IL-4 pretreatment selectively enhances cytokine and chemokine production in lipopolysaccharide-stimulated mouse peritoneal macrophages

Journal of Immunology

Volumn 168, Issue 5, 2002, Pages 2456-2463

  Major, Jennifer ^a   Fletcher, Julia E ^a   Hamilton, Thomas A ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOHEXIMIDE; INTERLEUKIN 1; INTERLEUKIN 12; INTERLEUKIN 4; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 2; PROTEIN SYNTHESIS INHIBITOR; STAT6 PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE ACTIVATION; GENE EXPRESSION; MOUSE; NONHUMAN; NORTHERN BLOTTING; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; RNA TRANSLATION;

EID: 0036498561     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.5.2456     Document Type: Article

References (44)

1. Interleutkin-4: A prototypic immunoregulatory lymphokine
2. Interleukin 4: Signalling mechanisms and control of T cell differentiation
3. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells
4. Regulation of macrophage gene expression by T cell derived lymphokines
5. IL-4 inhibits the production of TNF-α and IL-12 by STAT6-dependent and -independent mechanisms
6. IL-4 and IL-13 modulate IL-10 release in endotoxin-stimulated murine peritoneal mononuclear phagocytes
7. Interleukin-4 suppresses inflammatory cytokine gene transcription in porcine macrophages
8. IL-4 reciprocally regulates IL-1 and IL-1 receptor antagonist expression in human monocytes
9. Regulation of macrophage gene expression by pro- and anti-inflammatory cytokines
10. Dendritic cells
11. IL-4 is a mediator of IL-12p70 induction by human Th2 cells: Reversal of polarized Th2 phenotype by dendritic cells
12. IL-4 exacerbates disease in a Th1 cell transfer model of colitis
13. Myeloid dendritic cells
14. Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: Priming for IL-12 and tumor necrosis factor α production
15. Interleukin-4 regulates macrophage interleukin-12 protein synthesis through a c-fos mediated mechanism
16. STAT6 is required for the anti-inflammatory activity of interleukin-4 in mouse peritoneal macrophages
17. Interleukin-4/STAT6 represses STAT1 and NF-κB-dependent transcription through distinct mechanisms
18. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene
19. Oxidized LDL potentiates LPS-induced transcription of the chemokine KC gene
20. IL-4 suppresses cytokine gene expression induced by IFN-γ and/or IL-2 in murine peritoneal macrophages
21. Isolation of biologically active RNA from sources enriched in ribonuclease
22. TIA-1 is a translational silencer that selectively regulates the expression of TNF-α
23. An update on interleukin-4 and its receptor
24. Alternative versus classical activation of macrophages
25. Interferon-stimulated response element and NFκB sites cooperate to regulate double-stranded RNA-induced transcription of the IP-10 gene
26. IFN-γ and IL-2 cooperatively activate NFκB in murine peritoneal macrophages
27. IL-13 and IL-4 share signal transduction elements as well as receptor components in TF-1 cells
28. Interleukin-4 and interlieukin-13: Their similarities and discrepancies
29. IL-4 attenuates the transcriptional activation of both IFN-α- and IFN-γ-induced cellular gene expression in monocytes and monocytic cell lines
30. Mechanisms of IL-4-mediated suppression of IP-10 gene expression in murine macrophages
31. Paired Stat6 C-terminal transcription activation domains required both for inhibition of an IFN-responsive promoter and trans-activation
32. Essential role of Stat6 in IL-4 signalling
33. IL-4-induced expression of the IL-1 receptor antagonist gene is mediated by STAT6
34. Requirements for interleukin-4-induced gene expression and functional characterization of Stat6
35. Interleukin-4-induced STAT6 recognizes and activates a target site in the promoter of the interleukin-4 receptor gene
36. STAT6: Its role in interleukin 4-mediated biological functions
37. mRNA stability in mammalian cells
38. The cap-to-tail guide to mRNA turnover
39. From factors to mechanisms: Translation and translational control in eukaryotes
40. The essential role of the UA-rich sequence in endotoxin-induced cachectin/TNF synthesis
41. Translational blockade imposed by cytokine-derived UA-rich sequences
42. Interleukin-4 and interleukin-13 inhibit tumor necrosis factor-α mRNA translational activation in lipopolysaccharide-induced mouse macrophages
43. Receptors and cytokines involved in allergic TH2 cell responses
44. IL-13 in allergy: Home at last