Synthesis and PKCθ inhibitory activity of a series of 4-indolylamino-5-phenyl-3-pyridinecarbonitriles

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 9, 2009, Pages 2461-2463

  Dushin, Russell G ^a   Nittoli, Thomas ^a   Ingalls, Charles ^a   Boschelli, Diane H ^a   Cole, Derek C ^a   Wissner, Allan ^a   Lee, Julie ^b   Yang, Xiaoke ^b   Morgan, Paul ^b   Brennan, Agnes ^b   Chaudhary, Divya ^b  

^a WYETH RESEARCH   (United States)

^b PFIZER INC   (United States)

Author keywords

4 Amino 3 pyridinecarbonitrile; Inflammation; Kinase; PKC

Indexed keywords

4 INDOLYLAMINO 3 PYRIDINECARBONITRILE; ANTIINFLAMMATORY AGENT; PROTEIN KINASE C INHIBITOR; PROTEIN KINASE C THETA; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATE; ISOENZYME; ISOPROTEIN; PRKCQ PROTEIN, HUMAN; PROTEIN KINASE C; PROTEIN KINASE INHIBITOR; PYRIDINE DERIVATIVE;

ALKYLATION; AMINATION; ANTIINFLAMMATORY ACTIVITY; ARTICLE; DRUG SOLUBILITY; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; MOUSE; NONHUMAN; ANIMAL; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; HUMAN; METHODOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTI-INFLAMMATORY AGENTS; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; ISOENZYMES; MICE; MODELS, CHEMICAL; MOLECULAR STRUCTURE; PROTEIN ISOFORMS; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 64549155675     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.03.053     Document Type: Article

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