Transgenic mice expressing bovine PrP with a four extra repeat octapeptide insert mutation show a spontaneous, non-transmissible, neurodegenerative disease and an expedited course of BSE infection

FEBS Letters

Volumn 579, Issue 27, 2005, Pages 6237-6246

  Castilla, J ^a   Gutierrez Adan A ^b   Brun, A ^a   Pintado, B ^b   Salguero, F J ^a   Parra, B ^a   Diaz San Segundo F ^a   Ramirez M A ^b   Rabano A ^c   Cano, M J ^a   Torres, J M ^a  

^a Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria   (Spain)

^b INIA   (Spain)

^c HOSPITAL UNIVERSITARIO FUNDACIÓN ALCORCÓN   (Spain)

Author keywords

Genetic encephalopathy; Neuropathology; Octapeptide repeats; Prion; PrP; Scrapie; Transgenic

Indexed keywords

OCTAPEPTIDE; PRION PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATAXIA; BOVINE SPONGIFORM ENCEPHALOPATHY; BRAIN REGION; CELL VACUOLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; DISEASE COURSE; EMBRYO; FEMALE; GENE EXPRESSION; GENE INSERTION; GLIOSIS; GRANULE CELL; INOCULATION; MOUSE; NEUROPATHOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRION DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENE; TRANSGENIC MOUSE; WILD TYPE;

ANIMALS; CATTLE; CEREBELLUM; ENCEPHALOPATHY, BOVINE SPONGIFORM; ENDOPEPTIDASE K; HIPPOCAMPUS; MICE; MICE, TRANSGENIC; MUTATION; NEURODEGENERATIVE DISEASES; PRIONS; REPETITIVE SEQUENCES, AMINO ACID;

ANIMALIA; ATAXIA; BOVINAE; MUS MUSCULUS;

EID: 27544439092     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2005.09.099     Document Type: Article

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