A new antifibrotic target of Ac-SDKP: Inhibition of myofibroblast differentiation in rat lung with silicosis

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Xu, Hong ^a   Yang, Fang ^a,b   Sun, Ying ^b   Yuan, Yuan ^b   Cheng, Hua ^b   Wei, Zhongqiu ^b   Li, Shuyu ^b   Cheng, Tan ^a   Brann, Darrell ^c   Wang, Ruimin ^b  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b HEBEI UNITED UNIVERSITY   (China)

^c MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ANGIOTENSIN I; ANGIOTENSIN II; COLLAGEN TYPE 1; COLLAGEN TYPE 3; DIPEPTIDYL CARBOXYPEPTIDASE; MESSENGER RNA; RAS PROTEIN; SERASPENIDE; SERUM RESPONSE FACTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIFIBROTIC ACTIVITY; ARTICLE; CELL ACTIVATION; CELL DIFFERENTIATION; CELLULAR DISTRIBUTION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; DRUG TARGETING; EXTRACELLULAR MATRIX; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; LUNG FIBROBLAST; MALE; MYOFIBROBLAST; NONHUMAN; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; SILICOSIS; UPREGULATION;

ACTINS; ANGIOTENSIN II; ANIMALS; CELL DIFFERENTIATION; COLLAGEN TYPE I; COLLAGEN TYPE III; LUNG; MALE; MYOFIBROBLASTS; OLIGOPEPTIDES; PYRAZOLES; PYRROLES; RATS; RATS, WISTAR; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RNA, MESSENGER; SILICOSIS; TRANSFORMING GROWTH FACTOR BETA1;

ANIMALIA; RATTUS;

EID: 84863609092     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0040301     Document Type: Article

References (39)

1. Thomas CR, Kelley TR, (2010) A brief review of silicosis in the United States. Environ Health Insights 4: 21-26.
2. Chen W, Zhuang Z, Attfield MD, Chen BT, Gao P, et al. (2001) Exposure to silica and silicosis among tin miners in China: exposure-response analyses and risk assessment. Occup Environ Med 58: 31-37.
3. Health Mo (2011) In 2010 the prevention work situation of occupational disease. China.
4. Gauldie J, Sime PJ, Xing Z, Marr B, Tremblay GM, (1999) Transforming growth factor-beta gene transfer to the lung induces myofibroblast presence and pulmonary fibrosis. Curr Top Pathol 93: 35-45.
5. Arkwright PD, Laurie S, Super M, Pravica V, Schwarz MJ, et al. (2000) TGF-beta(1) genotype and accelerated decline in lung function of patients with cystic fibrosis. Thorax 55: 459-462.
6. Sun Y, Yang F, Yan J, Li Q, Wei Z, et al. (2010) New anti-fibrotic mechanisms of n-acetyl-seryl-aspartyl-lysyl-proline in silicon dioxide-induced silicosis. Life Sci 87: 232-239.
7. Jagirdar J, Begin R, Dufresne A, Goswami S, Lee TC, et al. (1996) Transforming growth factor-beta (TGF-beta) in silicosis. Am J Respir Crit Care Med 154: 1076-1081.
8. Hinz B, Phan SH, Thannickal VJ, Galli A, Bochaton-Piallat ML, et al. (2007) The myofibroblast: one function, multiple origins. Am J Pathol 170: 1807-1816.
9. Powell DW, Mifflin RC, Valentich JD, Crowe SE, Saada JI, et al. (1999) Myofibroblasts. I. Paracrine cells important in health and disease. Am J Physiol 277: C1-9.
10. Sopel MJ, Rosin NL, Lee TD, Legare JF, (2011) Myocardial fibrosis in response to Angiotensin II is preceded by the recruitment of mesenchymal progenitor cells. Lab Invest 91: 565-578.
11. Usuki J, Matsuda K, Azuma A, Kudoh S, Gemma A, (2012) Sequential Analysis of Myofibroblast Differentiation and Transforming Growth Factor-beta1/Smad Pathway Activation in Murine Pulmonary Fibrosis. J Nihon Med Sch 79: 46-59.
12. Horn A, Kireva T, Palumbo-Zerr K, Dees C, Tomcik M, et al. (2012) Inhibition of hedgehog signalling prevents experimental fibrosis and induces regression of established fibrosis. Ann Rheum Dis.
13. Balestrini JL, Chaudhry S, Sarrazy V, Koehler A, Hinz B, (2012) The mechanical memory of lung myofibroblasts. Integr Biol (Camb) 4: 410-421.
14. Miano JM, (2003) Serum response factor: toggling between disparate programs of gene expression. J Mol Cell Cardiol 35: 577-593.
15. Sandbo N, Kregel S, Taurin S, Bhorade S, Dulin NO, (2009) Critical role of serum response factor in pulmonary myofibroblast differentiation induced by TGF-beta. Am J Respir Cell Mol Biol 41: 332-338.
16. Azizi M, Rousseau A, Ezan E, Guyene TT, Michelet S, et al. (1996) Acute angiotensin-converting enzyme inhibition increases the plasma level of the natural stem cell regulator N-acetyl-seryl-aspartyl-lysyl-proline. J Clin Invest 97: 839-844.
17. Yang F, Yang XP, Liu YH, Xu J, Cingolani O, et al. (2004) Ac-SDKP reverses inflammation and fibrosis in rats with heart failure after myocardial infarction. Hypertension 43: 229-236.
18. Omata M, Taniguchi H, Koya D, Kanasaki K, Sho R, et al. (2006) N-acetyl-seryl-aspartyl-lysyl-proline ameliorates the progression of renal dysfunction and fibrosis in WKY rats with established anti-glomerular basement membrane nephritis. J Am Soc Nephrol 17: 674-685.
19. Perret-Guillaume C, Joly L, Jankowski P, Benetos A, (2009) Benefits of the RAS blockade: clinical evidence before the ONTARGET study. J Hypertens pp. S3-7.
20. Pereira RM, dos Santos RA, da Costa Dias FL, Teixeira MM, Simoes e Silva AC, (2009) Renin-angiotensin system in the pathogenesis of liver fibrosis. World J Gastroenterol 15: 2579-2586.
21. Schultz Jel J, Witt SA, Glascock BJ, Nieman ML, Reiser PJ, et al. (2002) TGF-beta1 mediates the hypertrophic cardiomyocyte growth induced by angiotensin II. J Clin Invest 109: 787-796.
22. Yang F, Chung AC, Huang XR, Lan HY, (2009) Angiotensin II induces connective tissue growth factor and collagen I expression via transforming growth factor-beta-dependent and-independent Smad pathways: the role of Smad3. Hypertension 54: 877-884.
23. Gao X, He X, Luo B, Peng L, Lin J, et al. (2009) Angiotensin II increases collagen I expression via transforming growth factor-beta1 and extracellular signal-regulated kinase in cardiac fibroblasts. Eur J Pharmacol 606: 115-120.
24. Martin MM, Buckenberger JA, Jiang J, Malana GE, Knoell DL, et al. (2007) TGF-beta1 stimulates human AT1 receptor expression in lung fibroblasts by cross talk between the Smad, p38 MAPK, JNK, and PI3K signaling pathways. Am J Physiol Lung Cell Mol Physiol 293: L790-799.
25. Yan JB, Zhang LJ, Li Q, (2008) [Anti-fibrotic effect of N-acetyl-seryl-aspartyl-lysyl-proline in lung of rat with silicosis]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 26: 401-405.
26. Yang F, Li DD, Li Q, Tian JR, Wei ZQ, et al. (2011) [Effect of N-acetyl-seryl-aspartyl-lysyl-proline on pulmonary fibrosis via inhibiton of TGF-beta 1 mediated Smad pathway in rats with silicosis.]. Xian Dai Yu Fang Yi Xue 38: 4930-4936.
27. Xu H, Song XD, Li Y, Dai J, (2009) [The new method of cells growing on the glass slide]. Zhongguo Ying Yong Sheng Li Xue Za Zhi 25: 283-285.
28. Herzog EL, Bucala R, (2010) Fibrocytes in health and disease. Exp Hematol 38: 548-556.
29. Thiery JP, Acloque H, Huang RY, Nieto MA, (2009) Epithelial-mesenchymal transitions in development and disease. Cell 139: 871-890.
30. Kalluri R, Weinberg RA, (2009) The basics of epithelial-mesenchymal transition. J Clin Invest 119: 1420-1428.
31. Hinz B, Gabbiani G, (2010) Fibrosis: recent advances in myofibroblast biology and new therapeutic perspectives. F1000 Biol Rep 2: 78.
32. Masszi A, Speight P, Charbonney E, Lodyga M, Nakano H, et al. (2010) Fate-determining mechanisms in epithelial-myofibroblast transition: major inhibitory role for Smad3. J Cell Biol 188: 383-399.
33. Kumar CC, Kim JH, Bushel P, Armstrong L, Catino JJ, (1995) Activation of smooth muscle alpha-actin promoter in ras-transformed cells by treatments with antimitotic agents: correlation with stimulation of SRF:SRE mediated gene transcription. J Biochem 118: 1285-1292.
34. Feng XH, Derynck R, (2005) Specificity and versatility in tgf-beta signaling through Smads. Annu Rev Cell Dev Biol 21: 659-693.
35. Derynck R, Zhang YE, (2003) Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 425: 577-584.
36. Rousseau A, Michaud A, Chauvet MT, Lenfant M, Corvol P, (1995) The hemoregulatory peptide N-acetyl-Ser-Asp-Lys-Pro is a natural and specific substrate of the N-terminal active site of human angiotensin-converting enzyme. J Biol Chem 270: 3656-3661.
37. Chou HC, Lang YD, Wang LF, Wu TY, Hsieh YF, et al. (2012) Angiotensin II type 1 receptor antagonist attenuates lung fibrosis in hyperoxia-exposed newborn rats. J Pharmacol Exp Ther 340: 169-175.
38. Molteni A, Wolfe LF, Ward WF, Ts'ao CH, Molteni LB, et al. (2007) Effect of an angiotensin II receptor blocker and two angiotensin converting enzyme inhibitors on transforming growth factor-beta (TGF-beta) and alpha-actomyosin (alpha SMA), important mediators of radiation-induced pneumopathy and lung fibrosis. Curr Pharm Des 13: 1307-1316.
39. Molteni A, Moulder JE, Cohen EF, Ward WF, Fish BL, et al. (2000) Control of radiation-induced pneumopathy and lung fibrosis by angiotensin-converting enzyme inhibitors and an angiotensin II type 1 receptor blocker. Int J Radiat Biol 76: 523-532.