The dock-and-lock method combines recombinant engineering with site-specific covalent conjugation to generate multifunctional structures

Bioconjugate Chemistry

Volumn 23, Issue 3, 2012, Pages 309-323

  Rossi, Edmund A ^a,c   Goldenberg, David M ^b   Chang, Chien Hsing ^a,c  

^a IBC Pharmaceuticals Inc   (United States)

^b CENTER FOR MOLECULAR MEDICINE AND IMMUNOLOGY   (United States)

^c IMMUNOMEDICS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; DIAGNOSIS; DOCKS; ENZYMES; HYDRAULIC STRUCTURES; RECOMBINANT PROTEINS;

COMPLEX FUSION; FLUORESCENT MARKERS; FUSION PROTEINS; IN-VITRO; MULTI-FUNCTIONAL DESIGN; MULTIFUNCTIONAL STRUCTURES; SITE-SPECIFIC; SPECIFIC CONJUGATIONS; VITRO AND IN VIVO; VIVO APPLICATIONS;

LOCKS (FASTENERS);

20 20 20 ANTIBODY; 20 2B 2B ANTIBODY; ALPHA INTERFERON; ANTIBODY CONJUGATE; ANTIBODY TF1; ANTIBODY TF2; BISPECIFIC ANTIBODY; CYCLIC AMP DEPENDENT PROTEIN KINASE; MACROGOL; PEGINTERFERON ALPHA2A; UNCLASSIFIED DRUG; VELTUZUMAB;

ARTICLE; CONJUGATION; COVALENT BOND; DIAGNOSTIC IMAGING; DOCK AND LOCK METHOD; DRUG STRUCTURE; DRUG TARGETING; HUMAN; LYMPHOMA; NONHODGKIN LYMPHOMA; NONHUMAN; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN STRUCTURE; STRUCTURE ANALYSIS; TUMOR;

RUMEX;

EID: 84863337696     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc2004999     Document Type: Article

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