메뉴 건너뛰기




Volumn 7, Issue 3, 2012, Pages

Toxoplasma gondii infection in the brain inhibits neuronal degeneration and learning and memory impairments in a murine model of alzheimer's disease

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; GAMMA INTERFERON; INTERLEUKIN 10; NITRIC OXIDE; TRANSFORMING GROWTH FACTOR BETA; AMYLOID;

EID: 84863358152     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0033312     Document Type: Article
Times cited : (82)

References (46)
  • 4
    • 0030062328 scopus 로고    scopus 로고
    • Contribution of nitric oxide to the host parasite equilibrium in toxoplasmosis
    • Hayashi S, Chan CC, Gazzinelli R, Roberge FG, (1996) Contribution of nitric oxide to the host parasite equilibrium in toxoplasmosis. J Immunol 156: 1476-1481.
    • (1996) J Immunol , vol.156 , pp. 1476-1481
    • Hayashi, S.1    Chan, C.C.2    Gazzinelli, R.3    Roberge, F.G.4
  • 5
    • 26244435812 scopus 로고    scopus 로고
    • Toxoplasma gondii prevents neuron degeneration by interferon-γ-activated microglia in a mechanism involving inhibition of inducible nitric oxide synthase and transforming growth factor-β1 production by infected microglia
    • Rosenfeld C, Martinez R, Seabra S, Sant'Anna C, Gonçalves JGR, et al. (2005) Toxoplasma gondii prevents neuron degeneration by interferon-γ-activated microglia in a mechanism involving inhibition of inducible nitric oxide synthase and transforming growth factor-β1 production by infected microglia. Am J Pathol 167: 1021-1031.
    • (2005) Am J Pathol , vol.167 , pp. 1021-1031
    • Rosenfeld, C.1    Martinez, R.2    Seabra, S.3    Sant'Anna, C.4    Gonçalves, J.G.R.5
  • 7
    • 0344405677 scopus 로고    scopus 로고
    • Soluble factors released by Toxoplasma gondii-infected astrocytes down-modulate nitric oxide production by gamma interferon-activated microglia and prevent neuronal degeneration
    • Rosenfeld C, Martinez R, Figueiredo RT, Bozza MT, Lima FRS, et al. (2003) Soluble factors released by Toxoplasma gondii-infected astrocytes down-modulate nitric oxide production by gamma interferon-activated microglia and prevent neuronal degeneration. Infect Immun 71: 2047-2057.
    • (2003) Infect Immun , vol.71 , pp. 2047-2057
    • Rosenfeld, C.1    Martinez, R.2    Figueiredo, R.T.3    Bozza, M.T.4    Lima, F.R.S.5
  • 11
    • 0025162755 scopus 로고
    • Brain microglia constitutively express β-2 integrins
    • Akiyama H, McGeer PL, (1990) Brain microglia constitutively express β-2 integrins. J Neuroimmunol 30: 81-93.
    • (1990) J Neuroimmunol , vol.30 , pp. 81-93
    • Akiyama, H.1    McGeer, P.L.2
  • 12
    • 0041784698 scopus 로고    scopus 로고
    • Inflammatory neurodegeneration mediated by nitric oxide, glutamate, and mitochondria
    • Brown GC, Bal-Price A, (2003) Inflammatory neurodegeneration mediated by nitric oxide, glutamate, and mitochondria. Mol Neurobiol 27: 325-355.
    • (2003) Mol Neurobiol , vol.27 , pp. 325-355
    • Brown, G.C.1    Bal-Price, A.2
  • 14
    • 33847613885 scopus 로고    scopus 로고
    • Inflammatory processes in Alzheimer's disease
    • Heneka MT, O'Banion MK, (2007) Inflammatory processes in Alzheimer's disease. J Neuroimmunol 184: 69-91.
    • (2007) J Neuroimmunol , vol.184 , pp. 69-91
    • Heneka, M.T.1    O'Banion, M.K.2
  • 17
    • 77952090141 scopus 로고    scopus 로고
    • Is there any role of Toxoplasma gondii in the etiology of obsessive-compulsive disorder?
    • Miman O, Mutlu EA, Ozcan O, Atambay M, Karlidag R, et al. (2010) Is there any role of Toxoplasma gondii in the etiology of obsessive-compulsive disorder? Psychiatry Research 177: 263-265.
    • (2010) Psychiatry Research , vol.177 , pp. 263-265
    • Miman, O.1    Mutlu, E.A.2    Ozcan, O.3    Atambay, M.4    Karlidag, R.5
  • 18
    • 77952551644 scopus 로고    scopus 로고
    • The probable relation between Toxoplasma gondii and Parkinson's disease
    • Miman O, Kusbeci OY, Aktepe OC, Cetinkaya Z, (2010) The probable relation between Toxoplasma gondii and Parkinson's disease. Neuroscience letters 475: 129-131.
    • (2010) Neuroscience Letters , vol.475 , pp. 129-131
    • Miman, O.1    Kusbeci, O.Y.2    Aktepe, O.C.3    Cetinkaya, Z.4
  • 19
    • 84863374392 scopus 로고    scopus 로고
    • Does Toxoplasma gondii play a role in obsessive-compulsive disorder?
    • in press
    • Taylor S, (2011) Does Toxoplasma gondii play a role in obsessive-compulsive disorder? Psychiatry Research 178 in press.
    • (2011) Psychiatry Research , vol.178
    • Taylor, S.1
  • 20
    • 60149098421 scopus 로고    scopus 로고
    • Debris clearance by microglia: an essential link between degeneration and regeneration
    • Neumann H, Kotter MR, Franklin RJM, (2009) Debris clearance by microglia: an essential link between degeneration and regeneration. Brain 132: 288-295.
    • (2009) Brain , vol.132 , pp. 288-295
    • Neumann, H.1    Kotter, M.R.2    Franklin, R.J.M.3
  • 21
    • 0242609178 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-γ agonists modulate immunostimulated processing of amyloid precursor protein through regulation of β-secretase
    • Sastre M, Dewachter I, Landreth GE, Willson TM, Klockgether T, et al. (2003) Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-γ agonists modulate immunostimulated processing of amyloid precursor protein through regulation of β-secretase. J Neurosci 23: 9796-9804.
    • (2003) J Neurosci , vol.23 , pp. 9796-9804
    • Sastre, M.1    Dewachter, I.2    Landreth, G.E.3    Willson, T.M.4    Klockgether, T.5
  • 23
    • 0346055155 scopus 로고    scopus 로고
    • BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease
    • Ohno M, Sametsky EA, Younkin LH, Oakley H, Younkin SG, et al. (2004) BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease. Neuron 41: 27-33.
    • (2004) Neuron , vol.41 , pp. 27-33
    • Ohno, M.1    Sametsky, E.A.2    Younkin, L.H.3    Oakley, H.4    Younkin, S.G.5
  • 24
    • 0035881198 scopus 로고    scopus 로고
    • Toxoplasma gondii infection in the United States: seroprevalence and risk factors
    • Jones JL, Kruszon-Moran D, Wilson M, McQuillan G, Navin T, et al. (2001) Toxoplasma gondii infection in the United States: seroprevalence and risk factors. Am J Epidemiol 154: 357-365.
    • (2001) Am J Epidemiol , vol.154 , pp. 357-365
    • Jones, J.L.1    Kruszon-Moran, D.2    Wilson, M.3    McQuillan, G.4    Navin, T.5
  • 25
    • 68049116940 scopus 로고    scopus 로고
    • Toxoplasmosis snapshots: global status of Toxoplasma gondii seroprevalence and implications for pregnancy and congenital toxoplasmosis
    • Pappas G, Roussos N, Falagas ME, (2009) Toxoplasmosis snapshots: global status of Toxoplasma gondii seroprevalence and implications for pregnancy and congenital toxoplasmosis. Int J Parasitol 39: 1385-1394.
    • (2009) Int J Parasitol , vol.39 , pp. 1385-1394
    • Pappas, G.1    Roussos, N.2    Falagas, M.E.3
  • 26
    • 58849126114 scopus 로고    scopus 로고
    • Immunoregulation by Toxoplasma gondii infection prevents allergic immune responses in mice
    • Wagner A, Förster-Waldl E, Garner-Spitzer E, Schabussova I, Kundi M, et al. (2009) Immunoregulation by Toxoplasma gondii infection prevents allergic immune responses in mice. Int J Parasitol 39: 465-472.
    • (2009) Int J Parasitol , vol.39 , pp. 465-472
    • Wagner, A.1    Förster-Waldl, E.2    Garner-Spitzer, E.3    Schabussova, I.4    Kundi, M.5
  • 27
    • 0030841067 scopus 로고    scopus 로고
    • Host cells of Toxoplasma gondii encystation in infected primary culture from mouse brain
    • Fischer HG, Nitzgen B, Reichmann G, Groβ U, Hadding U, (1997) Host cells of Toxoplasma gondii encystation in infected primary culture from mouse brain. Parasitol Res 83: 637-641.
    • (1997) Parasitol Res , vol.83 , pp. 637-641
    • Fischer, H.G.1    Nitzgen, B.2    Reichmann, G.3    Groß, U.4    Hadding, U.5
  • 28
    • 0028954204 scopus 로고
    • IL-10 mediates immunosuppression following primary infection with Toxoplasma gondii in mice
    • Khan IA, Matsuura T, Kasper LH, (1995) IL-10 mediates immunosuppression following primary infection with Toxoplasma gondii in mice. Parasite Immunol 17: 185-195.
    • (1995) Parasite Immunol , vol.17 , pp. 185-195
    • Khan, I.A.1    Matsuura, T.2    Kasper, L.H.3
  • 29
    • 0030941325 scopus 로고    scopus 로고
    • Interleukin-10 downregulates the intracerebral immune response in chronic Toxoplasma encephalitis
    • Deckert-Schlüter M, Buck C, Weiner D, Kaefer N, Rang A, et al. (1997) Interleukin-10 downregulates the intracerebral immune response in chronic Toxoplasma encephalitis. J Neuroimmunol 76: 167-176.
    • (1997) J Neuroimmunol , vol.76 , pp. 167-176
    • Deckert-Schlüter, M.1    Buck, C.2    Weiner, D.3    Kaefer, N.4    Rang, A.5
  • 30
    • 22144487678 scopus 로고    scopus 로고
    • A critical role for IL-10 in limiting inflammation during toxoplasmic encephalitis
    • Wilson EH, Wille-Reece U, Dzierszinski F, Hunter CA, (2005) A critical role for IL-10 in limiting inflammation during toxoplasmic encephalitis. J Neuroimmunol 165: 63-74.
    • (2005) J Neuroimmunol , vol.165 , pp. 63-74
    • Wilson, E.H.1    Wille-Reece, U.2    Dzierszinski, F.3    Hunter, C.A.4
  • 31
    • 53349129897 scopus 로고    scopus 로고
    • Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation
    • doi:10.1186/1742-2094-5-37
    • Lee JW, Lee YK, Yuk DY, Choi DY, Ban SB, et al. (2008) Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation. J Neuroinflammation 5: 37 doi:10.1186/1742-2094-5-37.
    • (2008) J Neuroinflammation , vol.5 , pp. 37
    • Lee, J.W.1    Lee, Y.K.2    Yuk, D.Y.3    Choi, D.Y.4    Ban, S.B.5
  • 32
    • 77951617994 scopus 로고    scopus 로고
    • TGF-β1 blockade of microglial chemotaxis toward Aβ aggregates involves SMAD signaling and down-regulation of CCL5
    • doi:10.1186/1742-2094-7-28
    • Huang WC, Yen FC, Shie FS, Pan CM, Shiao YJ, et al. (2010) TGF-β1 blockade of microglial chemotaxis toward Aβ aggregates involves SMAD signaling and down-regulation of CCL5. J Neuroinflammation 7: 28 doi:10.1186/1742-2094-7-28.
    • (2010) J Neuroinflammation , vol.7 , pp. 28
    • Huang, W.C.1    Yen, F.C.2    Shie, F.S.3    Pan, C.M.4    Shiao, Y.J.5
  • 33
    • 0035731769 scopus 로고    scopus 로고
    • Interleukin-10 does not contribute to the pathogenesis of a virulent strain of Toxoplasma gondii
    • Wille U, Villegas EN, Striepen B, Roos DS, Hunter CA, (2001) Interleukin-10 does not contribute to the pathogenesis of a virulent strain of Toxoplasma gondii. Parasite Immunol 23: 291-296.
    • (2001) Parasite Immunol , vol.23 , pp. 291-296
    • Wille, U.1    Villegas, E.N.2    Striepen, B.3    Roos, D.S.4    Hunter, C.A.5
  • 34
    • 0037101616 scopus 로고    scopus 로고
    • Inflammation-dependent cerebral deposition of serum amyloid A protein in a mouse model of amyloidosis
    • Guo JT, Yu J, Grass D, de Beer FC, Kindy MS, (2002) Inflammation-dependent cerebral deposition of serum amyloid A protein in a mouse model of amyloidosis. J Neurosci 22: 5900-5909.
    • (2002) J Neurosci , vol.22 , pp. 5900-5909
    • Guo, J.T.1    Yu, J.2    Grass, D.3    de Beer, F.C.4    Kindy, M.S.5
  • 35
    • 0034744296 scopus 로고    scopus 로고
    • TGF-ß1 promotes microglial amyloid-ß clearance and reduces plaque burden in transgenic mice
    • Wyss-Coray T, Lin C, Yan F, Yu GQ, Rohde M, et al. (2001) TGF-ß1 promotes microglial amyloid-ß clearance and reduces plaque burden in transgenic mice. Nat Med 7: 612-618.
    • (2001) Nat Med , vol.7 , pp. 612-618
    • Wyss-Coray, T.1    Lin, C.2    Yan, F.3    Yu, G.Q.4    Rohde, M.5
  • 36
    • 33750591957 scopus 로고    scopus 로고
    • Deficiency in neuronal TGF-β signaling promotes neurodegeneration and Alzheimer's pathology
    • Tesseur I, Zou K, Esposito L, Bard F, Berber E, et al. (2006) Deficiency in neuronal TGF-β signaling promotes neurodegeneration and Alzheimer's pathology. J Clin Invest 116: 3060-3069.
    • (2006) J Clin Invest , vol.116 , pp. 3060-3069
    • Tesseur, I.1    Zou, K.2    Esposito, L.3    Bard, F.4    Berber, E.5
  • 37
    • 0031056838 scopus 로고    scopus 로고
    • Expression pattern and cellular origin of cytokines in the normal and Toxoplasma gondii-infected murine brain
    • Schlüter D, Kaefer N, Hof H, Wiestler OD, Deckert-Schlüter M, (1997) Expression pattern and cellular origin of cytokines in the normal and Toxoplasma gondii-infected murine brain. Am J Pathol 150: 1021-1035.
    • (1997) Am J Pathol , vol.150 , pp. 1021-1035
    • Schlüter, D.1    Kaefer, N.2    Hof, H.3    Wiestler, O.D.4    Deckert-Schlüter, M.5
  • 38
    • 77953289787 scopus 로고    scopus 로고
    • Acquired infection with Toxoplasma gondii in adult mice results in sensorimotor deficits but normal cognitive behavior despite widespread brain pathology
    • Gulinello M, Acquarone M, Kim JH, Spray DC, Barbosa HS, et al. (2010) Acquired infection with Toxoplasma gondii in adult mice results in sensorimotor deficits but normal cognitive behavior despite widespread brain pathology. Microb Infect 12: 528-537.
    • (2010) Microb Infect , vol.12 , pp. 528-537
    • Gulinello, M.1    Acquarone, M.2    Kim, J.H.3    Spray, D.C.4    Barbosa, H.S.5
  • 39
    • 0028886480 scopus 로고
    • Toxoplasma gondii comprises three clonal lineages: correlation of parasite genotype with human disease
    • Howe DK, Sibley LD, (1995) Toxoplasma gondii comprises three clonal lineages: correlation of parasite genotype with human disease. J Infect Dis 172: 1561-1566.
    • (1995) J Infect Dis , vol.172 , pp. 1561-1566
    • Howe, D.K.1    Sibley, L.D.2
  • 40
    • 0030997436 scopus 로고    scopus 로고
    • Determination of genotypes of Toxoplasma gondii strains isolated from patients with toxoplasmosis
    • Howe DK, Honoré S, Derouin F, Sibley LD, (1997) Determination of genotypes of Toxoplasma gondii strains isolated from patients with toxoplasmosis. J Clin Microbiol 35: 1411-1414.
    • (1997) J Clin Microbiol , vol.35 , pp. 1411-1414
    • Howe, D.K.1    Honoré, S.2    Derouin, F.3    Sibley, L.D.4
  • 41
    • 0029742199 scopus 로고    scopus 로고
    • Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice
    • Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, et al. (1996) Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice. Science 274: 99-102.
    • (1996) Science , vol.274 , pp. 99-102
    • Hsiao, K.1    Chapman, P.2    Nilsen, S.3    Eckman, C.4    Harigaya, Y.5
  • 42
    • 0035863055 scopus 로고    scopus 로고
    • Age-dependent changes in brain, CSF, and plasma amyloid β protein in the Tg2576 transgenic mouse model of Alzheimer's disease
    • Kawarabayashi T, Younkin LH, Saido TC, Shoji M, Ashe KH, et al. (2001) Age-dependent changes in brain, CSF, and plasma amyloid β protein in the Tg2576 transgenic mouse model of Alzheimer's disease. J Neurosci 21: 372-381.
    • (2001) J Neurosci , vol.21 , pp. 372-381
    • Kawarabayashi, T.1    Younkin, L.H.2    Saido, T.C.3    Shoji, M.4    Ashe, K.H.5
  • 43
    • 77749320911 scopus 로고    scopus 로고
    • S100a9 knockdown decreases the memory impairment and the neuropathology in Tg2576, AD animal model
    • Ha TY, Chang KA, Kim JA, Kim HS, Kim S, et al. (2010) S100a9 knockdown decreases the memory impairment and the neuropathology in Tg2576, AD animal model. PLoS One 5: e8840.
    • (2010) PLoS One , vol.5
    • Ha, T.Y.1    Chang, K.A.2    Kim, J.A.3    Kim, H.S.4    Kim, S.5
  • 44
    • 77954439852 scopus 로고    scopus 로고
    • Suppressed CD31 expression in sarcoma-180 tumors after injection with Toxoplasma gondii lysate antigen in BALB/c mice
    • Pyo KH, Jung BK, Chai JY, Shin EH, (2010) Suppressed CD31 expression in sarcoma-180 tumors after injection with Toxoplasma gondii lysate antigen in BALB/c mice. Korean J Parasitol 48: 171-174.
    • (2010) Korean J Parasitol , vol.48 , pp. 171-174
    • Pyo, K.H.1    Jung, B.K.2    Chai, J.Y.3    Shin, E.H.4
  • 45
    • 51149120624 scopus 로고    scopus 로고
    • Microglial dysfunction and defective β-amyloid clearance pathways in aging Alzheimer's disease mice
    • Hickman SE, Allison EK, El Khoury J, (2008) Microglial dysfunction and defective β-amyloid clearance pathways in aging Alzheimer's disease mice. J Neurosci 28: 8354-8360.
    • (2008) J Neurosci , vol.28 , pp. 8354-8360
    • Hickman, S.E.1    Allison, E.K.2    El Khoury, J.3
  • 46
    • 55749113001 scopus 로고    scopus 로고
    • Role of microglial IKKβ in kainic acid-induced hippocampal neuronal cell death
    • Cho IH, Hong J, Suh EC, Kim JH, Lee H, et al. (2008) Role of microglial IKKβ in kainic acid-induced hippocampal neuronal cell death. Brain 131: 3019-3033.
    • (2008) Brain , vol.131 , pp. 3019-3033
    • Cho, I.H.1    Hong, J.2    Suh, E.C.3    Kim, J.H.4    Lee, H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.