PI3K-γ inhibition ameliorates acute lung injury through regulation of IκBα/NF-κB pathway and innate immune responses

Journal of Clinical Immunology

Volumn 32, Issue 2, 2012, Pages 340-351

  Kim, Dong Im ^a   Kim, So Ri ^a   Kim, Hee Jung ^a   Lee, Su Jeong ^a   Lee, Heung Bum ^a   Park, Seoung Ju ^a   Im, Mie Jae ^a   Lee, Yong Chul ^a  

^a Chonbuk National University Medical School   (South Korea)

Author keywords

Acute lung injury; Innate immunity; NF B; PI3K ; TLR4

Indexed keywords

5 (6 QUINOXALINYLMETHYLENE) 2,4 THIAZOLIDINEDIONE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; INTERLEUKIN 4; LIPOPOLYSACCHARIDE; MYELOPEROXIDASE; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; REACTIVE OXYGEN METABOLITE; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN; 2,4 THIAZOLIDINEDIONE DERIVATIVE; 5 QUINOXALIN 6 YLMETHYLENETHIAZOLIDINE 2,4 DIONE; 5-QUINOXALIN-6-YLMETHYLENETHIAZOLIDINE-2,4-DIONE; AUTACOID; CYTOKINE; I KAPPA B; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA; PEROXIDASE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; PIK3CG PROTEIN, MOUSE; QUINOXALINE DERIVATIVE; VASCULOTROPIN A;

ACUTE LUNG INJURY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; INNATE IMMUNITY; LUNG PARENCHYMA; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PNEUMONIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; VASCULAR DISEASE; VASCULAR LEAKAGE; ANIMAL; C57BL MOUSE; CELL NUCLEUS; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; IMMUNOLOGY; METABOLISM; PATHOLOGY; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

ACUTE LUNG INJURY; ANIMALS; CELL NUCLEUS; CLASS IB PHOSPHATIDYLINOSITOL 3-KINASE; CYTOKINES; DENDRITIC CELLS; ENZYME ACTIVATION; FEMALE; I-KAPPA B PROTEINS; IMMUNITY, INNATE; INFLAMMATION MEDIATORS; INTERCELLULAR ADHESION MOLECULE-1; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; NF-KAPPA B; PEROXIDASE; PROTEIN TRANSPORT; QUINOXALINES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; THIAZOLIDINEDIONES; TOLL-LIKE RECEPTOR 4; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84863575573     PISSN: 02719142     EISSN: 15732592     Source Type: Journal    
DOI: 10.1007/s10875-011-9628-1     Document Type: Article

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