A unique, terminally glucosylated oligosaccharide is a common feature on Leishmania cell surfaces

Molecular and Biochemical Parasitology

Volumn 84, Issue 1, 1997, Pages 33-48

  Funk, Valerie A ^a   Thomas Oates, Jane E ^b   Kielland, Sandra L ^a   Bates, Paul A ^a   Olafson, Robert W ^a  

^a UNIVERSITY OF VICTORIA   (Canada)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Gp63; Leishmania; oligosaccharide structure; terminal glucose

Indexed keywords

GLYCAN; GLYCOPROTEIN; OLIGOSACCHARIDE;

ARTICLE; CELL SURFACE; CHEMICAL STRUCTURE; GLYCOSYLATION; LEISHMANIA; NONHUMAN; PRIORITY JOURNAL; SURFACE PROPERTY; VIRULENCE;

ANIMALS; LEISHMANIA MAJOR; MEMBRANE GLYCOPROTEINS; METALLOENDOPEPTIDASES; OLIGOSACCHARIDES; PROTOZOAN PROTEINS;

EID: 0031048315     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(96)02780-6     Document Type: Article

References (44)

1. Sacks, D.L., Hieny, S. and Sher, A. (1985) Identification of cell surface carbohydrate and antigenic changes between noninfective and infective developmental stages of Leishmania major promastigotes. J. Immunol. 135, 564-569.
2. Saraiva, E.M.B., Andrade, A.F.B. and Pereira, M.E.A. (1986) Cell surface carbohydrate of Leishmania mexicana amazonensis: differences between infective and non-infective forms. Eur. J. Cell Biol. 40, 219-225.
3. McConville, M.J., Turco, S.J., Ferguson, M.A.J. and Sacks, D.L. (1992) Developmental modification of lipophosphoglycan during the differentiation of Leishmania major promastigotes to an infectious stage. EMBO J. 11, 3593-3600.
4. Sacks, D.L., Pimenta, P.F.P., McConville, M.J., Schneider, P. and Turco, S.J. (1995) Stage-specific binding of Leishmania donovani to the sand fly vector midgut is regulated by conformational changes in the abundant surface lipophosphoglycan. J. Exp. Med. 181, 685-697.
5. Handman, E., Schnur, L.F., Spithill, T.W. and Mitchell, G.F. (1986) Passive transfer of Leishmania lipopolysaccharide confers parasite survival in macrophages. J. Immunol. 137, 3608-3613.
6. Elhay, M., Kelleher, M., Bacic, A., McConville, M.J., Tolson, D.L., Pearson, T.W. and Handman, E. (1990) Lipophosphoglycan expression and virulence in Ricin-resistant variants of Leishmania major. Mol. Biochem. Parasitol. 40, 255-268.
7. McNeely, T.B. and Turco, S.J. (1990) Requirement of lipophosphoglycan for intracellular survival of Leishmania donovani within human monocytes. J. Immunol. 144, 2745-2750.
8. Nolan, T.J. and Farrell, J.P. (1985) Inhibition of in vivo and in vitro infectivity of Leishmania donovani by tunicamycin. Mol. Biochem. Parasitol. 16, 127-135.
9. Kink, J.A. and Chang, K.-P. (1988) N-glycosylation as a biochemical basis for virulence in Leishmania mexicana amazonensis. Mol. Biochem. Parsitol. 27, 181-190.
10. Wilson, M.E. and Hardin, K.K. (1990) The major Leishmania donovani chagasi surface glycoprotein in tunicamycin-resistant promastigotes. J. Immunol. 144, 4825-4834.
11. Parodi, A.J., Martin-Barrientos, J. and Engel, J.C. (1984) Glycoprotein assembly in Leishmania mexicana. Biochem. Biophys. Res. Commun. 118, 1-7.
12. Olafson, R.W., Thomas, J.R., Ferguson, M.A.J., Dwek, R.A., Chaudhuri, M., Chang, K.-P. and Rademacher, T.W. (1990) Structures of the N-linked oligosaccharides of gp63, the major surface glycoprotein, from Leishmania mexicana amazonensis. J. Biol. Chem. 265, 12240-12247.
13. Parodi, A.J. (1993) N-glycosylation in trypanosomatid protozoa. Glycobiol. 3, 193-199.
14. Kornfeld, R. and Kornfeld, S. (1985) Assembly of asparagine-linked oligosaccharides. Ann. Rev. Biochem. 54, 631-664.
15. Kweider, M., Lemesre, J.-L., Darcy, F., Kusnierz, J.-P., Capron, A. and Santoro, F.(1987) Infectivity of Leishmania braziliensis proniastigotes is dependent on the increasing expression of a 65 000 Dalton surface antigen. J. Immunol. 138, 299-305.
16. Wilson, M.E., Hardin, K.K. and Donelson, J.E. (1989) Expression of the major surface glycoprotein of Leishmania donovani chagasi in virulent and attenuate proniastigotes. J. Immunol. 143, 678-684.
17. Neva, F.A., Wyler, D. and Nash, T. (1979) Cutaneous leishmaniasis - a case of persistent organisms after treatment in presence of normal immune response. Am. J. Trop. Med. Hyg. 28, 467-471.
18. Bates, P.A., Robertson, C.D., Tetley, L. and Coombs, G.H. (1992) Axenic cultivation and characterization of Leishmania mexicana amastigote-like forms. Parasitol. 105, 193-202.
19. Laemmli, U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
20. Parekh, R.B., Dwek, R.A., Thomas, J.R., Opdenakker, G. and Rademacher, T.W. (1989) Cell-type-specific and site-specific N-glycosylation of type I and type II human tissue plasminogen activator. Biochem. 28, 7644-7662.
21. Parekh, R.B., Tse, A.G.D., Dwek, R.A., Williams, A.F. and Rademacher, T.W. (1987) Tissue-specific N-glycosylation, site-specific oligosaccharide patterns and lentil lectin recognition of rat Thy-1. EMBO J. 6, 311-320.
22. Li, Y.-T. and Li, S.-C. (1972) α-Mannosidase, β-N-acetylhexosaminidase and β-galactosidase from Jack Bean meal. Methods Enzymol. 28, 702-713.
23. Kocourek, J. and Ballou, C.E. (1969) Method for finger-printing yeast cell wall mannans. J. Bact. 100, 1175-1181.
24. Anumula, R. and Taylor, P.B. (1992) A comprehensive procedure for preparation of partially methylated alditol acetates from glycoprotein carbohydrates. Anal. Biochem. 203, 101-108.
25. Michalski, J.-C., Peter-Katalinic, J., Egge, H., Paz-Parente, J., Montreuil, J. and Strecker, G. (1984) Behavior of the 2-acetamido-2-deoxy-α-D-glucopyranosyl residue during sequential hydrazinolysis, N-reacetylation, reduction, and methylation of glycoasparagines. Carbohydr. Res. 134, 177-189.
26. Tarentino, A.L., Trimble, R.B. and Maley, F. (1978) Endo-β-N-acetylglucosaminidase from Streptomyces plicatus. Methods Enzymol. 50, 574-580.
27. Plummer, T.H. Jr and Tarentino, A.L. (1981) Facile cleavage of complex oligosaccharides from glycopeptides by almond emulsin peptide:N-glycosidase. J. Biol. Chem. 256, 10243-10246.
28. Plummer, T.H. Jr., Elder, J.H., Alexander, S., Phelan, A.W. and Tarentino, A.L. (1984) Demonstration of Peptide:N-glycosidase F activity in endo-β-N-acetylgucosaminidase F preparation. J. Biol. Chem. 259, 10700-10704.
29. Tarentino, A.L., Gomez, C.M. and Plummer, T.H. Jr. (1985) Deglycosylation of asparagine-linked glycans by peptide:N-glycosidase F. Biochem. 24, 4665-4671.
30. Yamashita, K., Mizuochi, T. and Kobata, A. (1982) Analysis of oligosaccharides by gel filtration. Methods Enzymol. 83, 105-126.
31. Button, L.L. and McMaster, W.R. (1988) Molecular cloning of the major surface antigen of Leishmania. J. Exp. Med. 167, 724-729.
32. Miller, R.A., Reed, S.G. and Parsons, M. (1990) Leishmania gp63 molecule implicated in cellular adhesion lacks an arg-gly-asp sequence. Mol. Biochem. Parasitol. 39, 267-274.
33. McConville, M.J. and Blackwell, J.M. (1991) Developmental changes in the glycosylated phosphatidylinositol of Leishmania donovani. Characterization of the promastigote and amastigote glycolipids. J. Biol. Chem. 266, 15170-15179.
34. Schachter, H. (1986) Biosynthetic controls that determine the branching and microheterogeneity of protein-bound oligosaccharides. Biochem. Cell Biol. 64, 163-181.
35. Parodi, A.J. and Quesada-Allue, L.A. (1982) Protein glycosylation in Trypanosoma cruzi. I. Characterization of dolichol-bound monosaccharides and oligosaccharides synthesized 'in vivo.' J. Biol. Chem. 257, 7637-7640.
36. de la Canal, L. and Parodi, A.J. (1987) Synthesis of dolichol derivatives in trypanosomantids. Characterization of of enzymatic patterns. J. Biol. Chem. 262, 11128-11133.
37. Parodi, A.J., Lederkremer, G.Z. and Mendelzon, D.H. (1983) Protein glycosylation in Trypanosma cruzi. The mechanism of glycosylation and structure of protein-bound oligosaccharides. J. Biol. Chem. 258, 5589-5595.
38. Trombetta, S.E., Bosch, M. and Parodi, A.J. (1989) Glucosylation of glycoproteins by mammalian, plant, fungal, and trypanosomatid protozoa microsomal membranes. Biochem. 28, 8108-8116.
39. Ganan, S., Cazzulo, J.J. and Parodi, A.J. (1991) A major proportion of N-glycoproteins are transiently glucosylated in the endoplamic reticulum. Biochem. 30, 3098-3104.
40. Bosch, M., Trombetta, S., Engstrom, U. and Parodi, A.J. (1988) Characterization of dolichol diphosphate oligosaccharide: protein oligosaccharyltransferase and glycoportein-processing glucosidases occurring in trypanosomatid protozoa. J. Biol. Chem. 263, 17360-17365.
41. Roitsch, T. and Lehle, L. (1989) Structural requirements for protein N-glycosylation. Influence of acceptor peptides on cotranslational glycosylation of yeast invertase and site-directed mutagenesis around a sequon sequence. Eur. J. Biochem. 181, 525-529.
42. McGwire, B.S. and Chang, K.-P. (1996) Posttranslational regulation of a Leishmania HEXXH metalloprotease (gp63). The effects of site-specific mutagenesis of catalytic, zinc binding, N-glycosylation, and glycosyl phophatidylinositol addition sites on N-terminal end cleavage, intracellular stability, and extracellular exit. J. Biol. Chem. 271, 7903-7909.
43. Funk, V.A., Jardim, A. and Olafson, R.W. (1993) An investigation into the significance of the N-linked oligosaccharides of Leishmania gp63. Mol. Biochem. Parasitol. 63, 23-35.
44. Blackwell, J.M. (1985) Role of macrophage complement and lectin-like receptors in binding Leishmania parasites to host macrophages. Immunol. Lett. 11, 227-232.