Melittin modulates keratinocyte function through P2 receptor-dependent ADAM activation

Journal of Biological Chemistry

Volumn 287, Issue 28, 2012, Pages 23678-23689

  Sommer, Anselm ^a   Fries, Anja ^b   Cornelsen, Isabell ^b   Speck, Nancy ^a   Koch Nolte, Friedrich ^c   Gimpl, Gerald ^b   Andrä, Jörg ^d,e   Bhakdi, Sucharit ^b   Reiss, Karina ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^d RESEARCH CENTER BORSTEL   (Germany)

^e HAMBURG UNIVERSITY OF APPLIED SCIENCES   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESION MOLECULES; AMPHIPATHIC; ANTI-CANCER AGENTS; ANTI-INFLAMMATORIES; ATPASES; BEE VENOM; BIOLOGICAL EFFECTS; BIOLOGICAL PROPERTIES; CATIONIC PEPTIDES; CELL MIGRATION; E-CADHERINS; HUMAN NEUTROPHIL; KERATINOCYTES; MELITTIN; METALLOPROTEASES; MULTIPLE CELLULAR FUNCTIONS; MURINE FIBROBLASTS; P2 RECEPTOR; TRANSACTIVATION; UNDERLYING MECHANISM; WIDE SPECTRUM;

CELL CULTURE; DISEASES; ENDOTHELIAL CELLS; GLYCOPROTEINS; MOLECULAR BIOLOGY; PHOSPHORYLATION;

PEPTIDES;

ADAM PROTEIN; ADAM10 ENDOPEPTIDASE; ADENOSINE TRIPHOSPHATE; EPIDERMAL GROWTH FACTOR RECEPTOR; MELITTIN; MITOGEN ACTIVATED PROTEIN KINASE 1; PURINERGIC P2 RECEPTOR; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; UVOMORULIN;

ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME PHOSPHORYLATION; FIBROBLAST; GRANULOCYTE; HUMAN; HUMAN CELL; KERATINOCYTE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN SECRETION;

ADAM PROTEINS; ADENOSINE TRIPHOSPHATE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BLOTTING, WESTERN; CADHERINS; CELL LINE; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO, MAMMALIAN; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLASTS; HEK293 CELLS; HUMANS; KERATINOCYTES; MELITTEN; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; PHOSPHORYLATION; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, PURINERGIC P2X7; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

APOIDEA; MURINAE;

EID: 84863620892     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.362756     Document Type: Article

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