메뉴 건너뛰기




Volumn 27, Issue SUPPL.2, 2012, Pages 10-14

Obesity, autophagy and the pathogenesis of liver and pancreatic cancers

Author keywords

Autophagy; Hepatocellular carcinoma; Nuclear factor B; p62; Pancreatic ductal adenocarcinoma

Indexed keywords

BECLIN 1; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; JANUS KINASE 2; PROTEIN P62; REACTIVE OXYGEN METABOLITE; STAT3 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE 1; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR 1;

EID: 84863413028     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2011.07008.x     Document Type: Review
Times cited : (44)

References (50)
  • 1
    • 72549095406 scopus 로고    scopus 로고
    • Regulation mechanisms and signaling pathways of autophagy
    • He C, Klionsky DJ. Regulation mechanisms and signaling pathways of autophagy. Annu. Rev. Genet. 2009; 43: 67-93.
    • (2009) Annu. Rev. Genet. , vol.43 , pp. 67-93
    • He, C.1    Klionsky, D.J.2
  • 2
    • 77950495123 scopus 로고    scopus 로고
    • Physiological significance of selective degradation of p62 by autophagy
    • Komatsu M, Ichimura Y. Physiological significance of selective degradation of p62 by autophagy. FEBS Lett. 2010; 584: 1374-8.
    • (2010) FEBS Lett. , vol.584 , pp. 1374-1378
    • Komatsu, M.1    Ichimura, Y.2
  • 3
    • 57049186623 scopus 로고    scopus 로고
    • How to live long and prosper: autophagy, mitochondria, and aging
    • Yen WL, Klionsky DJ. How to live long and prosper: autophagy, mitochondria, and aging. Physiology (Bethesda) 2008; 23: 248-62.
    • (2008) Physiology (Bethesda) , vol.23 , pp. 248-262
    • Yen, W.L.1    Klionsky, D.J.2
  • 4
    • 0034767957 scopus 로고    scopus 로고
    • Cancer burden in the year 2000. The global picture
    • Parkin DM, Bray FI, Devesa SS. Cancer burden in the year 2000. The global picture. Eur. J. Cancer 2001; 37 (Suppl. 8): S4-66.
    • (2001) Eur. J. Cancer , vol.37 , Issue.8 SUPPL.
    • Parkin, D.M.1    Bray, F.I.2    Devesa, S.S.3
  • 5
    • 33747830764 scopus 로고    scopus 로고
    • Hepatocellular carcinoma pathogenesis: from genes to environment
    • Farazi PA, DePinho RA. Hepatocellular carcinoma pathogenesis: from genes to environment. Nat. Rev. Cancer 2006; 6: 674-87.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 674-687
    • Farazi, P.A.1    DePinho, R.A.2
  • 6
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: epidemiology and molecular carcinogenesis
    • El-Serag HB, Rudolph KL. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 2007; 132: 2557-76.
    • (2007) Gastroenterology , vol.132 , pp. 2557-2576
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 7
    • 37649005234 scopus 로고    scopus 로고
    • Autophagy in the pathogenesis of disease
    • Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008; 132: 27-42.
    • (2008) Cell , vol.132 , pp. 27-42
    • Levine, B.1    Kroemer, G.2
  • 8
    • 9144240441 scopus 로고    scopus 로고
    • Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
    • Qu X, Yu J, Bhagat G etal. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J. Clin. Invest. 2003; 112: 1809-20.
    • (2003) J. Clin. Invest. , vol.112 , pp. 1809-1820
    • Qu, X.1    Yu, J.2    Bhagat, G.3
  • 9
    • 21044455137 scopus 로고    scopus 로고
    • Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice
    • Komatsu M, Waguri S, Ueno T etal. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J. Cell Biol. 2005; 169: 425-34.
    • (2005) J. Cell Biol. , vol.169 , pp. 425-434
    • Komatsu, M.1    Waguri, S.2    Ueno, T.3
  • 10
    • 79955377420 scopus 로고    scopus 로고
    • Autophagy-deficient mice develop multiple liver tumors
    • Takamura A, Komatsu M, Hara T etal. Autophagy-deficient mice develop multiple liver tumors. Genes Dev. 2011; 25: 795-800.
    • (2011) Genes Dev. , vol.25 , pp. 795-800
    • Takamura, A.1    Komatsu, M.2    Hara, T.3
  • 11
    • 79955492012 scopus 로고    scopus 로고
    • Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells
    • Inami Y, Waguri S, Sakamoto A etal. Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells. J. Cell Biol. 2011; 193: 275-84.
    • (2011) J. Cell Biol. , vol.193 , pp. 275-284
    • Inami, Y.1    Waguri, S.2    Sakamoto, A.3
  • 12
    • 36849089101 scopus 로고    scopus 로고
    • Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice
    • Komatsu M, Waguri S, Koike M etal. Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell 2007; 131: 1149-63.
    • (2007) Cell , vol.131 , pp. 1149-1163
    • Komatsu, M.1    Waguri, S.2    Koike, M.3
  • 14
    • 0036144410 scopus 로고    scopus 로고
    • p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases
    • Zatloukal K, Stumptner C, Fuchsbichler A etal. p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases. Am. J. Pathol. 2002; 160: 255-63.
    • (2002) Am. J. Pathol. , vol.160 , pp. 255-263
    • Zatloukal, K.1    Stumptner, C.2    Fuchsbichler, A.3
  • 15
    • 77649265091 scopus 로고    scopus 로고
    • The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
    • Komatsu M, Kurokawa H, Waguri S etal. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat. Cell Biol. 2010; 12: 213-23.
    • (2010) Nat. Cell Biol. , vol.12 , pp. 213-223
    • Komatsu, M.1    Kurokawa, H.2    Waguri, S.3
  • 16
    • 77958115724 scopus 로고    scopus 로고
    • Regulation of the Nrf2-Keap1 antioxidant response by the ubiquitin proteasome system: an insight into cullin-ring ubiquitin ligases
    • Villeneuve NF, Lau A, Zhang DD. Regulation of the Nrf2-Keap1 antioxidant response by the ubiquitin proteasome system: an insight into cullin-ring ubiquitin ligases. Antioxid. Redox Signal. 2010; 13: 1699-712.
    • (2010) Antioxid. Redox Signal. , vol.13 , pp. 1699-1712
    • Villeneuve, N.F.1    Lau, A.2    Zhang, D.D.3
  • 17
    • 79960060305 scopus 로고    scopus 로고
    • Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
    • DeNicola GM, Karreth FA, Humpton TJ etal. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature 2011; 475: 106-9.
    • (2011) Nature , vol.475 , pp. 106-109
    • DeNicola, G.M.1    Karreth, F.A.2    Humpton, T.J.3
  • 18
    • 66449099090 scopus 로고    scopus 로고
    • Autophagy suppresses tumorigenesis through elimination of p62
    • Mathew R, Karp CM, Beaudoin B etal. Autophagy suppresses tumorigenesis through elimination of p62. Cell 2009; 137: 1062-75.
    • (2009) Cell , vol.137 , pp. 1062-1075
    • Mathew, R.1    Karp, C.M.2    Beaudoin, B.3
  • 19
    • 76349090912 scopus 로고    scopus 로고
    • The IKK complex contributes to the induction of autophagy
    • Criollo A, Senovilla L, Authier H etal. The IKK complex contributes to the induction of autophagy. EMBO J. 2010; 29: 619-31.
    • (2010) EMBO J. , vol.29 , pp. 619-631
    • Criollo, A.1    Senovilla, L.2    Authier, H.3
  • 20
    • 78650859531 scopus 로고    scopus 로고
    • NF-kappaB and STAT3-key players in liver inflammation and cancer
    • He G, Karin M. NF-kappaB and STAT3-key players in liver inflammation and cancer. Cell Res. 2011; 21: 159-68.
    • (2011) Cell Res. , vol.21 , pp. 159-168
    • He, G.1    Karin, M.2
  • 21
    • 21244472975 scopus 로고    scopus 로고
    • IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis
    • Maeda S, Kamata H, Luo JL, Leffert H, Karin M. IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 2005; 121: 977-90.
    • (2005) Cell , vol.121 , pp. 977-990
    • Maeda, S.1    Kamata, H.2    Luo, J.L.3    Leffert, H.4    Karin, M.5
  • 22
    • 9644254191 scopus 로고    scopus 로고
    • Application of comparative functional genomics to identify best-fit mouse models to study human cancer
    • Lee JS, Chu IS, Mikaelyan A etal. Application of comparative functional genomics to identify best-fit mouse models to study human cancer. Nat. Genet. 2004; 36: 1306-11.
    • (2004) Nat. Genet. , vol.36 , pp. 1306-1311
    • Lee, J.S.1    Chu, I.S.2    Mikaelyan, A.3
  • 23
    • 74549217325 scopus 로고    scopus 로고
    • Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation
    • He G, Yu GY, Temkin V etal. Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation. Cancer Cell 2010; 17: 286-97.
    • (2010) Cancer Cell , vol.17 , pp. 286-297
    • He, G.1    Yu, G.Y.2    Temkin, V.3
  • 24
    • 14844327760 scopus 로고    scopus 로고
    • Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases
    • Kamata H, Honda S, Maeda S, Chang L, Hirata H, Karin M. Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 2005; 120: 649-61.
    • (2005) Cell , vol.120 , pp. 649-661
    • Kamata, H.1    Honda, S.2    Maeda, S.3    Chang, L.4    Hirata, H.5    Karin, M.6
  • 25
    • 33846839443 scopus 로고    scopus 로고
    • Deletion of NEMO/IKKgamma in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma
    • Luedde T, Beraza N, Kotsikoris V etal. Deletion of NEMO/IKKgamma in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma. Cancer Cell 2007; 11: 119-32.
    • (2007) Cancer Cell , vol.11 , pp. 119-132
    • Luedde, T.1    Beraza, N.2    Kotsikoris, V.3
  • 26
    • 76249087046 scopus 로고    scopus 로고
    • Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis
    • Inokuchi S, Aoyama T, Miura K etal. Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis. Proc. Natl Acad. Sci. U.S.A. 2010; 107: 844-9.
    • (2010) Proc. Natl Acad. Sci. U.S.A. , vol.107 , pp. 844-849
    • Inokuchi, S.1    Aoyama, T.2    Miura, K.3
  • 27
    • 74549167737 scopus 로고    scopus 로고
    • Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression
    • Park EJ, Lee JH, Yu GY etal. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell 2010; 140: 197-208.
    • (2010) Cell , vol.140 , pp. 197-208
    • Park, E.J.1    Lee, J.H.2    Yu, G.Y.3
  • 29
    • 34247863931 scopus 로고    scopus 로고
    • Abnormal lipid and glucose metabolism in obesity: implications for nonalcoholic fatty liver disease
    • Parekh S, Anania FA. Abnormal lipid and glucose metabolism in obesity: implications for nonalcoholic fatty liver disease. Gastroenterology 2007; 132: 2191-207.
    • (2007) Gastroenterology , vol.132 , pp. 2191-2207
    • Parekh, S.1    Anania, F.A.2
  • 30
    • 65949095803 scopus 로고    scopus 로고
    • Autophagy regulates lipid metabolism
    • Singh R, Kaushik S, Wang Y etal. Autophagy regulates lipid metabolism. Nature 2009; 458: 1131-5.
    • (2009) Nature , vol.458 , pp. 1131-1135
    • Singh, R.1    Kaushik, S.2    Wang, Y.3
  • 31
    • 77956400005 scopus 로고    scopus 로고
    • Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance
    • Yang L, Li P, Fu S, Calay ES, Hotamisligil GS. Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metab. 2010; 11: 467-78.
    • (2010) Cell Metab. , vol.11 , pp. 467-478
    • Yang, L.1    Li, P.2    Fu, S.3    Calay, E.S.4    Hotamisligil, G.S.5
  • 32
    • 56449107131 scopus 로고    scopus 로고
    • Association of autophagy defect with a malignant phenotype and poor prognosis of hepatocellular carcinoma
    • Ding ZB, Shi YH, Zhou J etal. Association of autophagy defect with a malignant phenotype and poor prognosis of hepatocellular carcinoma. Cancer Res. 2008; 68: 9167-75.
    • (2008) Cancer Res. , vol.68 , pp. 9167-9175
    • Ding, Z.B.1    Shi, Y.H.2    Zhou, J.3
  • 33
    • 33645976174 scopus 로고    scopus 로고
    • Ubiquitous activation of Ras and Jak/Stat pathways in human HCC
    • Calvisi DF, Ladu S, Gorden A etal. Ubiquitous activation of Ras and Jak/Stat pathways in human HCC. Gastroenterology 2006; 130: 1117-28.
    • (2006) Gastroenterology , vol.130 , pp. 1117-1128
    • Calvisi, D.F.1    Ladu, S.2    Gorden, A.3
  • 34
    • 70449426665 scopus 로고    scopus 로고
    • Impaired autophagic flux mediates acinar cell vacuole formation and trypsinogen activation in rodent models of acute pancreatitis
    • Mareninova OA, Hermann K, French SW etal. Impaired autophagic flux mediates acinar cell vacuole formation and trypsinogen activation in rodent models of acute pancreatitis. J. Clin. Invest. 2009; 119: 3340-55.
    • (2009) J. Clin. Invest. , vol.119 , pp. 3340-3355
    • Mareninova, O.A.1    Hermann, K.2    French, S.W.3
  • 36
    • 80053634368 scopus 로고    scopus 로고
    • The dynamic nature of autophagy in cancer
    • Kimmelman AC. The dynamic nature of autophagy in cancer. Genes Dev. 2011; 25: 1999-2010.
    • (2011) Genes Dev. , vol.25 , pp. 1999-2010
    • Kimmelman, A.C.1
  • 37
    • 38049090214 scopus 로고    scopus 로고
    • DNA replication stress, genome instability and aging
    • Burhans WC, Weinberger M. DNA replication stress, genome instability and aging. Nucleic Acids Res. 2007; 35: 7545-56.
    • (2007) Nucleic Acids Res. , vol.35 , pp. 7545-7556
    • Burhans, W.C.1    Weinberger, M.2
  • 38
    • 77957150824 scopus 로고    scopus 로고
    • KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma
    • Morris JPT, Wang SC, Hebrok M. KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma. Nat. Rev. Cancer 2010; 10: 683-95.
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 683-695
    • Morris, J.P.T.1    Wang, S.C.2    Hebrok, M.3
  • 39
    • 70350694254 scopus 로고    scopus 로고
    • Widespread activation of the DNA damage response in human pancreatic intraepithelial neoplasia
    • Koorstra JB, Hong SM, Shi C etal. Widespread activation of the DNA damage response in human pancreatic intraepithelial neoplasia. Mod. Pathol. 2009; 22: 1439-45.
    • (2009) Mod. Pathol. , vol.22 , pp. 1439-1445
    • Koorstra, J.B.1    Hong, S.M.2    Shi, C.3
  • 40
    • 79953295757 scopus 로고    scopus 로고
    • Autophagy in Ras-induced malignant transformation: fatal or vital?
    • Marino G, Martins I, Kroemer G. Autophagy in Ras-induced malignant transformation: fatal or vital? Mol. Cell 2011; 42: 1-3.
    • (2011) Mol. Cell , vol.42 , pp. 1-3
    • Marino, G.1    Martins, I.2    Kroemer, G.3
  • 41
    • 76249108357 scopus 로고    scopus 로고
    • Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer
    • Morton JP, Timpson P, Karim SA etal. Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer. Proc. Natl Acad. Sci. U.S.A. 2010; 107: 246-51.
    • (2010) Proc. Natl Acad. Sci. U.S.A. , vol.107 , pp. 246-251
    • Morton, J.P.1    Timpson, P.2    Karim, S.A.3
  • 42
    • 79958710624 scopus 로고    scopus 로고
    • Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence
    • Guerra C, Collado M, Navas C etal. Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence. Cancer Cell 2011; 19: 728-39.
    • (2011) Cancer Cell , vol.19 , pp. 728-739
    • Guerra, C.1    Collado, M.2    Navas, C.3
  • 43
    • 64349123107 scopus 로고    scopus 로고
    • Autophagy mediates the mitotic senescence transition
    • Young AR, Narita M, Ferreira M etal. Autophagy mediates the mitotic senescence transition. Genes Dev. 2009; 23: 798-803.
    • (2009) Genes Dev. , vol.23 , pp. 798-803
    • Young, A.R.1    Narita, M.2    Ferreira, M.3
  • 44
    • 64349105425 scopus 로고    scopus 로고
    • Eating to exit: autophagy-enabled senescence revealed
    • White E, Lowe SW. Eating to exit: autophagy-enabled senescence revealed. Genes Dev. 2009; 23: 784-7.
    • (2009) Genes Dev. , vol.23 , pp. 784-787
    • White, E.1    Lowe, S.W.2
  • 45
    • 79953306808 scopus 로고    scopus 로고
    • Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival
    • Elgendy M, Sheridan C, Brumatti G, Martin SJ. Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival. Mol. Cell 2011; 42: 23-35.
    • (2011) Mol. Cell , vol.42 , pp. 23-35
    • Elgendy, M.1    Sheridan, C.2    Brumatti, G.3    Martin, S.J.4
  • 46
    • 41249084239 scopus 로고    scopus 로고
    • The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesis
    • Duran A, Linares JF, Galvez AS etal. The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesis. Cancer Cell 2008; 13: 343-54.
    • (2008) Cancer Cell , vol.13 , pp. 343-354
    • Duran, A.1    Linares, J.F.2    Galvez, A.S.3
  • 47
    • 33847419143 scopus 로고    scopus 로고
    • Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice
    • Guerra C, Schuhmacher AJ, Canamero M etal. Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer Cell 2007; 11: 291-302.
    • (2007) Cancer Cell , vol.11 , pp. 291-302
    • Guerra, C.1    Schuhmacher, A.J.2    Canamero, M.3
  • 48
    • 79952229430 scopus 로고    scopus 로고
    • Pancreatic cancers require autophagy for tumor growth
    • Yang S, Wang X, Contino G etal. Pancreatic cancers require autophagy for tumor growth. Genes Dev. 2011; 25: 717-29.
    • (2011) Genes Dev. , vol.25 , pp. 717-729
    • Yang, S.1    Wang, X.2    Contino, G.3
  • 49
    • 79952228407 scopus 로고    scopus 로고
    • Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis
    • Guo JY, Chen HY, Mathew R etal. Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev. 2011; 25: 460-70.
    • (2011) Genes Dev. , vol.25 , pp. 460-470
    • Guo, J.Y.1    Chen, H.Y.2    Mathew, R.3
  • 50
    • 78751511180 scopus 로고    scopus 로고
    • Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation
    • Lock R, Roy S, Kenific CM etal. Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation. Mol. Biol. Cell 2011; 22: 165-78.
    • (2011) Mol. Biol. Cell , vol.22 , pp. 165-178
    • Lock, R.1    Roy, S.2    Kenific, C.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.