A benzodiazepines derived compound, 4-(3-chlorophenyl)-1,3-dihydronaphtho [2,3-b][1,4]diazepin-2-one (ND700C), inhibits fMLP-induced superoxide anion release by activating protein phosphatase 2A in human neutrophils

Biochemical Pharmacology

Volumn 76, Issue 12, 2008, Pages 1728-1739

  Liao, Chang Hui ^a   Lin, Shinn Zhi ^a   Tseng, Ching Ping ^a   Day, Yuan Ji ^c   Chang, Chih Shiang ^b   Chang, Yu Hsun ^b   Kuo, Shen Chu ^b  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

fMLP; ND700C; Neutrophil; Phosphodiesterase 4; Protein phosphatase 2A

Indexed keywords

4 (3 CHLOROPHENYL) 1,3 DIHYDRONAPHTHO [2,3 B][1,4]DIAZEPIN 2 ONE; BENZODIAZEPINE DERIVATIVE; CALYCULIN A; CATHEPSIN G; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; FORMYLMETHIONYLLEUCYLPHENYLALANINE; MITOGEN ACTIVATED PROTEIN KINASE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; OKADAIC ACID; PHOSPHODIESTERASE IV; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN KINASE B; SUPEROXIDE; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CONTROLLED STUDY; DRUG INHIBITION; DRUG STRUCTURE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; NEUTROPHIL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

BENZODIAZEPINES; CALCIUM SIGNALING; CATHEPSINS; CYCLIC AMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; ENZYME ACTIVATION; HUMANS; INHIBITORY CONCENTRATION 50; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NEUTROPHILS; PHOSPHORYLATION; PROTEIN PHOSPHATASE 2; SERINE ENDOPEPTIDASES; SUPEROXIDES;

EID: 56549102069     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2008.09.002     Document Type: Article

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