Synthesis and characterization of novel 2-amino-3-benzoylthiophene derivatives as biased allosteric agonists and modulators of the adenosine A 1 receptor

Journal of Medicinal Chemistry

Volumn 55, Issue 5, 2012, Pages 2367-2375

  Valant, Celine ^a   Aurelio, Luigi ^a   Devine, Shane M ^a   Ashton, Trent D ^a   White, Jonathan M ^b   Sexton, Patrick M ^a   Christopoulos, Arthur ^a   Scammells, Peter J ^a  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 3 BENZOYLTHIOPHENE; 2 AMINO 5 METHYL 4 3 TRIFLUOROMETHYL PHENYL THIOPHEN 3 YL 4 CHLOROPHENYL METHANONE; 2 AMINO 5 METHYL 4 3 TRIFLUOROMETHYL PHENYL THIOPHEN 3 YL PHENYL METHANONE; 2 BENZOYLTHIOPHENE DERIVATIVE; ADENOSINE A1 RECEPTOR; BENZENE DERIVATIVE; BENZOYL PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CHO CELL; CONTROLLED STUDY; DRUG SYNTHESIS; ELECTRON; FEMALE; HUMAN; HUMAN CELL; PHOSPHORYLATION; PROTEIN CONFORMATION; SYNTHESIS;

ADENOSINE A1 RECEPTOR AGONISTS; ALLOSTERIC REGULATION; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; CYCLIC AMP; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHORYLATION; RECEPTOR, ADENOSINE A1; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 84863416234     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201600e     Document Type: Article

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