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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 14, 2012, Pages 4645-4649

Structure-based optimization of aminopyridines as PKCθ inhibitors

(13) Jimenez, Juan Miguel a Davis, Christopher a Boyall, Dean a Fraysse, Damien a Knegtel, Ronald a Settimo, Luca a Young, Stephen a Bolton, Claire a Chiu, Peter a Curnock, Adam a Rasmussen, Richele a Tanner, Adam a Ager, Ian a

a VERTEX PHARMACEUTICALS (United States)

Author keywords

Aminopyridine; Kinase; PKC ; SEB IL2; T cell receptor

Indexed keywords

(6 AMINOPYRIDIN 2 YL)(2 AMINOPYRIDIN 3 YL)METHANONE; AMINOPYRIDINE DERIVATIVE; INTERLEUKIN 2; PROTEIN KINASE C INHIBITOR; PROTEIN KINASE C THETA; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOKINE PRODUCTION; DRUG IDENTIFICATION; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; MOLECULAR DOCKING; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

AMINOPYRIDINES; ANIMALS; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84863494449 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.05.114 Document Type: Article

Times cited : (9)

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