Liver hyperplasia after tamoxifen induction of Myc in a transgenic medaka model

DMM Disease Models and Mechanisms

Volumn 5, Issue 4, 2012, Pages 492-502

  Menescal, Luciana A ^a   Schmidt, Cornelia ^a   Liedtke, Daniel ^a   Schartl, Manfred ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MYC PROTEIN; TAMOXIFEN;

ADULT ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BIOLOGICAL FUNCTIONS; CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; HUMAN; IN VIVO STUDY; LIVER CANCER; LIVER HYPERPLASIA; NONHUMAN; ORYZIAS; PRIORITY JOURNAL; TRANSGENICS;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CELL DEATH; CELL PROLIFERATION; CLONING, MOLECULAR; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HUMANS; HYPERPLASIA; LIVER; ORYZIAS; PHYLOGENY; PROTO-ONCOGENE PROTEINS C-MYC; RECOMBINANT FUSION PROTEINS; TAMOXIFEN; TRANSGENES;

ANIMALIA; ORYZIAS LATIPES; ORYZIINAE; TELEOSTEI; VERTEBRATA;

EID: 84863448554     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.008730     Document Type: Article

References (69)

1. Adhikary, S. and Eilers, M. (2005). Transcriptional regulation and transformation by Myc proteins. Nat. Rev. Mol. Cell Biol. 6, 635-645. (Pubitemid 41081267)
2. Amati, B., Frank, S. R., Donjerkovic, D. and Taubert, S. (2001). Function of the c-Myc oncoprotein in chromatin remodeling and transcription. Biochim. Biophys. Acta 1471, 135-145.
3. Bhatia, K., Huppi, K., Spangler, G., Siwarski, D., Iyer, R. and Magrath, I. (1993). Point mutations in the c-Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas. Nat. Genet. 5, 56-61. (Pubitemid 23261519)
4. Blyth, K., Terry, A., O'Hara, M., Baxter, E. W., Campbell, M., Stewart, M., Donehower, L. A., Onions, D. E., Neil, J. C. and Cameron, E. R. (1995). Synergy between a human c-myc transgene and p53 null genotype in murine thymic lymphomas: contrasting effects of homozygous and heterozygous p53 loss. Oncogene 10, 1717-1723.
5. Blyth, K., Stewart, M., Bell, M., James, C., Evan, G., Neil, J. C. and Cameron, E. R. (2000). Sensitivity to myc-induced apoptosis is retained in spontaneous and transplanted lymphomas of CD2-mycER mice. Oncogene 19, 773-782. (Pubitemid 30107708)
6. Catchen, J. M., Conery, J. S. and Postlethwait, J. H. (2009). Automated identification of conserved synteny after whole-genome duplication. Genome Res. 19, 1497-1505.
7. Coezy, E., Borgna, J. L. and Rochefort, H. (1982). Tamoxifen and metabolites in MCF7 cells: correlation between binding to estrogen receptor and inhibition of cell growth. Cancer Res. 42, 317-323. (Pubitemid 12207285)
8. Dang, C. V., O'Donnell, K. A., Zeller, K. I., Nguyen, T., Osthus, R. C. and Li, F. (2006). The c-Myc target gene network. Semin. Cancer. Biol. 16, 253-264. (Pubitemid 44311039)
9. Davis, A. C., Wims, M., Spotts, G. D., Hann, S. R. and Bradley, A. (1993). A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice. Genes Dev. 7, 671-682. (Pubitemid 23125266)
10. De Masi, F., Grove, C. A., Vedenko, A., Alibés, A., Gisselbrecht, S. S., Serrano, L., Bulyk, M. L. and Walhout, A. J. (2011). Using a structural and logics systems approach to infer bHLH-DNA binding specificity determinants. Nucleic Acids Res. 39, 4553-4563.
11. Eilers, M., Picard, D., Yamamoto, K. R. and Bishop, J. M. (1989). Chimaeras of Myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells. Nature 340, 66-68. (Pubitemid 19172604)
12. Evan, G. I., Wyllie, A. H., Gilbert, C. S., Littlewood, T. D., Land, H., Brooks, M., Waters, C. M., Penn, L. Z. and Hancock D. C. (1992). Induction of apoptosis by c-myc protein in fibroblasts. Cell 69, 119-128.
13. Feng, H., Langenau, D. M., Madge, J. A., Quinkertz, A., Gutierrez, A., Neuberg, D. S., Kanki, J. P. and Look, A. T. (2007). Heat-shock induction of T-cell lymphoma/leukaemia in conditional Cre/lox-regulated transgenic zebrafish. Br. J. Haematol. 138, 169-175. (Pubitemid 46976317)
14. Grandori, C., Cowley, S. M., James, L. P. and Eisenman, R. N. (2000). The Myc/Max/Mad network and the transcriptional control of the cell behavior. Annu. Rev. Cell Dev. Biol. 16, 653-699. (Pubitemid 32037520)
15. Gregory, M. A. and Hann, S. R. (2000). c-Myc proteolysis by the ubiquitin-proteasome pathway: stabilization of c-Myc in Burkitt's lymphoma cells. Mol. Cell. Biol. 20, 2423-2435. (Pubitemid 30152050)
16. Gupta, S. and Davis, R. J. (1994). MAP kinase binds to the NH2-terminal activation domain of c-Myc. FEBS Lett. 353, 281-285. (Pubitemid 24327015)
17. Gutierrez, A., Grebliunaite, R., Feng, H., Kozakewich, E., Zhu, S., Guo, F., Payne, E., Mansour, M., Dahlberg, S. E., Neuberg, D. S. et al. (2011). Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia. J. Exp. Med. 208, 1595-1603.
18. Hauptmann, G. and Gerster, T. (1994). Two-color whole-mount in situ hybridization to vertebrate and Drosophila embryos. Trends Genet. 10, 266. (Pubitemid 24238896)
19. Iwamatsu, T. (2004). Stages of normal development in medaka Orysias latipes. Mech. Dev. 121, 605-618.
20. Jacobs, J. J. L., Scheijen, B., Voncken, J.-W., Kieboom, K., Berns, A. and van Lohuizen, M. (1999). Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF. Genes Dev. 13, 2678-2690. (Pubitemid 29508555)
21. Jin, Z., Gao, F., Flagg, T. and Deng, X. (2004). Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone promotes functional cooperation of Bcl2 and c-Myc through phosphorylation in regulating cell survival and proliferation. J. Biol. Chem. 279, 40209-40219. (Pubitemid 39258297)
22. Junttila, M. R. and Westermarck, J. (2008). Mechanisms of MYC stabilization in human malignancies. Cell Cycle 7, 592-596. (Pubitemid 351498996)
23. Kirchen, R. V. and West, W. R. (1976). The Japanese Medaka: Its Care and Development. North Carolina: Carolina Biological Supply Company.
24. Klapproth, K. and Wirth, T. (2010). Advances in the understanding of MYC-induced lymphomagenesis. Br. J. Haematol. 149, 484-497.
25. Kuhn, C., Vielkind, U. and Anders, F. (1979). Cell cultures derived from embryos and melanoma of poeciliid fish. In Vitro 15, 537-544. (Pubitemid 10230811)
26. Lakin, N. D., Boardman, M. and Woodland, H. R. (1993). Determination of the sequence requirements for the expression of a Xenopus borealis embryonic/larval skeletal actin gene. Eur. J. Biochem. 214, 425-435. (Pubitemid 23173792)
27. Land, H., Parada, L. F. and Weinberg, L. A. (1983). Tumorigenic conversion of primary embryo fibloblasts require at least two cooperating oncogenes. Nature 304, 596-602. (Pubitemid 13035496)
28. Langenau, D. M., Traver, D., Ferrando, A. A., Kutok, J. L., Aster, J. C., Kanki, J. P., Lin, S., Prochownik, E., Trede, N. S., Zon, L. I. et al. (2003). Myc-induced T cell leukemia in transgenic zebrafish. Science 299, 887-890. (Pubitemid 36182446)
29. Langenau, D. M., Ferrando, A. A., Traver, D., Kutok, J. L., Hezel, J.-P. D., Kanki, J. P., Zon, L. I., Look, A. T. and Trede, N. S. (2004). In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish. Proc. Natl. Acad. Sci. USA 101, 7369-7374. (Pubitemid 38638039)
30. Langenau, D. M., Feng, H., Berghmans, S., Kanki, J. P., Kutok, J. L. and Look, A. T. (2005). Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia. Proc. Natl. Acad. Sci. USA 102, 6068-6073. (Pubitemid 40594256)
31. Lüscher, B. and Larsson, L.-G. (1999). The basic region/helix-loop-helix/leucine zipper domain of Myc proto-oncoproteins: Function and regulation. Oncogene 18, 2955-2966. (Pubitemid 29276536)
32. Lutz, W., Leon, J. and Eilers, M. (2002). Contributions of Myc to tumorigenesis. Biochim. Biophys. Acta 1602, 61-71. (Pubitemid 34311900)
33. Mao, D. Y. L., Watson, J. D., Yan, P. S., Barsyte-lovejoy, D., Khosravi, F., Wong, W. W., Farnham, P. L., Huang, T. H. and Penn, L. Z. (2003). Analysis of Myc bound loci identified by CpG island arrays shows that Max is essential for Myc-dependent repression. Curr. Biol. 13, 882-886. (Pubitemid 36573259)
34. Marandel, L., Labbe, C., Bobe, J. and Le Bail, P. Y. (2012). Evolutionary history of c-myc in teleosts and characterization of the duplicated c-myca genes in goldfish embryos. Mol. Reprod. Dev. 79, 85-96.
35. Meyer, A. and Schartl, M. (1999). Gene and genome duplications in vertebrates: the one-to-four (-to-eight in fish) rule and the evolution of novel gene functions. Curr. Opin. Cell Biol. 11, 699-704.
36. Meyer, N. and Penn, L. Z. (2008). Reflecting on 25 years with MYC. Nat. Rev. Cancer 8, 976-990.
37. Mione, M. C. and Trede, N. S. (2010). The zebrafish as a model for cancer. Dis. Model. Mech. 3, 517-523.
38. Murphy, D. J., Junttila, M. R., Pouyet, L., Karnezis, A., Shchors, K., Bui, D. A., Brown-Swigart, L., Johnson, L. and Evan, G. I. (2008). Distinct thresholds govern Myc's biological output in vivo. Cancer Cell 14, 447-457.
39. Nguyen, A. T., Emelyanov, A., Koh, C. H. V., Spitsbergen, J. M., Lam, S. H., Mathavan, S., Parinov, S. and Gong, Z. (2011). A high level of liver-specific expression of oncogenic KrasV12 drives robust liver tumorigenesis in transgenic zebrafish. Dis. Model. Mech. 4, 801-813.
40. Nilsson, J. A. and Cleveland, J. L. (2003). Myc pathways provoking cell suicide and cancer. Oncogene 22, 9007-9021. (Pubitemid 38121701)
41. Nowak, M. A., Boerlijst, M. C., Cooke, J. and Smith, J. M. (1997). Evolution of genetic redundancy. Nature 388, 167-171.
42. Patel, J. H., Du, Y., Ard, P. G., Phillips, C., Carella, B., Chen, C. J., Rakowski, C., Chatterjee, C., Lieberman, P. M., Lane et al. (2004). The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60. Mol. Cell. Biol. 24, 10826-10834. (Pubitemid 39603138)
43. Pelengaris, S, Littlewood, T., Khan, M, Elia, G. and Evan, G. (1999). Reversible activation of c-Myc in skin: induction of a complex neoplastic phenotype by a single oncogenic lesion. Mol. Cell 3, 565-577. (Pubitemid 29268440)
44. Pelengaris, S., Khan, M. and Evan, G. I. (2002). Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression. Cell 109, 321-334. (Pubitemid 34606875)
45. Santoni-Rugiu, E., Preisegger, K. H., Kiss, A., Audolfsson, T., Shiota, G., Schmidt, E. V. and Thorgeirsson, S. S. (1996). Inhibition of neoplastic development in the liver by hepatocyte growth factor in a transgenic mouse model. Proc. Natl. Acad. Sci. USA 93, 9577-9582. (Pubitemid 26296650)
46. Schreiber-Agus, N., Horner, J., Torres, R., Chiu, F.-C. and DePinho, R. A. (1993). Zebra fish myc family and max genes: differential expression and oncogenic activity throughout vertebrate evolution. Mol. Cell. Biol. 13, 2765-2775. (Pubitemid 23133949)
47. Schulte, J. H., Horn, S., Otto, T., Samans, B., Heukamp, L. C., Eilers, U. C., Krause, M., Astrahantseff, K., Klein-Hitpass, L., Buettner, R. et al. (2008). MYCN regulates oncogenic MicroRNAs in neuroblastoma. Int. J. Cancer 122, 699- 704.
48. Sears, R., Nuckolls, F., Haura, E., Taya, Y., Tamai, K. and Nevins, J. R. (2000). Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability. Genes Dev. 14, 2501-2514.
49. Spencer, C. A. and Groudine, M. (1991). Control of c-myc regulation in normal and neoplastic cells. Adv. Cancer Res. 56, 1-48.
50. Staller, P., Peukert, K., Kiermaier, A., Seoane, J., Lukas, J., Karsunky, H., Möröy, T., Bartek, J., Massagué, J., Hänel, F. et al. (2001). Repression of p15 INK4b expression by Myc through association with Miz-1. Cell Biol. 3, 392-399. (Pubitemid 32288447)
51. Steiner, P., Philipp, A., Lukas, J., Godden-Kent, D., Pagano, M., Mittnacht, S., Bartek J. and Eilers, M. (1995). Identification of a Myc-dependent step during the formation of active G1 cyclin-cdk complexes. EMBO J. 14, 4814-4826.
52. Stoletov, K. and Klemke, R. (2008). Catch of the day: zebrafish as a human cancer model. Oncogene 27, 4509-4520.
53. Strasser, A., Harris, A. W., Bath, M. L. and Cory, S. (1990). Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2. Nature 348, 331-333. (Pubitemid 120029100)
54. Sun, L., Zha, J., Spear, P. A. and Wang, Z. (2007). Tamoxifen effects on the early life stages and reproduction of Japanese medaka (Oryzias latipes). Environ. Toxicol. Pharmacol. 24, 23-29. (Pubitemid 46604882)
55. Taniguchi, Y., Takeda, S., Furutani-Seiki, M., Kamei, Y., Todo, T., Sasado, T., Deguchi, T., Kondoh, H., Mudde, J., Yamazoe et al. (2006). Generation of medaka gene knockout models by target-selected mutagenesis. Genome Biol. 7, R116.
56. Thermes, V., Grabher, C., Ristoratore, F., Bourrat, F., Choulika, A., Wittbrodt, J. and Joly, J.-S. (2002). I-SceI meganuclease mediates highly efficient transgenesis in fish. Mech. Dev. 118, 91-98. (Pubitemid 35292124)
57. Thompson, J. D., Higgins, D. G. and Gibson, T. J. (1994). CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22, 4673-4680. (Pubitemid 24354800)
58. Trumpp, A., Refaeli, Y., Oskarsson, T., Gasser, S., Murphy, M., Martin, G. R. and Bishop, M. (2001). c-Myc regulates mammalian body size by controlling cell number but not cell size. Nature 414, 768-773. (Pubitemid 34000776)
59. Vervoorts, J., Lüscher-Firzlaff, J. M., Rottmann, S., Lilischkis, R., Walsemann, G., Dohmann, K., Austen, M. and Lüscher, B. (2003). Stimulation of c-MYC transcriptional activity and acetylation by recruitment of the cofactor CBP. EMBO Rep. 4, 484-490. (Pubitemid 36789847)
60. Vita, M. and Henriksson, M. (2006). The Myc oncoprotein as a therapeutic target for human cancer. Semin. Cancer Biol. 16, 318-330. (Pubitemid 44311040)
61. Wagner, A. J., Meyers, C., Laimins, L. A. and Hay, N. (1993). c-Myc induces the expression and activity of ornithine decarboxylase. Cell Growth Differ. 4, 879-883.
62. Wakeling, A. E. and Slater, S. R. (1980). Estrogen-receptor binding and biologic activity of tamoxifen and its metabolites. Cancer Treat. Rep. 64, 741-744. (Pubitemid 11199489)
63. Wang, C., Tai, Y., Lisanti, M. P. and Liao, D. J. (2011). c-Myc induction of programmed cell death may contribute to carcinogenesis: A perspective inspired by several concepts of chemical carcinogenesis. Cancer Biol. Ther. 11, 615-626.
64. Watnick, R. S., Cheng, Y. N., Rangarajan, A., Ince, T. A. and Weinberg, R. A. (2003). Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis. Cancer Cell 3, 219-231.
65. Westermarck, J. (2010). Regulation of transcription factor function by targeted protein degradation: an overview focusing on p53, c-Myc, and c-Jun. Methods Mol. Biol. 647, 31-36.
66. Ha proto-oncogenes in cancers are frequent and show clinical correlation. Science 231, 261-265.
67. Zeller, K. I., Jegga, A. G., Aronow, B. J., O'Donnell, K. A. and Dang, C. V. (2003). An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets. Genome Biol. 4, R69.
68. Zhang, J. (2003). Evolution by gene duplication: an update. Trends Ecol. Evol. 18, 292- 298.
69. Zhang, K., Faiola, F. and Martinez, E. (2005). Six lysine residues on c-Myc are direct substrates for acetylation by p300. Biochim. Biophys. Res. Commun. 336, 274-280. (Pubitemid 41253431)