Expression pattern and cellular origin of cytokines in the normal and Toxoplasma gondii-infected murine brain

American Journal of Pathology

Volumn 150, Issue 3, 1997, Pages 1021-1035

  Schlüter, Dirk ^a   Kaefer, Nadja ^a   Hof, Herbert ^a   Wiestler, Otmar D ^b   Deckert Schlüter, Martina ^b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY HOSPITAL BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; NITRIC OXIDE SYNTHASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM INFECTION; CHOROID PLEXUS; CONTROLLED STUDY; ENCEPHALITIS; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INFLAMMATION; INFLAMMATORY CELL; LYMPHOCYTE SUBPOPULATION; MICROGLIA; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TOXOPLASMA GONDII; TOXOPLASMOSIS;

ANIMALS; BASE SEQUENCE; BRAIN; CYTOKINES; ENCEPHALITIS; FEMALE; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; IMMUNOMAGNETIC SEPARATION; IMMUNOPHENOTYPING; IN SITU HYBRIDIZATION; LYMPHOCYTE SUBSETS; MICE; MICE, INBRED BALB C; NERVE GROWTH FACTORS; POLYMERASE CHAIN REACTION; RNA, MESSENGER; TOXOPLASMA; TOXOPLASMOSIS, ANIMAL; UP-REGULATION;

EID: 0031056838     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Farrar WL, Hill JM, Harel-Bellan A, Vinocour M: The immune logical brain. Immunol Rev 1987, 100:361-378
2. Wesselingh SL, Levine B, Fox RJ, Choi S, Griffin DE: Intracerebral cytokine mRNA expression during fatal and nonfatal α-virus encephalitis suggests a predominant type 2 T cell response. J Immunol 1994, 152: 1289-1297
3. Hunter CA, Roberts CW, Alexander J: Kinetics of cytokine mRNA production in the brains of mice with progressive toxoplasmic encephalitis. Eur J Immunol 1992, 22:2317-2322
4. Deckert-Schlüter M, Albrecht S, Hof H, Wiestler OD, Schlüter D: Dynamics of the intracerebral and splenic cytokine mRNA production in Toxoplasma gondii-resistant and -susceptible congenic strains of mice. Immunology 1995, 408-418
5. Schlüter D, Deckert-Schlüter M, Schwendemann G, Brunner H, Hof H: Expression of major histocompatibility complex class II antigens and levels of interferon-γ, tumor necrosis factor, and interleukin-6 in cerebrospinal fluid and serum in Toxoplasma gondii-infected SCID and immunocompetent C.B-17 mice. Immunology 1993, 78:430-435
6. Deckert-Schlüter M, Schlüter D Schmidt D, Schwendemann G, Wiestler OD, Hof H: Toxoplasma encephalitis in congenic B10 and BALB mice: impact of genetic factors on the immune response. Infect Immun 1994, 62:221-228
7. Suzuki Y, Orellana MA, Schreiber RD, Remington JS: Interferon-γ: the major mediator of resistance against Toxoplasma gondii. Science 1988, 240:516-518
8. + T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii. J Immunol 1992, 149:175-180
9. Gazzinelli RT, Eltoum I, Wynn TA, Sher A: Acute cerebral toxoplasmosis is induced by in vivo neutralization of tumor necrosis factor-α and correlates with the the down-regulated expression of inducible nitric oxide synthase and other markers of macrophage activation. J Immunol 1993, 151:3672-3681
10. Langermanns JAM, van der Hulst MEB, Nibberding PH, van Furth R: Endogenous tumor necrosis factor-α is required for enhanced antimicrobial activity against Toxoplasma gondii and Listeria monocytogenes in recombinant γ-interferon-treated mice. Infect Immun 1992, 60:5107-5112