Pharmacological and histological effects of Centaurea bruguierana ssp. belangerana on indomethacin-induced peptic ulcer in rats

Journal of Natural Medicines

Volumn 66, Issue 2, 2012, Pages 343-349

  Khanavi, Mahnaz ^a   Ahmadi, Reza ^a   Rajabi, Afsaneh ^a   Arfaee, Shaghayegh Jabbari ^a   Hassanzadeh, Gholamreza ^a   Khademi, Rahim ^b   Hadjiakhoondi, Abbas ^a   Beyer, Cordian ^c   Sharifzadeh, Mohammad ^a,c  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b Agricultural and Natural Resources Research Center   (Iran)

^c RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

Asteraceae; Centaurea bruguierana ssp. belangerana; CHCl 3 fraction; Indomethacin induced ulcerogenesis; Total extract

Indexed keywords

ALCOHOL; CENTAUREA BRUGUIERANA EXTRACT; CHLOROFORM; CIMETIDINE; INDOMETACIN; PETROLEUM; PLANT EXTRACT; SOLVENT; UNCLASSIFIED DRUG; ANTIULCER AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIULCER ACTIVITY; ARTICLE; ASTERACEAE; CENTAUREA BRUGUIERANA; CONTROLLED STUDY; DOSE RESPONSE; FLOWER; FRACTIONATION; GROWTH INHIBITION; HERBAL MEDICINE; HISTOPATHOLOGY; IRAN; MALE; NEUTROPHIL; NONHUMAN; PEPTIC ULCER; RAT; TRADITIONAL MEDICINE; ANIMAL; CENTAUREA; CHEMICALLY INDUCED DISORDER; CHEMISTRY; STOMACH ULCER; WISTAR RAT;

ANIMALS; ANTI-ULCER AGENTS; CENTAUREA; INDOMETHACIN; MALE; PLANT EXTRACTS; RATS; RATS, WISTAR; STOMACH ULCER;

EID: 84863515124     PISSN: 13403443     EISSN: 18610293     Source Type: Journal    
DOI: 10.1007/s11418-011-0598-7     Document Type: Article

References (43)

1. Celik S, Rosselli S, Maggio AM, Raccuglia RA, Uysal I, Kisiel W, Michalska K, Bruno M (2006) Guaianolides and lignans from the aerial parts of Centaurea ptosimopappa. J Biochem Syst Ecol 34:349-352
2. Rechinger F (1980) Flora Iranica. Akademische Druck und Verlagsanstalt, Graz. 139b:385-387
3. 2 colon cancer cell. Tetrahedron 62:11172-11177
4. Flamini G, Pardini M, Morelli I, Ertugrul K, Dural H, Bagci Y, Kargioglu M (2002) Flavonoid glycosides from Centaurea pseudoscabiosa subsp. pseudoscabiosa from Turkey. Phytochemistry 61:433-437
5. Erol MK, Tuzlaci E (1999) Turkish folk medicinal plants, part II: Egirdir (Isparta). Fitoter 70:593-610
6. Chucla MT, Lamela M, Gato A, Cadavid I (1998) Centaurea corcubionensis: a study of its hypoglycemic activity in rats. Planta Med 54:107-109
7. Talhouk RS, El-Jouni W, Baalbaki R, Gali-Muhtasib H, Kogan J, Talhouk AN (2008) Anti-inflammatory bioactivities in water extract of Centaurea ainetensis. J Med Plant Res 2:24-33
8. Yesilada E, Gurbuz I, Bedir E, Tatli I, Khan IA (2004) Isolation of anti-ulcerogenic sesquiterpene lactones from Centaurea solstitialis L. ssp. solstitialis through bioassay-guided fractionation procedures in rats. J Ethnopharmacol 95:213-219
9. Marco JA, Sanz-Cervera JF, Yuste A, Sancenon F, Carda M (2005) Sesquiterpenes from Centaurea aspera. Phytochemistry 66:1644-1650
10. Robles M, Wang N, Kim R, Choi BH (1997) Cytotoxic effects of repin, a principal sesquiterpene lactone of Russian knapweed. J Neurosci Res 47:90-97
11. Flamini G, Pardini M, Morelli I (2001) A flavonoid sulphate and other compounds from the roots of Centaurea bracteata. Phytochemistry 58:1229-1233
12. Akkal S, Benayache F, Medjroubi K, Tillequin F, Seguin E (2003) Flavonoids from Centaurea furfuracea (Asteraceae). J Biochem Syst Ecol 31:641-643
13. Shoeb M, Celik S, Jaspars M, Kumarasamy Y, MacManus SM, Nahar L, Thoo-Lin PK, Sarker SD (2005) Isolation, structure elucidation and bioactivity of schischkiniin, a unique indole alkaloid from the seeds of Centaurea schischkinii. Tetrahedron 61:9001-9006
14. Yesilada E, Honda G, Sezik E, Tabata M, Fujita T, Tanaka T, Takeda Y, Takaishi Y (1995) Traditional medicine in Turkey V. Folk medicine in inner Taurus Mountains. J Ethnopharmacol 46:133-152
15. Gürbüz I, Yesilada E (2007) Evaluation of the antiulcerogenic effect of the sesquiterpene lactones from Centaurea solstitialis ssp. solstitialis by using various in vivo and biochemical techniques. J Ethnopharmacol 112:284-295
16. Rustaiyan A, Niknejad A, Aynehchi Y (1982) Chemical constituents of Centaurea brugueriana. Planta Med 44:185-186
17. Harraz FM, Kassem FF, El-Shaer NS (1994) Sesquiterpene lactones and flavonoids from Centaurea bruguierana. Alex J Pharm Sci 8:219
18. Suzuki Y, Hayachi M, Ito M, Yamagani T (1976) Anti-ulcer effect of cetraxate on various experimental gastric ulcer in rat. Jpn J Pharmacol 26:471-480
19. Yesilada E, Honda G, Sezik E, Tabata M, Goto K, Ikeshiro Y (1993) Traditional medicine in Turkey, IV. Folk medicine in the Mediterranean subdivision. J Ethnopharmacol 39:31-38
20. Robert A, Nezamis JE, Lancester C, Hanchar AJ (1979) Cytoprotection by prostaglandins in rats. J Gastroenterol 77:433-443
21. Khanavi M, Sharifzadeh M, Hadjiakhondi A, Shafiee A (2005) Phytochemical investigation and anti-inflammatory activity of aerial parts of Stachys byzanthina C. Koch. J Ethnopharmacol 97:463-468
22. Koca U, Toker G, Akkol EK (2009) Assessment of the extracts of Centaurea tchihatcheffii Fischer for anti-inflammatory and analgesic activities in animal models. Trop J Pharm Res 8:193-200
23. Giordano OS, Pestchanker MJ, Guerreiro E, Saad JR, Enriz RD, Rodriguez AM, Jauregui EA, Guzman J, Maria OMA, Wendel GH (1992) Structure-activity relationship in the gastric cytoprotective effect of several sesquiterpene lactones. J Med Chem 35:2452-2458
24. Al-Saghir J, Al-Ashi R, Salloum R, Saliba NA, Talhouk RS, Homaidan FR (2009) Anti-inflammatory properties of salograviolide A purified from Lebanese plant Centaurea ainetensis. BMC Complement Altern Med 9:36-45. ISSN 1472-6882
25. Orallo F, Lamela M, Camina M, Uriatre E, Calleja M (1998) Preliminary study of the potential vasodilator effects on rat aorta of centaurein and centaureidin, two flavonoids from Centaurea corcubionensis. Planta Med 64:116-119
26. Dermot OT, Abdel-Latif MM, Long A, Windle HJ, Murphy AM, Bowie A, O'Neill LAJ, Weir DJ, Kelleher D (2005) Low pH and helicobacter pylori increase nuclear factor kappa B binding in gastric epithelial cells: a common pathway for epithelial cell injury? J Cell Biochem 96:589-598
27. Ma JJ, Hou DQ, Zhang QB, Korsten MA (2001) Reversal of the gastric effects of nicotine by nitric oxide donor treatment. J Gastroenterol 63:102-107
28. Hall IH, Lee KH, Starnes CO, Sumida Y, Wu RY, Waddell TG, Cochran JW, Gerhart KG (1979) Anti-inflammatory activity of sesquiterpene lactones and related compounds. J Pharm Sci 68:537-542
29. Helal AM, Nakamura N, Meselhy MH, El-Fishawy A, Hattori M, Mahran GH (1997) Guaianolides from Centaurea scoparia. Phytochemistry 45:551-554
30. Lin CC, Tsai CC, Yen MH (1995) The evaluation of hepatoprotective effects of Taiwan folk medicine 'teng-khia-u'. J Ethnopharmacol 45:113-123
31. Morton JF (1981) Atlas of medicinal plants of Middle America: Bahamas to Yucatan. Charles C. Thomas, Springfield, IL
32. Poli A, Nicolau M, Simoes CM, Nicolau RM, Zanin M (1992) Preliminary pharmacologic evaluation of crude whole plant extracts of Elephantopus scaber. Part I: In vivo studies. J Ethnopharmacol 37:71-76
33. Tsai CC, Lin CC (1999) Anti-inflammatory effects of Taiwan folk medicine 'Teng-Khia-U' on carrageenan- and adjuvantinduced paw edema in rats. J Ethnopharmacol 64:85-89
34. Valerio DA, Cunha TM, Arakawa NS, Lemos HP, Da Costa FB, Parada CA, Ferreira SH, Cunha FQ, WAJr Verri (2007) Antiinflammatory and analgesic effects of the sesquiterpene lactone budlein A in mice: inhibition of cytokine production-dependent mechanism. Eur J Pharmacol 562:155-163
35. Cavin C, Delannoy M, Malnoe A, Debefve E, Touche A, Courtois D, Schilter B (2004) Inhibition of the expression and activity of cyclooxygenase 2 by chicory extract. Biochem Biophys Res Commun 327:742-749
36. Hall IH, Lee KH, Starnes CO, Muraoka O, Sumida Y, Waddell TG (1980) Antihyperlipidemic activity of sesquiterpene lactones and related compounds. J Pharm Sci 69:694-697
37. Schroder H, Losche W, Strobach H, Leven W, Willuhn G, Till U, Schror K (1990) Helenalin and 11 alpha,13-dihydrohelenalin, two constituents from Arnica montana L., inhibit human platelet function via thiol-dependent pathways. Thromb Res 57:839-845
38. Rungeler P, Lyss G, Castro V, Mora G, Pahl HL, Merfort I (1998) Study of three sesquiterpene lactones from Tithonia diversifolia on their anti-inflammatory activity using the transcription factor NF-kappa B and enzymes of the arachidonic acid pathway as targets. Planta Med 64:588-593
39. Tornhamre S, Schmidt TJ, Näsman-Glaser B, Ericsson I, Lindgren JA (2001) Inhibitory effects of helenalin and related compounds on 5-lipoxygenase and leukotriene C(4) synthase in human blood cells. J Biochem Pharmacol 62:903-911
40. Jin HZ, Lee JH, Le e D, Hong YS, Kim YH, Lee JJ (2004) Inhibitors of the LPS-induced NF-kappaB activation from Artemisia sylvatica. Phytochemistry 65:2247-2253
41. Kim EJ, Jin HK, Kim YK, Lee HY, Lee SY, Lee KR, Zee OP, Han JW, Lee HW (2001) Suppression by a sesquiterpene lactone from Carpesium divaricatum of inducible nitric oxide synthase by inhibiting nuclear factor-kappaB activation. J Biochem Pharmacol 61:903-910
42. Lyss G, Schmidt TJ, Merfort I, Pahl HL (1997) Helenalin, an anti-inflammatory sesquiterpene lactone from Arnica, selectively inhibits transcription factor NF-kappaB. J Biochem Pharmacol 378:951-961
43. Rachmilewitz D, Karmeli F, Eliakim R, Stalnikowicz R, Ackerman Z, Amir G, Stamler JS (1994) Enhanced gastric nitric oxide synthase activity in duodenal ulcer patients. Gut 35:1394-1397