 179-189

  Mould, A Paul ^a   Koper, Ewa J ^a   Byron, Adam ^a   Zahn, Grit ^b   Humphries, Martin J ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b Jerini AG   (Germany)

Author keywords

Antagonist; Fibronectin; Gain of function; Integrin; RGD motif; Synergy region

Indexed keywords

ARG GLY ASPS; CYCLIC PEPTIDES; EXTRACELLULAR MATRIX PROTEIN; GAIN-OF-FUNCTION; GAIN-OF-FUNCTION ANALYSIS; HOMOLOGY MODELS; HUMAN FIBRONECTIN; IN-VIVO; INTEGRINS; LIGAND BINDING; LOOP RESIDUES; RGD MOTIF; SYNERGY SEQUENCE; THERAPEUTIC POTENTIALS; UPPER SURFACE; ZEBRAFISH;

AMINES; GLYCOPROTEINS; PEPTIDES;

FACE RECOGNITION;

ALANINE; ARGININE; ASPARAGINE; FIBRONECTIN; GLYCINE; HISTIDINE; INTEGRIN RECEPTOR; PROLINE; SERINE; VERY LATE ACTIVATION ANTIGEN 5;

ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; LIGAND BINDING; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN STRUCTURE; RING FINGER MOTIF; SOLID PHASE SYNTHESIS;

ANIMALS; BINDING SITES; CHO CELLS; CRICETINAE; CRICETULUS; FIBRONECTINS; HUMANS; INTEGRIN ALPHA5BETA1; MODELS, MOLECULAR; MUTATION; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; STRUCTURAL HOMOLOGY, PROTEIN; ZEBRAFISH;

DANIO RERIO;

EID: 70450203639     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20090992     Document Type: Article

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