Trypanosomes lacking uracil-DNA glycosylase are hypersensitive to antifolates and present a mutator phenotype

International Journal of Biochemistry and Cell Biology

Volumn 44, Issue 9, 2012, Pages 1555-1568

  Castillo Acosta, Víctor M ^a   Aguilar Pereyra, Fernando ^a   Vidal, Antonio E ^a   Navarro, Miguel ^a   Ruiz Pérez, Luis M ^a   González Pacanowska, Dolores ^a  

^a INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

Author keywords

Genome stability; Infectivity; Methotrexate; Trypanosoma brucei; Uracil; Uracil DNA glycosylase

Indexed keywords

CELL EXTRACT; FOLIC ACID ANTAGONIST; HYDROGEN PEROXIDE; METHOTREXATE; SINGLE STRANDED DNA; URACIL; URACIL DNA GLYCOSIDASE;

AFRICAN TRYPANOSOMIASIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC SENSITIVITY; ARTICLE; CELL MUTANT; CONTROLLED STUDY; DNA REPAIR; DNA STRAND BREAKAGE; ENZYME ACTIVITY; EXCISION REPAIR; FEMALE; GENE INSERTION; GENE MUTATION; IN VIVO STUDY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PARASITE VIRULENCE; PHENOTYPE; TRYPANOSOMA BRUCEI;

ANIMALS; CELL CYCLE; CELL LINE; CELL PROLIFERATION; DNA BREAKS; DNA FRAGMENTATION; DNA REPAIR; DNA, PROTOZOAN; FEMALE; FOLIC ACID ANTAGONISTS; GC RICH SEQUENCE; GENE KNOCKOUT TECHNIQUES; HYDROGEN PEROXIDE; METHOTREXATE; MICE; MUTATION; PHENOTYPE; TRYPANOSOMA BRUCEI BRUCEI; URACIL-DNA GLYCOSIDASE;

MAMMALIA; TRYPANOSOMA BRUCEI;

EID: 84863493743     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2012.06.014     Document Type: Article

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