Irsogladine, an anti-ulcer drug, suppresses superoxide production by inhibiting phosphodiesterase type 4 in human neutrophils

Life Sciences

Volumn 76, Issue 1, 2004, Pages 71-83

  Kyoi, Takashi ^a   Noda, Kumiko ^a   Oka, Michiko ^a   Ukai, Yojiro ^a  

^a NIPPON SHINYAKU CO LTD   (Japan)

Author keywords

cAMP; Irsogladine; Neutrophil; Phosphodiesterase; Superoxide

Indexed keywords

ANTIULCER AGENT; CALCIMYCIN; CYCLIC AMP; FORMYLMETHIONYLLEUCYLPHENYLALANINE; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); IRSOGLADINE MALEATE; ISOBUTYLMETHYLXANTHINE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHODIESTERASE; PHOSPHODIESTERASE 2; PHOSPHODIESTERASE I; PHOSPHODIESTERASE III; PHOSPHODIESTERASE IV; ROLIPRAM; SUPEROXIDE; UNCLASSIFIED DRUG; ZYMOSAN;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; ENZYME INHIBITION; HUMAN; HUMAN CELL; NEUTROPHIL; OXIDATIVE STRESS; PROTEIN CONTENT; STOMACH MUCOSA LESION; STOMACH PROTECTION; ULCEROGENESIS;

1-METHYL-3-ISOBUTYLXANTHINE; 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ADULT; ANTI-ULCER AGENTS; BUCLADESINE; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; GASTRIC MUCOSA; HUMANS; ISOENZYMES; ISOQUINOLINES; NEUTROPHILS; ROLIPRAM; SULFONAMIDES; SUPEROXIDES; TRIAZINES;

HELICOBACTER; HELICOBACTER PYLORI;

EID: 6344252678     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2004.06.016     Document Type: Article

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