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Volumn 18, Issue 2, 2012, Pages 123-133

Interplay between insulin resistance and estrogen deficiency as co-activators in carcinogenesis

Author keywords

Carcinogenesis; Cardiovascular disease; Estrogen deficiency; Growth factor, menopause, sexual steroid; Insulin resistance; Obesity; Type 2 diabetes

Indexed keywords

ANDROGEN; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GESTAGEN; GLUCOSE; INSULIN; METFORMIN;

EID: 84863466729     PISSN: 12194956     EISSN: 15322807     Source Type: Journal    
DOI: 10.1007/s12253-011-9466-8     Document Type: Review
Times cited : (54)

References (132)
  • 1
    • 0027424828 scopus 로고
    • Molecular determinant of insulin action
    • Kahn CR, Folli F (1993) Molecular determinant of insulin action. Hormon Res 39:93-101
    • (1993) Hormon Res , vol.39 , pp. 93-101
    • Kahn, C.R.1    Folli, F.2
  • 2
    • 0024160877 scopus 로고
    • Banting lecture 1988: Role of insulin resistance in human disease
    • Reaven GM (1988) Banting lecture 1988: Role of insulin resistance in human disease. Diabetes 37:1595-1607
    • (1988) Diabetes , vol.37 , pp. 1595-1607
    • Reaven, G.M.1
  • 3
    • 67650234495 scopus 로고    scopus 로고
    • Insulin resistance, hyperinsulinemia and cancer risk
    • Chapter 2. Nova Science Publishers Inc, New York
    • Suba Zs (2009) Insulin resistance, hyperinsulinemia and cancer risk. Chapter 2, pp 19-40. In: Estrogen versus Cancer. Nova Science Publishers Inc, New York
    • (2009) Estrogen Versus Cancer , pp. 19-40
    • Suba, Zs.1
  • 4
    • 15444368857 scopus 로고    scopus 로고
    • Mechanisms of estrogen receptor signaling: Convergence of genomic and nongenomic actions on target genes
    • Björnström L, Sjöberg M (2005) Mechanisms of estrogen receptor signaling: Convergence of genomic and nongenomic actions on target genes. Mol Endocrinol 19:833-842
    • (2005) Mol Endocrinol , vol.19 , pp. 833-842
    • Björnström, L.1    Sjöberg, M.2
  • 5
    • 13144256679 scopus 로고    scopus 로고
    • Sex steroids, cardiovascular disease, and hypertension
    • Reckelhoff JF (2005) Sex steroids, cardiovascular disease, and hypertension. Hypertension 45:170-174
    • (2005) Hypertension , vol.45 , pp. 170-174
    • Reckelhoff, J.F.1
  • 6
    • 84867507628 scopus 로고    scopus 로고
    • Insulin resistance, estrogen deficiency and cancer risk
    • Chapter 7. Nova Science Publishers Inc. New York
    • Suba Zs (2009) Insulin resistance, estrogen deficiency and cancer risk. Chapter 7 In: Estrogen versus Cancer. Nova Science Publishers Inc. New York
    • (2009) Estrogen Versus Cancer
    • Suba, Zs.1
  • 7
    • 0344286476 scopus 로고    scopus 로고
    • Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome
    • Ehrmann DA, Barnes RB, Rosenfield RL, Cavaghan MK, Imperial J (1999) Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome. Diabetes Care 22:141-146
    • (1999) Diabetes Care , vol.22 , pp. 141-146
    • Ehrmann, D.A.1    Barnes, R.B.2    Rosenfield, R.L.3    Cavaghan, M.K.4    Imperial, J.5
  • 10
    • 0035146518 scopus 로고    scopus 로고
    • The impact of years since menopause on the development of impaired glucose tolerance
    • Wu ShI, Chou P, Tsai ShT (2001) The impact of years since menopause on the development of impaired glucose tolerance. J Clin Epidemiol 54:117-120
    • (2001) J Clin Epidemiol , vol.54 , pp. 117-120
    • Shi, W.1    Chou, P.2    Sht, T.3
  • 11
    • 0031790832 scopus 로고    scopus 로고
    • Insulin stimulates testosterone biosynthesis by human thecal cells from women polycystic ovary syndrome by activating its own receptor and using inositolglycan mediators as the signal transduction system
    • Nestler JE, Jakubowicz DJ, DdeVargas AF, Brik C, Quintero N, Medina F (1998) Insulin stimulates testosterone biosynthesis by human thecal cells from women polycystic ovary syndrome by activating its own receptor and using inositolglycan mediators as the signal transduction system. J Clin Endocrinol Metab 83:2001-2005
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 2001-2005
    • Nestler, J.E.1    Jakubowicz, D.J.2    Ddevargas, A.F.3    Brik, C.4    Quintero, N.5    Medina, F.6
  • 12
    • 0026021161 scopus 로고
    • Insulin resistance: A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia and atherosclerotic cardiovascular disease
    • DeFronzo RA, Ferrannini E (1991) Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia and atherosclerotic cardiovascular disease. Diabetes Care 14:173-194
    • (1991) Diabetes Care , vol.14 , pp. 173-194
    • Defronzo, R.A.1    Ferrannini, E.2
  • 13
    • 21544449740 scopus 로고    scopus 로고
    • Second World Congress on the Insulin Resistance Syndrome: Mediators, pediatric insulin resistance, the polycystic ovary syndrome, and malignancy
    • Bloomgarden ZT (2005) Second World Congress on the Insulin Resistance Syndrome: mediators, pediatric insulin resistance, the polycystic ovary syndrome, and malignancy. Diabetes Care 28:1821-1830
    • (2005) Diabetes Care , vol.28 , pp. 1821-1830
    • Bloomgarden, Z.T.1
  • 14
    • 0037125379 scopus 로고    scopus 로고
    • Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial
    • Wrighting Group for the Women's Health Initiative Investigators
    • Wrighting Group for the Women's Health Initiative Investigators (2002) Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA 288:321-333
    • (2002) JAMA , vol.288 , pp. 321-333
  • 15
    • 36849096092 scopus 로고    scopus 로고
    • Gender-related hormonal risk factors for oral cancer
    • Suba Z (2007) Gender-related hormonal risk factors for oral cancer. Pathol Oncol Res 13:195-202
    • (2007) Pathol Oncol Res , vol.13 , pp. 195-202
    • Suba, Z.1
  • 16
    • 77954564373 scopus 로고    scopus 로고
    • Common soil of smoking-associated and hormone-related cancers: Estrogen deficiency
    • Suba Z (2010) Common soil of smoking-associated and hormone-related cancers: estrogen deficiency. Oncol Rev 4:73-87
    • (2010) Oncol Rev , vol.4 , pp. 73-87
    • Suba, Z.1
  • 17
    • 79958028665 scopus 로고    scopus 로고
    • Dual estrogen effects on breast cancer: Endogenous estrogen stimulates, exogenous estrogen protects. Further investigation of estrogen chemoprevention is warranted
    • Ragaz J, Wilson K, Frohlich J, Muraca G, Budlovsky J (2010) Dual estrogen effects on breast cancer: endogenous estrogen stimulates, exogenous estrogen protects. Further investigation of estrogen chemoprevention is warranted. Cancer Res 70(suppl 24):441
    • (2010) Cancer Res , vol.70 , Issue.SUPPL. 24 , pp. 441
    • Ragaz, J.1    Wilson, K.2    Frohlich, J.3    Muraca, G.4    Budlovsky, J.5
  • 19
    • 0034692430 scopus 로고    scopus 로고
    • Role of insulin-like growth factor family in cancer development and progression
    • Yu H, Rohan Th (2000) Role of insulin-like growth factor family in cancer development and progression. J Natl Cancer Inst 92:1472-1489
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1472-1489
    • Yu, H.1    Rohan, Th.2
  • 21
    • 0035346964 scopus 로고    scopus 로고
    • HS: Hyperinsulinemia predicts fatal liver cancer but is inversely associated with fatal cancer at some other sites: The Paris Prospective Study
    • Balkau B, Kahn H (2001) HS: Hyperinsulinemia predicts fatal liver cancer but is inversely associated with fatal cancer at some other sites: The Paris Prospective Study. Diabetes Care 24:843-849
    • (2001) Diabetes Care , vol.24 , pp. 843-849
    • Balkau, B.1    Kahn, H.2
  • 22
    • 0028113617 scopus 로고
    • Epidemiology of colorectal cancer revisited: Are serum triglycerides and/or plasma glucose associated with risk?
    • McKeown-Eyssen (1994) Epidemiology of colorectal cancer revisited: are serum triglycerides and/or plasma glucose associated with risk? Cancer Epidemiol Biomark and Prev 3:687-695
    • (1994) Cancer Epidemiol Biomark and Prev , vol.3 , pp. 687-695
    • McKeown-Eyssen1
  • 23
    • 0038246527 scopus 로고    scopus 로고
    • Diabetes mellitus and bladder cancer. An epidemiological relationship?
    • Yeung NG, Husain I, Waterfall N (2003) Diabetes mellitus and bladder cancer. An epidemiological relationship? Pathol Oncol Res 9:30-31
    • (2003) Pathol Oncol Res , vol.9 , pp. 30-31
    • Yeung, N.G.1    Husain, I.2    Waterfall, N.3
  • 24
    • 0036852701 scopus 로고    scopus 로고
    • Prostate cancer: Another aspect of the insulin-resistance syndrome?
    • Barnard RJ, Aronson WJ, Tymchuk CN, Ngo TH (2002) Prostate cancer: another aspect of the insulin-resistance syndrome? Obes Rev 3:303-308
    • (2002) Obes Rev , vol.3 , pp. 303-308
    • Barnard, R.J.1    Aronson, W.J.2    Tymchuk, C.N.3    Ngo, T.H.4
  • 26
    • 11844286254 scopus 로고    scopus 로고
    • Increased prevalence of diabetes and obesity in patients with salivary gland tumors
    • Suba Z, Barabás J, Szabó Gy, Takács D, Ujpál M (2005) Increased prevalence of diabetes and obesity in patients with salivary gland tumors. Diabetes Care 28:228
    • (2005) Diabetes Care , vol.28 , pp. 228
    • Suba, Z.1    Barabás, J.2    Szabó, Gy.3    Takács, D.4    Ujpál, M.5
  • 27
    • 0042412430 scopus 로고    scopus 로고
    • Body mass index, serum sex hormones and breast cancer risk in postmenopausal women
    • Key TJ, Applyby PN, Reeves GK (2003) Body mass index, serum sex hormones and breast cancer risk in postmenopausal women. J Natl Cancer Inst 95:1218-1226
    • (2003) J Natl Cancer Inst , vol.95 , pp. 1218-1226
    • Key, T.J.1    Applyby, P.N.2    Reeves, G.K.3
  • 29
    • 33947653911 scopus 로고    scopus 로고
    • The metabolic syndrome: A highrisk state for cancer?
    • Cowey S, Hardy RW (2006) The metabolic syndrome: a highrisk state for cancer? Am J Pathol 169:1505-1522
    • (2006) Am J Pathol , vol.169 , pp. 1505-1522
    • Cowey, S.1    Hardy, R.W.2
  • 30
    • 50549123220 scopus 로고
    • On the treatment of inoperable cases of carcinoma of the mamma. Suggestion for a new treatment with illustrative cases
    • Beatson TG (1896) On the treatment of inoperable cases of carcinoma of the mamma. Suggestion for a new treatment with illustrative cases. Lancet 2:104-107
    • (1896) Lancet , vol.2 , pp. 104-107
    • Beatson, T.G.1
  • 32
    • 0035949162 scopus 로고    scopus 로고
    • Menopause, hormone replacement therapy and cancer
    • La Vecchia C, Brinton LA, McTiernan A (2001) Menopause, hormone replacement therapy and cancer. Maturitas 39:97-115
    • (2001) Maturitas , vol.39 , pp. 97-115
    • La Vecchia, C.1    Brinton, L.A.2    McTiernan, A.3
  • 35
    • 1242272127 scopus 로고    scopus 로고
    • Hormone replacement therapy and risk of malignancy
    • Diamanti-Kandarakis E (2004) Hormone replacement therapy and risk of malignancy. Curr Opinion Obstet Gynecol 16:73-78
    • (2004) Curr Opinion Obstet Gynecol , vol.16 , pp. 73-78
    • Diamanti-Kandarakis, E.1
  • 36
    • 0023857383 scopus 로고
    • The dose-effect relationship between'unopposed' oestrogens and endometrial mitotic rate: Its central role in explaining and predicting endometrial cancer risk
    • Key TJ, Pike MC (1988) The dose-effect relationship between'unopposed' oestrogens and endometrial mitotic rate: its central role in explaining and predicting endometrial cancer risk. Br J Cancer 57:205-212
    • (1988) Br J Cancer , vol.57 , pp. 205-212
    • Key, T.J.1    Pike, M.C.2
  • 38
    • 0027450031 scopus 로고
    • Hormonal chemoprevention of cancer in women
    • Henderson BE, Ross RK, Pike MC (1993) Hormonal chemoprevention of cancer in women. Science 259:633-638
    • (1993) Science , vol.259 , pp. 633-638
    • Henderson, B.E.1    Ross, R.K.2    Pike, M.C.3
  • 39
    • 0028132860 scopus 로고
    • Steroid hormones and risk of breast cancer
    • Hulka BS, Liu ET, Lininger RA (1993) Steroid hormones and risk of breast cancer. Cancer 74:1111-1124
    • (1993) Cancer , vol.74 , pp. 1111-1124
    • Hulka, B.S.1    Liu, E.T.2    Lininger, R.A.3
  • 40
    • 0002943172 scopus 로고
    • Exogenous hormones and breast cancer risk
    • Neiderhuber J (ed). St. Louis, MO
    • Pike M, Bernstein L, Spicer D (1993) Exogenous hormones and breast cancer risk. In: Neiderhuber J (ed) Current Therapy in Oncol BC Decker. St. Louis, MO, pp 292-302
    • (1993) Current Therapy in Oncol BC Decker , pp. 292-302
    • Pike, M.1    Bernstein, L.2    Spicer, D.3
  • 41
    • 0034463957 scopus 로고    scopus 로고
    • Is estradiol a genotoxic and mutagenic carcinogen?
    • Liehr JG (2000) Is estradiol a genotoxic and mutagenic carcinogen? Endocrine Rev 21:40-54
    • (2000) Endocrine Rev , vol.21 , pp. 40-54
    • Liehr, J.G.1
  • 42
    • 0017646141 scopus 로고
    • Endometrial cancer after menopausal use of estrogens
    • Greenwald P, Caputo TA, Wolfgang PE (1977) Endometrial cancer after menopausal use of estrogens. Obstet Gynecol 50:239-243
    • (1977) Obstet Gynecol , vol.50 , pp. 239-243
    • Greenwald, P.1    Caputo, T.A.2    Wolfgang, P.E.3
  • 43
    • 0035925788 scopus 로고    scopus 로고
    • Estrogen replacement therapy and ovarian cancer mortality in a large prospective study of US women
    • Rodriguez C, Patel AV, Calle EE, Jacob EJ (2001) Estrogen replacement therapy and ovarian cancer mortality in a large prospective study of US women. JAMA 285:1460-1465
    • (2001) JAMA , vol.285 , pp. 1460-1465
    • Rodriguez, C.1    Patel, A.V.2    Calle, E.E.3    Jacob, E.J.4
  • 44
    • 0033559179 scopus 로고    scopus 로고
    • Hormonal therapy for menopause and ovarian cancer in a collaborative re-analysis of European studies
    • Negri E, Tzonou A, Beral V et al (1999) Hormonal therapy for menopause and ovarian cancer in a collaborative re-analysis of European studies. Int J Cancer 80:848-85l
    • (1999) Int J Cancer , vol.80
    • Negri, E.1    Tzonou, A.2    Beral, V.3
  • 49
    • 0030031782 scopus 로고    scopus 로고
    • Estrogen receptors: Bioactivity and interactions with cell signaling pathways
    • Katzenellenbogen BS (1996) Estrogen receptors: bioactivity and interactions with cell signaling pathways. Biol Reprod 54:287-293
    • (1996) Biol Reprod , vol.54 , pp. 287-293
    • Katzenellenbogen, B.S.1
  • 50
    • 0027848672 scopus 로고
    • DNA lesions, inducible DNA repair and cell division: Three key factors in mutagenesis and carcinogenesis
    • Ames BN, Shigenaga MK, Gold LS (1993) DNA lesions, inducible DNA repair and cell division: three key factors in mutagenesis and carcinogenesis. Environ Perspect 101:35-44
    • (1993) Environ Perspect , vol.101 , pp. 35-44
    • Ames, B.N.1    Shigenaga, M.K.2    Gold, L.S.3
  • 51
    • 0025223739 scopus 로고
    • Estrogen carcinogenesis in hamster tissues: A critical review
    • Li JJ, Li SA (1990) Estrogen carcinogenesis in hamster tissues: a critical review. Endocr Rev 11:524-531
    • (1990) Endocr Rev , vol.11 , pp. 524-531
    • Li, J.J.1    Li, S.A.2
  • 52
    • 0018068889 scopus 로고
    • Role of hormones in mammary neoplasia
    • Nandi S (1978) Role of hormones in mammary neoplasia. Cancer Res 38:4046-4049
    • (1978) Cancer Res , vol.38 , pp. 4046-4049
    • Nandi, S.1
  • 53
    • 0030670385 scopus 로고    scopus 로고
    • Dissociation between steroid receptor expression and cell proliferation in human breast
    • Clark RB, Howell A, Potten CS, Anderson E (1997) Dissociation between steroid receptor expression and cell proliferation in human breast. Cancer Res 57:4987-4991
    • (1997) Cancer Res , vol.57 , pp. 4987-4991
    • Clark, R.B.1    Howell, A.2    Potten, C.S.3    Anderson, E.4
  • 54
    • 0027418572 scopus 로고
    • Microsomal hydroxylation of 2- and 4-fluorestradiol to catechol metabolites and their conversion to methyl ethers: Catechol estrogens as possible mediators of hormonal carcinogenesis
    • Ashburn SP, Han X, Liehr JG (1993) Microsomal hydroxylation of 2- and 4-fluorestradiol to catechol metabolites and their conversion to methyl ethers: catechol estrogens as possible mediators of hormonal carcinogenesis. Mol Pharmacol 43:534-541
    • (1993) Mol Pharmacol , vol.43 , pp. 534-541
    • Ashburn, S.P.1    Han, X.2    Liehr, J.G.3
  • 57
    • 0030960009 scopus 로고    scopus 로고
    • Neoplastic transformation of cultured mammalian cells by estrogens and estrogen-like chemicals
    • Tsutsui T, Barrett JC (1997) Neoplastic transformation of cultured mammalian cells by estrogens and estrogen-like chemicals. Environ Health Perspect 105(suppl3):619-624
    • (1997) Environ Health Perspect , vol.105 , Issue.SUPPL. 3 , pp. 619-624
    • Tsutsui, T.1    Barrett, J.C.2
  • 58
    • 0028104962 scopus 로고
    • Induction of chromosome aberrations in Syrian hamster renal cortical cells by various estrogens
    • Banerjee SK, Banerjee S, Li SA, Li JJ (1994) Induction of chromosome aberrations in Syrian hamster renal cortical cells by various estrogens. Mutat Res 311:191-197
    • (1994) Mutat Res , vol.311 , pp. 191-197
    • Banerjee, S.K.1    Banerjee, S.2    Li, S.A.3    Li, J.J.4
  • 59
    • 0019860726 scopus 로고
    • Diethylstilbestrol induces neoplastic transformation without measurable gene mutation at two loci
    • Barrett JC, Wong A, McLachlan JA (1981) Diethylstilbestrol induces neoplastic transformation without measurable gene mutation at two loci. Science 212:1402-1404
    • (1981) Science , vol.212 , pp. 1402-1404
    • Barrett, J.C.1    Wong, A.2    McLachlan, J.A.3
  • 60
    • 0033018334 scopus 로고    scopus 로고
    • Measurement of oxidative DNA damage by catechol estrogens and analogues in vitro
    • Mobley JA, Bhat AS, Brueggemeier RW (1999) Measurement of oxidative DNA damage by catechol estrogens and analogues in vitro. Chem Res Toxicol 12:270-277
    • (1999) Chem Res Toxicol , vol.12 , pp. 270-277
    • Mobley, J.A.1    Bhat, A.S.2    Brueggemeier, R.W.3
  • 61
    • 33746379928 scopus 로고    scopus 로고
    • Antioxidant protection during menstrual cycle: The effects of estradiol on ascorbic-dehydroascorbic acid plasma levels and total antioxidant plasma status in eumenorrhoic women during menstrual cycle
    • Michos C, Kiortsis DN, Evangelou A, Karkabounas S (2006) Antioxidant protection during menstrual cycle: the effects of estradiol on ascorbic-dehydroascorbic acid plasma levels and total antioxidant plasma status in eumenorrhoic women during menstrual cycle. Acta Obstet Gynecol Scand 85:960-965
    • (2006) Acta Obstet Gynecol Scand , vol.85 , pp. 960-965
    • Michos, C.1    Kiortsis, D.N.2    Evangelou, A.3    Karkabounas, S.4
  • 62
    • 77949366041 scopus 로고    scopus 로고
    • The association of menstrual and reproductive factors with upper gastrointestinal tract cancers in the NIH-AARP Cohort
    • Freedman ND, Lacey JV, Hollenbeck AR, Leitzmann MF, Schatzkin A, Abnet ChC (2010) The association of menstrual and reproductive factors with upper gastrointestinal tract cancers in the NIH-AARP Cohort. Cancer 116:1572-1581
    • (2010) Cancer , vol.116 , pp. 1572-1581
    • Freedman, N.D.1    Lacey, J.V.2    Hollenbeck, A.R.3    Leitzmann, M.F.4    Schatzkin, A.5    Abnet, Ch.C.6
  • 63
    • 31344466962 scopus 로고    scopus 로고
    • Hormonal and reproductive factors and the risk of bladder cancer in women
    • McGrath M, Michaud DS, De Vivo I (2006) Hormonal and reproductive factors and the risk of bladder cancer in women. Am J Epidemiol 163:236-244
    • (2006) Am J Epidemiol , vol.163 , pp. 236-244
    • McGrath, M.1    Michaud, D.S.2    De Vivo, I.3
  • 67
    • 25144485300 scopus 로고    scopus 로고
    • Parity, other reproductive factors, and risk of pancreatic cancer mortality in a large cohort of U.S. women
    • Teras LR, Patel AV, Rodriguez C, Thun MJ, Calle EE (2005) Parity, other reproductive factors, and risk of pancreatic cancer mortality in a large cohort of U.S. women. Cancer Causes and Control 16:1035-40
    • (2005) Cancer Causes and Control , vol.16 , pp. 1035-1040
    • Teras, L.R.1    Patel, A.V.2    Rodriguez, C.3    Thun, M.J.4    Calle, E.E.5
  • 69
    • 67650216047 scopus 로고    scopus 로고
    • Estrogen deficiency as cancer risk factor
    • Chapter 5. Nova Science Publishers Inc, New York
    • Suba Zs (2009) Estrogen deficiency as cancer risk factor. Chapter 5. pp 85-106. In: Estrogen versus Cancer. Nova Science Publishers Inc, New York
    • (2009) Estrogen Versus Cancer , pp. 85-106
    • Suba, Zs.1
  • 70
    • 0141921343 scopus 로고    scopus 로고
    • Are smokingassociated cancers prevented or postponed in women using hormone replacement therapy?
    • Olsson H, Bladström AM, Ingvar C (2003) Are smokingassociated cancers prevented or postponed in women using hormone replacement therapy? Obstet Gynecol 102:565-570
    • (2003) Obstet Gynecol , vol.102 , pp. 565-570
    • Olsson, H.1    Bladström, A.M.2    Ingvar, C.3
  • 72
    • 0030812445 scopus 로고    scopus 로고
    • Case-control study of estrogen replacement therapy and risk of cervical cancer
    • Parazzini F, La Vecchia C, Negri E, Franceschi S, Bolis G (1997) Case-control study of estrogen replacement therapy and risk of cervical cancer. Br Med J 315:85-88
    • (1997) Br Med J , vol.315 , pp. 85-88
    • Parazzini, F.1    La Vecchia, C.2    Negri, E.3    Franceschi, S.4    Bolis, G.5
  • 73
    • 0037717082 scopus 로고    scopus 로고
    • Hormone replacement therapy and cancer risk: A systematic analysis from a network of case-control studies
    • Fernandez E, Gallus S, Bosetti C, Franceschi S, Negri E, La Vecchia C (2003) Hormone replacement therapy and cancer risk: a systematic analysis from a network of case-control studies. Int J Cancer 105:408-412
    • (2003) Int J Cancer , vol.105 , pp. 408-412
    • Fernandez, E.1    Gallus, S.2    Bosetti, C.3    Franceschi, S.4    Negri, E.5    La Vecchia, C.6
  • 75
    • 0141593565 scopus 로고    scopus 로고
    • Women's Health Initiative Investigators. Effects of estrogen plus progestin on gynaecologic cancers and associated diagnostic procedures: The Women's Health Initiative randomized trial
    • Anderson GL, Judd HL, Kaunitz AM, Barad DH, Beresford SA, Pettinger M, Liu J, McNeeley SG, Lopez AM (2003) Women's Health Initiative Investigators. Effects of estrogen plus progestin on gynaecologic cancers and associated diagnostic procedures: The Women's Health Initiative randomized trial. JAMA 290:1739-1748
    • (2003) JAMA , vol.290 , pp. 1739-1748
    • Anderson, G.L.1    Judd, H.L.2    Kaunitz, A.M.3    Barad, D.H.4    Beresford, S.A.5    Pettinger, M.6    Liu, J.7    McNeeley, S.G.8    Lopez, A.M.9
  • 76
    • 36749089608 scopus 로고    scopus 로고
    • False alarm: Postmenopausal hormone therapy and ovarian cancer
    • Schapiro S (2007) False alarm: postmenopausal hormone therapy and ovarian cancer. Climacteric 10:466-470
    • (2007) Climacteric , vol.10 , pp. 466-470
    • Schapiro, S.1
  • 77
    • 1842867053 scopus 로고    scopus 로고
    • Effects of conjugated equine estrogen in postmenopausal women with hysterctomy: The Women's Health Intitative randomized controlled trial
    • Women's Health Intitative Steering Committee
    • Anderson GL, Limacher M, Assaf AR, Bassford T, Beresford SA, Black H, Bonds D et al (2004) Women's Health Intitative Steering Committee. Effects of conjugated equine estrogen in postmenopausal women with hysterctomy: the Women's Health Intitative randomized controlled trial. JAMA 291:1701-1712
    • (2004) JAMA , vol.291 , pp. 1701-1712
    • Anderson, G.L.1    Limacher, M.2    Assaf, A.R.3    Bassford, T.4    Beresford, S.A.5    Black, H.6    Bonds, D.7
  • 78
    • 79953743574 scopus 로고    scopus 로고
    • Health outcomes after stopping conjugated equine estrogens among postmenopausal women with prior hysterectomy. A randomized controlled trial
    • LaCroix AZ, Chlebowski RT, Manson JE, Aragaki AK, Johnson KC, Martin L et al (2011) Health outcomes after stopping conjugated equine estrogens among postmenopausal women with prior hysterectomy. A randomized controlled trial. JAMA 305:1305-1314
    • (2011) JAMA , vol.305 , pp. 1305-1314
    • Lacroix, A.Z.1    Chlebowski, R.T.2    Manson, J.E.3    Aragaki, A.K.4    Johnson, K.C.5    Martin, L.6
  • 80
    • 0033304993 scopus 로고    scopus 로고
    • The estrogen receptor β-isoform (ERβ) of the human estrogen receptor modulates ERα transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens
    • Hall JM, McDonnell DP (1999) The estrogen receptor β-isoform (ERβ) of the human estrogen receptor modulates ERα transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens. Endocrinol 140:5566-5578
    • (1999) Endocrinol , vol.140 , pp. 5566-5578
    • Hall, J.M.1    McDonnell, D.P.2
  • 81
    • 0036780306 scopus 로고    scopus 로고
    • Estrogen action and cytoplasmic signaling cascades. Part I: Membrane-associated signaling complexes
    • Segars J, Driggers P (2002) Estrogen action and cytoplasmic signaling cascades. Part I: Membrane-associated signaling complexes. Trends Endocrin Metab 13:349-354
    • (2002) Trends Endocrin Metab , vol.13 , pp. 349-354
    • Segars, J.1    Driggers, P.2
  • 82
    • 27144524273 scopus 로고    scopus 로고
    • Estrogen receptors α (ERα) and β (ERβ) differentially regulate proliferation and apoptosis of the normal murine mammary epithelial cell line HC11
    • Helguero LA, Faulds MH, Gustafsson JA, Haldosen LA (2005) Estrogen receptors α (ERα) and β (ERβ) differentially regulate proliferation and apoptosis of the normal murine mammary epithelial cell line HC11. Oncogene 24:6605-6616
    • (2005) Oncogene , vol.24 , pp. 6605-6616
    • Helguero, L.A.1    Faulds, M.H.2    Gustafsson, J.A.3    Haldosen, L.A.4
  • 83
    • 84892116971 scopus 로고    scopus 로고
    • Antiestrogen or estrogen as anticancer drug
    • Ch. 4. Hoffmann AB (ed). Nova Science Publishers Inc, New York
    • Suba Zs (2011) Antiestrogen or estrogen as anticancer drug. Ch. 4. In: Hoffmann AB (ed) Sex Hormones, Development, Regulation and Disorders. Nova Science Publishers Inc, New York
    • (2011) Sex Hormones, Development, Regulation and Disorders
    • Suba, Zs.1
  • 84
    • 0001548401 scopus 로고    scopus 로고
    • Cell membrane and nuclear estrogen receptors (ERs) originate from a single transcript: Studies of ERα and ERβ expressed in Chinese hamster ovary cells
    • Razandi M, Pedram A, Greene GL, Levin ER (1999) Cell membrane and nuclear estrogen receptors (ERs) originate from a single transcript: studies of ERα and ERβ expressed in Chinese hamster ovary cells. Mol Endocrinol 13:307-319
    • (1999) Mol Endocrinol , vol.13 , pp. 307-319
    • Razandi, M.1    Pedram, A.2    Greene, G.L.3    Levin, E.R.4
  • 85
    • 0038407651 scopus 로고    scopus 로고
    • Estrogen action and cytoplasmic signaling pathways. Part II: The role of growth factors and phosphorylation in estrogen signaling
    • Driggers PH, Segars JH (2002) Estrogen action and cytoplasmic signaling pathways. Part II: The role of growth factors and phosphorylation in estrogen signaling. Trends Endocrin Metab 13:422-427
    • (2002) Trends Endocrin Metab , vol.13 , pp. 422-427
    • Driggers, P.H.1    Segars, J.H.2
  • 87
    • 0034866694 scopus 로고    scopus 로고
    • Growth inhibition and growth stimulation by estradiol of estrogen receptor transfected human breast epithelial cell lines involve different pathways
    • Lundholt BK, Briand P, Lykkesfeldt AE (2001) Growth inhibition and growth stimulation by estradiol of estrogen receptor transfected human breast epithelial cell lines involve different pathways. Breast Cancer Res Treat 67:199-214
    • (2001) Breast Cancer Res Treat , vol.67 , pp. 199-214
    • Lundholt, B.K.1    Briand, P.2    Lykkesfeldt, A.E.3
  • 88
    • 33846869263 scopus 로고    scopus 로고
    • Resistance to endocrine therapy in breast cancer: Exploiting estrogen receptor/growth factor crosstalk
    • Massarweh S, Schiff R (2006) Resistance to endocrine therapy in breast cancer: exploiting estrogen receptor/growth factor crosstalk. Endocrin-Related Cancer Suppl 13(1):S15-24
    • (2006) Endocrin-Related Cancer Suppl , vol.13 , Issue.1
    • Massarweh, S.1    Schiff, R.2
  • 90
    • 0026086048 scopus 로고
    • Epidermal growth factor replaces estrogen in the stimulation of female genital-tract growth and differentiation
    • Nelson KG, Takahashi T, Bossert NL, Walmer DK, McLachlan JA (1991) Epidermal growth factor replaces estrogen in the stimulation of female genital-tract growth and differentiation. Proceed Natl Acad Sci USA 88:21-25
    • (1991) Proceed Natl Acad Sci USA , vol.88 , pp. 21-25
    • Nelson, K.G.1    Takahashi, T.2    Bossert, N.L.3    Walmer, D.K.4    McLachlan, J.A.5
  • 91
    • 0029985147 scopus 로고    scopus 로고
    • Physiological coupling of growth factor and steroid receptor signaling pathway: Estrogen receptor knockout mice lack estrogen-like response to epidermal growth factor
    • Curtis SW, Washburn T, Sewall C, DiAugustine R, Lindzey J, Couse JF, Korach KS (1996) Physiological coupling of growth factor and steroid receptor signaling pathway: estrogen receptor knockout mice lack estrogen-like response to epidermal growth factor. Proceed Natl Acad Sci USA 93:12626-12630
    • (1996) Proceed Natl Acad Sci USA , vol.93 , pp. 12626-12630
    • Curtis, S.W.1    Washburn, T.2    Sewall, C.3    Diaugustine, R.4    Lindzey, J.5    Couse, J.F.6    Korach, K.S.7
  • 93
    • 26844582510 scopus 로고    scopus 로고
    • Estrogen and exercise may enhance β-cell function and mass via insulin receptor substrate 2 induction in ovarectomized diabetic rats
    • Choi SB, Jang JS, Park S (2005) Estrogen and exercise may enhance β-cell function and mass via insulin receptor substrate 2 induction in ovarectomized diabetic rats. Endocrinology 146:4786-4794
    • (2005) Endocrinology , vol.146 , pp. 4786-4794
    • Choi, S.B.1    Jang, J.S.2    Park, S.3
  • 94
    • 33244495940 scopus 로고    scopus 로고
    • Evidence that oestrogen receptor-alpha plays an important role in the regulation of glucose homeostasis in mice: Insulin sensitivity in the liver
    • Bryzgalova G, Gao H, Ahren B, Zierath JR, Galuska D, Steiler TL et al (2006) Evidence that oestrogen receptor-alpha plays an important role in the regulation of glucose homeostasis in mice: insulin sensitivity in the liver. Diabetologia 49:588-597
    • (2006) Diabetologia , vol.49 , pp. 588-597
    • Bryzgalova, G.1    Gao, H.2    Ahren, B.3    Zierath, J.R.4    Galuska, D.5    Steiler, T.L.6
  • 95
    • 0033304699 scopus 로고    scopus 로고
    • Regulation of glucose transporters by estradiol in the immature rat uterus
    • Welch RD, Gorski J (1999) Regulation of glucose transporters by estradiol in the immature rat uterus. Endocrinology 140:3602-3608
    • (1999) Endocrinology , vol.140 , pp. 3602-3608
    • Welch, R.D.1    Gorski, J.2
  • 96
    • 0002377198 scopus 로고
    • Impact of menopause on metabolism
    • Diamond MP, Naftolin K (eds). Ares Seerono Symposia, Rome
    • Godsland IF, Walton C, Stevenson JC (1993) Impact of menopause on metabolism. In: Diamond MP, Naftolin K (eds) Metabolism in the female life cycle. Ares Seerono Symposia, Rome, pp 171-189
    • (1993) Metabolism in the Female Life Cycle , pp. 171-189
    • Godsland, I.F.1    Walton, C.2    Stevenson, J.C.3
  • 98
    • 33846027512 scopus 로고    scopus 로고
    • Estrogen receptor alpha regulates insulin sensitivity trough IRS-1 thyrosin phosphorylation in mature 3 T3-L1 adipocytes
    • Muraki K, Okuya S, Tanizawa Y (2006) Estrogen receptor alpha regulates insulin sensitivity trough IRS-1 thyrosin phosphorylation in mature 3 T3-L1 adipocytes. Endocr J 53:841-851
    • (2006) Endocr J , vol.53 , pp. 841-851
    • Muraki, K.1    Okuya, S.2    Tanizawa, Y.3
  • 99
    • 0030741639 scopus 로고    scopus 로고
    • 17β-Estradiol modulation of glucose transporter 1 expression in blood-brain barrier
    • Shi J, Simpkins JW (1997) 17β-Estradiol modulation of glucose transporter 1 expression in blood-brain barrier. Am J Physiol 272:1016-1022
    • (1997) Am J Physiol , vol.272 , pp. 1016-1022
    • Shi, J.1    Simpkins, J.W.2
  • 100
    • 0027450302 scopus 로고
    • Insulin resistance in polycystic ovary syndrome: Decreased expression of GLUT-4 glucose transporters in adipocytes
    • Rosenbaum D, Haber RS, Dunaif A (1993) Insulin resistance in polycystic ovary syndrome: decreased expression of GLUT-4 glucose transporters in adipocytes. Am J Physiol 264:197-202
    • (1993) Am J Physiol , vol.264 , pp. 197-202
    • Rosenbaum, D.1    Haber, R.S.2    Dunaif, A.3
  • 101
    • 30944442454 scopus 로고    scopus 로고
    • Altered subcellular distribution of estrogen receptor is implicated in estradiolinduced dual regulation of insulin signaling in 3 T3-L1 adipocytes
    • Nagira K, Sasaoka T, Wada T, Fukui K, Ikubo M, Hori S, Tsuneki H, Saito S, Kobayashi M (2006) Altered subcellular distribution of estrogen receptor is implicated in estradiolinduced dual regulation of insulin signaling in 3 T3-L1 adipocytes. Endocrinology 147:1020-1028
    • (2006) Endocrinology , vol.147 , pp. 1020-1028
    • Nagira, K.1    Sasaoka, T.2    Wada, T.3    Fukui, K.4    Ikubo, M.5    Hori, S.6    Tsuneki, H.7    Saito, S.8    Kobayashi, M.9
  • 103
    • 0026072558 scopus 로고
    • Effects of postmenopausal estrogen replacement on the concentrations and metabolism of plasma lipoproteins
    • Walsh BW, Schiff I, Rosner B, Greenberg L, Ravinkar V, Sacks FM (1991) Effects of postmenopausal estrogen replacement on the concentrations and metabolism of plasma lipoproteins. New England J Med 325:1196-1204
    • (1991) New England J Med , vol.325 , pp. 1196-1204
    • Walsh, B.W.1    Schiff, I.2    Rosner, B.3    Greenberg, L.4    Ravinkar, V.5    Sacks, F.M.6
  • 104
    • 39049173131 scopus 로고    scopus 로고
    • Protective effect of 17beta-estradiol on oxidative stress and liver dysfunction in aged male rats
    • Hamden K, Carreau S, Ellouz F, Masmoudi H, El FA (2007) Protective effect of 17beta-estradiol on oxidative stress and liver dysfunction in aged male rats. J Physiol Biochem 63:195-201
    • (2007) J Physiol Biochem , vol.63 , pp. 195-201
    • Hamden, K.1    Carreau, S.2    Ellouz, F.3    Masmoudi, H.4    El, F.A.5
  • 105
    • 0030857452 scopus 로고    scopus 로고
    • Androgen receptor-mediated antagonism of estrogendependent low density lipoprotein receptor transcription in cultured hepatocytes
    • Croston GE, Milan LB, Marschke KB, Reichman M, Briggs MR (1997) Androgen receptor-mediated antagonism of estrogendependent low density lipoprotein receptor transcription in cultured hepatocytes. Endocrinology 138:3779-3786
    • (1997) Endocrinology , vol.138 , pp. 3779-3786
    • Croston, G.E.1    Milan, L.B.2    Marschke, K.B.3    Reichman, M.4    Briggs, M.R.5
  • 107
    • 64649104155 scopus 로고    scopus 로고
    • Sex and depot differences in adipocyte insulin sensitivity and glucose
    • Macotela Y, Boucher J, Tran TT, Kahn CR (2009) Sex and depot differences in adipocyte insulin sensitivity and glucose. Diabetes 58:803-812
    • (2009) Diabetes , vol.58 , pp. 803-812
    • MacOtela, Y.1    Boucher, J.2    Tran, T.T.3    Kahn, C.R.4
  • 108
    • 0028882708 scopus 로고
    • Changes in energy balance and body composition at menopause
    • Poehlman ET, Toth MJ, Gardner AW (1995) Changes in energy balance and body composition at menopause. Ann Intern Med 123:673-675
    • (1995) Ann Intern Med , vol.123 , pp. 673-675
    • Poehlman, E.T.1    Toth, M.J.2    Gardner, A.W.3
  • 109
    • 84856105507 scopus 로고    scopus 로고
    • Correlations between obesity and risk for salivary gland tumors
    • Suba Z (2009) Correlations between obesity and risk for salivary gland tumors. Cancer Res J 3:55-68
    • (2009) Cancer Res J , vol.3 , pp. 55-68
    • Suba, Z.1
  • 110
    • 3543072186 scopus 로고    scopus 로고
    • Overweight, obesity and cancer: Epidemiological evidence and proposed mechanisms
    • Calle EE, Kaaks R (2004) Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer 4:579-591
    • (2004) Nat Rev Cancer , vol.4 , pp. 579-591
    • Calle, E.E.1    Kaaks, R.2
  • 112
    • 0029972402 scopus 로고    scopus 로고
    • The regulation of adipose tissue distribution in humans
    • Björntorp P (1996) The regulation of adipose tissue distribution in humans. Int J Obes Relat Metab Disord 20:291-302
    • (1996) Int J Obes Relat Metab Disord , vol.20 , pp. 291-302
    • Björntorp, P.1
  • 113
    • 29244490639 scopus 로고    scopus 로고
    • Polycystic ovarian syndrome and the metabolic syndrome
    • Sartor BM, Dickey RP (2005) Polycystic ovarian syndrome and the metabolic syndrome. Am J Med 330:336-342
    • (2005) Am J Med , vol.330 , pp. 336-342
    • Sartor, B.M.1    Dickey, R.P.2
  • 114
    • 0023772227 scopus 로고
    • Insulin-like growth factor i and insulin potentiate luteinizing hormone induced androgen synthesis by rat ovarian thecal-interstitial cells
    • Cara JF, Rosenfield RL (1988) Insulin-like growth factor I and insulin potentiate luteinizing hormone induced androgen synthesis by rat ovarian thecal-interstitial cells. Endrocrinology 123:733-739
    • (1988) Endrocrinology , vol.123 , pp. 733-739
    • Cara, J.F.1    Rosenfield, R.L.2
  • 115
    • 0034892698 scopus 로고    scopus 로고
    • Metformin directly inhibits androgen production in human thecal cells
    • Attia GR, Rainey WE, Carr BR (2001) Metformin directly inhibits androgen production in human thecal cells. Fertil Steril 76:517-524
    • (2001) Fertil Steril , vol.76 , pp. 517-524
    • Attia, G.R.1    Rainey, W.E.2    Carr, B.R.3
  • 116
    • 0029927833 scopus 로고    scopus 로고
    • Insulin infusion amplifies 17-(alpha)-hydroxy-corticosteroid intermediates response to adrenocorticotropin in hyperandrogenicwomen: Apparent relative impairment of 17,20-lyase activity
    • Moghetti P, Castello R, Negri C, Tosi F, Spiazzi GG, Brun E, Balducci R, Toscano V, Muggeo M (1996) Insulin infusion amplifies 17-(alpha)-hydroxy- corticosteroid intermediates response to adrenocorticotropin in hyperandrogenicwomen: apparent relative impairment of 17,20-lyase activity. J Clin Endocrinol Metab 81:881-886
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 881-886
    • Moghetti, P.1    Castello, R.2    Negri, C.3    Tosi, F.4    Spiazzi, G.G.5    Brun, E.6    Balducci, R.7    Toscano, V.8    Muggeo, M.9
  • 117
    • 59349107509 scopus 로고    scopus 로고
    • Role of androgen excess on metabolic aberrations and cardiovascular risk in women with polycystic ovary syndrome
    • Christakou C, Diamanti-Kandarakis E (2008) Role of androgen excess on metabolic aberrations and cardiovascular risk in women with polycystic ovary syndrome. Women's Health 4:583-594
    • (2008) Women's Health , vol.4 , pp. 583-594
    • Christakou, C.1    Diamanti-Kandarakis, E.2
  • 119
    • 0035109106 scopus 로고    scopus 로고
    • Prevalence of diabetes mellitus, hypertension and cardiac complaints in a follow-up study of a Dutch PCOS population
    • Elting MW, Dorsen TJM, Bezemer PD, Schoemaker J (2001) Prevalence of diabetes mellitus, hypertension and cardiac complaints in a follow-up study of a Dutch PCOS population. Hum Reprod 16:556-560
    • (2001) Hum Reprod , vol.16 , pp. 556-560
    • Elting, M.W.1    Tjm, D.2    Bezemer, P.D.3    Schoemaker, J.4
  • 122
    • 0027532914 scopus 로고
    • WHO Ad Hoc Diabetes Reporting Group: Global estimates for prevalence of diabetes mellitus and impaired glucose tolerance in adults
    • King H, Rewers M (1993) WHO Ad Hoc Diabetes Reporting Group: Global estimates for prevalence of diabetes mellitus and impaired glucose tolerance in adults. Diabetes Care 21:157-177
    • (1993) Diabetes Care , vol.21 , pp. 157-177
    • King, H.1    Rewers, M.2
  • 123
    • 0032184908 scopus 로고    scopus 로고
    • Does estrogen reduce glycemic levels?
    • Wilson PWE (1998) Does estrogen reduce glycemic levels? Diabetes Care 21:1585-1586
    • (1998) Diabetes Care , vol.21 , pp. 1585-1586
    • Pwe, W.1
  • 126
    • 27744532581 scopus 로고    scopus 로고
    • Oestrogens and insulin secretion
    • Godsland IF (2005) Oestrogens and insulin secretion. Diabetologia 48:2213-2220
    • (2005) Diabetologia , vol.48 , pp. 2213-2220
    • Godsland, I.F.1
  • 127
    • 0026655766 scopus 로고
    • Aging and the response of plasma insulin, glucose and C-peptide concentrations to intravenous glucose in postmenopausal women
    • Proudler AJ, Felton CV, Stevenson JC (1992) Aging and the response of plasma insulin, glucose and C-peptide concentrations to intravenous glucose in postmenopausal women. Clin Sci 83:489-494
    • (1992) Clin Sci , vol.83 , pp. 489-494
    • Proudler, A.J.1    Felton, C.V.2    Stevenson, J.C.3
  • 128
    • 0034537163 scopus 로고    scopus 로고
    • Coronary artery disease: Is menopause a risk factor?
    • Gohlke-Barwolf C (2000) Coronary artery disease: is menopause a risk factor? Basic Res Cardiol 95:177-183
    • (2000) Basic Res Cardiol , vol.95 , pp. 177-183
    • Gohlke-Barwolf, C.1
  • 132
    • 79958064654 scopus 로고    scopus 로고
    • Decreased oral cancer risk by moderate alcohol consumption in non-smoker postmenopausal women
    • Takács D, Koppány F, Mihályi S, Suba Z (2011) Decreased oral cancer risk by moderate alcohol consumption in non-smoker postmenopausal women. Oral Oncol 47:537-540
    • (2011) Oral Oncol , vol.47 , pp. 537-540
    • Takács, D.1    Koppány, F.2    Mihályi, S.3    Suba, Z.4


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