Soy proteins and isoflavones affect bone mineral density in older women: A randomized controlled trial

American Journal of Clinical Nutrition

Volumn 90, Issue 1, 2009, Pages 234-242

  Kenny, Anne M ^a   Mangano, Kelsey M ^b   Abourizk, Robin H ^b   Bruno, Richard S ^b   Anamani, Denise E ^b   Kleppinger, Alison ^a   Walsh, Stephen J ^a   Prestwood, Karen M ^a   Kerstetter, Jane E ^b  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CITRATE CALCIUM; CYSTINE; DAIDZEIN; DAIDZIN; EQUOL; GENISTEIN; GLYCITEIN; ISOFLAVONE; ISOLEUCINE; LEUCINE; METHIONINE; PHENYLALANINE; PLACEBO; SOYBEAN PROTEIN; THREONINE; TRYPTOPHAN; TYROSINE; VALINE; VITAMIN D; AMINO ACID; COLLAGEN; ISOFLAVONE DERIVATIVE;

ADULT; AGED; ARTICLE; BLOOD PRESSURE; BONE DENSITY; BONE TURNOVER; BREAST TENDERNESS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG SAFETY; ENDOMETRIUM; FEMALE; GASTROINTESTINAL SYMPTOM; HEART DISEASE; HUMAN; NORMAL HUMAN; PATIENT COMPLIANCE; PILL; POSTMENOPAUSE; PROTEIN INTAKE; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT INFECTION; SIDE EFFECT; TABLET FORMULATION; TREATMENT DURATION; TREATMENT OUTCOME; BONE; CHEMISTRY; FOLLOW UP; METABOLISM; MIDDLE AGED; PHYSIOLOGY;

AGED; AGED, 80 AND OVER; AMINO ACIDS; BONE AND BONES; BONE DENSITY; COLLAGEN; DOUBLE-BLIND METHOD; FEMALE; FOLLOW-UP STUDIES; HUMANS; ISOFLAVONES; MIDDLE AGED; PATIENT COMPLIANCE; PLACEBOS; SOYBEAN PROTEINS;

EID: 67649887107     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.3945/ajcn.2009.27600     Document Type: Article

References (50)

1. Anderson GL, Judd HL, Kaunitz AM, et al. Effects of estrogen plus progestin on gynecologic cancers and associated diagnostic procedures: the Women's Health Initiative randomized trial. JAMA 2003;290:1739-1748 (Pubitemid 37430624)
2. Kuiper GG, Lemmen JG, Carlsson B, et al. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 1998;139:4252-4263 (Pubitemid 28513713)
3. Kostelac D, Rechkemmer G, Briviba K. Phytoestrogens modulate binding response of estrogen receptors alpha and beta to the estrogen response element. J Agric Food Chem 2003;51:7632-7635
4. Margeat E, Bourdoncle A, Margueron R, Poujol N, Cavailles V, Royer C. Ligands differentially modulate the protein interactions of the human estrogen receptors alpha and beta. J Mol Biol 2003;326:77-92. (Pubitemid 36284723)
5. Prestwood K, Kenny AM. Osteoporosis: pathogenesis, diagnosis and treatment in older adults. In: Loeser RF, ed. Clinics in geriatric medicine: musculoskeletal and connective tissue disorders. Philadelphia, PA: WB Saunders Co, 1998:577-599
6. Prestwood KM, Kenny AM, Kleppinger A, Kulldorff M. Ultralow-dose micronized 17beta-estradiol and bone density and bone metabolism in older women: a randomized controlled trial. JAMA 2003;290:1042-1048 (Pubitemid 37430444)
7. Potter SM, Baum JA, Teng H, Stillman RJ, Shay NF, Erdman JW Jr. Soy protein and isoflavones: their effects on blood lipids and bone density in postmenopausal women. Am J Clin Nutr 1998;68:1375S-9S. (Pubitemid 28550915)
8. Alekel DL, Germain AS, Peterson CT, Hanson KB, Stewart JW, Toda T. Isoflavone-rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women. Am J Clin Nutr 2000;72:844-852 (Pubitemid 30667108)
9. Chen YM, Ho SC, Lam SS, Ho SS, Woo JL. Soy isoflavones have a favorable effect on bone loss in Chinese postmenopausal women with lower bone mass: a double-blind, randomized, controlled trial. J Clin Endocrinol Metab 2003;88:4740-4747
10. Lydeking-Olsen E, Beck-Jensen JE, Setchell KD, Holm-Jensen T. Soymilk or progesterone for prevention of bone loss - a 2 year randomized, placebo-controlled trial. Eur J Nutr 2004;43:246-257 (Pubitemid 39222536)
11. Morabito N, Crisafulli A, Vergara C, et al. Effects of genistein and hormone-replacement therapy on bone loss in early postmenopausal women: a randomized double-blind placebo-controlled study. J Bone Miner Res 2002;17:1904-1912
12. Marini H, Minutoli L, Polito F, et al. Effects of the phytoestrogen genistein on bone metabolism in osteopenic postmenopausal women: a randomized trial. Ann Intern Med 2007;146:839-847 (Pubitemid 351650484)
13. Ma DF, Qin LQ, Wang PY, Katoh R. Soy isoflavone intake inhibits bone resorption and stimulates bone formation in menopausal women: meta-analysis of randomized controlled trials. Eur J Clin Nutr 2007. (Pubitemid 351234248)
14. Huang HY, Yang HP, Yang HT, Yang TC, Shieh MJ, Huang SY. One-year soy isoflavone supplementation prevents early postmenopausal bone loss but without a dose-dependent effect. J Nutr Biochem 2006;17:509-517
15. Dalais FS, Ebeling PR, Kotsopoulos D, McGrath BP, Teede HJ. The effects of soy protein containing isoflavones on lipids and indices of bone resorption in postmenopausal women. Clin Endocrinol (Oxf) 2003;58:704-709 (Pubitemid 36702729)
16. Kreijkamp-Kaspers S, Kok L, Grobbee DE, et al. Effect of soy protein containing isoflavones on cognitive function, bone mineral density, and plasma lipids in postmenopausal women: a randomized controlled trial. JAMA 2004;292:65-74. (Pubitemid 38923795)
17. Gallagher JC, Satpathy R, Rafferty K, Haynatzka V. The effect of soy protein isolate on bone metabolism. Menopause 2004;11:290-298 (Pubitemid 40362183)
18. Roughead ZK, Hunt JR, Johnson LK, Badger TM, Lykken GI. Controlled substitution of soy protein for meat protein: effects on calcium retention, bone, and cardiovascular health indices in postmenopausal women. J Clin Endocrinol Metab 2005;90:181-189
19. Spence LA, Lipscomb ER, Cadogan J, et al. The effect of soy protein and soy isoflavones on calcium metabolism in postmenopausal women: a randomized crossover study. Am J Clin Nutr 2005;81:916-922 (Pubitemid 41725003)
20. Balk E, Chung M, Chew P, et al. Effects of soy on health outcomes. Evid Rep Technol Assess (Summ) 2005;126:1-8.
21. Cheong JM, Martin BR, Jackson GS, et al. Soy isoflavones do not affect bone resorption in postmenopausal women: a dose-response study using a novel approach with 41Ca. J Clin Endocrinol Metab 2007;92:577-582
22. Brink E, Coxam V, Robins S, Wahala K, Cassidy A, Branca F. Long-term consumption of isoflavone-enriched foods does not affect bone mineral density, bone metabolism, or hormonal status in early postmenopausal women: a randomized, double-blind, placebo controlled study. Am J Clin Nutr 2008;87:761-770
23. Liu J, Ho SC, Su YX, Chen WQ, Zhang CX, Chen YM. Effect of long-term intervention of soy isoflavones on bone mineral density in women: a meta-analysis of randomized controlled trials. Bone 2009:44:948-953
24. Craft NE, Mitchell T. Comparison of plasma isoflavone extraction. FASEB J 2007;21:701.27.
25. Setchell KD, Cole SJ. Method of defining equol-producer status and its frequency among vegetarians. J Nutr 2006;136:2188-2193
26. Horiuchi T, Onouchi T, Takahashi M, Ito H, Orimo H. Effect of soy protein on bone metabolism in postmenopausal Japanese women. Osteoporos Int 2000;11:721-724 (Pubitemid 30786254)
27. Kim MK, Chung BC, Yu VY, et al. Relationships of urinary phytooestrogen excretion to BMD in postmenopausal women. Clin Endocrinol (Oxf) 2002;56:321-328
28. Kritz-Silverstein D, Goodman-Gruen DL. Usual dietary isoflavone intake, bone mineral density, and bone metabolism in postmenopausal women. J Womens Health Gend Based Med 2002;11:69-78. (Pubitemid 34196286)
29. Mei J, Yeung SS, Kung AW. High dietary phytoestrogen intake is associated with higher bone mineral density in postmenopausal but not premenopausal women. J Clin Endocrinol Metab 2001;86:5217-5221 (Pubitemid 33070238)
30. Somekawa Y, Chiguchi M, Ishibashi T, Aso T. Soy intake related to menopausal symptoms, serum lipids, and bone mineral density in postmenopausal Japanese women. Obstet Gynecol 2001;97:109-115 (Pubitemid 32057167)
31. Greendale GA, FitzGerald G, Huang MH, et al. Dietary soy isoflavones and bone mineral density: results from the study of women's health across the nation. Am J Epidemiol 2002;155:746-754 (Pubitemid 34297655)
32. Zhang X, Shu XO, Li H, et al. Prospective cohort study of soy food consumption and risk of bone fracture among postmenopausal women. Arch Intern Med 2005;165:1890-1895 (Pubitemid 41352084)
33. Ikeda Y, Iki M, Morita A, et al. Intake of fermented soybeans, natto, is associated with reduced bone loss in postmenopausal women: Japanese Population-Based Osteoporosis (JPOS) Study. J Nutr 2006;136:1323-1328
34. Kardinaal AF, Morton MS, Bruggemann-Rotgans IE, van Beresteijn EC. Phyto-oestrogen excretion and rate of bone loss in postmenopausal women. Eur J Clin Nutr 1998;52:850-855 (Pubitemid 28512863)
35. Nagata C, Inaba S, Kawakami N, Kakizoe T, Shimizu H. Inverse association of soy product intake with serum androgen and estrogen concentrations in Japanese men. Nutr Cancer 2000;36:14-18 (Pubitemid 30317830)
36. Harkness LS, Fiedler K, Sehgal AR, Oravec D, Lerner E. Decreased bone resorption with soy isoflavone supplementation in postmenopausal women. J Womens Health (Larchmt) 2004;13:1000-1007 (Pubitemid 40017338)
37. Uesugi T, Fukui Y, Yamori Y. Beneficial effects of soybean isoflavone supplementation on bone metabolism and serum lipids in postmenopausal Japanese women: a four-week study. J Am Coll Nutr 2002;21:97-102. (Pubitemid 38639154)
38. Roudsari AH, Tahbaz F, Hossein-Nezhad A, Arjmandi B, Larijani B, Kimiagar SM. Assessment of soy phytoestrogens' effects on bone turnover indicators in menopausal women with osteopenia in Iran: a before and after clinical trial. Nutr J 2005;4:30. (Pubitemid 41751155)
39. Atteritano M, Mazzaferro S, Frisina A, et al. Genistein effects on quantitative ultrasound parameters and bone mineral density in osteopenic postmenopausal women. Osteoporos Int (Epub ahead of print 24 February 2009).
40. Wangen KE, Duncan AM, Merz-Demlow BE, et al. Effects of soy isoflavones on markers of bone turnover in premenopausal and postmenopausal women. J Clin Endocrinol Metab 2000;85:3043-3048 (Pubitemid 30944501)
41. Zittermann A, Geppert J, Baier S, et al. Short-term effects of high soy supplementation on sex hormones, bone markers, and lipid parameters in young female adults. Eur J Nutr 2004;43:100-108 (Pubitemid 38661223)
42. Upmalis DH, Lobo R, Bradley L, Warren M, Cone FL, Lamia CA. Vasomotor symptom relief by soy isoflavone extract tablets in postmenopausal women: a multicenter, double-blind, randomized, placebo-controlled study. Menopause 2000;7:236-242 (Pubitemid 30445953)
43. Vupadhyayula PM, Gallagher JC, Templin T, Logsdon SM, Smith LM. Effects of soy protein isolate on bone mineral density and physical performance indices in postmenopausal women-a 2-year randomized, double-blind, placebo-controlled trial. Menopause (Epub ahead of print 21 January 2009).
44. de Pascual-Teresa S, Hallund J, Talbot D, et al. Absorption of isoflavones in humans: effects of food matrix and processing. J Nutr Biochem 2006;17:257-264
45. Song KB, Atkinson C, Frankenfeld CL, et al. Prevalence of daidzein-metabolizing phenotypes differs between Caucasian and Korean American women and girls. J Nutr 2006;136:1347-1351
46. Atkinson C, Frankenfeld CL, Lampe JW. Gut bacterial metabolism of the soy isoflavone daidzein: exploring the relevance to human health. Exp Biol Med (Maywood) 2005;230:155-170 (Pubitemid 40293689)
47. Setchell KD, Clerici C, Lephart ED, et al. S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora. Am J Clin Nutr 2005;81:1072-1079 (Pubitemid 41724948)
48. Massey LK. Dietary animal and plant protein and human bone health: a whole foods approach. J Nutr 2003;133:862S-5S.
49. Schuette SA, Hegsted M, Zemel MB, Linkswiler HM. Renal acid, urinary cyclic AMP, and hydroxyproline excretion as affected by level of protein, sulfur amino acid, and phosphorus intake. J Nutr 1981;111:2106-2116
50. Kerstetter JE, O'Brien KO, Caseria DM, Wall DE, Insogna KL. The impact of dietary protein on calcium absorption and kinetic measures of bone turnover in women. J Clin Endocrinol Metab 2005;90:26-31.