Acute angiotensin-converting enzyme inhibition increases the plasma level of the natural stem cell regulator N-acetyl-seryl-aspartyl-lysyl-proline

Journal of Clinical Investigation

Volumn 97, Issue 3, 1996, Pages 839-844

  Azizi, Michel ^a   Rousseau, Anne ^b   Ezan, Eric ^c   Guyene, Thanh Tam ^a   Michelet, Sandrine ^b   Grognet, Jean Marc ^c   Lenfant, Maryse ^b   Corvol, Pierre ^d   Ménard, Joël ^a  

^a HÔPITAL BROUSSAIS   (France)

^b CNRS   (France)

^c Institut National de la Recherche Agronomique   (France)

^d INSERM   (France)

Author keywords

angiotensin converting enzyme inhibitor; hematopoiesis; metabolism; oligopeptides; peptidyl dipeptidase A

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN I; CAPTOPRIL; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; PLACEBO; RENIN; SERASPENIDE; TETRAPEPTIDE;

ADULT; ARTICLE; CELL CYCLE S PHASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; ENZYME INHIBITION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; HYDROLYSIS; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL;

EID: 0030027331     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118484     Document Type: Article

References (32)

1. Erdos, E. G. 1990. Angiotensin I converting enzyme and the changes in our concepts through the years Hypertension (Dallas). 16.363-370.
2. Skidgel, R. A., and E. G. Erdös. 1987. The broad substrate specificity of human angiotensin I converting enzyme. Clin. Exp. Hypertens. 9:243-259.
3. Rieger, K -J., N. Saez-Servent, M.-P. Papet, J. Wdzieczak-Bakala, J.-L. Morgat, J. Thierry, W. Voelter, and M. Lenfant. 1993. Involvement of human plasma angiotensin I-converting enzyme in the degradation of the haemoregulatory peptide N-acetyl seryl aspartyl lysyl proline. Biochem. J. 296:1-6.
4. Rousseau, A., A. Michaud, M.-T. Chauvet, M. Lenfant, and P. Corvol. 1995. The hemoregulatory peptide N-Acetyl-Ser-Asp-Lys-Pro is a natural and specific substrate of the N-terminal active site of human angiotensin-converting enzyme. J. Biol. Chem. 270:3656-3661.
5. Lenfant, M., J. Wdzieczak-Bakala, E. Guittet, J. C. Prome, D. Sotty, and E. Frindel. 1989. Inhibitor of hematopoietic pluripotent stem cell proliferation: purification and determination of its structure. Proc. Natl. Acad. Sci. USA. 86: 779-782.
6. Bonnet, D., F. M. Lemoine, S. Ponvert-Delucq, C. Baillou, A. Najman, and M. Guignon. 1993. Direct and reversible inhibitory effect of the tetrapeptide acetyl-N-Ser-Asp-Lys-Pro (Serapenide) on the growth of human CD34+ subpopulations in response to growth factors. Blood. 82:3307-3314.
7. Robinson, S., M. Lenfant, J. Wdziecazk-Bakala, J. Melville, and A. Riches. 1992. The mechanism of action of the tetrapeptide Acetyl-N-Ser-Asp-Lys-Pro (AcSDKP) in the control of haematopoietic stem cell proliferation. Cell Proliferation. 25:623-632.
8. Bogden, A. E., P. Carde, E. Deschamps de Paillette, J.-P. Moreau, M. Tubiana, and E. Frindel. 1991. Amelioration of chemotherapy-induced toxicity by cotreatment with AcSDKP, a tetrapeptide inhibitor of hematopoietic stem cell proliferation. Ann. NY Acad. Sci. 628:126-139.
9. Lombard, M. N., D. Sotty, J. Wdzieczak-Bakala, and M. Lenfant. 1990. In vivo effect of the tetrapeptide, N-acetyl-Ser-Asp-Lys-Pro on the G1-S transition of rat hepatocytes. Cell Tissue Kinet 23:99-103
10. Grillon, C., K. Reiger, J. Bakala, D. Schott, D. Morgat, E. Hannappel, W. Voelter, and M. Lenfant. 1990. Involvement of thymosin β4 and endoproteinase asp-N in the biosynthesis of the tetrapeptide Ac-Ser-Asp-Lys-Pro, a regulator of the haematopoietic system. FEBS Lett. 274:30-34.
11. Wdziecazk-Bakala, J., M. P. Fache, M. Lenfant, E. Frindel, and F. Sainteny. 1990. AcSDKP, an inhibitor of CFU-S proliferation is synthesized in mice under steady-state conditions and secreted by bone marrow in long term culture. Leukemia (Baltimore). 4.235-237.
12. Pradelles, P., Y Frobert, C. Crémmon, E. Liozon, A. Massé, and E. Frindel. 1990 Negative regulator of pluripotent hematopoietic stem cell proliferation in human white blood cells and plasma as analysed by enzyme immunoassay. Biochem. Biophys. Res. Commun 170:986-993.
13. Pradelles, P., Y. Frobert, C. Créminon, H. Ivonine, and E. Frindel. 1991. Distribution of a negative regulator of haematopoietic stem cell proliferation (AcSDKP) and thymosin β4 in mouse tissues. FEBS Lett. 289.171-175.
14. Nussberger, J., D. B. Brunner, B Waeber, and H. R. Brunner. 1988. In vitro renin inhibition to prevent generation of angiotensins during determination of angiotensin I and II. Life Sci 42:1683-1688.
15. Ezan, E., P. Carde, J. Le Kerneau, T. Ardouin, F. Thomas, F. Isnard, E. Deschamps de Paillette, and J M. Grognet. 1994. Pharmacokinetics in healthy volunteers and patients of NAc-SDKP (Seraspenide), a negative regulator of hematopoiesis. Drug Metab. Dispos. 22:843-848.
16. Ménard, J., T. T. Guyene, P. Corvol, B. Pau, D. Simon, and R. Roncucci. 1985. Direct radioimnumoassay of active renin in human plasma. J. Hypertens. 3(Suppl. 3):275-278.
17. Cushman, D. W., and M. S. Cheung. 1971. Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung. Biochem. Pharmacol. 20:1637-1648.
18. Imbs, J. L., D. Bakish, M. Schmidt, and J. Schwartz. 1981. Low temperature sustains inhibition of angiotensin converting enzyme activity in serum from patients taking captopril. N. Engl. J. Med. 305:229.
19. Rigat, B., C. Hubert, P. Corvol, and F. Soubrier. 1992. PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase 1). Nucleic Acids Res. 20.1433.
20. Armitage, P., and G. Berry. 1987. The simple cross-over design. In Statistical Methods in Medical Research. Blackwell Scientific Publications, Oxford. 222-226.
21. Juillerat, L., J. Nussberger, J. Ménard, V. Mooser, Y. Christen, B. Waeber, P. Graf, and H. R. Brunner. 1990. Determinants of angiotensin II generation during converting enzyme inhibition. Hypertension (Dallas). 16:564-572.
22. Wei, L., E Clauser, F. Alhenc-Gelas, and P. Corvol. 1992. The two homologous domains of human angiotensin I-converting enzyme interact differently with competitive inhibitors. J. Biol. Chem. 267:13398-13405.
23. Carde, P., C. Chastang, E Goncalves, N. Mathieu-Tubiana, E. Vuillemin, V. Delwail, O. Corbion, A Vekhoff, F. Isnard, J.-M Ferrero, et al. 1992. Séraspénide (acétyl SDKP): étude en phase I-II d'un inhibiteur de l'hématopoièse la protégeant de la toxicité de monochimiothérapies aracytine et ifosfamide. CR Acad. Sci. Paris. 315.545-550.
24. Jaspard, E., L Wei, and F. Alhenc-Gelas. 1993. Differences in the properties and enzymatic specificities of the two active sites of angiotensin I-converting enzyme (kininase II). Studies with bradykinin and other natural peptides. J. Biol. Chem. 268:9496-9503.
25. Wei, L., F. Alhenc-Gelas, P Corvol, and E. Clauser. 1991. The two homologous domains of human angiotensin I-converting enzyme are both catalytically active. J. Biol. Chem. 266:9002-9008.
26. Hirakata, H., K. Onoyama, K. Iseki, H. Kumagai, S. Fujimi, and T. Omae. 1984. Worsening of anemia induced by long-term use of captopril in hemodialysis patients. Am. J. Nephrol. 4:355-360.
27. Vlahakos, D. V., V. J. Canzanello, M. P. Madaio, and N. E. Madias. 1991. Enalapril-associated anemia in renal transplant recipients treated for hypertension. Am. J. Kidney Dis. 17:199-205.
28. Shand, B. I., N. L. Gilchrist, M. G. Nicholls, and R. R. Bailey 1995. Effects of losartan on haematology and haemorheology in elderly patients with essential hypertension: a pilot study. J. Hum. Hypertens. 9:233-236.
29. Powell, J. S., J. P. Clozel, R. K. M Muller, H. Kuhn, F. Hefti, M. Hosang, and H. R. Baumgartner. 1989. Inhibitors of angiotensin-converting enzyme prevent myointimal injury after vascular injury. Science (Wash. DC) 245: 186-188.
30. Ward, W. F., A. Molteni, C. H. Ts'ao, and J. M. Hinz. 1990. Captopril reduces collagen and mast cell accumulation in irradiated rat lung. Int. J. Radiat. Oncol. Biol. Phys. 19:1405-1409.
31. Nguyen, L., W. F. Ward, C. H. Ts'ao, and A. Molteni. 1994. Captopril inhibits proliferation of human lung fibroblasts in culture: a potential antifibrotic mechanism. Proc. Soc. Exp. Biol. Med 205:80-84.
32. Yoon, S. C. J. M. Park, H. S. Jang, K. S. Shinn, and Y. W. Bahk. 1994. Radioprotective effect of captopril on the mouse jejunal mucosa. Int. J. Radiat. Oncol. Biol. Phys. 30:873-878.