3- and 6-Substituted 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridines as A1 adenosine receptor allosteric modulators and antagonists

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 20, 2009, Pages 7353-7361

  Aurelio, Luigi ^a   Valant, Celine ^a   Figler, Heidi ^b   Flynn, Bernard L ^a   Linden, Joel ^b   Sexton, Patrick M ^a   Christopoulos, Arthur ^a   Scammells, Peter J ^a  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

A1 adenosine receptor (A1AR); Allosteric modulator

Indexed keywords

2 AMINO 4,5,6,7 TETRAHYDROTHIENO[2,3 C]PYRIDINE DERIVATIVE; ADENOSINE A1 RECEPTOR ANTAGONIST; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHEMICAL MODIFICATION; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ALLOSTERIC REGULATION; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; MAGNETIC RESONANCE SPECTROSCOPY; PYRIDINES; RECEPTOR, ADENOSINE A1; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 71749111336     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.08.024     Document Type: Article

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