The CYP19 gene and associations with androgens and abdominal obesity in premenopausal women

Obesity Research

Volumn 11, Issue 4, 2003, Pages 578-585

  Baghaei, Fariba ^a   Rosmond, Roland ^a   Westberg, Lars ^b   Hellstrand, Monica ^b   Eriksson, Elias ^b   Holm, Göran ^a   Björntorp, Per ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Aromatase gene; Hyperandrogenicity; Polymorphism; Risk factors; Type 2 diabetes

Indexed keywords

ANDROGEN; AROMATASE; HYDROCORTISONE; MICROSATELLITE DNA; PRASTERONE SULFATE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

ABDOMEN; ADRENAL GLAND; ADULT; ALLELE; ARTICLE; BLOOD; BODY CONSTITUTION; CHEMISTRY; CIRCADIAN RHYTHM; COHORT ANALYSIS; FEMALE; GENE DELETION; GENETIC POLYMORPHISM; GENETICS; HUMAN; HYPOPHYSIS; HYPOTHALAMUS; INTRON; OBESITY; PATHOPHYSIOLOGY; PREMENOPAUSE; SALIVA;

ABDOMEN; ADRENAL GLANDS; ADULT; ALLELES; ANDROGENS; AROMATASE; BODY CONSTITUTION; CIRCADIAN RHYTHM; COHORT STUDIES; DEHYDROEPIANDROSTERONE SULFATE; FEMALE; HUMANS; HYDROCORTISONE; HYPOTHALAMUS; INTRONS; MICROSATELLITE REPEATS; OBESITY; PITUITARY GLAND; POLYMORPHISM, GENETIC; PREMENOPAUSE; SALIVA; SEQUENCE DELETION; SEX HORMONE-BINDING GLOBULIN; TESTOSTERONE;

EID: 0142186758     PISSN: 10717323     EISSN: None     Source Type: Journal    
DOI: 10.1038/oby.2003.81     Document Type: Article

References (32)

1. Achard MC, Thiers MJ. Le virilism pilaire et son association a l'insufficance glycolytique (Diabète des femmes a barbe). Bull Med Natl Med (Paris). 1921;86:51-66.
2. Wild RA, Painter PC, Coulson PB, Carruth KB, Ranney GB. Lipoprotein lipid concentrations and cardiovascular risk in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 1985;61:946-51.
3. Lindstedt G, Lundberg PA, Lapidus L, Lundgren H, Bengtsson C, Björntorp P. Low sex-hormone-binding globulin concentration as independent risk factor for development of NIDDM. 12-yr follow-up of population study of women in Gothenburg, Sweden. Diabetes. 1991;40:123-8.
4. Haffner SM. Sex hormone-binding protein, hyperinsulinemia, insulin resistance and non insulin-dependent diabetes. Horm Res. 1996;45:233-7.
5. Lapidus L, Helgesson Ö, Merck C, Björntorp P. Adipose tissue distribution and female carcinomas. A 12 year follow-up of the participants in the population study of women in Gothenburg, Sweden. Int J Obes Relat Metab Disord. 1988;12:361-8.
6. Ackerman GE, Smith ME, Mendelson CR, MacDonald PC, Simpson ER. Aromatization of androstenedione by human adipose tissue stromal cells in monolayer culture. J Clin Endocrinol Metab. 1981;53:412-7.
7. Simpson ER, Clyne C, Rubin G, et al. Aromatase: a brief overview. Annu Rev Physiol. 2002;64:93-127.
8. Comings DE. Polygenic inheritance and micro/minisatellites. Mol Psychiatry. 1998;3:21-31.
9. Riggins GJ, Lokey LK, Chastain JL, et al. Human genes containing trinucleotide repeats. Nat Genet. 1992;2:186-91.
10. Berstein LM, Imyanitov EN, Suspitsin EN, et al. CYP19 gene polymorphism in endometrial cancer patients. J Cancer Res Clin Oncol. 2001;127:135-8.
11. Baxter SW, Choong DYH, Eccles DM, Campbell IG. Polymorphic variation in CYP 19 and the risk of breast cancer. Carcinogenesis. 2001;22:347-9.
12. Masi L, Becherini L, Gennari L, et al. Polymorphism of the aromatase gene in postmenopausal Italian women: distribution and correlation with bone mass and fracture risk. J Clin Endocrinol Metab. 2001;86:2263-9.
13. Probst-Hensch NM, Ingles SA, Diep AT, et al. Aromatase and breast cancer susceptibility. Endocr Relat Cancer. 1999;6:165-73.
14. Haiman CA, Hankinson SE, Splegelman D, et al. A tetranucleotide repeat polymorphism in CYP 19 and breast cancer risk. Int J Cancer. 2000;87:204-10.
15. Khaw KT, Chir B, Tazuke S, Barrett-Connor E. Cigarette smoking and levels of adrenal androgens in postmenopausal women. New Engl J Med. 1988;318:1705-9.
16. Rosmond R, Björntorp P. Psychosocial and socioeconomic factors in women and their relationship to obesity and regional body fat distribution. Int J Obes Relat Metab Disord. 1999;23:138-45.
17. Kvist H, Chowdhury B, Grangård U, Tylén U, Sjöström L. Total and visceral adipose tissue volumes derived from measurements with computed tomography in adult men and women: predictive equations. Am J Clin Nutr. 1988;48:1351-61.
18. Wiklund O, Fager G, Craigh IH. Alphalipoprotein cholesterol levels in relation to acute myocardial infarction and its risk factors. Scand J Clin Lab Invest. 1980;40:239-47.
19. Polymeropoulos MH, Xiao H, Rath DS, Merril CR. Tetranucleotide repeat polymorphism at the human aromatase cytochrome P450 gene (CYP 19). Nucleic Acid Res. 1991;19:195.
20. Latil AG, Azzouzi R, Cancel GS, et al. Prostate carcinoma risk and allelic variants of genes involved in androgen biosynthesis and metabolism pathways. Cancer. 2001;92:1130-7.
21. Barbieri RL, McShane PM, Ryan KJ. Constituents of cigarette smoke inhibit human granulosa cell aromatase. Fertil Steril. 1987;46:232-6.
22. Dallman MF, Akana SF, Scribner KA, et al. Stress, feedback and facilitation in the hypothalamic-pituitary-adrenal axis. J Neuroendocrinol. 1992;4:156-9.
23. Björntorp P, Rosmond R. Obesity and cortisol. Nutrition. 2000;16:924-36.
24. Baghaei F, Rosmond R, Westberg L, et al. The lean woman. Obes Res. 2002;10:115-21.
25. Jones MEE, Thorburn AW, Britt KL, et al. Aromatase-deficient (ArKO) mice have a phenotype of increased adiposity. Proc Natl Acad Sci USA. 2000;97:12735-40.
26. Kirschner MA, Samojlik E, Drejka M, Szmal E, Schneider G, Ertel N. Androgen-estrogen metabolism in women with upper body versus lower body obesity. J Clin Endocr Metab. 1990;70:473-9.
27. Plymate SR, Matej LA, Jones RE, Friedl KE. Inhibition of sex hormone binding globulin in the human hepatoma (HEP G 2) cell line by insulin and prolactin. J Clin Endocr Metab. 1988;67:460-4.
28. Selby C. Sex hormone binding globulin; origin, function and clinical significance. Ann Clin Biochem. 1990;27:532-41.
29. Lovejoy JC, Bray G, Bourgeois MO, et al. Exogenous androgens influence body composition and regional fat distribution in obese postmenopausal women. A clinical research center study. J Clin Endocrinol Metab. 1996;81:2189-203.
30. Elbers JMH, Asscheman H, Seidell JC, Megens JA, Gooren LJG. Long-term testosterone administration increases visceral fat in female to male transsexuals. J Clin Endocrinol Metab. 1997;82:2044-7.
31. Holmäng A, Svedberg J, Jennische E, Björntorp P. Effects of testosterone on muscle insulin sensitivity and morphology in female rats. Am J Physiol. 1990;257:E555-E60.
32. Kirschner MA, Jacobs JB. Combined ovarian and adrenal vein catheterization to determine the site(s) of androgen overproduction in hirsute women. J Clin Endocrinol. 1971;33:199-209.