Comparative analysis of DNA breakage, chromosomal aberrations and apoptosis induced by the anti-herpes purine nucleoside analogues aciclovir, ganciclovir and penciclovir

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 505, Issue 1-2, 2002, Pages 1-11

  Tomicic, Maja T ^a   Bey, Erato ^a   Wutzler, Peter ^b   Thust, Rudolf ^b   Kaina, Bernd ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Anti herpes nucleoside analogues; Apoptosis; Chromosomal aberrations; DNA breakage

Indexed keywords

ACICLOVIR; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; DNA; DOUBLE STRANDED DNA; GANCICLOVIR; PENCICLOVIR; PURINE NUCLEOSIDE DERIVATIVE; SINGLE STRANDED DNA; THYMIDINE KINASE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER MODEL; CELL DEATH; CELL KILLING; CHO CELL; CHROMOSOME ABERRATION; CHROMOSOME STRUCTURE; COLONY FORMING CELL; COMET ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY TEST; DNA DETERMINATION; DNA STRAND BREAKAGE; DRUG EFFECT; DRUG EXPOSURE; DRUG MECHANISM; DRUG POTENCY; DRUG SENSITIVITY; GENE EXPRESSION; GENOTOXICITY; HERPES SIMPLEX VIRUS 1; KINETICS; LETHAL DOSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ACYCLOVIR; ANIMALS; ANTIVIRAL AGENTS; APOPTOSIS; CHO CELLS; CHROMOSOME ABERRATIONS; CHROMOSOMES; COLONY-FORMING UNITS ASSAY; CRICETINAE; CRICETULUS; DNA; DNA DAMAGE; ENZYME INHIBITORS; GANCICLOVIR; NECROSIS; SIMPLEXVIRUS; THYMIDINE KINASE;

HUMAN HERPESVIRUS 1; SIMPLEXVIRUS;

EID: 0037194665     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(02)00105-7     Document Type: Article

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