Discovery of inhibitors of leishmania β-1,2-mannosyltransferases using a click-chemistry-derived guanosine monophosphate library

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  van der Peet, Phillip ^a   Ralton, Julie E ^a   McConville, Malcolm J ^a   Williams, Spencer J ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYNE; ANTILEISHMANIAL AGENT; AZIDE; BETA 1,2 MANNOSYLTRANSFERASE; BETA 1,2 MANNOSYLTRANSFERASE INHIBITOR; CARBOHYDRATE DERIVATIVE; ENZYME INHIBITOR; GUANOSINE DIPHOSPHATE MANNOSE; GUANOSINE PHOSPHATE; GUANOSINE PHOSPHATE ALKYNE; MANNOGEN; MANNOSYLTRANSFERASE; OCTYL ALPHA DEXTRO MANNOPYRANOSIDE 1; POLYMER; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; ANTIPARASITIC AGENT; BETA 1,2 MANNOSYLTRANSFERASE IV; BETA-1,2-MANNOSYLTRANSFERASE IV; GUANOSINE DIPHOSPHATE; LIGAND;

ARTICLE; CARBOHYDRATE SYNTHESIS; CLICK CHEMISTRY; COMBINATORIAL LIBRARY; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ASSAY; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME KINETICS; IC 50; LEISHMANIA MEXICANA; NONHUMAN; ANIMAL; CELL FREE SYSTEM; CHEMICAL MODEL; CHEMISTRY; COMBINATORIAL CHEMISTRY; ENZYMOLOGY; FEMALE; GENE LIBRARY; HUMAN; KINETICS; LEISHMANIA; METHODOLOGY; PSYCHODIDAE;

MAMMALIA; PROTOZOA;

ANIMALS; ANTIPARASITIC AGENTS; AZIDES; CELL-FREE SYSTEM; CHEMISTRY, PHARMACEUTICAL; COMBINATORIAL CHEMISTRY TECHNIQUES; FEMALE; GENE LIBRARY; GUANOSINE DIPHOSPHATE; GUANOSINE DIPHOSPHATE MANNOSE; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; LEISHMANIA; LIGANDS; MANNOSYLTRANSFERASES; MODELS, CHEMICAL; POLYMERS; PSYCHODIDAE; TRIAZOLES;

EID: 84863411350     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0032642     Document Type: Article

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