메뉴 건너뛰기




Volumn 24, Issue 8, 2012, Pages 1106-1119

Overexpression of Cannabinoid CB2 Receptor in the Brain Induces Hyperglycaemia and a Lean Phenotype in Adult Mice

Author keywords

Body weight; Cnr2; CNS; Diabetes; Glucose homeostasis

Indexed keywords

CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; GALANIN; GLUCAGON; GLUCOSE; PROOPIOMELANOCORTIN;

EID: 84863594672     PISSN: 09538194     EISSN: 13652826     Source Type: Journal    
DOI: 10.1111/j.1365-2826.2012.02325.x     Document Type: Article
Times cited : (51)

References (44)
  • 1
    • 32444440208 scopus 로고    scopus 로고
    • The emerging role of the endocannabinoid system in endocrine regulation and energy balance
    • Pagotto U, Marsicano G, Cota D, Lutz B, Pasquali R. The emerging role of the endocannabinoid system in endocrine regulation and energy balance. Endocr Rev 2006; 27: 73-100.
    • (2006) Endocr Rev , vol.27 , pp. 73-100
    • Pagotto, U.1    Marsicano, G.2    Cota, D.3    Lutz, B.4    Pasquali, R.5
  • 6
    • 33745493475 scopus 로고    scopus 로고
    • Endocannabinoids as novel mediators of liver diseases
    • Mallat A, Lotersztajn S. Endocannabinoids as novel mediators of liver diseases. J Endocrinol Invest 2006; 29: 58-65.
    • (2006) J Endocrinol Invest , vol.29 , pp. 58-65
    • Mallat, A.1    Lotersztajn, S.2
  • 12
    • 78649331179 scopus 로고    scopus 로고
    • Deficiency of CB2 cannabinoid receptor in mice improves insulin sensitivity but increases food intake and obesity with age
    • Agudo J, Martin M, Roca C, Molas M, Bura AS, Zimmer A, Bosch F, Maldonado R. Deficiency of CB2 cannabinoid receptor in mice improves insulin sensitivity but increases food intake and obesity with age. Diabetologia 2010; 53: 2629-2640.
    • (2010) Diabetologia , vol.53 , pp. 2629-2640
    • Agudo, J.1    Martin, M.2    Roca, C.3    Molas, M.4    Bura, A.S.5    Zimmer, A.6    Bosch, F.7    Maldonado, R.8
  • 14
    • 56549089453 scopus 로고    scopus 로고
    • Postsynaptic localization of CB2 cannabinoid receptors in the rat hippocampus
    • Brusco A, Tagliaferro P, Saez T, Onaivi ES. Postsynaptic localization of CB2 cannabinoid receptors in the rat hippocampus. Synapse 2008; 62: 944-949.
    • (2008) Synapse , vol.62 , pp. 944-949
    • Brusco, A.1    Tagliaferro, P.2    Saez, T.3    Onaivi, E.S.4
  • 16
    • 27544439092 scopus 로고    scopus 로고
    • Transgenic mice expressing bovine PrP with a four extra repeat octapeptide insert mutation show a spontaneous, non-transmissible, neurodegenerative disease and an expedited course of BSE infection
    • Castilla J, Gutiérrez-Adán A, Brun A, Pintado B, Salguero FJ, Parra B, Segundo FD, Ramírez MA, Rábano A, Cano MJ, Torres JM. Transgenic mice expressing bovine PrP with a four extra repeat octapeptide insert mutation show a spontaneous, non-transmissible, neurodegenerative disease and an expedited course of BSE infection. FEBS Lett 2005; 579: 6237-6246.
    • (2005) FEBS Lett , vol.579 , pp. 6237-6246
    • Castilla, J.1    Gutiérrez-Adán, A.2    Brun, A.3    Pintado, B.4    Salguero, F.J.5    Parra, B.6    Segundo, F.D.7    Ramírez, M.A.8    Rábano, A.9    Cano, M.J.10    Torres, J.M.11
  • 21
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001; 25: 402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 22
    • 84855340630 scopus 로고    scopus 로고
    • Chronic blockade of cannabinoid CB(2) receptors induces anxiolytic-like actions associated to alterations in GABA(A) receptors
    • García-Gutiérrez MS, García-Bueno B, Zoppi S, Leza JC, Manzanares J. Chronic blockade of cannabinoid CB(2) receptors induces anxiolytic-like actions associated to alterations in GABA(A) receptors. Br J Pharmacol 2012; 165: 951-964.
    • (2012) Br J Pharmacol , vol.165 , pp. 951-964
    • García-Gutiérrez, M.S.1    García-Bueno, B.2    Zoppi, S.3    Leza, J.C.4    Manzanares, J.5
  • 23
    • 67649563560 scopus 로고    scopus 로고
    • The endocannabinoid system as a link between homoeostatic and hedonic pathways involved in energy balance regulation
    • Di Marzo V, Ligresti A, Cristino L. The endocannabinoid system as a link between homoeostatic and hedonic pathways involved in energy balance regulation. Int J Obes (Lond) 2009; 33: S18-S24.
    • (2009) Int J Obes (Lond) , vol.33
    • Di Marzo, V.1    Ligresti, A.2    Cristino, L.3
  • 24
    • 84856481281 scopus 로고    scopus 로고
    • The role of the endocannabinoid system in the neuroendocrine regulation of energy balance
    • Bermudez-Silva FJ, Cardinal P, Cota D. The role of the endocannabinoid system in the neuroendocrine regulation of energy balance. J Psychopharmacol 2012; 26: 114-124.
    • (2012) J Psychopharmacol , vol.26 , pp. 114-124
    • Bermudez-Silva, F.J.1    Cardinal, P.2    Cota, D.3
  • 25
    • 35548953757 scopus 로고    scopus 로고
    • CB1 receptors: emerging evidence for central and peripheral mechanisms that regulate energy balance, metabolism, and cardiovascular health
    • Cota D. CB1 receptors: emerging evidence for central and peripheral mechanisms that regulate energy balance, metabolism, and cardiovascular health. Diabetes Metab Res Rev 2007; 23: 507-517.
    • (2007) Diabetes Metab Res Rev , vol.23 , pp. 507-517
    • Cota, D.1
  • 26
    • 43249100162 scopus 로고    scopus 로고
    • Targeting the endocannabinoid system: to enhance or reduce?
    • Di Marzo V. Targeting the endocannabinoid system: to enhance or reduce? Nat Rev Drug Discov 2008; 7: 438-455.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 438-455
    • Di Marzo, V.1
  • 30
    • 48249140762 scopus 로고    scopus 로고
    • Immunohistochemical description of the endogenous cannabinoid system in the rat cerebellum and functionally related nuclei
    • Suárez J, Bermúdez-Silva FJ, Mackie K, Ledent C, Zimmer A, Cravatt BF, de Fonseca FR. Immunohistochemical description of the endogenous cannabinoid system in the rat cerebellum and functionally related nuclei. J Comp Neurol 2008; 509: 400-421.
    • (2008) J Comp Neurol , vol.509 , pp. 400-421
    • Suárez, J.1    Bermúdez-Silva, F.J.2    Mackie, K.3    Ledent, C.4    Zimmer, A.5    Cravatt, B.F.6    de Fonseca, F.R.7
  • 31
    • 84863011465 scopus 로고    scopus 로고
    • CNS effects of CB2 cannabinoid receptors: beyond neuro-immuno-cannabinoid activity
    • Onaivi ES, Ishiguro H, Gu S, Liu QR. CNS effects of CB2 cannabinoid receptors: beyond neuro-immuno-cannabinoid activity. J Psychopharmacol 2012; 26: 92-103.
    • (2012) J Psychopharmacol , vol.26 , pp. 92-103
    • Onaivi, E.S.1    Ishiguro, H.2    Gu, S.3    Liu, Q.R.4
  • 35
    • 53549118886 scopus 로고    scopus 로고
    • Behavioral effects of CB2 cannabinoid receptor activation and its influence on food and alcohol consumption
    • Onaivi ES, Carpio O, Ishiguro H, Schanz N, Uhl GR, Benno R. Behavioral effects of CB2 cannabinoid receptor activation and its influence on food and alcohol consumption. Ann NY Acad Sci 2008; 1139: 426-433.
    • (2008) Ann NY Acad Sci , vol.1139 , pp. 426-433
    • Onaivi, E.S.1    Carpio, O.2    Ishiguro, H.3    Schanz, N.4    Uhl, G.R.5    Benno, R.6
  • 36
    • 72449209233 scopus 로고    scopus 로고
    • A nonsynonymous polymorphism in cannabinoid CB2 receptor gene is associated with eating disorders in humans and food intake is modified in mice by its ligands
    • Ishiguro H, Carpio O, Horiuchi Y, Shu A, Higuchi S, Schanz N, Benno R, Arinami T, Onaivi ES. A nonsynonymous polymorphism in cannabinoid CB2 receptor gene is associated with eating disorders in humans and food intake is modified in mice by its ligands. Synapse 2010; 64: 92-96.
    • (2010) Synapse , vol.64 , pp. 92-96
    • Ishiguro, H.1    Carpio, O.2    Horiuchi, Y.3    Shu, A.4    Higuchi, S.5    Schanz, N.6    Benno, R.7    Arinami, T.8    Onaivi, E.S.9
  • 37
    • 78650595351 scopus 로고    scopus 로고
    • Overexpression of CB2 cannabinoid receptors decreased vulnerability to anxiety and impaired anxiolytic action of alprazolam in mice
    • García-Gutiérrez MS, Manzanares J. Overexpression of CB2 cannabinoid receptors decreased vulnerability to anxiety and impaired anxiolytic action of alprazolam in mice. J Psychopharmacol 2011; 25: 111-120.
    • (2011) J Psychopharmacol , vol.25 , pp. 111-120
    • García-Gutiérrez, M.S.1    Manzanares, J.2
  • 38
    • 27144550404 scopus 로고    scopus 로고
    • Differential regulation of synaptic inputs by constitutively released endocannabinoids and exogenous cannabinoids
    • Hentges ST, Low MJ, Williams JT. Differential regulation of synaptic inputs by constitutively released endocannabinoids and exogenous cannabinoids. J Neurosci 2005; 25: 9746-9751.
    • (2005) J Neurosci , vol.25 , pp. 9746-9751
    • Hentges, S.T.1    Low, M.J.2    Williams, J.T.3
  • 39
    • 66449135959 scopus 로고    scopus 로고
    • Involvement of hypothalamic peptides in the anorectic action of the CB receptor antagonist rimonabant (SR 141716)
    • Verty AN, Boon WM, Mallet PE, McGregor IS, Oldfield BJ. Involvement of hypothalamic peptides in the anorectic action of the CB receptor antagonist rimonabant (SR 141716). Eur J Neurosci 2009; 29: 2207-2216.
    • (2009) Eur J Neurosci , vol.29 , pp. 2207-2216
    • Verty, A.N.1    Boon, W.M.2    Mallet, P.E.3    McGregor, I.S.4    Oldfield, B.J.5
  • 40
    • 79951672612 scopus 로고    scopus 로고
    • Effects of cannabinoids on neuropeptide Y and β-endorphin expression in the rat hypothalamic arcuate nucleus
    • Bakkali-Kassemi L, El Ouezzani S, Magoul R, Merroun I, Lopez-Jurado M, Errami M. Effects of cannabinoids on neuropeptide Y and β-endorphin expression in the rat hypothalamic arcuate nucleus. Br J Nutr 2011; 105: 654-660.
    • (2011) Br J Nutr , vol.105 , pp. 654-660
    • Bakkali-Kassemi, L.1    El Ouezzani, S.2    Magoul, R.3    Merroun, I.4    Lopez-Jurado, M.5    Errami, M.6
  • 42
    • 3543040629 scopus 로고    scopus 로고
    • Transient receptor potential vanilloid subfamily 1 expressed in pancreatic islet beta cells modulates insulin secretion in rats
    • Akiba Y, Kato S, Katsube K, Nakamura M, Takeuchi K, Ishii H, Hibi T. Transient receptor potential vanilloid subfamily 1 expressed in pancreatic islet beta cells modulates insulin secretion in rats. Biochem Biophys Res Commun 2004; 321: 219-225.
    • (2004) Biochem Biophys Res Commun , vol.321 , pp. 219-225
    • Akiba, Y.1    Kato, S.2    Katsube, K.3    Nakamura, M.4    Takeuchi, K.5    Ishii, H.6    Hibi, T.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.