-
3
-
-
2542510245
-
ICH-Harmonised guidances on genotoxicity testing of pharmaceuticals: Evolution, reasoning and impact
-
DOI 10.1016/S1383-5742(99)00004-6, PII S1383574299000046
-
Müller, L., Kikuchi, Y., Probst, G., Schechtman, L., Shimada, H., Sofuni, T. and Tweats, D. (1999) ICH-harmonized guidance on genotoxicity testing of pharmaceuticals; evolution, reasoning and impact. Mutat. Res., 436, 195-225. (Pubitemid 29246090)
-
(1999)
Mutation Research - Reviews in Mutation Research
, vol.436
, Issue.3
, pp. 195-225
-
-
Muller, L.1
Kikuchi, Y.2
Probst, G.3
Schechtman, L.4
Shimada, H.5
Sofuni, T.6
Tweats, D.7
-
5
-
-
0242293690
-
-
US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER)
-
US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER). (1997) Guidance for Industry. S1B. Testing for Carcinogenicity of Pharmaceuticals.
-
(1997)
Guidance for Industry. S1B. Testing for Carcinogenicity of Pharmaceuticals
-
-
-
7
-
-
0035012857
-
A review of the genotoxicity of marketed pharmaceuticals
-
DOI 10.1016/S1383-5742(01)00055-2, PII S1383574201000552
-
Snyder, R. D. and Green, J. W. (2001) A review of the genotoxicity of marketed pharmaceuticals. Mutat. Res., 488, 151-169. (Pubitemid 32436429)
-
(2001)
Mutation Research - Reviews in Mutation Research
, vol.488
, Issue.2
, pp. 151-169
-
-
Snyder, R.D.1
Green, J.W.2
-
10
-
-
19944372857
-
-
59th edn. Thomson PDR, Montvale, NJ
-
(2005) Physicians' Desk Reference. 59th edn. Thomson PDR, Montvale, NJ.
-
(2005)
Physicians' Desk Reference
-
-
-
11
-
-
84870940120
-
-
U.S. National Library of Medicine-Toxnet, Toxicology Data Network. http://www.toxnet.nlm.nih.gov.
-
Toxicology Data Network
-
-
-
12
-
-
84863519878
-
Some antiviral and antineoplastic drugs, and other pharmaceutical agents
-
International Agency for Research on Cancer
-
International Agency for Research on Cancer. (2000) Some antiviral and antineoplastic drugs, and other pharmaceutical agents. IARC Monogr. Eval. Carcinog. Risks Hum., 76, 47-71.
-
(2000)
IARC Monogr. Eval. Carcinog. Risks Hum.
, vol.76
, pp. 47-71
-
-
-
13
-
-
0037194665
-
Comparative analysis of DNA breakage, chromosomal aberrations and apoptosis induced by the anti-herpes purine nucleoside analogues aciclovir, ganciclovir and penciclovir
-
Tomicic, M. T., Bey, E., Wutzler, P., Thust, R. and Kaina, B. (2002) Comparative analysis of DNA breakage, chromosomal aberrations and apoptosis induced by the anti-herpes purine nucleoside analogues aciclovir, ganciclovir and penciclovir. Mutat. Res., 505, 1-11.
-
(2002)
Mutat. Res.
, vol.505
, pp. 1-11
-
-
Tomicic, M.T.1
Bey, E.2
Wutzler, P.3
Thust, R.4
Kaina, B.5
-
14
-
-
0023855146
-
A comparative analysis of data on the clastogenicity of 951 chemical substances tested in mammalian cell cultures
-
Ishidate, M. Jr., Harnois, M. C. and Sofuni, T. (1988) A comparative analysis of data on the clastogenicity of 951 chemical substances tested in mammalian cell cultures. Mutat. Res., 195, 151-213. (Pubitemid 18066068)
-
(1988)
Mutation Research
, vol.195
, Issue.2
, pp. 151-213
-
-
Ishidate Jr., M.1
Harnois, M.C.2
Sofuni, T.3
-
15
-
-
0003459737
-
-
International Agency for Research on Cancer. Pharmaceutical Drugs, IARC, Lyon, France
-
International Agency for Research on Cancer. (1990). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 50. Pharmaceutical Drugs, IARC, Lyon, France.
-
(1990)
IARC Monographs on the Evaluation of Carcinogenic Risks to Humans
, vol.50
-
-
-
16
-
-
0027235350
-
Preclinical toxicology studies with azithromycin: Genetic toxicology evaluation
-
Amacher, D. E., Ellis, J. H. Jr., Joice, A. J., Muehlbauer, P. A., Turner, G. N., Wahrenburg, M. G., Holden, H. E. and Ray, V. A. (1993) Preclinical toxicology studies with azithromycin: genetic toxicology evaluation. Mutat. Res., 300, 79-90. (Pubitemid 23181724)
-
(1993)
Mutation Research - Genetic Toxicology Testing and Biomonitoring of Environmental or Occupational Exposure
, vol.300
, Issue.2
, pp. 79-90
-
-
Amacher, D.E.1
Ellis Jr., J.H.2
Joyce, A.J.3
Muehlbauer, P.A.4
Turner, G.N.5
Wahrenburg, M.G.6
Holden, H.E.7
Ray, V.A.8
-
17
-
-
0023493481
-
Frameshift mutagenesis by chloroquine in Escherichia coli and Salmonella typhimurium
-
Thomas, S. M., Silburn, K. A. and MacPhee, D. G. (1987) Frameshift mutagenesis by chloroquine in Escherichia coli and Salmonella typhimurium. Mutat. Res., 192, 233-237. (Pubitemid 18002291)
-
(1987)
Mutation Research
, vol.192
, Issue.4
, pp. 233-237
-
-
Thomas, S.M.1
Silburn, K.A.2
MacPhee, D.G.3
-
18
-
-
0024560465
-
Influence of the UVR-repair system on the mutagenicity of antiparasitic drugs
-
Espinosa-Aguirre, J. J., Ramirez Santos, J. and Cortinas de Nava, C. (1989) Influence of the UVR-repair system on the mutagenicity of antiparasitic drugs. Mutat. Res., 222, 161-166.
-
(1989)
Mutat. Res.
, vol.222
, pp. 161-166
-
-
Espinosa-Aguirre, J.J.1
Ramirez Santos, J.2
Cortinas De Nava, C.3
-
19
-
-
0022965360
-
Comparison of the Ames assay and the induction of sister chromatid exchanges: Results with ten pharmaceuticals and five selected agents
-
198
-
Shubber, E. K., Jacobson-Kram, D. and Williams, J. R. (198) Comparison of the Ames assay and the induction of sister chromatid exchanges: results with ten pharmaceuticals and five selected agents. Cell Biol. Toxicol., 2, 379-399.
-
Cell Biol. Toxicol.
, vol.2
, pp. 379-399
-
-
Shubber, E.K.1
Jacobson-Kram, D.2
Williams, J.R.3
-
20
-
-
0021688019
-
Mutagenicity examination of several non-steroidal anti-inflammatory drugs in bacterial systems
-
Kadotani, S., Arisawa, M. and Maruyama, H. B. (1984) Mutagenicity examination of several non-steroidal anti-inflammatory drugs in bacterial systems. Mutat. Res., 138, 133-136. (Pubitemid 15178009)
-
(1984)
Mutation Research
, vol.138
, Issue.2-3
, pp. 133-136
-
-
Kadotani, S.1
Arisawa, M.2
Maruyama, H.B.3
-
21
-
-
0025077877
-
The comparative responses of Salmonella typhimurium TA1537 and TA97A to a range of reference mutagens and novel compounds
-
O'Donovan, M. R. (1990) The comparative responses of Salmonella typhimurium TA1537 and TA97A to a range of reference mutagens and novel compounds. Mutagenesis, 5, 267-274.
-
(1990)
Mutagenesis
, vol.5
, pp. 267-274
-
-
O'Donovan, M.R.1
-
22
-
-
0021590871
-
Evaluation of microbial testing methods for the mutagenicity of quinoline and its derivatives
-
Sideropoulos, A. S. and Specht, S. M. (1984) Evaluation of microbial testing methods for the mutagenicity of quinoline and its derivatives. Curr. Microbiol., 11, 59-65.
-
(1984)
Curr. Microbiol.
, vol.11
, pp. 59-65
-
-
Sideropoulos, A.S.1
Specht, S.M.2
-
23
-
-
0031726186
-
Comparative mutagenic and genotoxic effects of three antimalarial drugs, chloroquine, primaquine and amodiaquine
-
Chatterjee, T., Mukopadhyay, A., Khan, K. A. and Giri, K. (1998) Comparative mutagenic and genotoxic effects of three antimalarial drugs, chloroquine, primaquine and amodiaquine. Mutagenesis, 13, 619-624. (Pubitemid 28523826)
-
(1998)
Mutagenesis
, vol.13
, Issue.6
, pp. 619-624
-
-
Chatterjee, T.1
Muhkopadhyay, A.2
Khan, K.A.3
Giri, A.K.4
-
24
-
-
84874189614
-
-
Center for Drug Evaluation and Research
-
FDA, Center for Drug Evaluation and Research. http://www.FDA.gov.cder.
-
-
-
-
25
-
-
0021883903
-
Mutagenicity of N-acetyl and N,N'-diacetyl derivatives of 3 aromatic amines used as epoxy-resin hardeners
-
Tanaka, K., Ino, T., Sawahata, T., Marui, S., Igaki, H. and Yashima, H. (1985) Mutagenicity of N-acetyl and N, N′-diacetyl derivatives of 3 aromatic amines used as epoxy-resin hardeners. Mutat. Res., 143, 11-15. (Pubitemid 15005780)
-
(1985)
Mutation Research
, vol.143
, Issue.1-2
, pp. 11-15
-
-
Tanaka, K.1
Ino, T.2
Sawahata, T.3
-
26
-
-
0142036542
-
Mutagenicity assessment in 44 epoxy resin hardeners in Salmonella typhimurium tester strains
-
Takahashi, A. and Ono, H. (1993) Mutagenicity assessment in 44 epoxy resin hardeners in Salmonella typhimurium tester strains. Chem. Exp., 8, 785-788.
-
(1993)
Chem. Exp.
, vol.8
, pp. 785-788
-
-
Takahashi, A.1
Ono, H.2
-
27
-
-
84863530371
-
Some pharmaceutical drugs
-
IARC
-
IARC. (1980) Some pharmaceutical drugs. IARC Monogr. Eval. Carcinog. Risk Hum., 24, 59-76.
-
(1980)
IARC Monogr. Eval. Carcinog. Risk Hum.
, vol.24
, pp. 59-76
-
-
-
28
-
-
0022330775
-
Reproducibility of microbial mutagenicity assays: II. Testing of carcinogens and noncarcinogens in Salmonella thyphimurium and Escherichia coli
-
Dunkel, V. C., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H. S. and Simmon, V. F. (1985) Reproducibility of microbial mutagenicity assays: II. Testing of carcinogens and noncarcinogens in Salmonella thyphimurium and Escherichia coli. Environ. Mol. Mutagen., 7 (Suppl. 5), 1-248.
-
(1985)
Environ. Mol. Mutagen.
, vol.7
, Issue.SUPPL. 5
, pp. 1-248
-
-
Dunkel, V.C.1
Zeiger, E.2
Brusick, D.3
McCoy, E.4
McGregor, D.5
Mortelmans, K.6
Rosenkranz, H.S.7
Simmon, V.F.8
-
29
-
-
84863515717
-
-
NCI/NTP. National Cancer Institute/National Toxicology Program; U.S. Department of Health and Human Services, TR-20
-
NCI/NTP. (1977) Carcinogenesis Technical Report Series; National Cancer Institute/National Toxicology Program; U.S. Department of Health and Human Services, TR-20.
-
(1977)
Carcinogenesis Technical Report Series
-
-
-
30
-
-
0021257162
-
Splenic fibrosis and sarcomas in F344 rats fed diets containing aniline hydrochloride, p-chloroaniline, azobenzene, o-toluidine hydrochloride, 4,4'-sulfonyldianiline, or D & C red No. 9
-
Goodman, D. G., Ward, J. M. and Reichardt, W. D. (1984) Splenic fibrosis and sarcomas in F344 rats fed diets containing aniline hydrochloride, p-chloroaniline, azobenzene, o-toluidine hydrochloride, 4,4′- sulfonyldianiline, or D & C red No. 9. J. Natl Cancer Inst., 73, 265-273. (Pubitemid 14090855)
-
(1984)
Journal of the National Cancer Institute
, vol.73
, Issue.1
, pp. 265-273
-
-
Goodman, D.G.1
Ward, J.M.2
Reichardt, W.D.3
-
31
-
-
59449086578
-
Evaluation of mutagenicity of ethambutol hydrochloride using Ames test
-
Shaheen, S. and Rao, M. S. (1990) Evaluation of mutagenicity of ethambutol hydrochloride using Ames test. Trends Life Sci., 5, 7-9.
-
(1990)
Trends Life Sci.
, vol.5
, pp. 7-9
-
-
Shaheen, S.1
Rao, M.S.2
-
32
-
-
0025352906
-
The in vivo micronucleus assay in mammalian bone marrow and peripheral blood. A report of the U.S. Environmental Protection Agency Gene-Tox Program
-
Mavournin, K. H., Blakey, D. H., Cimino, M. C., Salamone, M. F. and Heddle, J. H. (1990) The in vivo micronucleus assay in mammalian bone marrow and peripheral blood. A report of the U.S. Environmental Protection Agency Gene-Tox Program. Mutat. Res., 239, 29-80.
-
(1990)
Mutat. Res.
, vol.239
, pp. 29-80
-
-
Mavournin, K.H.1
Blakey, D.H.2
Cimino, M.C.3
Salamone, M.F.4
Heddle, J.H.5
-
33
-
-
0023704076
-
Salmonella mutagenicity tests: IV. Results from the testing of 300 chemicals
-
Zeiger, E., Anderson, B., Haworth, S., Lawlor, T. and Mortelmans, K. (1988) Salmonella mutagenicity tests: IV. Results from the testing of 300 chemicals. Environ. Mol. Mutagen., 11 (Suppl. 12), 1-158.
-
(1988)
Environ. Mol. Mutagen.
, vol.11
, Issue.SUPPL. 12
, pp. 1-158
-
-
Zeiger, E.1
Anderson, B.2
Haworth, S.3
Lawlor, T.4
Mortelmans, K.5
-
34
-
-
84916143058
-
-
NCI/NTP. National Cancer Institute/National Toxicology Program; US Department of Health and Human Services, TR-46
-
NCI/NTP. (1978) Carcinogenesis Technical Report Series; National Cancer Institute/National Toxicology Program; US Department of Health and Human Services, TR-46.
-
(1978)
Carcinogenesis Technical Report Series
-
-
-
35
-
-
0031831669
-
Chromosome aberrations in vitro related to cytotoxicity of nonmutagenic chemicals and metabolic poisons
-
DOI 10.1002/(SICI)1098-2280(1998)31:4<316::AID-EM3>3.0.CO;2-G
-
Hilliard, C. A., Armstrong, M. J., Bradt, C. I., Hill, R. B., Greenwood, S. K. and Galloway, S. M. (1998) Chromosome aberrations in vitro related to cytotoxicity of nonmutagenic chemicals and metabolic poisons. Environ. Mol. Mutagen., 31, 316-326. (Pubitemid 28308461)
-
(1998)
Environmental and Molecular Mutagenesis
, vol.31
, Issue.4
, pp. 316-326
-
-
Hilliard, C.A.1
Armstrong, M.J.2
Bradt, C.I.3
Hill, R.B.4
Greenwood, S.K.5
Galloway, S.M.6
-
36
-
-
3042929672
-
Sister-chromatid exchange: Second report of the Gene-Tox Program
-
DOI 10.1016/0165-1110(93)90001-4
-
Tucker, J. D., Auletta, A., Cimino, M. C., Dearfield, K. L., Jacobson-Kram, D., Tice, R. R. and Carrano, A. V. (1993) Sister-chromatid exchange: second report of the Gene-Tox Program. Mutat. Res., 297, 101-180. (Pubitemid 23214970)
-
(1993)
Mutation Research - Reviews in Genetic Toxicology
, vol.297
, Issue.2
, pp. 101-180
-
-
Tucker, J.D.1
Auletta, A.2
Cimino, M.C.3
Dearfield, K.L.4
Jacobson-Kram, D.5
Tice, R.R.6
Carrano, A.V.7
-
37
-
-
84863513794
-
-
International Agency for Research on Cancer. Some Miscellaneous Pharmaceutical Substances. IARC, Lyon, France
-
International Agency for Research on Cancer. (1977). IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man, Vol. 13. Some Miscellaneous Pharmaceutical Substances. IARC, Lyon, France, pp. 83-89.
-
(1977)
IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man
, vol.13
, pp. 83-89
-
-
-
38
-
-
0011531579
-
-
International Agency for Research on Cancer. Some Thyrotropic Agents, IARC, Lyon, France
-
International Agency for Research on Cancer. (2001). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 79. Some Thyrotropic Agents, IARC, Lyon, France, pp. 291-315.
-
(2001)
IARC Monographs on the Evaluation of Carcinogenic Risks to Humans
, vol.79
, pp. 291-315
-
-
-
39
-
-
0023034964
-
The Salmonella typhimurium mammalian microsomal assay. A report of the U.S. Environmental Protection Agency Gene-Tox Program
-
Kier, L. E., Brusik, D. J., Auletta, A. E. et al. (1986) The Salmonella typhimurium mammalian microsomal assay. A report of the U.S. Environmental Protection Agency Gene-Tox Program. Mutat. Res., 168, 9-240.
-
(1986)
Mutat. Res.
, vol.168
, pp. 9-240
-
-
Kier, L.E.1
Brusik, D.J.2
Auletta, A.E.3
-
40
-
-
0026503111
-
Salmonella mutagenicity tests. V. Results from the testing of 311 chemicals
-
Zeiger, E., Anderson, B., Haworth, S., Lawlor, T. and Mortelmans, K. (1992) Salmonella mutagenicity tests. V. Results from the testing of 311 chemicals. Environ. Mol. Mutagen., 18 (Suppl. 21), 2-141.
-
(1992)
Environ. Mol. Mutagen.
, vol.18
, Issue.SUPPL. 21
, pp. 2-141
-
-
Zeiger, E.1
Anderson, B.2
Haworth, S.3
Lawlor, T.4
Mortelmans, K.5
-
41
-
-
0021267081
-
Testing of chemicals for genetic activity with Saccharomyces cerevisiae: A report of the US Environmental Protection Agency Gene-Tox Program
-
Zimermann, F. K., Von Borstel, R. C., Von Halle, E. S., Parry, J. M., Siebert, D., Zetterberg, G., Barale, R. and Loprieno, N. (1984) Testing of chemicals for genetic activity with Saccharomyces cerevisiae: a report of the U.S. Environmental Protection Agency Gene-Tox Program. Mutat. Res., 133, 199-244. (Pubitemid 14105533)
-
(1984)
Mutation Research
, vol.133
, Issue.3
, pp. 199-244
-
-
Zimmermann, F.K.1
Von Borstel, R.C.2
Von Halle, E.S.3
-
42
-
-
49049133783
-
Aspergillus nidulans: Systems and results of tests for chemical induction of mitotic segregation and mutation. I. Diploid and duplication assay systems
-
Käfer, E., Scott, B. R., Dorn, G. L. and Stafford, R. (1982) Aspergillus nidulans: systems and results of tests for chemical induction of mitotic segregation and mutation. I. Diploid and duplication assay systems. A report of the U.S. EPA Gene-Tox Program. Mutat. Res., 98, 1-48. (Pubitemid 12163274)
-
(1982)
Mutation Research
, vol.98
, Issue.1
, pp. 1-48
-
-
Kafer, E.1
Scott, B.R.2
Dorn, G.L.3
Stafford, R.4
-
43
-
-
0019918283
-
Chromosome aberrations assays in Allium. A report of the U.S. Environmental Protection Agency Gene-Tox Program
-
Grant, W. F. (1982) Chromosome aberrations assays in Allium. A report of the U.S. Environmental Protection Agency Gene-Tox Program. Mutat. Res., 99, 273-291.
-
(1982)
Mutat. Res.
, vol.99
, pp. 273-291
-
-
Grant, W.F.1
-
44
-
-
8944224535
-
Detection of in vitro clastogens and spindle poisons by the mouse lymphoma assay using the microwell method: Interim report of an international collaborative study
-
DOI 10.1093/mutage/11.4.349
-
Sofuni, T., Honma, M., Hayashi, M. et al. (1996) Detection of in vitro clastogenic and spindle poisons by the mouse lymphoma assay using the microwell method: interim report of an international collaborative study. Mutagenesis, 11, 349-355. (Pubitemid 26235486)
-
(1996)
Mutagenesis
, vol.11
, Issue.4
, pp. 349-355
-
-
Sofuni, T.1
Honma, M.2
Hayashi, M.3
Shimada, H.4
Tanaka, N.5
Wakuri, S.6
Awogi, T.7
Yamamoto, K.I.8
Nishi, Y.9
Nakadate, M.10
-
45
-
-
0037182151
-
A protocol for the in vitro micronucleus test: I. Contributions to the development of a protocol suitable for regulatory submissions from an examination of 16 chemicals with different mechanisms of action and different levels of activity
-
DOI 10.1016/S1383-5718(02)00059-1, PII S1383571802000591
-
Garriott, M. L., Phelps, J. B. and Hoffman, W. P. (2002) A protocol for the in vitro micronucleus test. I. Contributions to the development of a protocol suitable for regulatory submissions from an examination of 16 chemicals with different mechanisms of action and different levels of activity. Mutat. Res., 517, 123-134. (Pubitemid 34597012)
-
(2002)
Mutation Research - Genetic Toxicology and Environmental Mutagenesis
, vol.517
, Issue.1-2
, pp. 123-134
-
-
Garriott, M.L.1
Barry, P.J.2
Hoffman, W.P.3
-
46
-
-
0034632256
-
In vitro micronucleus assay with Chinese hamster V79 cells - Results of a collaborative study with in situ exposure to 26 chemical substances
-
DOI 10.1016/S1383-5718(00)00045-0, PII S1383571800000450
-
Von der Hude, W., Kalweit, S., Enghelhardt, G. et al. (2000) In vitro micronucleus assay with Chinese hamster V79 cells: results of a collaborative study with in situ exposure to 26 chemical substances. Mutat. Res., 468, 137-163. (Pubitemid 30406853)
-
(2000)
Mutation Research - Genetic Toxicology and Environmental Mutagenesis
, vol.468
, Issue.2
, pp. 137-163
-
-
Von Der, H.W.1
Kalweit, S.2
Engelhardt, G.3
McKiernan, S.4
Kasper, P.5
Slacik-Erben, R.6
Miltenburger, H.G.7
Honarvar, N.8
Fahrig, R.9
Gorlitz, B.10
Albertini, S.11
Kirchner, S.12
Utesch, D.13
Potter-Locher, F.14
Stopper, H.15
Madle, S.16
-
47
-
-
22144459783
-
Detection of numerical chromosomal aberrations by flow cytometry: A novel process for identifying aneugenic agents
-
Muehlbauer, P. A. Q. and Schuler, M. J. (2005) Detection of numerical chromosomal aberrations by flow cytometry: a novel process for identifying aneugenic agents. Mutat. Res., 585, 156-169.
-
(2005)
Mutat. Res.
, vol.585
, pp. 156-169
-
-
Muehlbauer, P.A.Q.1
Schuler, M.J.2
-
48
-
-
0021145592
-
Induction of sister-chromatid exchanges in vivo in mice by the mycotoxins sterigmatocystin and griseofulvin
-
Curry, P. T., Reed, R. N., Martini, R. M. and Kitchin, R. M. (1984) Induction of sister-chromatid exchanges in vivo in mice by the mycotoxins sterigmatocystin and griseofulvin. Mutat. Res., 137, 111-115. (Pubitemid 14028709)
-
(1984)
Mutation Research
, vol.137
, Issue.2-3
, pp. 111-115
-
-
Curry, P.T.1
Reed, R.N.2
Martino, R.M.3
Kitchin, R.M.4
-
49
-
-
0020622741
-
An evaluation of the mouse sperm morphology test and other sperm tests in nonhuman mammals: A report of the U.S. Environmental Protection Agency Gene-Tox Program
-
Wyrobek, A. J., Gordon, L. A., Burkhart, J. G., Francis, M. W., Kapp, R. W., Letz, G., Malling, H. V., Topham, J. C. and Whorton, M. D. (1983) An evaluation of the mouse sperm morphology test and other sperm tests in non human mammals. A report of the U.S. Environmental Protection Agency Gene-Tox Program. Mutat. Res., 115, 1-72. (Pubitemid 13122041)
-
(1983)
Mutation Research
, vol.115
, Issue.1
, pp. 1-72
-
-
Wyrobek, A.J.1
Gordon, L.A.2
Burkhart, J.G.3
-
50
-
-
0017221887
-
-
International Agency for Research on Cancer. Some Naturally Occurring Substances. IARC, Lyon, France
-
International Agency for Research on Cancer. (1976). IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man, Vol. 10. Some Naturally Occurring Substances. IARC, Lyon, France, pp. 153-161.
-
(1976)
IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man
, vol.10
, pp. 153-161
-
-
-
51
-
-
0023264925
-
Chemical carcinogens. A review and analysis of the literature of selected chemicals and the establishment of the gene-tox carcinogen data base. A report of the U.S. Environmental Protection Agency Gene-Tox program
-
Nesnow, S., Argus, M., Bergman, H. et al. (1986) Chemical carcinogens. A review and analysis of the literature of selected chemicals and the establishment of the Gene-Tox Carcinogen Data Base. A report of the U.S. Environmental Protection Agency Gene-Tox Program. Mutat. Res., 185, 1-195. (Pubitemid 17215638)
-
(1987)
Mutation Research
, vol.185
, Issue.1-2
, pp. 1-195
-
-
Nesnow, S.1
Argus, M.2
Bergman, H.3
-
52
-
-
0021158961
-
Genetic effects of isoniazid and the relationship to in vivo and in vitro biotransformation
-
Braun, R., Jäkel, H.-P. and Schöneich, J. (1984) Genetic effects of isoniazid and the relationship to in vivo and in vitro biotransformation. Mutat. Res., 137, 61-69.
-
(1984)
Mutat. Res.
, vol.137
, pp. 61-69
-
-
Braun, R.1
Jäkel, H.-P.2
Schöneich, J.3
-
53
-
-
49049135145
-
An evaluation of the host-mediated assay and body fluid analysis. A report of the U.S. Environmental Protection Agency gene-tox program
-
Legator, M. S., Bueding, E., Batzinger, R. et al. (1982) An evaluation of the host-mediated assay and body fluid analysis. A report of the U.S. Environmental Protection Agency Gene-Tox Program. Mutat. Res., 98, 319-374. (Pubitemid 12074502)
-
(1982)
Mutation Research
, vol.98
, Issue.3
, pp. 319-374
-
-
Legator, M.S.1
Bueding, E.2
Batzinger, R.3
-
54
-
-
0019518609
-
Use of the mouse spot test in chemical mutagenesis: Interpretation of past data and recommendations for future work
-
Russel, L. B., Selby, P. B., Von Halle, E., Sheridan, W. and Valcovic, L. (1981) Use of the mouse spot test in chemical mutagenesis: interpretation of past data and recommendation for future work. Mutat. Res., 86, 355-379. (Pubitemid 11063721)
-
(1981)
Mutation Research
, vol.86
, Issue.3
, pp. 355-379
-
-
Russell, L.B.1
Selby, P.B.2
Von Halle, E.3
-
55
-
-
0019483223
-
Sister-chromatid exchanges: A report of the GENE-TOX Program
-
Latt, S. A., Allen, J., Bloom, S. E. et al. (1981) Sister-chromatid exchanges. A report of the Gene-Tox Program. Mutat. Res., 87, 17-62. (Pubitemid 11042443)
-
(1981)
Mutation Research
, vol.87
, Issue.1
, pp. 17-62
-
-
Latt, S.A.1
Allen, J.2
Bloom, S.E.3
-
56
-
-
0021845525
-
Current status of bioassays in genetic toxicology - The dominant lethal assay. A report of the U.S. Environmental Protection Agency Gene-Tox Program
-
Green, S., Auletta, A., Fabricant, J., Kapp, R., Marrandhar, M., Sheu, C., Springer, J. and Whitefield, B. (1985) Current status of bioassays in genetic toxicology - the dominant lethal test. A report of the U.S. Environmental Protection Agency Gene-Tox program. Mutat. Res., 154, 49-67. (Pubitemid 15039544)
-
(1985)
Mutation Research
, vol.154
, Issue.1
, pp. 49-67
-
-
Green, S.1
Auletta, A.2
Fabricant, J.3
-
58
-
-
84872379383
-
Some aromatic amines, hydrazine and related substances, N-nitroso compounds and miscellaneous alkylating agents
-
International Agency for Research on Cancer. IARC, Lyon, France
-
International Agency for Research on Cancer. (1974). IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man, Vol. 4. Some aromatic amines, hydrazine and related substances, N-nitroso compounds and miscellaneous alkylating agents. IARC, Lyon, France, pp. 159-172.
-
(1974)
IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man
, vol.4
, pp. 159-172
-
-
-
60
-
-
0023250909
-
Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals
-
Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K. and Speck, W. (1987) Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ. Mol. Mutagen., 9 (Suppl. 9), 1-110. (Pubitemid 17115119)
-
(1987)
Environmental Mutagenesis
, vol.9
, Issue.SUPPL. 9
, pp. 1-110
-
-
Zeiger, E.1
Anderson, B.2
Haworth, S.3
-
61
-
-
84916143058
-
-
NCI/NTP National Cancer Institute/National Toxicology Program; US Department of Health and Human Services, TR-48.
-
NCI/NTP (1978) Carcinogenesis Technical Report Series; National Cancer Institute/National Toxicology Program; US Department of Health and Human Services, TR-48.
-
(1978)
Carcinogenesis Technical Report Series
-
-
-
62
-
-
0019839464
-
An evaluation of tests using DNA repair-deficient bacteria for predicting genotoxicity and carcinogenicity. A report of the U.S. EPA's Gene-Tox Program
-
Leifer, Z., Tikada, T., Mandel, M., Zeiger, E., Stafford, R. and Rosenkranz, H. S. (1981) An evaluation of tests using DNA repair-deficient bacteria for predicting genotoxicity and carcinogenicity. A report of the U.S. EPA's Gene-Tox Program. Mutat. Res., 87, 211-297. (Pubitemid 12207743)
-
(1981)
Mutation Research
, vol.87
, Issue.3
, pp. 211-297
-
-
Leifer, Z.1
Kada, T.2
Mandel, M.3
-
63
-
-
0021042686
-
Salmonella mutagenicity test results for 250 chemicals
-
DOI 10.1002/em.2860050703
-
Haworth, S., Lawlor, T., Mortelmans, K., Speck, W. and Zeiger, E. (1983) Salmonella mutagenicity test results for 250 chemicals. Environ. Mutagen., 5, 3-142. (Pubitemid 14168891)
-
(1983)
Environmental Mutagenesis
, vol.5
, Issue.SUPPL. 1
, pp. 3-142
-
-
Haworth, S.1
Lawlor, T.2
Mortelmans, K.3
-
64
-
-
0033673434
-
Comparison of the sensitivities of Salmonella typhimurium strains TA102 and TA 2638A to 16 mutagens
-
Ryden, E., Ekstrom, C., Hellmer, L. and Bolcsfoldi, G. (2000) Comparison of the sensitivities of Salmonella typhimurium strains TA102 and TA 2638A to 16 mutagens. Mutagenesis, 15, 495-502.
-
(2000)
Mutagenesis
, vol.15
, pp. 495-502
-
-
Ryden, E.1
Ekstrom, C.2
Hellmer, L.3
Bolcsfoldi, G.4
-
65
-
-
0021705783
-
Mutagenicity testing with TA97 and TA102 of 30 DNA-damaging compounds, negative with other Salmonella strains
-
De Flora, S., Camoirano, A., Zanacchi, P. and Bennicelli, C. (1984) Mutagenicity testing with Salmonella typhimurium strains TA97 and TA102 of 30 DNA-damaging compounds, negative with other Salmonella strains. Mutat. Res., 134, 159-165. (Pubitemid 15216570)
-
(1984)
Mutation Research
, vol.134
, Issue.2-3
, pp. 159-165
-
-
De Flora, S.1
Camoirano, A.2
Zanacchi, P.3
Bennicelli, C.4
-
66
-
-
0019905149
-
Vicia cytogenetic tests for environmental mutagens. A report of the U.S. Environmental Protection Agency Gene-Tox Program
-
Ma, T.-H. (1982) Vicia cytogenetic tests for environmental mutagens. A report of the U.S. Environmental Protection Agency Gene-Tox Program. Mutat. Res., 99, 257-271.
-
(1982)
Mutat. Res.
, vol.99
, pp. 257-271
-
-
Ma, T.-H.1
-
68
-
-
0030865830
-
Toxic effects of griseofulvin: Disease models, mechanisms, and risk assessment
-
Knasmüller, S., Parzefall, W., Helma, C., Kassie, F., Ecker, S. and Schulte-Hermann, R. (1997) Toxic effects of griseofulvin: disease models, mechanism, and risk assessment. Crit. Rev. Toxicol., 27, 495-537. (Pubitemid 27448569)
-
(1997)
Critical Reviews in Toxicology
, vol.27
, Issue.5
, pp. 495-537
-
-
Knasmuller, S.1
Parzefall, W.2
Helma, C.3
Kassie, F.4
Ecker, S.5
Schulte-Hermann, R.6
-
69
-
-
0035250772
-
Genetic risks of antiviral nucleoside analogues - A survey
-
DOI 10.1016/S0166-3542(00)00139-X, PII S016635420000139X
-
Wutzler, P. and Thust, R. (2001) Genetic risks of antiviral nucleoside analogues - a survey. Antivir. Res., 49, 55-74. (Pubitemid 32206741)
-
(2001)
Antiviral Research
, vol.49
, Issue.2
, pp. 55-74
-
-
Wutzler, P.1
Thust, R.2
-
70
-
-
0023239438
-
Prediction of chemical carcinogenicity in rodents from in vitro genetic toxicity assays
-
Tennant, R. W., Margolin, B. H. et al. (1987) A comprehensive analysis of data on the clastogenicity genesis in rodents from in vitro genetic toxicity assays. Science, 236, 933-941. (Pubitemid 17107941)
-
(1987)
Science
, vol.236
, Issue.4804
, pp. 933-941
-
-
Tennant, R.W.1
Margolin, B.H.2
Shelby, M.D.3
-
71
-
-
0025184162
-
Evaluation of four in vitro genetic toxicity tests for predicting rodent carcinogenicity: Confirming of earlier results with 41 additional chemicals
-
Zeiger, E., Haseman, J. K., Shelby, M. D., Margolin, B. H. and Tennant, R. W. (1990) Evaluation of four in vitro genetic toxicity tests for predicting rodent carcinogenicity: confirmation of earlier results with 41 additional chemicals. Environ. Mol. Mutagen., 16 (Suppl. 18), 1-14. (Pubitemid 20376833)
-
(1990)
Environmental and Molecular Mutagenesis
, vol.16
, Issue.SUPPL. 18
, pp. 1-14
-
-
Zeiger, E.1
Haseman, J.K.2
Shelby, M.D.3
Margolin, B.H.4
Tennant, R.W.5
-
72
-
-
21544473568
-
Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens: I. Sensitivity, specificity and relative predictivity
-
DOI 10.1016/j.mrgentox.2005.02.004, PII S1383571805000835
-
Kirkland, D., Aardema, M., Henderson, L. and Muller, L. (2005) Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens. I. Sensitivity, specificity and relative predictivity. Mutat. Res., 584, 1-256. (Pubitemid 40922793)
-
(2005)
Mutation Research - Genetic Toxicology and Environmental Mutagenesis
, vol.584
, Issue.1-2
, pp. 1-256
-
-
Kirkland, D.1
Aardema, M.2
Henderson, L.3
Muller, L.4
-
73
-
-
33846237598
-
Summary of major conclusions from the 4th IWGT, San Francisco, 9-10 September, 2005
-
DOI 10.1016/j.mrgentox.2006.08.009, PII S1383571806003664, Reports of the 4th International Workshop on Genotoxicity Testing (IWGT), September 9-10, 2005, San Francisco, CA, USA
-
Kirkland, D. J., Hayashi, M., Jacobson-Kram, D., Kasper, P., MacGregor, J. T., Müller, L. and Uno, Y. (2007) Summary of major conclusions from the 4th IWGT, San Francisco, 9-10 September 2005. Mutat. Res., 627, 5-9. (Pubitemid 46091763)
-
(2007)
Mutation Research - Genetic Toxicology and Environmental Mutagenesis
, vol.627
, Issue.1
, pp. 5-9
-
-
Kirkland, D.J.1
Hayashi, M.2
Jacobson-Kram, D.3
Kasper, P.4
MacGregor, J.T.5
Muller, L.6
Uno, Y.7
-
74
-
-
33846165551
-
Strategy for genotoxicity testing: Hazard identification and risk assessment in relation to in vitro testing
-
DOI 10.1016/j.mrgentox.2006.10.003, PII S1383571806003706, Reports of the 4th International Workshop on Genotoxicity Testing (IWGT), September 9-10, 2005, San Francisco, CA, USA
-
Thybaud, V., Aardema, M., Clements, J. et al. (2007) Strategy for genotoxicity testing: Hazard identification and risk assessment in relation to in vitro testing. Mutat. Res., 627, 41-58. (Pubitemid 46091766)
-
(2007)
Mutation Research - Genetic Toxicology and Environmental Mutagenesis
, vol.627
, Issue.1
, pp. 41-58
-
-
Thybaud, V.1
Aardema, M.2
Clements, J.3
Dearfield, K.4
Galloway, S.5
Hayashi, M.6
Jacobson-Kram, D.7
Kirkland, D.8
MacGregor, J.T.9
Marzin, D.10
Ohyama, W.11
Schuler, M.12
Suzuki, H.13
Zeiger, E.14
-
75
-
-
33846186786
-
Report of the IWGT working group on strategies and interpretation of regulatory in vivo tests. I. Increases in micronucleated bone marrow cells in rodents that do not indicate genotoxic hazards
-
DOI 10.1016/j.mrgentox.2006.10.005, PII S138357180600372X, Reports of the 4th International Workshop on Genotoxicity Testing (IWGT), September 9-10, 2005, San Francisco, CA, USA
-
Tweats, D. J., Blakey, D., Heflich, R. H. et al. (2007) Report of the IWGT working group on strategies and interpretation of regulatory in vivo tests. I. Increases in micronucleated bone marrow cells in rodents that do not indicate genotoxic hazards. Mutat. Res., 627, 78-91. (Pubitemid 46098931)
-
(2007)
Mutation Research - Genetic Toxicology and Environmental Mutagenesis
, vol.627
, Issue.1
, pp. 78-91
-
-
Tweats, D.J.1
Blakey, D.2
Heflich, R.H.3
Jacobs, A.4
Jacobsen, S.D.5
Morita, T.6
Nohmi, T.7
O'Donovan, M.R.8
Sasaki, Y.F.9
Sofuni, T.10
Tice, R.11
-
76
-
-
47849089737
-
Evaluation of the ability of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens. III. Appropriate follow-up testing in vivo
-
Kirkland, D. and Speit, G. (2008) Evaluation of the ability of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens. III. Appropriate follow-up testing in vivo. Mutat. Res., 654, 114-132.
-
(2008)
Mutat. Res.
, vol.654
, pp. 114-132
-
-
Kirkland, D.1
Speit, G.2
-
77
-
-
33947600311
-
Genotoxic and carcinogenic risk to humans of drug-nitrite interaction products
-
DOI 10.1016/j.mrrev.2006.09.003, PII S1383574206000937
-
Brambilla, G. and Martelli, A. (2007) Genotoxic and carcinogenic risk to humans of drug-nitrite interaction products. Mutat. Res., 635, 17-52. (Pubitemid 46482377)
-
(2007)
Mutation Research - Reviews in Mutation Research
, vol.635
, Issue.1
, pp. 17-52
-
-
Brambilla, G.1
Martelli, A.2
|