(2R,3R)-2-(3′,4′-dihydroxybenzyl)-3-(3″,4″-dimethoxybenzyl)butyrolactone suppresses fMLP-induced superoxide production by inhibiting fMLP-receptor binding in human neutrophils

Biochemical Pharmacology

Volumn 75, Issue 3, 2008, Pages 688-697

  Huang, Yi Jia ^a   Chen, Ih Sheng ^b   Tseng, Ching Ping ^a   Day, Yuan Ji ^c   Lin, Yin Chou ^c   Liao, Chang Hui ^a  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

fMLP; Lignan; Neutrophil; Piper philippinum; PP 6; Superoxide anion

Indexed keywords

(2,3) 2 (3',4' DIHYDROXYBENZYL) 3 (3'',4'' DIMETHOXYBENZYL)BUTYROLACTONE; 4 METHOXYAMPHETAMINE; CD11B ANTIGEN; CYCLIC AMP; FLUORESCEIN ISOTHIOCYANATE; FLUORIDE SODIUM; FORMYLMETHIONYLLEUCYLPHENYLALANINE; GUANINE NUCLEOTIDE BINDING PROTEIN; LEUKOTRIENE B4; LIGNAN DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; SUPEROXIDE; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG INHIBITION; DRUG PROTEIN BINDING; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IC 50; MEDICINAL PLANT; NEUTROPHIL; PIPER PHILIPPINUM; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN TARGETING; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

4-BUTYROLACTONE; ADULT; CALCIUM; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; HUMANS; LIGNANS; MACROPHAGE-1 ANTIGEN; MALE; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NEUTROPHILS; PHOSPHORYLATION; PIPER; RECEPTORS, FORMYL PEPTIDE; SUPEROXIDES;

EID: 37849034007     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2007.10.002     Document Type: Article

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