A protocol for the in vitro micronucleus test: I. Contributions to the development of a protocol suitable for regulatory submissions from an examination of 16 chemicals with different mechanisms of action and different levels of activity

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 517, Issue 1-2, 2002, Pages 123-134

  Garriott, Michael L ^a   Barry Phelps, J ^a   Hoffman, Wherly P ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

Chinese hamster ovary (CHO) cells; Cytochalasin B; In vitro micronucleus (IVM) test; Statistics

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; BLEOMYCIN; BROMINE DERIVATIVE; CHEMICAL COMPOUND; CYCLOPHOSPHAMIDE; CYTOCHALASIN B; DACTINOMYCIN; ETOPOSIDE; FLUORENE; GRISEOFULVIN; HYDROGEN PEROXIDE; HYDROXYUREA; MERCAPTOPURINE; MESYLIC ACID METHYL ESTER; MITOMYCIN C; PHENOL; PYRENE; VINBLASTINE SULFATE;

ANALYTIC METHOD; ANALYTICAL PARAMETERS; ANIMAL CELL; ARTICLE; CELL COUNT; CELL LINE; CHEMICAL ANALYSIS; CONTROLLED STUDY; DATA ANALYSIS; EXPOSURE; IN VITRO MICRONUCLEUS TEST; METABOLIC ACTIVATION; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; STATISTICAL ANALYSIS; VALIDATION PROCESS;

ANIMALS; CHO CELLS; CRICETINAE; CYTOCHALASIN B; MICRONUCLEUS TESTS; MUTAGENICITY TESTS; MUTAGENS;

CRICETINAE; CRICETULUS GRISEUS;

EID: 0037182151     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(02)00059-1     Document Type: Article

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